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Some observations on the histopathology of corneal hypersensitivity
MEETINGS, CONFERENCES, SYMPOSIA EDITED BY THOMA
UNIVERSITY OF NORTH CAROLINA The sixth annual staff meeting of the Di vision of Ophthalmology of the University of North Carolina School of Medicine, rep resenting North Carolina Memorial Hospital and McPherson Hospital, was held January 13, 1968. Frank W. Newell, M.D., editorin-chief of the American Journal of Oph thalmology, delivered the Sixth S. Dace McPherson lecture on endocrine exophthalmos. The following papers were presented: Microsurgery for glaucoma. Samuel D. McPherson, Jr., M.D. The use of microsurgical instruments and the slitlamp microscope in operations for glaucoma was described in peripheral iridectomy, scleral cautery and anterior-posterior lip sclerectomy. These techniques enabled the operator to avoid perforation of the conjunctival flap, to enter the anterior chamber more exactly and to be certain that iridectomies were penetrating. In addition, the operator could gonioscope the patient at the beginning and end of operation and determine the need for air injection into the anterior chamber. A film was shown demonstrating these procedures. Treatment of Pseudomonas corneal ul cer with Povidone-Iodine. Leslie M. Hale, M.D. When iodine is combined with polyvinylpyrolidone, virtually all the side-effects of iodine can be eliminated. This solution is known as Povidone-Iodine. Half-strength solution has no harmful effects on corneal tissue and retains the outstanding broadspectrum bactericidal effect of iodine. Four cases of Pseudomonas corneal ulcers were treated with half-strength Povidone-Io-
CHALKLEY,
M.D.
dine and a mixture of neomycin, polymiyxin and bacitracin. In each the corneal ulcer did not progress after treatment was begun and each was left with a well-healed scar. Some observations on the histopathology of corneal hypersensitivity. Lawrence W. Moore, Jr., M.D. Rabbits sensitized to bovine serum albu min were given repeated intracorneal injec tions of this and developed Wessely rings, ground-glass haze, ring ulcer, and neovascularization. Eyes enucleated after the first through seventh injections, and one to three months after the fifth, were stained with hematoxylin and eosin, PAS, colloidal iron, and oil-red O. Increased acid mucopolysaccharides were noted in all. PAS-positive material was found in the stroma after the first injection and disappeared gradually after injections were discontinued. Intracellular lipids were seen after the second injec tion, became extracellular after the third in jection, and gradually disappeared after dis continuing injections. Rotating autokeratoplasty. Frederick W. Stacker, M.D. Homograft reaction in keratoplasty can be avoided by using the patient's own tissue. If a corneal scar extends from one side into the pupillary area, leaving a peripheral part of the cornea on the other side clear, a satisfac tory result can be obtained by trephining a corneal disc and rotating it in such a way that the clear part will occupy the pupillary area. This procedure was demonstrated in a motion picture. Three months after the rotating autograft, vision improved from counting fingers to 20/60. The pupillary part of the cornea was quite clear, and remained clear for one year after the operation.
UNIVERSITY OF NORTH CAROLINA The sixth annual staff meeting of the Di vision of Ophthalmology of the University of North Carolina School of Medicine, rep resenting North Carolina Memorial Hospital and McPherson Hospital, was held January 13, 1968. Frank W. Newell, M.D., editorin-chief of the American Journal of Oph thalmology, delivered the Sixth S. Dace McPherson lecture on endocrine exophthalmos. The following papers were presented: Microsurgery for glaucoma. Samuel D. McPherson, Jr., M.D. The use of microsurgical instruments and the slitlamp microscope in operations for glaucoma was described in peripheral iridectomy, scleral cautery and anterior-posterior lip sclerectomy. These techniques enabled the operator to avoid perforation of the conjunctival flap, to enter the anterior chamber more exactly and to be certain that iridectomies were penetrating. In addition, the operator could gonioscope the patient at the beginning and end of operation and determine the need for air injection into the anterior chamber. A film was shown demonstrating these procedures. Treatment of Pseudomonas corneal ul cer with Povidone-Iodine. Leslie M. Hale, M.D. When iodine is combined with polyvinylpyrolidone, virtually all the side-effects of iodine can be eliminated. This solution is known as Povidone-Iodine. Half-strength solution has no harmful effects on corneal tissue and retains the outstanding broadspectrum bactericidal effect of iodine. Four cases of Pseudomonas corneal ulcers were treated with half-strength Povidone-Io-
CHALKLEY,
M.D.
dine and a mixture of neomycin, polymiyxin and bacitracin. In each the corneal ulcer did not progress after treatment was begun and each was left with a well-healed scar. Some observations on the histopathology of corneal hypersensitivity. Lawrence W. Moore, Jr., M.D. Rabbits sensitized to bovine serum albu min were given repeated intracorneal injec tions of this and developed Wessely rings, ground-glass haze, ring ulcer, and neovascularization. Eyes enucleated after the first through seventh injections, and one to three months after the fifth, were stained with hematoxylin and eosin, PAS, colloidal iron, and oil-red O. Increased acid mucopolysaccharides were noted in all. PAS-positive material was found in the stroma after the first injection and disappeared gradually after injections were discontinued. Intracellular lipids were seen after the second injec tion, became extracellular after the third in jection, and gradually disappeared after dis continuing injections. Rotating autokeratoplasty. Frederick W. Stacker, M.D. Homograft reaction in keratoplasty can be avoided by using the patient's own tissue. If a corneal scar extends from one side into the pupillary area, leaving a peripheral part of the cornea on the other side clear, a satisfac tory result can be obtained by trephining a corneal disc and rotating it in such a way that the clear part will occupy the pupillary area. This procedure was demonstrated in a motion picture. Three months after the rotating autograft, vision improved from counting fingers to 20/60. The pupillary part of the cornea was quite clear, and remained clear for one year after the operation.