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Soluble Ointment Base*
210
JOURNAL OF THE AMERICAN
the oral cavity and the understanding of their relation to the general health of the patient. Thus the dentist and physician have joined hands in their effort to keep the public well and increase the span of human life. BIBLIOGRAPHY (1) Koch, Charles, R. C., "A History of Dental Surgery."
PHARMACEUTICAL ASSOCIATION
(2) Taylor, "Dental History." (3) Brenner, "The Story of Dentistry." (4) Weinberger, E. W., "Historic Review of Orthodontics. " (5) Lufkin, A. W., "History of Dentistry." (6) American Academy of Dental Science"History of Dental and Oral Science in America." (7) Prinz, Hermann, "Dental Materia Medica and Thera peu tics. "
Soluble Ointment Base* By Cyru.r L. Coxt and Paul Goedricht Believing that there is a need for an ointment base that is easily removable by simply washing with water and that many medicaments would be more effective when applied to the skin in a non-oily but soluble vehicle led the authors to the development of the following formula:
Sprinkle the bentonite upon 50 cc. of distilled water and after it is thoroughly wetted, stir until a uniform magma results. Melt the glyceryl monostearate in the glycerin on a water-bath and add to it the magma. warmed to the same temperature, and enough distilled water to make the product weigh 100 Gm. Stir until cool. The purpose of the bentonite in this preparation is to act as a stabilizing colloid and thereby give smoothness to the ointment. The bentonite can
be conveniently kept in the form of a seven per cent magma. Such magma is stable and is about the highest concentration that can readily be poured from a bottle. "Qsing this Soluble Ointment Base and the process of incorporation, a boric acid ointment of the official strength was prepared. In a like manner tannic acid, iodine, phenol, sulfur, compound benzoic acid, calamine, ichthammol and potassium iodide ointments were prepared. An ointment containing ten per- cent balsam of peru, prepared by incorporation, was a very smooth preparation. An ointment containing the U. S. P. amount of sulfur and ointments of calamine and of potassium iodide of the N. F. strength were prepared by adding the medicament while preparing the ointment base. These appeared to be quite satisfactory. Ointment of potassium iodide, made without sodium thiosulfate, shows no discoloration and gives no color with starch after six months' standing. Further work will be carried out to determine the relative absorbability of drugs and chemicals from this base as compared with the base directed in the U. S. P. XI.
* Presented before the Section on Practical Pharmacy and Dispensing, A. PH. A., Atlanta meeting, 1939. t Rutgers University College of Pharmacy, 1 Lincoln Ave., Newark, N. J.
The authors are indebted to Th. Goldschmidt Corp., 153 Waverly Place, N. Y., for the glyceryl monostearate, and to American Colloid Co., 163 West Superior Street, Chicago, for the bentonite.
The D. C. Pharmaceutical Association met at Wardman Park Hotel, May 23rd and 24th. Among those on the program were: Edgar Morris, chairman, Greater National Capital Committee, Board of Trade; W. H. Whittlesey, president of the Association; Dr. H. S. Hoffman, "The Failing Heart of Middle Life;" Dr. Lloyd W. Hazelton, "The Pharmacology of Drug Combinations;" Dr. J. C. Krantz, Jr., "Anesthesia;" Dr. Charles O. Wilson, "Liquid Petrolatum Solutions of Ephedrine Chlorotone and Similar Compounds;" Dr. L. G. Gramling, "Newer Biologicals;" S. J. Waddell, president, Travelers Auxiliary; Mrs. W. H.
Whittlesey, president of Womens Auxiliary; Charles Suter; Dr. George C. Schicks, "A New Source of Business for the Pharmacist;" Dr. R. L. Sexton, "The Gastro-Enterology of the Alimentary Canal" and "What We Have Learned by Looking into the Stomach through the Gastroscope;" Dr. G. C. Ruhland, "Pharmacy as Viewed by Public Health;" J. W. Snowden, "Inner Store Promotion of the Professional Department." Dr. E. F. Kelly and Dr. R. L. Swain were speakers at the banquet. A motion picture, "Know Your Money," was shown under the auspices of U. S. Secret Service.
