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Spinal and forearm bone mass in relation to ageing and menopause in healthy Italian women
347 orally and intravenously active amino-substituted bisphosphonate which produces potent and specific inhibition of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralisation. Clinical trials indicate that pamidronate is effective in a variety of conditions characterised by pathologicallyenhanced bone turnover. inrtuding Paget’sdisease.hypercalcaemiaof malignancy.osteolytic bone metastasis, steroid-induced osteoporosis and idiopathic osteoporosis. Pamidronate is highly eflective in restoring normocalcaemia in patients with hypercalcaemia of malignancy associated with bone metastasesbut, in common with other bisphosphonates. is marginally les effective against humoral hypercalcaemia of malignancy. Comparative studies in this area have suggested that. at therapeutic doses, patnidronatehas a more pronouncedcalcium-lowering action than etidronate (etidronic acid) and clodronate (clodronic acid) and provides a longer period of normocalcaemic remission. In Paget’sdiseasearrest and, in some patients, reversal of the progression of osteolytic lesionsby pamidronate is associatedwith a sustained reduction in bone pain, improved mobility and a possiblereduced risk of bone fracture. In patients with osteolytic bone metastasis pamidronate reduces skeletal morbidity and slows the progression of metastatic bone destruction. Long term use of low-dose pamidronate in conjunction with conventional antiosteoporotic therapy may halt bone loss in steroid-induced and idiopathc osteoporosis.Pamidronate appears to represent a valuable addition to the drugs currently avaiable for the treatment of symptomatic Paget’s diseaseand cancer-associated hyperculcaemia, and shows promise in the treatment of ostcolytic bone metastasis and osteoporosis.
91105357 Spinal aad forearm bone mass in relrtwlr .~r dgeing rml mewpruse in healthy Italian women Ortolani S.; Ttevisan C., Bianchi M.L.; Caraceni M.P.; Ulivieri F.M.; Gandolini Cl.; MontesanoA.; Polli E.E. lstituto di Scipnze Mediche. University of Milan, Via F. :;for:a 3.5, 20122 Milun EUR. J. CLIN. INVEST. 1991 21/l (33-39) Most studiesconcerning bone status have been performed in Nordic and Anglo-Saxon countries and few data are available on southern European populations. We performed a cross-sectionalstudy on spine and forearm bone mass in 234 healthy Italian women and related the results to age and time since menopause. Forearm bone mass does not decline in premenopausal age, whereas. as far as the spine is concerned. a significant reduction appears 3 years before the mean age of menopause: in both cases. the occurrence of menopauseaccounted for an accelerated phase of bone loss. In postmenopausal women both spine and forearm bone mass show a stronger correlation with years since menopause than with age. According to a linear exponential model. the rate of spinal bone loss per year since menopause is around 4% in the first 3 years which slows down to around 2% iin the 5th year; the corresponding rates of forearm bone loss are 2% and 1.3%, respectively. 91105957 Patters of referral to a menopauseclinic Garnett T.; Mitchell A.; Studd J. Menopause Clinic. Dulivich Hospital, London SE22 8PT J. R. SOC. MED. 1991 8413 (128-130) One hundred and Efty new patients attending the Menopause Clinic at Dulwich Hospital were questioned on their attitudes and fears about hormone replacement therapy and ibJb: perceivedattitudes of their general practitioner. The majority of patients attending the clinic had initia:ed referral themselvesand many had travelled from outside the health authority area in order to be seen. The waiting list for an appointment was often unacceptable. We conclude that specialist menopause clinics in teaching hospitals are unable to cope with the demand for information about tire menopause and hormone replacement from postmenopausal women and suggestalternative means for providing this service.
91 II0357 Adverse urinary symptams after total rbdomiral hysterectomy- Fact of fiction? Griffith-Jones M.D.; Jarvis G.J.; McNamara H.M. Department olobstetrics and Gynaecolqy. St James :TUniversity Haspitul, Beskett Street, Lwh BR. J. UROL.
1991 6713 (295-297)
LSY 7TF
91105357 Spinal aad forearm bone mass in relrtwlr .~r dgeing rml mewpruse in healthy Italian women Ortolani S.; Ttevisan C., Bianchi M.L.; Caraceni M.P.; Ulivieri F.M.; Gandolini Cl.; MontesanoA.; Polli E.E. lstituto di Scipnze Mediche. University of Milan, Via F. :;for:a 3.5, 20122 Milun EUR. J. CLIN. INVEST. 1991 21/l (33-39) Most studiesconcerning bone status have been performed in Nordic and Anglo-Saxon countries and few data are available on southern European populations. We performed a cross-sectionalstudy on spine and forearm bone mass in 234 healthy Italian women and related the results to age and time since menopause. Forearm bone mass does not decline in premenopausal age, whereas. as far as the spine is concerned. a significant reduction appears 3 years before the mean age of menopause: in both cases. the occurrence of menopauseaccounted for an accelerated phase of bone loss. In postmenopausal women both spine and forearm bone mass show a stronger correlation with years since menopause than with age. According to a linear exponential model. the rate of spinal bone loss per year since menopause is around 4% in the first 3 years which slows down to around 2% iin the 5th year; the corresponding rates of forearm bone loss are 2% and 1.3%, respectively. 91105957 Patters of referral to a menopauseclinic Garnett T.; Mitchell A.; Studd J. Menopause Clinic. Dulivich Hospital, London SE22 8PT J. R. SOC. MED. 1991 8413 (128-130) One hundred and Efty new patients attending the Menopause Clinic at Dulwich Hospital were questioned on their attitudes and fears about hormone replacement therapy and ibJb: perceivedattitudes of their general practitioner. The majority of patients attending the clinic had initia:ed referral themselvesand many had travelled from outside the health authority area in order to be seen. The waiting list for an appointment was often unacceptable. We conclude that specialist menopause clinics in teaching hospitals are unable to cope with the demand for information about tire menopause and hormone replacement from postmenopausal women and suggestalternative means for providing this service.
91 II0357 Adverse urinary symptams after total rbdomiral hysterectomy- Fact of fiction? Griffith-Jones M.D.; Jarvis G.J.; McNamara H.M. Department olobstetrics and Gynaecolqy. St James :TUniversity Haspitul, Beskett Street, Lwh BR. J. UROL.
1991 6713 (295-297)
LSY 7TF