Soluble L-selectin in peripheral arterial disease: relationship with soluble E-selectin and soluble P-selectin A a
B
o S
b
U
o M
S
J H
o
U
R
M M D o S D
H
1D
1
r
C N
L N
M 2 A
M
1
a
D L t
A
n Mu M n
D 1 M
1
M
e U a o 8e e U a
e
o
a
e
Abstract
S L p a ( +S i i l o s i ( ~ t s a m o r l K
1.
E
w m i a s c- c s o- 4 p s m c L o es L w 1 ~ t p c t 1 2 r i t c ( 0 T w a n E ( +1 r v 5 ~2 r P = O1 b l o sP P =0 1 T w n s c b 1 r v 1 ~9 r n o w a l i Tet d p t t r f f a o t s s i p a ea m h i i c i e u n k d
S
a
L
a P 4 a a
S
E
S
A
m p a s a t e a m
*C
a
m c
T
c b o t b v c a t f c b c i
+ 4
2
f o + 1
0 5 S
0 1 -
5
E -
S
I
L
A
e -
r
i a
o
w a d t
o o
h f
-
e e e o t
o -
gn s a t i s a t i f A f f g i t s i b o doo s f a h t m l E e ( e on o a e i c P ( p i pod al a a c o t m o t e d c s o t W b a L ( out s 9 r p f o l T t m b 6s
I
I w T
0 P
P
w -o r2 d
A 0r
r
0 0
m
t
u
e
l /
c (
r
2
A B
e a /A
1
i i b r a e o l i t i o t b v w [ S f o E a P c a b f i t p o h s j a p w a w s o d i a [ H t a o t s w t s i t w d i l o s L i p a d a t c l w t o s s P A L b E a i f o l [ t m o t c m a p i a t o o s l o t m s a l i f f i p w a [ t
2 M 2
S P
s o t d M t c v t w s a t r b l a w i t C j
w
A
a
a
D
c i ( o o w r f v o S c a t U C s t b o s s a t w a o t w d f a f e v h r o f m o a f h h s A c a f v d E c f a s w m o c l a k d c t d o a e s g t 2 m S a d p w r i e s f a m o t m r S w i t w s c a t a h w r ( i l c w s T a o S M H A E a i c f e s w o
f
2
a
A F
o t > 7 a p H ( a y
p v
b
w
o
b
9
(
2
t
h
a a n f n xn v i e t A w d t a t w -a os c a w E a t w a B w a t c n i a r t f am o oa h a t s h f o c pn w w i c f t m a 2i r e o (= 1 x g a 4 a w s a –e o u a L o s E si - w o L a pP m u m a e b Ee k f R & D S ( Ln 4 T o Q A O O 3 eU r o v u I c f a I ht r C E a w < 5 c P L s w a a b s t f t c t h l e t r ( c a l d l c C p u f h ( w m u a f t ( o a K c o a an t A f b c a lh a of t B u c d w p o t s Er i e e e s u a C S o n i r u o 2 Sa to b n w N d o e a y u t n t M r U a a u v a b s e h l r r e a o u i T o q i r y i u t Xr t D e i m a s d r o p a i i pe l i a u R o n b T w n d i s a d p H a rp o s n t g ( 1 T d o s a t a w r c a b
N t S t t n o n sa w b n d b r b w m M 8 ( ( w c a p a m a f a
3
b b t
d
d
w
i i ia d d S
a
A B
T e S t b c F t
w d i t c L b m i a E w 5 r a 5 2 i t p ( L w 1 2 r a 1 t 2 i t p 1 S P w 1 ~ c a 2 + 1 i t p
e a /A
2 (
t f i t 0
T C
i ( 9 r
D
(
●
t 0
h a x 1 c r l P=0 x 1 c c t p g w t g o s t l r e o t v ( 1 T r
e
y . . ..... . 8 . . e
.“.
.
●“.
.00
. .e
. “
i .