Soluble Ointment Base Glyceryl monostearate Glycerin Bentonite Distilled water, a sufficient quantity to make
10 Gm. 25Gm. 2Gm. 100 Gm.
JOURNAL OF THE AMERICAN
the oral cavity and the understanding of their relation to the general health of the patient. Thus the dentist and physician have joined hands in their effort to keep the public well and increase the span of human life. BIBLIOGRAPHY (1) Koch, Charles, R. C., "A History of Dental Surgery."
PHARMACEUTICAL ASSOCIATION
(2) Taylor, "Dental History." (3) Brenner, "The Story of Dentistry." (4) Weinberger, E. W., "Historic Review of Orthodontics. " (5) Lufkin, A. W., "History of Dentistry." (6) American Academy of Dental Science"History of Dental and Oral Science in America." (7) Prinz, Hermann, "Dental Materia Medica and Thera peu tics. "
Soluble Ointment Base* By Cyru.r L. Coxt and Paul Goedricht Believing that there is a need for an ointment base that is easily removable by simply washing with water and that many medicaments would be more effective when applied to the skin in a non-oily but soluble vehicle led the authors to the development of the following formula:
Sprinkle the bentonite upon 50 cc. of distilled water and after it is thoroughly wetted, stir until a uniform magma results. Melt the glyceryl monostearate in the glycerin on a water-bath and add to it the magma. warmed to the same temperature, and enough distilled water to make the product weigh 100 Gm. Stir until cool. The purpose of the bentonite in this preparation is to act as a stabilizing colloid and thereby give smoothness to the ointment. The bentonite can
be conveniently kept in the form of a seven per cent magma. Such magma is stable and is about the highest concentration that can readily be poured from a bottle. "Qsing this Soluble Ointment Base and the process of incorporation, a boric acid ointment of the official strength was prepared. In a like manner tannic acid, iodine, phenol, sulfur, compound benzoic acid, calamine, ichthammol and potassium iodide ointments were prepared. An ointment containing ten per- cent balsam of peru, prepared by incorporation, was a very smooth preparation. An ointment containing the U. S. P. amount of sulfur and ointments of calamine and of potassium iodide of the N. F. strength were prepared by adding the medicament while preparing the ointment base. These appeared to be quite satisfactory. Ointment of potassium iodide, made without sodium thiosulfate, shows no discoloration and gives no color with starch after six months' standing. Further work will be carried out to determine the relative absorbability of drugs and chemicals from this base as compared with the base directed in the U. S. P. XI.
* Presented before the Section on Practical Pharmacy and Dispensing, A. PH. A., Atlanta meeting, 1939. t Rutgers University College of Pharmacy, 1 Lincoln Ave., Newark, N. J.
The authors are indebted to Th. Goldschmidt Corp., 153 Waverly Place, N. Y., for the glyceryl monostearate, and to American Colloid Co., 163 West Superior Street, Chicago, for the bentonite.
The D. C. Pharmaceutical Association met at Wardman Park Hotel, May 23rd and 24th. Among those on the program were: Edgar Morris, chairman, Greater National Capital Committee, Board of Trade; W. H. Whittlesey, president of the Association; Dr. H. S. Hoffman, "The Failing Heart of Middle Life;" Dr. Lloyd W. Hazelton, "The Pharmacology of Drug Combinations;" Dr. J. C. Krantz, Jr., "Anesthesia;" Dr. Charles O. Wilson, "Liquid Petrolatum Solutions of Ephedrine Chlorotone and Similar Compounds;" Dr. L. G. Gramling, "Newer Biologicals;" S. J. Waddell, president, Travelers Auxiliary; Mrs. W. H.
Whittlesey, president of Womens Auxiliary; Charles Suter; Dr. George C. Schicks, "A New Source of Business for the Pharmacist;" Dr. R. L. Sexton, "The Gastro-Enterology of the Alimentary Canal" and "What We Have Learned by Looking into the Stomach through the Gastroscope;" Dr. G. C. Ruhland, "Pharmacy as Viewed by Public Health;" J. W. Snowden, "Inner Store Promotion of the Professional Department." Dr. E. F. Kelly and Dr. R. L. Swain were speakers at the banquet. A motion picture, "Know Your Money," was shown under the auspices of U. S. Secret Service.
Soluble Ointment Base Glyceryl monostearate Glycerin Bentonite Distilled water, a sufficient quantity to make
10 Gm. 25Gm. 2Gm. 100 Gm.