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SPANISH FAMILIAL HYPERCHOLESTEROLAEMIA (FH) COHORT FOLLOW-UP STUDY. DESIGN AND BASELINE CHARACTERISTICS
Poster Sessions PO22 Epidemiology of CVD risk factors PO22-300
HYPERTENSION IN TURKISH AND GERMAN FIRST GRADERS PARTICIPATING IN THE PEP FAMILY HEART STUDY
G. Haas 1 , P. Schwandt 1,2 . 1 Arteriosklerose-Praeventions-Institut, Muenchen-Nuernberg; 2 Ludwig-Maximilians-Universitaet, Muenchen
PO22-301
THE AUTOMATED MONITORING OF CARDIO VASCULAR DISEASES RISK FACTORS
N.V. Nasonova, L.V. Sherbakova. Institute of Internal Medicene SB RAMN, Novosibirsk, Russia The creation of the automated system for monitoring risk factors of cardiovascular diseases (CDV) is necessary link for CDV morbidity and mortality decrease. Material and methods: Medical data by using population studies (MONICA, N=8946 subject, age group 35-64 years old) was investigated for monitoring risk factors of CDV. The intellectual analysis of the data was used for automated of process data collection, handling and analysis, decision-making. Realization this decision-making was applied on different levels: for population and individual patients. Results: Diagnostic and prognosis models are constructed by a method of the discriminate analysis and logistical regress. Define significant factors of CVD: age, systolic blood pressure, diastolic blood pressure, triglycerides, body mass index, total cholesterol, cholesterol low density. Quality of estimation of models was defined by criterion of diagnostic accuracy. Diagnostic accuracy of models has made 76-83%. The measure, named total risk (T), made for obtain integrated estimation of risk factors at the patients. Graphical scales of the estimation risk factors were constructed by logistical regress. Conclusions: Thus, the automated system of complex monitoring of CVD risk factors was created by heterogeneous medical data determinate prognosis for CVD at the individual patients and population. PO22-302
SPANISH FAMILIAL HYPERCHOLESTEROLAEMIA (FH) COHORT FOLLOW-UP STUDY. DESIGN AND BASELINE CHARACTERISTICS
R. Alonso 1 , N. Mata 2 , F. Fuentes 3 , J. Villar 4 , R. Figueras 5 , P. Saenz 6 , D. Zambon 7 , C. Vazquez 8 , J.F. Sanchez 9 , P. Mata 1 . 1 Lipid Clinic, Internal Medicine Department, Fundacion Jimenez Diaz, Madrid, Spain; 2 Epidemiology Department, Public Health Institute, Madrid, Spain; 3 Lipid Clinic, Internal Medicine Department, Hospital Reina Sofia, Cordoba, Spain; 4 Internal Medicine Department, Hospital Virgen del Rocio, Sevilla, Spain; 5 Lipid Clinic, Hospital Belvitge, Barcelona, Spain; 6 Internal Medicine Department, Hospital de Merida, Merida, Spain; 7 Lipid Clinic, Hospital Clinic de Barcelona, Barcelona, Spain; 8 Nutrition Department, Endocrinology, Hospital Ramon y Cajal, Madrid, Spain; 9 Internal Medicine Department, Hospital San Pedro Alcantara, Badajoz, Spain Background and aims: FH is caused by mutations in the low-density
lipoprotein receptor gene (LDLr), and is associated with the development of cardiovascular disease (CVD). We describe the design and baseline characteristics of a large cohort of families with FH from Spain. Methods: Patients with genetic diagnosis of FH and their relatives were invited to participate. Demographic data, cardiovascular history, physical examination and treatment were included in a centralized database. Blood samples were obtained after 12 hours fast. LDLr gene mutations were detected using a DNA-microarray (Lipochip® ). Lipid profile was measured using enzymatic methods in a central laboratory. For the follow-up of this cohort, a standardized phone call is performed every 6 months to detect cardiovascular events and blood samples and clinical data are collected every 3 years. Results: 1260 subjects (303 index cases and 957 relatives) have been included (49.7% males, mean age 40.0±16.0 years and 50.3% females, mean age 43.2±16.9 years). Up to now, 756 cases have a mutation (M+) in LDLr gene (110 different functional mutations) and 320 cases are negative (M-). CVD was present in 13,2% of M+ (192 different events) and 3,8% of M- (16 different events). No differences were found in smoking, hypertension and diabetes between M+ carriers and M-. At inclusion 75.5% of M+ were under lipid lowering treatment Conclusions: This is the first follow up study of families with genetic diagnosis of FH in Spain. The follow-up will determine the gene-gene and gene-enviromental interactions in the development of CVD in FH patients. PO22-303
DEPRESSIVE SYMPTOMS - ARE THEY THE LIMITATION OF CARDIOVASCULAR DISEASES PREVENTION?
