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Social cognition in children with 22q11 deletion syndrome
e u r o p e a n j o u r n a l o f p a e d i a t r i c n e u r o l o g y 2 1 ( 2 0 1 7 ) e 1 4 1 ee 1 4 4
Official Journal of the European Paediatric Neurology Society
Abstracts of EPNS 2017 e 12th European Paediatric Neurology Society Congress, 20e24 June 2017, Lyon, France
Thursday, June 22
population of children with 22s11 deletion syndrome. Researches concerning the relationships between social cognition and both cognitive deficits and functioning in daily life had to be continued.
NEUROPSYCHIATRY
http://dx.doi.org/10.1016/j.ejpn.2017.04.1284
P2-139 Social cognition in children with 22q11 deletion syndrome
P2-140 Correlation between sleep disorders and ADHD in children with absence epilepsy: An observational study
POSTER PRESENTATIONS
€lle Babinet, Caroline Demily, Elodie Peyroux, Marie Noe Costanza Cannarsa, George Michael. GENOPSY e Centre regional de depistage et de prises en charge des troubles psychiatriques d'origine genetique e CH Le Vinatier, France Objective: 22q11 deletion syndrome is the most common microdeletion syndrome in the general population. Neurocognitive and social cognitive impairments are frequently observed in people with 22q11 deletion syndrome. Nevertheless, only few studies have examined the links between social cognition and both neurocognitive impairments and social functioning. However, social cognition seems to play the role of mediator between neurocognition and behavior in other psychiatric populations such as schizophrenia. Methods: In this study, we compared two groups of participants from 5 to 13 years old: a group of 20 children carrying microdeletion 22q11 and a group of 20 healthy controls matched in age and sex. We used a new experimental paradigm (ACQUISS) assessing 3 components of social cognition: facial emotion recognition, social situations understanding and vocal emotion recognition. In addition, we studied links between social cognitive measures and both attentional and visuo-spatial abilities, and we assessed impacts of social cognitive impairments on both components of functioning, such as aggression or behavioral disorders, and clinical features, such as depression and attentional disorders. Results: Patients with 22q11 deletion syndrome had significantly lower results in the three components of social cognition assessed (facial emotions recognition: controls¼88%; 22q11¼76%; p<.01; social situations understanding: controls¼72%; 22q11¼49%; p<.01; and vocal emotion recognition: controls¼81%; 22q11¼46%; p<.01). However, results did not show any significant impact of attentional and/or visuospatial processes on social cognitive abilities. Moreover results obtained by participants in ACQUISS'tasks did not predict the behavioral disorders of patients with 22q11 deletion syndrome. Conclusion: These results contribute to the understanding of social cognitive impairment in
1090-3798
Maddalena Ducaa,b, Carlo Cottonea,b, Lucia Maltonia,b, Matteo Miglioria,b, Antonia Parmeggiania,b, Emilio Franzonia, Leslie Nollacea,b, Vania Herbillona,b, Faustine Ilski-Lecoaneta,b, Julitta De Bellescizea,b, Eleni Panagiotakakia,b, Patricia Francoa,b, Alexis Arzimanogloub. aUO Neuropsichiatria Infantile, Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna, Italy. bDepartment of Pediatric Clinical Epileptology, Sleep Disorders and Functional Neurology, University Hospitals of Lyon, Lyon, France Objective: The authors investigated sleep disorders (SD) and ADHD in children with absence epilepsy (AE) and the correlation with adverse effects of antiepileptics drugs (AED). Methods: Inclusion criteria: age 5-16 years, epilepsy with typical absences diagnosis, normal neurological examination. Parents completed questionnaires on sleep, AED side effects, school performances, learning problems, ADHD rating scale. Results were compared to an healthy sample. Our population was then divided into 2 groups: with and without seizures at last examination. Number, gender, family and personal history for epilepsy or febrile convulsions, AED, neuropsychological tests results when available, presence of SD were analyzed. The statistical relationships between a) SD and ADHD with AED adverse effects, b) SD and ADHD symptoms, c) the variance analysis between ADHD and SD considering the presence of seizures with the adverse effects as covariate, were considered. Results: Seventy children with absence seizures were included in the study; 59% controlled by AED. Neuropsychological evaluation was performed in 63%, in 51% identifying one or more deficient domains. 50% had ADHD clinical diagnosis, ADHD Rating scale, performed by all sample, was positive in 37%. SD were reported in 43 % of patients: 21% breath disorders, 16% insomnia, 19% parasomnia, 11% non-restoring sleep and 11% excessive sleepiness. Statistical difference for SD was found between children with epilepsy and healthy controls (p < 0.001), no difference in SD between subgroups with and without seizures; statistical correlation respectively of SD (p<0.001), and ADHD (p¼0.000) with
Official Journal of the European Paediatric Neurology Society
Abstracts of EPNS 2017 e 12th European Paediatric Neurology Society Congress, 20e24 June 2017, Lyon, France
Thursday, June 22
population of children with 22s11 deletion syndrome. Researches concerning the relationships between social cognition and both cognitive deficits and functioning in daily life had to be continued.
