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Spontaneous Hemorrhage or Myopic Neovascularization on OCT Angiography
Ophthalmology Retina Volume 1, Number 4, July/August 2017 Footnotes and Financial Disclosures Originally received: October 6, 2016. Final revision: December 9, 2016. Accepted: December 9, 2016. Available online: January 26, 2017.
Author Contributions: Research design: Ying, Pan, Quinn, Daniel, Repka, Baumritter Manuscript no. ORET_2106_68.
1
Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
2
Division of Pediatric Ophthalmology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
3
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Part of this material was presented at the ARVO 2016 Annual Meeting, Seattle, Washington, May 5, 2016. *A listing of the members of the e-ROP Cooperative Group can be found in the Appendix (available at www.ophthalmologyretina.org).
Financial Disclosure(s): Supported by National Eye Institute of the National Institutes of Health, Department of Health and Human Services (grant nos. U10 EY017014 and R21EY025686).
Data analysis and/or interpretation: Ying, Pan, Quinn, Daniel, Repka, Baumritter Data acquisition and/or research execution: Ying, Pan, Quinn, Daniel, Repka, Baumritter Manuscript preparation: Ying, Quinn, Daniel, Repka, Baumritter Abbreviations and Acronyms: CI ¼ confidence interval; CRYO-ROP ¼ cryotherapy for retinopathy of prematurity; e-ROP ¼ evaluating of acute-phase retinopathy of prematurity; PMA ¼ postmenstrual age; ROP ¼ retinopathy of prematurity; RWROP ¼ referral-warranted retinopathy of prematurity. Correspondence: Gui-shuang Ying, PhD, University of Pennsylvania, 3535 Market St, Suite 700, Philadelphia, PA 19104-3309. E-mail: [email protected].
Pictures & Perspectives Spontaneous Hemorrhage or Myopic Neovascularization on OCT Angiography An asymptomatic man with high myopia was diagnosed during routine examination with a very small perifoveal spontaneous hemorrhage. A well-isolated, hyper-reflective lesion at the level of the retinal pigment epithelium could be detected on spectral-domain OCT (Fig 1A, yellow arrow). A little spot was evident on OCT angiography in the outer retina (Fig 1D) and in the choriocapillaris (Fig 1G). One week later, the lesion increased in size on spectral-domain OCT (Fig 1B), causing a small symptomatic scotoma. A naïve neovascular network became evident in the outer retina (Fig 1E) and in the choriocapillaris (Fig 1H). After intravitreal treatment with anti-vascular endothelial growth factor, the network resolved completely on spectral-domain OCT (Fig 1C), in the outer retina (Fig 1F), and in the choriocapillaris (Fig 1I).
PAOLO MILANI, MD1 LUISA PIERRO, MD2 ALFREDO PECE, MD3 1
Istituto Auxologico Italiano, Milan, Italy; Università Vita e Salute, Ospedale San Raffaele, Milan, Italy; 3 Ospedale Vizzolo Predabissi, Melegnano, Milan, Italy 2
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Author Contributions: Research design: Ying, Pan, Quinn, Daniel, Repka, Baumritter Manuscript no. ORET_2106_68.
1
Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
2
Division of Pediatric Ophthalmology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
3
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Part of this material was presented at the ARVO 2016 Annual Meeting, Seattle, Washington, May 5, 2016. *A listing of the members of the e-ROP Cooperative Group can be found in the Appendix (available at www.ophthalmologyretina.org).
Financial Disclosure(s): Supported by National Eye Institute of the National Institutes of Health, Department of Health and Human Services (grant nos. U10 EY017014 and R21EY025686).
Data analysis and/or interpretation: Ying, Pan, Quinn, Daniel, Repka, Baumritter Data acquisition and/or research execution: Ying, Pan, Quinn, Daniel, Repka, Baumritter Manuscript preparation: Ying, Quinn, Daniel, Repka, Baumritter Abbreviations and Acronyms: CI ¼ confidence interval; CRYO-ROP ¼ cryotherapy for retinopathy of prematurity; e-ROP ¼ evaluating of acute-phase retinopathy of prematurity; PMA ¼ postmenstrual age; ROP ¼ retinopathy of prematurity; RWROP ¼ referral-warranted retinopathy of prematurity. Correspondence: Gui-shuang Ying, PhD, University of Pennsylvania, 3535 Market St, Suite 700, Philadelphia, PA 19104-3309. E-mail: [email protected].
Pictures & Perspectives Spontaneous Hemorrhage or Myopic Neovascularization on OCT Angiography An asymptomatic man with high myopia was diagnosed during routine examination with a very small perifoveal spontaneous hemorrhage. A well-isolated, hyper-reflective lesion at the level of the retinal pigment epithelium could be detected on spectral-domain OCT (Fig 1A, yellow arrow). A little spot was evident on OCT angiography in the outer retina (Fig 1D) and in the choriocapillaris (Fig 1G). One week later, the lesion increased in size on spectral-domain OCT (Fig 1B), causing a small symptomatic scotoma. A naïve neovascular network became evident in the outer retina (Fig 1E) and in the choriocapillaris (Fig 1H). After intravitreal treatment with anti-vascular endothelial growth factor, the network resolved completely on spectral-domain OCT (Fig 1C), in the outer retina (Fig 1F), and in the choriocapillaris (Fig 1I).
PAOLO MILANI, MD1 LUISA PIERRO, MD2 ALFREDO PECE, MD3 1
Istituto Auxologico Italiano, Milan, Italy; Università Vita e Salute, Ospedale San Raffaele, Milan, Italy; 3 Ospedale Vizzolo Predabissi, Melegnano, Milan, Italy 2
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