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Special section: Monitoring Photodynamic Therapy
Journal of Photochemistry and Photobiology B: Biology 79 (2005) 209 www.elsevier.com/locate/jphotobiol
Preface
Special section: Monitoring Photodynamic Therapy In this issue we have grouped together four papers into a special section addressing the issue of monitoring photodynamic therapy (PDT). While light dosimetry has long been recognised as an essential part of PDT of hollow and solid organs, more recently attention has been focused on the importance of the other parameters that influence tissue response. In this context both Weersink et al. and Zhu et al. describe the use of state-of-the-art light dosimetry during Phase I/II clinical trials of PDT for recurrent prostate carcinoma using the photosensitisers TOOKAD and motexafin lutetium. In each case the authors have employed techniques to extend the potential for monitoring PDT. Absorption and fluorescence spectroscopy is employed to determine photosensitiser pharmacokinetics and diffuse reflection spectroscopy is used to monitor tumour oxygenation and blood volume. The fact that both groups are using different photosensitisers for PDT in the prostate highlights the different localisation properties of each photosensitiser and illustrates that methods to monitor PDT must take this into account. Both groups foresee that further development and application of these monitoring techniques will allow on-line monitoring of PDT that will enable real-time, patient-specific, optimised therapy. Harada et al. also illustrate how the localisation of the photosensitiser and its relation to treatment time can dramatically affect the response of tissue to PDT using a novel photosensitiser ATX-S10Na. Amelink et al. report a method for monitoring the local absorption and scattering properties during PDT in the skin. By performing white light reflectance spectroscopy using a single fibre probe they show it is possible to determine various properties of the microvasculature, such as blood saturation and blood volume fraction, and the local scattering properties of the tissue. They report how these properties vary during PDT and how they may relate to tissue response. Dominic Robinson Rotterdam The Netherlands
1011-1344/$ - see front matter Ó 2005 Elsevier B.V. All rights reserved. doi:10.1016/j.jphotobiol.2005.04.004
Preface
Special section: Monitoring Photodynamic Therapy In this issue we have grouped together four papers into a special section addressing the issue of monitoring photodynamic therapy (PDT). While light dosimetry has long been recognised as an essential part of PDT of hollow and solid organs, more recently attention has been focused on the importance of the other parameters that influence tissue response. In this context both Weersink et al. and Zhu et al. describe the use of state-of-the-art light dosimetry during Phase I/II clinical trials of PDT for recurrent prostate carcinoma using the photosensitisers TOOKAD and motexafin lutetium. In each case the authors have employed techniques to extend the potential for monitoring PDT. Absorption and fluorescence spectroscopy is employed to determine photosensitiser pharmacokinetics and diffuse reflection spectroscopy is used to monitor tumour oxygenation and blood volume. The fact that both groups are using different photosensitisers for PDT in the prostate highlights the different localisation properties of each photosensitiser and illustrates that methods to monitor PDT must take this into account. Both groups foresee that further development and application of these monitoring techniques will allow on-line monitoring of PDT that will enable real-time, patient-specific, optimised therapy. Harada et al. also illustrate how the localisation of the photosensitiser and its relation to treatment time can dramatically affect the response of tissue to PDT using a novel photosensitiser ATX-S10Na. Amelink et al. report a method for monitoring the local absorption and scattering properties during PDT in the skin. By performing white light reflectance spectroscopy using a single fibre probe they show it is possible to determine various properties of the microvasculature, such as blood saturation and blood volume fraction, and the local scattering properties of the tissue. They report how these properties vary during PDT and how they may relate to tissue response. Dominic Robinson Rotterdam The Netherlands
1011-1344/$ - see front matter Ó 2005 Elsevier B.V. All rights reserved. doi:10.1016/j.jphotobiol.2005.04.004