- Email: [email protected]
Specific cognitive complaints are associated with objective cognitive performance
Poster Presentations: P4
functions contribute with distinct forms in each stage of cognitive impairment. P4-112
SENSITIVE TASK MEASURE OF MEMORY FUNCTION ON THE STORY RECALL TEST IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT AND MILD ALZHEIMER’S DISEASE
Kyung Won Park1,2, Hyuntae Park3, Jong-Hwan Park3, Sang Wuk Sohn4, Dong -A University College of Medicine, Busan, South Korea; 2Busan Metropolitan Dementia Center, Busan, South Korea; 3Dong-A University, Busan, South Korea; 4Dong-A University College of Medicine, Busan, South Korea. Contact e-mail: [email protected] 1
Background: The story recall test (SRT) is one of the reliable
neuropsychological assessment for detecting verbal memory function in patients with cognitive impairment in company with word list learning test. The aim of this study is to examine the useful performance on SRT compared with the word list learning test and to demonstrate the correlation between two memory scales in patient with mild stage of Alzheimer’s disease (AD), mild cognitive impairment (MCI) and subjective memory impairment (SMI). Methods: We consecutively recruited 30 very mild AD, 47 MCI and 23 SMI patients according to the NINCDS-ADRDA criteria for probable Alzheimer’s disease and the Petersen’s clinical diagnostic criteria in a memory clinic of university hospital. We performed detailed neuropsychological test including word list learning and SRT. We compared the scores of SRT with the scores of Seoul Verbal Learning Test (SVLT), the Korean version of MiniMental State Examination (K-MMSE) and the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D) Test using one way ANOVA followed by post-hoc analysis. The relationship between the SRT, K-MMSE, SVLT and SNSB-D were analyzed the degree of correlation among the assessments. Results: Significant differences among the three groups were found for the KMMSE, the SNSB-D, other cognitive function tests and the two memory scales, which included tasks of SVLT and the SRT. Post hoc analysis revealed that the performance on delayed recall task of SVLT was equally worse in both groups of mild AD and MCI than in the SMI group. However, delayed recall task of SRT showed significant worse performance in patients with mild AD than those of MCI patients in the post hoc analysis (p < 0.01). The scores of SRT were well-correlated with those of SVLT, K-MMSE, and SNSB-D in patients with mild AD, MCI and SMI (p < 0.01). Conclusions: Our results suggest that SRT might be a more sensitive measure of memory function than word list learning test to detect early stage of cognitive deficits depending on the disease progress in patients with MCI and mild AD.
P4-113
SPECIFIC COGNITIVE COMPLAINTS ARE ASSOCIATED WITH OBJECTIVE COGNITIVE PERFORMANCE
Hana Markova1,2, Jakub Hort1,2, Tomas Nikolai1,2, Jan Laczo1,2, Katerina Sheardova1, Martin Vyhnalek1,2, 1International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic; 2 Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic. Contact e-mail: [email protected] Background: Subjective cognitive complaints (SCC) in individuals
with normal performance on neuropsychological tests may be indicative of preclinical Alzheimer’s disease (AD). The SCC may reflect subtle cognitive decline in patients who do not fulfil criteria for
P819
mild cognitive impairment (MCI) because of normal performance on neuropsychological tests. However, SCC may also reflect depressive symptomatology. The aim of this study was to examine the relationship between subjective cognitive complaints and cognition in patients with SCC and MCI. Methods: Seventy-five non-demented subjects referred to the Memory Clinic for SCC were classified into amnestic MCI (n¼29) and SCC (n¼46) groups based on clinical evaluation and complex neuropsychological assessment. The participants were administered Thirty-nine-item McNair’s Cognitive Difficulties Scale (CDS) and 10-item Questionnaire de la plainte mnesique (QPM) to evaluate SCC. Geriatric depression scale (15-item version, GDS-15) was used to assess depressive symptoms. The subjects with extensive vascular changes on MRI (Fazekas > 2) and those scoring more than six points on GDS-15 and were not included. The composite scores of episodic memory, attention, working memory, executive function and language were calculated as the averages of z-scores of at least two neuropsychological tests for each cognitive domain. Results: The total scores of QPM and CDS correlated with GDS-15 score (rh o¼.425, p<.001 and rh o¼.341, p¼.009, respectively). There was no correlation between QPM and CDS scores and composite scores of each cognitive domain. When analyzing the QPM and CDS questions separately, several items correlated with memory, attention, working memory, executive function and language. SCC and amnestic MCI did not differ in the amount of depressive symptoms (p¼.430). Conclusions: Currently used questionnaires of SCC seem to reflect more depressive symptomatology than cognitive impairment in patients with SCC and MCI. Detailed evaluation of specific questions may provide more valuable information on cognitive functions in SCC and MCI patients. New reliable questionnaires are needed to reflect cognitive impairment in non-demented elderly.