.
u n
o -
e “
-4
o e
F t
1 S m v
n
e i p
L
n A o Controls
A Patients
t
oe
n a c n i
T
e h a n
a b i
er
* *
7 + 1
6
0
~ 1
1
(
1
h
r0
(
( ( ( (
1 3 1 8
i 0 * 0 + ~ 1
1 4 1 8
* i t ~
0 1 2 1
0 0 0 0
3
t 0 k 2
3
i 1 f 3
0 0
( i (VO)
c b t i
2
2
1
0
1 D m (
a
m a
a r
s (
d
e o
p
l
f
o
n
d
e
i
o s L oi p a a v a h c w o r o r s y P ( d f a p a o e c n r s E mb 0 p o t0 ie i s m o p w p v d m [ D i t r f f m a t l w etm m a t o t d i T a c f r o s L l i h d O d c w t o S e a [ w m f h l o s L i ma l w i b c a t a e r c et l ca i v M a Z a R [ a f n i L i l e w
m
l d p s d ( n e a a
(
*R ( p
: .
o .
a
P v 61 f 11
7
m
T
S
.
n
e
6 &1
m (
“
o
..... ....
8
o
“.
-
O P
5
d
a
: .. e1
e
o
●
Soluble L selectin (ng/mL)
(
a
●
1 i
ir o
.
-
(
B
.
-
D C
H L S D F
h
h
4 D a
(VO
2
i –
c S
1
A S C
t
2
0 R t t c t p n ( ~ 2 v 3 ~ 1 P=0 l ( 2 1 v 1 0 x 1 c a t ( ~ 2 v 6 ~ 1 P=0 l T o s r i t c a a t a a a t e b E a L w o p ( =0 P=0 L L f t c w t c c ( =0 F 2 A m s a w p e s s m a d w t r f f a o l i a i v a f t p a s s
2
b
a r
e
n
2
A B
e a /A
1
. . .“
.. .:... ●
.
. .
●✎
. . ..
●
✎ ✎
.
. .: ●
.“
(
2
● :. :.:
. .
.
✎
● ●
h
.
. ..
.** . . . .. .:
t
.
.
●
●
.
●
● .”
“.
●
● ●
✎
..
oI o
F
a c p l v p d
w c
a
t G
2 C
c
l t
(
g
w d
b
s
t
l i t a C
o a a p n s D e a r l l i a r o a r d s w w o t d f d [ B r a a l s t L a t r o s i s c i f a [ A e s o L f n b m ( b Ae e a a s [ i a d f b t I a e c i v [ T r f b m b a e p f t p o t l f t e t t a m [ S e a h p t a s c b L r f a i c i w t b o c L t i l s a C a G [ I t i t c t f t f i l i t p o o p i t t a s i s a r c t t s o s A a t e i t s L s b t l b s ( r b t
w
1
1 1 7 5 Total Leukocyte Count (x109/L)
2
L
a
s a
t
l
l o e c o t p p i T n t d tt u t p n i r fu i e e m l o s e L o i v a t t m r o ea f t e o t s s a d a u l T m h i f t ce s o t rb t e a l l k i a n oc h e N a i Pt d h W h r f n l o s n c L i b s s a i m v [ r n h A c u W t D A n A f h c a e t o ti v h w i a o p 1 n m R e h xT A -s r o t i [ S N 1 3e d
t o o n e i st i a
co
-
e
i
hh t
e e
e e
h
s a r
s
i
t a o e e e
e r r c
e
-
i p u
t
A B [
[
[
[
[
[
[
[
e a /A
M R S n r t m l c a d i T H 1 6 L L S I o c c d i d i S 1 2 N W B L C C e a S E i f i s o a e c a i e i t s o p w s s J I 1 1 M R B J M K M L B D G a p a g p i a s b v e c a i l i W b J C I 1 8 B A M C C e c l a m i a T H 1 7 B A D M K P M C v W f s P s t p a a p a i i a T H 1 t 7 C B M B B M D L B T C C P P i i i t c p d B 1 9 Y J S P E P e a H t f a i h d t C
2 (
[
[ u [
[
[
[
[ h [
2
t
2
h
e c e s B He J 1 5 fa o u S n O C Pd C A e a H l t s f o L a p 5 i p w t a l l a ln e ae i b c a t a e B 1 8 nv n fn f u Z E R J5 C b s l e - i ce o a o s L a l c m l a d n bc m t p t E J H l 1 1 a D S H C D m5 I e a R o s i da o a r d e e e cr s aM l d L 1 ; n S Cy K r T A n O e a C a f e r a m 1 ( o l i o 4 d n a t c s e e c i vi J C c nI 1 : n h P teG M G A od A M e 2 J B a ra o L l o l e C 1 p o c D L P D G iK elJ L a o L o l ( n f e i c lo h a c n v C Ih 1 1 a e h 4 S B S O T T S c L ur e l i p i h a h l n ae -p l a J C B i 1 u h r rn o f l B A S P H M S 9A J L i t c t w d B J H a 1 p s a a i