J. Piwonski 1 , W. Piotrowski 1 , A. Piwonska 2 . 1 Department of CVD Epidemiology, Prevention and Health Promotion; 2 on behalf of WOBASZ Investigators Background and aim: Depression is a kind of disease that completely changes the life of our patients and causes the disapproval of life. So it could reflect their behaviour to more unhealthy. We try to assess the behaviour of persons with and without depressive symptoms (DS) in relation to CVD prevention. Methods: The polish population sample of 6076 men and 6846 women, aged 20-74, filled-in psychological questionnaire in 2003-2005 (National Multicenter Health Survey WOBASZ). DS were assessed using Beck Depression Scale (≥ 10 pt). Results: Out of screened persons 24% of men and 34% of women had DS. Men with DS significantly more often than those without DS smoked cigarettes (42% vs 37%, p<0.001), rarely made regular physical activity (37% of physically inactive persons vs 30%, p<0.001), more often drank alcohol more than 3 times a week (4% vs 2%, p<0.05) and more often did not take the prescribed medication (18% vs 12%, p<0.001). Depressive women more often smoked cigarettes (26% vs 23%), 43% of them did not exercise regularly (without DS – 35%, p<0.001), more depressive women drank alcohol at least 3 times a week and high percent of women with DS did not take the prescribed medication (although they had bought them) – 22% vs 14% (p<0.0001). Conclusions: We observed a high percentage of persons with depressive symptoms in polish population. More women than men had depressive symptoms. Persons with depression had more unhealthy behaviour than those without depression, so it could be the significant limitation of prevention. PO22-304
PROGNOSTIC IMPLICATIONS OF ERECTILE DYSFUNCTION AS EARLY SIGN OF ATHEROSCLEROSIS
D. Tint 1 , C. Stanescu 2 , G. Pamfil 1 , M. Radoi 1 . 1 Faculty of Medicine; Emergency County Hospital Brasov, Romania
2 Clinical
Background: There are increasing evidence to consider erectile dysfunction (ED) as a vascular disease and an early sign of atherosclerosis. Aim: To investigate the prevalence of atherosclerosis risk factors and the cardiovascular events prevalence in patients associating ED. Method: We retrospectively analysed files of 558 males with mean age 46.5 years (23-76) presented in a sexual dysfunction clinic, followed up for 3 years. Laboratory assessments and clinical examination were performed in all patients. According the Doppler flow velocities in the penile artery patients were divided in: group 1 (389 pts. with ED) and group 2 (169 pts. without ED).
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
POSTER SESSIONS
Background and aims: There are no data on Turkish children born and living in Germany regarding their risk factors for cardiovascular diseases, especially regarding hypertension. The purpose was to assess the prevalence of hypertension and obesity in Turkish and German first graders participating in the PEP Family Heart Study. Methods: In 2473 children aged 6 and 7 years blood pressure, body mass index and waist circumference were measured by standard methods. BMI (kg/m2 ) was calculated. Hypertension was defined as ≥95th percentile, obesity ≥ 97th percentile of BMI, abdominal obesity ≥ 97th percentile of waist circumference according to age- and gender specific percentiles. Results: The prevalence of hypertension was 19.2% in Turkish girls and 14.7% in Turkish boys; 10% in German girls and 11.4% in German boys. The prevalence of obesity was higher in Turkish (13.7%) than in German (5.6%) boys and higher in Turkish (12.5%) than in German (3.6%) girls. The prevalence of abdominal obesity was higher in Turkish (11.5%) than in German (3.2%)girls and in Turkish (10.8%) higher than in German (4.7%) boys. In obese children the prevalence of hypertension was significantly higher in Turkish (53.6%) than in German girls (36.6%) with smaller differences in boys (35.7% vs. 32.3%). However, the prevalence of hypertension in abdominal obesity was similar in Turkish and German first graders. Conclusions: The prevalence of hypertension of Turkish girls living in Nuernberg is two times higher and of obesity and abdominal obesity four times higher than in German girls.
