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Smooth muscle motor-units in small blood vessels
430
AMERICAN
Fulton, G. P., and Lutz, Vessels. Am. J. Physiol.
HEART
Smooth
B. R.: 135:
531,
JOURNAL
Muscle
Motor-Units
in Small
Blood
1942.
Stimulation of minute nerves, with a microelectrode, produced vascular responses, generally dilatation followed by constriction, in vessels of the retrolingual membrane of the frog, Bonn pi@e%s. The suggest the concept of smooth muscle motor-units in small blood
spatially limited the small blood limited responses vessels.
Seymour, w. B., Pritchard, w. H., Longley, L. P., and Hayman, J. M.: Cardiac Output, Blood and Interstitial Fluid Volumes, Total Circulating Serum Protein, and Kidney Function During Cardiac Failure and After Improvement. J. Clin. Investigation
21:
229, 1942.
Estimations of cardiac output, volume of blood and interstitial fluid, coneentration and total amount of plasma proteins, and of inulin, phenol red and urea clearances were made on six patients with congestive heart failure and again after restoration of compensation by digitalis and diuretics. Cardiac output and stroke volume increased with improvement in all cases. The mean minute output during failure was 31 per cent less than after improvement. Effective peripheral resistance decreased coincidentally with improvement. Blood and serum volumes also decreased with recovery, the mean change in blood volume being 1.15 liters or 25 per cent, and in serum volume 0.92 liter or 35 per cent of the volumes during failure. In spite of a marked decrease in the volume of intercellular fluid, the mean value after restoration of compensation was 32 per cent total body weight, or almost 50 per cent above normal. While the concentration of serum proteins, particularly of the globulin fraction, increased with clinical improvement, the total amount of circulating protein decreased, due almost entirely to a decrease in serum albumin. Inulin clearance showed no significant change with improvement, while phenol red clearance increased to approximately the same degree as cardiac output. AUTHORS.
Theis, F. V., and Freeland,
M. R.:
Thromboangiitis
Obliterans.
Surgery
11:
101,
1942. The clinical results in the treatment of the biochemical blood changes in acute or active thromboangiitis obliterans with sodium tetrathionate or sodium thiosulfate and of the peripheral circulatory deficiency due to arterial thromboses with pavaex treatment have been most encouraging. Deficient oxygenation of the arterial blood was usually present during the active stage of the disease. Following treatment for two to six weeks, the increased oxygenation of the arterial blood was accompanied by clinical improvement and in some cases by clinical recovery (five years). The oxygenation of the arterial blood in the majority of patients with thromboangiitis obliterans which we studied was affected by smoking. AUTHORS.
of Cardiovascular Dublin, L. I., and Marks, H. II.: A Note on the Inheritance Disease-Results of Life Insurance Investigations. J. Mt. Sinai Hosp. 8: 483, 1942. These several studies point to a definite relationship between parents and offspring The clinical studies have generally shown with respect to cardiovascular diseases. that among patients with any form or symptom of the diseases, there is a high inIn the insurance cidence of these diseases or symptoms in the parental history.
AMERICAN
Fulton, G. P., and Lutz, Vessels. Am. J. Physiol.
HEART
Smooth
B. R.: 135:
531,
JOURNAL
Muscle
Motor-Units
in Small
Blood
1942.
Stimulation of minute nerves, with a microelectrode, produced vascular responses, generally dilatation followed by constriction, in vessels of the retrolingual membrane of the frog, Bonn pi@e%s. The suggest the concept of smooth muscle motor-units in small blood
spatially limited the small blood limited responses vessels.
Seymour, w. B., Pritchard, w. H., Longley, L. P., and Hayman, J. M.: Cardiac Output, Blood and Interstitial Fluid Volumes, Total Circulating Serum Protein, and Kidney Function During Cardiac Failure and After Improvement. J. Clin. Investigation
21:
229, 1942.
Estimations of cardiac output, volume of blood and interstitial fluid, coneentration and total amount of plasma proteins, and of inulin, phenol red and urea clearances were made on six patients with congestive heart failure and again after restoration of compensation by digitalis and diuretics. Cardiac output and stroke volume increased with improvement in all cases. The mean minute output during failure was 31 per cent less than after improvement. Effective peripheral resistance decreased coincidentally with improvement. Blood and serum volumes also decreased with recovery, the mean change in blood volume being 1.15 liters or 25 per cent, and in serum volume 0.92 liter or 35 per cent of the volumes during failure. In spite of a marked decrease in the volume of intercellular fluid, the mean value after restoration of compensation was 32 per cent total body weight, or almost 50 per cent above normal. While the concentration of serum proteins, particularly of the globulin fraction, increased with clinical improvement, the total amount of circulating protein decreased, due almost entirely to a decrease in serum albumin. Inulin clearance showed no significant change with improvement, while phenol red clearance increased to approximately the same degree as cardiac output. AUTHORS.
Theis, F. V., and Freeland,
M. R.:
Thromboangiitis
Obliterans.
Surgery
11:
101,
1942. The clinical results in the treatment of the biochemical blood changes in acute or active thromboangiitis obliterans with sodium tetrathionate or sodium thiosulfate and of the peripheral circulatory deficiency due to arterial thromboses with pavaex treatment have been most encouraging. Deficient oxygenation of the arterial blood was usually present during the active stage of the disease. Following treatment for two to six weeks, the increased oxygenation of the arterial blood was accompanied by clinical improvement and in some cases by clinical recovery (five years). The oxygenation of the arterial blood in the majority of patients with thromboangiitis obliterans which we studied was affected by smoking. AUTHORS.
of Cardiovascular Dublin, L. I., and Marks, H. II.: A Note on the Inheritance Disease-Results of Life Insurance Investigations. J. Mt. Sinai Hosp. 8: 483, 1942. These several studies point to a definite relationship between parents and offspring The clinical studies have generally shown with respect to cardiovascular diseases. that among patients with any form or symptom of the diseases, there is a high inIn the insurance cidence of these diseases or symptoms in the parental history.