P4-114
THE APPLICABILITY OF NEW SCREENING INSTRUMENTS FOR COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE IN TURKEY
Hakan I. Gurvit1, Rabia Selvitop2,3, 1Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey; 2Istanbul University, Institute of Experimental Medical Research, Istanbul, Turkey; 3Bezmialem University, Istanbul, Turkey. Contact e-mail: [email protected] Background: Recent insight suggests that cognitive impairment is an
early and inevitable feature of Parkinson’s disease (PD). The relevant evidence also suggests that its neuropsychological profile is distinct than that of Alzheimer’s disease (AD), being mostly non-amnestic. Moreover, there may even be a benign dysexecutive and a progressive visuospatial subtypes. Hence, there is a need for cognitive screening instruments specifically designed for PD, for practical use in Movement Disorders clinics. Our aim was to see the applicability of the Turkish versions of 3 such instruments, as compared to traditional cognitive screening tests with established Turkish norms. Methods: The study was conducted in Bezmialem University’s Movement Disoreders outpatient clinic, which generally attracts low-income, relatively poorly educated individuals. Eightty (56 males), consecutive, non-demented PD patients, who were rated as 1 (slight cognitive impairment; n¼77) or 2 (mild cognitive impairment; n¼3) in item 1.1 of MDS-UPDRS were included in the study. They were tested with 2 traditional (Addenbrooke’s Cognitive Examination-Revised [ACE-R] and Montreal Cognitive Examination [MOCA]) and 3 newer tests that were specifically designed for PD (Scales for Outcomes in Parkinson’s Disease-Cognition [SCOPA-COG], Parkinson’s Disease-Cognitive Rating Scale [PD-CRS] and Parkinson’s
functions contribute with distinct forms in each stage of cognitive impairment. P4-112
SENSITIVE TASK MEASURE OF MEMORY FUNCTION ON THE STORY RECALL TEST IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT AND MILD ALZHEIMER’S DISEASE
Kyung Won Park1,2, Hyuntae Park3, Jong-Hwan Park3, Sang Wuk Sohn4, Dong -A University College of Medicine, Busan, South Korea; 2Busan Metropolitan Dementia Center, Busan, South Korea; 3Dong-A University, Busan, South Korea; 4Dong-A University College of Medicine, Busan, South Korea. Contact e-mail: [email protected] 1
Background: The story recall test (SRT) is one of the reliable
neuropsychological assessment for detecting verbal memory function in patients with cognitive impairment in company with word list learning test. The aim of this study is to examine the useful performance on SRT compared with the word list learning test and to demonstrate the correlation between two memory scales in patient with mild stage of Alzheimer’s disease (AD), mild cognitive impairment (MCI) and subjective memory impairment (SMI). Methods: We consecutively recruited 30 very mild AD, 47 MCI and 23 SMI patients according to the NINCDS-ADRDA criteria for probable Alzheimer’s disease and the Petersen’s clinical diagnostic criteria in a memory clinic of university hospital. We performed detailed neuropsychological test including word list learning and SRT. We compared the scores of SRT with the scores of Seoul Verbal Learning Test (SVLT), the Korean version of MiniMental State Examination (K-MMSE) and the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D) Test using one way ANOVA followed by post-hoc analysis. The relationship between the SRT, K-MMSE, SVLT and SNSB-D were analyzed the degree of correlation among the assessments. Results: Significant differences among the three groups were found for the KMMSE, the SNSB-D, other cognitive function tests and the two memory scales, which included tasks of SVLT and the SRT. Post hoc analysis revealed that the performance on delayed recall task of SVLT was equally worse in both groups of mild AD and MCI than in the SMI group. However, delayed recall task of SRT showed significant worse performance in patients with mild AD than those of MCI patients in the post hoc analysis (p < 0.01). The scores of SRT were well-correlated with those of SVLT, K-MMSE, and SNSB-D in patients with mild AD, MCI and SMI (p < 0.01). Conclusions: Our results suggest that SRT might be a more sensitive measure of memory function than word list learning test to detect early stage of cognitive deficits depending on the disease progress in patients with MCI and mild AD.