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HYPERTENSION IN TURKISH AND GERMAN FIRST GRADERS PARTICIPATING IN THE PEP FAMILY HEART STUDY
G. Haas 1 , P. Schwandt 1,2 . 1 Arteriosklerose-Praeventions-Institut, Muenchen-Nuernberg; 2 Ludwig-Maximilians-Universitaet, Muenchen
PO22-301
THE AUTOMATED MONITORING OF CARDIO VASCULAR DISEASES RISK FACTORS
N.V. Nasonova, L.V. Sherbakova. Institute of Internal Medicene SB RAMN, Novosibirsk, Russia The creation of the automated system for monitoring risk factors of cardiovascular diseases (CDV) is necessary link for CDV morbidity and mortality decrease. Material and methods: Medical data by using population studies (MONICA, N=8946 subject, age group 35-64 years old) was investigated for monitoring risk factors of CDV. The intellectual analysis of the data was used for automated of process data collection, handling and analysis, decision-making. Realization this decision-making was applied on different levels: for population and individual patients. Results: Diagnostic and prognosis models are constructed by a method of the discriminate analysis and logistical regress. Define significant factors of CVD: age, systolic blood pressure, diastolic blood pressure, triglycerides, body mass index, total cholesterol, cholesterol low density. Quality of estimation of models was defined by criterion of diagnostic accuracy. Diagnostic accuracy of models has made 76-83%. The measure, named total risk (T), made for obtain integrated estimation of risk factors at the patients. Graphical scales of the estimation risk factors were constructed by logistical regress. Conclusions: Thus, the automated system of complex monitoring of CVD risk factors was created by heterogeneous medical data determinate prognosis for CVD at the individual patients and population. PO22-302
SPANISH FAMILIAL HYPERCHOLESTEROLAEMIA (FH) COHORT FOLLOW-UP STUDY. DESIGN AND BASELINE CHARACTERISTICS
R. Alonso 1 , N. Mata 2 , F. Fuentes 3 , J. Villar 4 , R. Figueras 5 , P. Saenz 6 , D. Zambon 7 , C. Vazquez 8 , J.F. Sanchez 9 , P. Mata 1 . 1 Lipid Clinic, Internal Medicine Department, Fundacion Jimenez Diaz, Madrid, Spain; 2 Epidemiology Department, Public Health Institute, Madrid, Spain; 3 Lipid Clinic, Internal Medicine Department, Hospital Reina Sofia, Cordoba, Spain; 4 Internal Medicine Department, Hospital Virgen del Rocio, Sevilla, Spain; 5 Lipid Clinic, Hospital Belvitge, Barcelona, Spain; 6 Internal Medicine Department, Hospital de Merida, Merida, Spain; 7 Lipid Clinic, Hospital Clinic de Barcelona, Barcelona, Spain; 8 Nutrition Department, Endocrinology, Hospital Ramon y Cajal, Madrid, Spain; 9 Internal Medicine Department, Hospital San Pedro Alcantara, Badajoz, Spain Background and aims: FH is caused by mutations in the low-density
lipoprotein receptor gene (LDLr), and is associated with the development of cardiovascular disease (CVD). We describe the design and baseline characteristics of a large cohort of families with FH from Spain. Methods: Patients with genetic diagnosis of FH and their relatives were invited to participate. Demographic data, cardiovascular history, physical examination and treatment were included in a centralized database. Blood samples were obtained after 12 hours fast. LDLr gene mutations were detected using a DNA-microarray (Lipochip® ). Lipid profile was measured using enzymatic methods in a central laboratory. For the follow-up of this cohort, a standardized phone call is performed every 6 months to detect cardiovascular events and blood samples and clinical data are collected every 3 years. Results: 1260 subjects (303 index cases and 957 relatives) have been included (49.7% males, mean age 40.0±16.0 years and 50.3% females, mean age 43.2±16.9 years). Up to now, 756 cases have a mutation (M+) in LDLr gene (110 different functional mutations) and 320 cases are negative (M-). CVD was present in 13,2% of M+ (192 different events) and 3,8% of M- (16 different events). No differences were found in smoking, hypertension and diabetes between M+ carriers and M-. At inclusion 75.5% of M+ were under lipid lowering treatment Conclusions: This is the first follow up study of families with genetic diagnosis of FH in Spain. The follow-up will determine the gene-gene and gene-enviromental interactions in the development of CVD in FH patients. PO22-303
DEPRESSIVE SYMPTOMS - ARE THEY THE LIMITATION OF CARDIOVASCULAR DISEASES PREVENTION?