NEUROPSYCHIATRY
http://dx.doi.org/10.1016/j.ejpn.2017.04.1284
P2-139 Social cognition in children with 22q11 deletion syndrome
P2-140 Correlation between sleep disorders and ADHD in children with absence epilepsy: An observational study
POSTER PRESENTATIONS
€lle Babinet, Caroline Demily, Elodie Peyroux, Marie Noe Costanza Cannarsa, George Michael. GENOPSY e Centre regional de depistage et de prises en charge des troubles psychiatriques d'origine genetique e CH Le Vinatier, France Objective: 22q11 deletion syndrome is the most common microdeletion syndrome in the general population. Neurocognitive and social cognitive impairments are frequently observed in people with 22q11 deletion syndrome. Nevertheless, only few studies have examined the links between social cognition and both neurocognitive impairments and social functioning. However, social cognition seems to play the role of mediator between neurocognition and behavior in other psychiatric populations such as schizophrenia. Methods: In this study, we compared two groups of participants from 5 to 13 years old: a group of 20 children carrying microdeletion 22q11 and a group of 20 healthy controls matched in age and sex. We used a new experimental paradigm (ACQUISS) assessing 3 components of social cognition: facial emotion recognition, social situations understanding and vocal emotion recognition. In addition, we studied links between social cognitive measures and both attentional and visuo-spatial abilities, and we assessed impacts of social cognitive impairments on both components of functioning, such as aggression or behavioral disorders, and clinical features, such as depression and attentional disorders. Results: Patients with 22q11 deletion syndrome had significantly lower results in the three components of social cognition assessed (facial emotions recognition: controls¼88%; 22q11¼76%; p<.01; social situations understanding: controls¼72%; 22q11¼49%; p<.01; and vocal emotion recognition: controls¼81%; 22q11¼46%; p<.01). However, results did not show any significant impact of attentional and/or visuospatial processes on social cognitive abilities. Moreover results obtained by participants in ACQUISS'tasks did not predict the behavioral disorders of patients with 22q11 deletion syndrome. Conclusion: These results contribute to the understanding of social cognitive impairment in
1090-3798
Maddalena Ducaa,b, Carlo Cottonea,b, Lucia Maltonia,b, Matteo Miglioria,b, Antonia Parmeggiania,b, Emilio Franzonia, Leslie Nollacea,b, Vania Herbillona,b, Faustine Ilski-Lecoaneta,b, Julitta De Bellescizea,b, Eleni Panagiotakakia,b, Patricia Francoa,b, Alexis Arzimanogloub. aUO Neuropsichiatria Infantile, Azienda Ospedaliero Universitaria Policlinico S. Orsola-Malpighi, Bologna, Italy. bDepartment of Pediatric Clinical Epileptology, Sleep Disorders and Functional Neurology, University Hospitals of Lyon, Lyon, France Objective: The authors investigated sleep disorders (SD) and ADHD in children with absence epilepsy (AE) and the correlation with adverse effects of antiepileptics drugs (AED). Methods: Inclusion criteria: age 5-16 years, epilepsy with typical absences diagnosis, normal neurological examination. Parents completed questionnaires on sleep, AED side effects, school performances, learning problems, ADHD rating scale. Results were compared to an healthy sample. Our population was then divided into 2 groups: with and without seizures at last examination. Number, gender, family and personal history for epilepsy or febrile convulsions, AED, neuropsychological tests results when available, presence of SD were analyzed. The statistical relationships between a) SD and ADHD with AED adverse effects, b) SD and ADHD symptoms, c) the variance analysis between ADHD and SD considering the presence of seizures with the adverse effects as covariate, were considered. Results: Seventy children with absence seizures were included in the study; 59% controlled by AED. Neuropsychological evaluation was performed in 63%, in 51% identifying one or more deficient domains. 50% had ADHD clinical diagnosis, ADHD Rating scale, performed by all sample, was positive in 37%. SD were reported in 43 % of patients: 21% breath disorders, 16% insomnia, 19% parasomnia, 11% non-restoring sleep and 11% excessive sleepiness. Statistical difference for SD was found between children with epilepsy and healthy controls (p < 0.001), no difference in SD between subgroups with and without seizures; statistical correlation respectively of SD (p<0.001), and ADHD (p¼0.000) with