Some aspects of immunogenic sterility of animals

8! replaced with certain plant oils, (jojoba oil is one of the most effective) and, the mycobacterial component can be replaced with purified fractions from Corynebacterium rubrum as well as the synthetic peptide N-acetyl-muramyl--L-alaD-GIu-Nii~ in ug. amounts. ~mlongst the ineffective adjuvants were Evans Blue (T-1824)~and sodium phthalyl lipo-polysaccharide (E. Coli K235). Adjuvants effective in inducing high humoral antibody are not able to induce aspermatogenesis in a single injection. These studies are important not only in immuno-reproduction but also for immuno-oncology. As a result of these series of studies, we believe an adjuvant compatible with human use has been constructed. (Supported by grants from the NSF, the Population Council, the NIH and the Ford Foundation). ~0i',i~ A ~ I ~ C T S

OF Ii~.,~UhOGLNIC

~STLIIILITY

OP AN I M A L S EUGENE

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USSR,

350044,

~'he p o s s i b i l i t y observed monas

in bulls

occered.

moantibodies the

sterility

for

the

even

the

spontaneous

using

of

the

the

KALININ

stimulus

INSTITUTE.

ST.,

I3.

autospermoantibodies and

experimental

bulls'

fertilisation

if

AGI{ICULTURAL

KRASNODAR,

of m a k i n g

when

The

,KUBAN

of

sperm the

with

cows

pseudomonas

was

pseudoautosper-

carried had

to

influence

on n e g a t i v e l y . The titis ral

is

breaking explained

regulation

mation

of

structure

of

the of

of

the

not the

cows'

only

the

sexual

and

the

changes

processes,

spermoantibodies sperme

reproduction

during

of

the n e u r o - h u m o -

but

associated

pathologically

the m a s -

also

with

by

the

for-

antigenic

changes

of m i l k .

INDUCTION, IMMUNOPATHOLOGY AND PATHOGENESIS OF MURINE EXPERIMENTAL ALLERGIC ORCHITIS (EAO). K.S.K. Tung, C. Teuscher, Suzanne M. Smith, T. Williams, J. Huser and S. Kohno. Dept. Pathology, Univ. New Mexico, Albuquerque, NM, USA EAO was induced consistently in Balb/c (H-2 d) mice by immunization with homologous testis homogenate in CFA and i ~g of B. pertussis extract (Infec. Immun.3:495, 1981). All animals developed orchitis and/or vasitis 20 day~ later. Murine EAObiS controlled, in part, by MHC genes since Balb. K (H-2~) and Balb. B10 (H-2) mice did not develop orchitis. Furthermore, orchitis and vasitis are probably dissociable since some mouse strains (SJL, NZB, C57BI/6) presented mainly orchitis, while other strains (Balb/c. Ig-c, Balb/c. Ig-d and Balb. K) developed mainly vasitis. By immunofluorescence, Ig was found in, or adjacent to Sertoli cells which showed degenerative changes on electron microscopy. The transitory changes, which occurred before EAO onset, are anti-