J. Piwonski 1 , W. Piotrowski 1 , A. Piwonska 2 . 1 Department of CVD Epidemiology, Prevention and Health Promotion; 2 on behalf of WOBASZ Investigators Background and aim: Depression is a kind of disease that completely changes the life of our patients and causes the disapproval of life. So it could reflect their behaviour to more unhealthy. We try to assess the behaviour of persons with and without depressive symptoms (DS) in relation to CVD prevention. Methods: The polish population sample of 6076 men and 6846 women, aged 20-74, filled-in psychological questionnaire in 2003-2005 (National Multicenter Health Survey WOBASZ). DS were assessed using Beck Depression Scale (≥ 10 pt). Results: Out of screened persons 24% of men and 34% of women had DS. Men with DS significantly more often than those without DS smoked cigarettes (42% vs 37%, p<0.001), rarely made regular physical activity (37% of physically inactive persons vs 30%, p<0.001), more often drank alcohol more than 3 times a week (4% vs 2%, p<0.05) and more often did not take the prescribed medication (18% vs 12%, p<0.001). Depressive women more often smoked cigarettes (26% vs 23%), 43% of them did not exercise regularly (without DS – 35%, p<0.001), more depressive women drank alcohol at least 3 times a week and high percent of women with DS did not take the prescribed medication (although they had bought them) – 22% vs 14% (p<0.0001). Conclusions: We observed a high percentage of persons with depressive symptoms in polish population. More women than men had depressive symptoms. Persons with depression had more unhealthy behaviour than those without depression, so it could be the significant limitation of prevention. PO22-304
PROGNOSTIC IMPLICATIONS OF ERECTILE DYSFUNCTION AS EARLY SIGN OF ATHEROSCLEROSIS
D. Tint 1 , C. Stanescu 2 , G. Pamfil 1 , M. Radoi 1 . 1 Faculty of Medicine; Emergency County Hospital Brasov, Romania
2 Clinical
Background: There are increasing evidence to consider erectile dysfunction (ED) as a vascular disease and an early sign of atherosclerosis. Aim: To investigate the prevalence of atherosclerosis risk factors and the cardiovascular events prevalence in patients associating ED. Method: We retrospectively analysed files of 558 males with mean age 46.5 years (23-76) presented in a sexual dysfunction clinic, followed up for 3 years. Laboratory assessments and clinical examination were performed in all patients. According the Doppler flow velocities in the penile artery patients were divided in: group 1 (389 pts. with ED) and group 2 (169 pts. without ED).
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
POSTER SESSIONS
Background and aims: There are no data on Turkish children born and living in Germany regarding their risk factors for cardiovascular diseases, especially regarding hypertension. The purpose was to assess the prevalence of hypertension and obesity in Turkish and German first graders participating in the PEP Family Heart Study. Methods: In 2473 children aged 6 and 7 years blood pressure, body mass index and waist circumference were measured by standard methods. BMI (kg/m2 ) was calculated. Hypertension was defined as ≥95th percentile, obesity ≥ 97th percentile of BMI, abdominal obesity ≥ 97th percentile of waist circumference according to age- and gender specific percentiles. Results: The prevalence of hypertension was 19.2% in Turkish girls and 14.7% in Turkish boys; 10% in German girls and 11.4% in German boys. The prevalence of obesity was higher in Turkish (13.7%) than in German (5.6%) boys and higher in Turkish (12.5%) than in German (3.6%) girls. The prevalence of abdominal obesity was higher in Turkish (11.5%) than in German (3.2%)girls and in Turkish (10.8%) higher than in German (4.7%) boys. In obese children the prevalence of hypertension was significantly higher in Turkish (53.6%) than in German girls (36.6%) with smaller differences in boys (35.7% vs. 32.3%). However, the prevalence of hypertension in abdominal obesity was similar in Turkish and German first graders. Conclusions: The prevalence of hypertension of Turkish girls living in Nuernberg is two times higher and of obesity and abdominal obesity four times higher than in German girls.
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