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Simultaneous radiochemotherapy in the treatment of inoperable, locally advanced head and neck cancers: a single-institution study
Copyright 9 Munksgaard 1997
Int, J, Oral Maxillofac. Surg. 1997; 26:399 Printed in Denmark. All rights reserved
InternationalJournal of
Oral 8c MaxillofacialSurgery ISSN 0901-5027
Abstracts from international literature Cherubism: regression of the lesions and spontaneous bone regeneration G. C. Timosca Rev Stomatol Chir Maxillofac 1996: 97: 172-97
Three case reports of spontaneous regression of central bony lesions in patients with cherubism are described. During a 7-year follow up, the bony lesions became smaller spontaneously but osseous regeneration occurred only partially. Radiographically some radiolucent areas of low intensity and some areas of sclerotic bone still persisted. In one case, a peripheral giant cell granuloma was found in the oral cavity but was not associated with a bony lesion of the cherubism. The author does not suggest any hypothesis to try to explain this spontaneous regression but only confirms previous similar reports. H. REYCHLER
Internal derangement of the temporomandibular joint: correlation of magnetic resonance imaging and clinical parameters Ch. MQIler-Leise, M. Augthun, A. Roth, W. Bauer, R. W. GLinther
internal derangement of the temporomandibular joints. 117 temporomandibular joints were investigated prospectively in 59 symptomatic patients and 31 asymptomatic volunteers. The results were correlated with clinical parameters. Increasing degrees of internal derangements were associated with increasing deformity of the disc, signal intensity of the posterior band, decreasing thickness of the bilaminar zone and the maximum mouth opening, increasing proliferative bony changes, and reduced transitory movement of the condyle, which in addition was displaced upward and backward in the cranial fossa. The reported intensity of pain was dependent on the degree of disc displacement and condylar changes. Other clinical parameters such as joint noises and muscle pain were found to be inaccurate in predicting disc displacement. H. SCHLIEPHAKE
Simultaneous radiochemotherapy in the treatment of inoperable, locally advanced head and neck cancers: a single-institution study G. Franchin, C. Gobitti, E. Minatel, L. Barzan, A. De Paoli, G. Boz, M. Mascarin, S. Lamon, M. G. Trovo
Fortschr R~ntgenstr 1996: 165(3): 264-9
Cancer 1995: 75:1025-9
A study is reported, the purpose of which was to evaluate the value of magnetic resonance imaging in symptomatic patients with different degrees of
Patients with advanced, inoperable head and neck cancers have cure rates of approximately 10-15%. In these patients, concomitant chemo- and radio-
therapy seem to improve local control and survival. 5-Fluomuracil (5-FU), administered by continuous infusion, and cisplatin plus concomitant conventional radiation therapy may be promising in treating advanced, inoperable head and neck cancers. Forty-five evaluable patients with primary nonmetastatic, inoperable head and neck cancers were treated. From January 1987 to April 1988, the patients were treated with cisplatin plus radiation therapy (group 1), and from May 1988 to November 1990, they were treated with the same combination plus 5-FU, given in continuous infusion (group 2). Clinical and pathologic responses were assessed after radiation therapy was completed. Patients who relapsed underwent salvage surgery, if possible. The diseasefree and overall survival rates of the patients were evaluated. The overall response rate (complete and partial response) was 93%, 60% of which comprised complete remissions. Despite the high response rates obtained in the two groups, the time to progression for complete responses and the median survival time were unsatisfactory (13 9[group 1] and 10 months [group 2], and 17 [group 1] and 16 months [group 2], respectively). The toxicity rate from two treatments was not relevant. Grade II mucositis, according to the World Health Organization, was found in 25 patients, in five of whom the treatment was interrupted for 7 10 days. In this study, despite an improvement in the number of complete responses, the chemotherapeutic regimen with or without 5-FU did not prolong the overall patient survival rate significantly. H, TIDEMAN
Int, J, Oral Maxillofac. Surg. 1997; 26:399 Printed in Denmark. All rights reserved
InternationalJournal of
Oral 8c MaxillofacialSurgery ISSN 0901-5027
Abstracts from international literature Cherubism: regression of the lesions and spontaneous bone regeneration G. C. Timosca Rev Stomatol Chir Maxillofac 1996: 97: 172-97
Three case reports of spontaneous regression of central bony lesions in patients with cherubism are described. During a 7-year follow up, the bony lesions became smaller spontaneously but osseous regeneration occurred only partially. Radiographically some radiolucent areas of low intensity and some areas of sclerotic bone still persisted. In one case, a peripheral giant cell granuloma was found in the oral cavity but was not associated with a bony lesion of the cherubism. The author does not suggest any hypothesis to try to explain this spontaneous regression but only confirms previous similar reports. H. REYCHLER
Internal derangement of the temporomandibular joint: correlation of magnetic resonance imaging and clinical parameters Ch. MQIler-Leise, M. Augthun, A. Roth, W. Bauer, R. W. GLinther
internal derangement of the temporomandibular joints. 117 temporomandibular joints were investigated prospectively in 59 symptomatic patients and 31 asymptomatic volunteers. The results were correlated with clinical parameters. Increasing degrees of internal derangements were associated with increasing deformity of the disc, signal intensity of the posterior band, decreasing thickness of the bilaminar zone and the maximum mouth opening, increasing proliferative bony changes, and reduced transitory movement of the condyle, which in addition was displaced upward and backward in the cranial fossa. The reported intensity of pain was dependent on the degree of disc displacement and condylar changes. Other clinical parameters such as joint noises and muscle pain were found to be inaccurate in predicting disc displacement. H. SCHLIEPHAKE
Simultaneous radiochemotherapy in the treatment of inoperable, locally advanced head and neck cancers: a single-institution study G. Franchin, C. Gobitti, E. Minatel, L. Barzan, A. De Paoli, G. Boz, M. Mascarin, S. Lamon, M. G. Trovo
Fortschr R~ntgenstr 1996: 165(3): 264-9
Cancer 1995: 75:1025-9
A study is reported, the purpose of which was to evaluate the value of magnetic resonance imaging in symptomatic patients with different degrees of
Patients with advanced, inoperable head and neck cancers have cure rates of approximately 10-15%. In these patients, concomitant chemo- and radio-
therapy seem to improve local control and survival. 5-Fluomuracil (5-FU), administered by continuous infusion, and cisplatin plus concomitant conventional radiation therapy may be promising in treating advanced, inoperable head and neck cancers. Forty-five evaluable patients with primary nonmetastatic, inoperable head and neck cancers were treated. From January 1987 to April 1988, the patients were treated with cisplatin plus radiation therapy (group 1), and from May 1988 to November 1990, they were treated with the same combination plus 5-FU, given in continuous infusion (group 2). Clinical and pathologic responses were assessed after radiation therapy was completed. Patients who relapsed underwent salvage surgery, if possible. The diseasefree and overall survival rates of the patients were evaluated. The overall response rate (complete and partial response) was 93%, 60% of which comprised complete remissions. Despite the high response rates obtained in the two groups, the time to progression for complete responses and the median survival time were unsatisfactory (13 9[group 1] and 10 months [group 2], and 17 [group 1] and 16 months [group 2], respectively). The toxicity rate from two treatments was not relevant. Grade II mucositis, according to the World Health Organization, was found in 25 patients, in five of whom the treatment was interrupted for 7 10 days. In this study, despite an improvement in the number of complete responses, the chemotherapeutic regimen with or without 5-FU did not prolong the overall patient survival rate significantly. H, TIDEMAN