P4-113
SPECIFIC COGNITIVE COMPLAINTS ARE ASSOCIATED WITH OBJECTIVE COGNITIVE PERFORMANCE
Hana Markova1,2, Jakub Hort1,2, Tomas Nikolai1,2, Jan Laczo1,2, Katerina Sheardova1, Martin Vyhnalek1,2, 1International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic; 2 Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic. Contact e-mail: [email protected] Background: Subjective cognitive complaints (SCC) in individuals
with normal performance on neuropsychological tests may be indicative of preclinical Alzheimer’s disease (AD). The SCC may reflect subtle cognitive decline in patients who do not fulfil criteria for
P819
mild cognitive impairment (MCI) because of normal performance on neuropsychological tests. However, SCC may also reflect depressive symptomatology. The aim of this study was to examine the relationship between subjective cognitive complaints and cognition in patients with SCC and MCI. Methods: Seventy-five non-demented subjects referred to the Memory Clinic for SCC were classified into amnestic MCI (n¼29) and SCC (n¼46) groups based on clinical evaluation and complex neuropsychological assessment. The participants were administered Thirty-nine-item McNair’s Cognitive Difficulties Scale (CDS) and 10-item Questionnaire de la plainte mnesique (QPM) to evaluate SCC. Geriatric depression scale (15-item version, GDS-15) was used to assess depressive symptoms. The subjects with extensive vascular changes on MRI (Fazekas > 2) and those scoring more than six points on GDS-15 and were not included. The composite scores of episodic memory, attention, working memory, executive function and language were calculated as the averages of z-scores of at least two neuropsychological tests for each cognitive domain. Results: The total scores of QPM and CDS correlated with GDS-15 score (rh o¼.425, p<.001 and rh o¼.341, p¼.009, respectively). There was no correlation between QPM and CDS scores and composite scores of each cognitive domain. When analyzing the QPM and CDS questions separately, several items correlated with memory, attention, working memory, executive function and language. SCC and amnestic MCI did not differ in the amount of depressive symptoms (p¼.430). Conclusions: Currently used questionnaires of SCC seem to reflect more depressive symptomatology than cognitive impairment in patients with SCC and MCI. Detailed evaluation of specific questions may provide more valuable information on cognitive functions in SCC and MCI patients. New reliable questionnaires are needed to reflect cognitive impairment in non-demented elderly.
P4-114
THE APPLICABILITY OF NEW SCREENING INSTRUMENTS FOR COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE IN TURKEY
Hakan I. Gurvit1, Rabia Selvitop2,3, 1Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey; 2Istanbul University, Institute of Experimental Medical Research, Istanbul, Turkey; 3Bezmialem University, Istanbul, Turkey. Contact e-mail: [email protected] Background: Recent insight suggests that cognitive impairment is an
early and inevitable feature of Parkinson’s disease (PD). The relevant evidence also suggests that its neuropsychological profile is distinct than that of Alzheimer’s disease (AD), being mostly non-amnestic. Moreover, there may even be a benign dysexecutive and a progressive visuospatial subtypes. Hence, there is a need for cognitive screening instruments specifically designed for PD, for practical use in Movement Disorders clinics. Our aim was to see the applicability of the Turkish versions of 3 such instruments, as compared to traditional cognitive screening tests with established Turkish norms. Methods: The study was conducted in Bezmialem University’s Movement Disoreders outpatient clinic, which generally attracts low-income, relatively poorly educated individuals. Eightty (56 males), consecutive, non-demented PD patients, who were rated as 1 (slight cognitive impairment; n¼77) or 2 (mild cognitive impairment; n¼3) in item 1.1 of MDS-UPDRS were included in the study. They were tested with 2 traditional (Addenbrooke’s Cognitive Examination-Revised [ACE-R] and Montreal Cognitive Examination [MOCA]) and 3 newer tests that were specifically designed for PD (Scales for Outcomes in Parkinson’s Disease-Cognition [SCOPA-COG], Parkinson’s Disease-Cognitive Rating Scale [PD-CRS] and Parkinson’s