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SRS-A and leukotrienes
TIPS - Fehruury
thetopics
I Y82
and authors fnr the scctionsdeal-
ing with the basic electmphysiology of the heatt. The chapters by Gettes on the involvemen of ions in dirlurhdncer ot
chapter should help to nrach a wider rcader\hlp. My oVerall impn%iWI after readinp thi\
rhythm is one of the best in the book. Simi-
volume ir that it i\ a *orthy addition to the Encyclopaedia and one which wdl urve as
larly it was a splendid idea to invite Krinsky
a useful btx~h IO many different t)pe\of
IO contribute a chapter on mathematical models of cardiac arrhythmias. The lauer
enlists over the next few years.
worker has made an important contribution toour understanding of the subject but most of the material was pKviously published in Russian. Consequently it has not been as widely known as it deserve* to be. This
A
wi-
J \~HTltO~tt?
Some gems
hr* colleagues a\ SRS-A. The name Icukcb tnene wa\ coined by Samuel\um BYdcuxdu
SRS-A and Leukotrienes
Ihe= compound%, becaux leuhcr)te* acre uwd a5 the original source and the product\ were trienes (that IX they contained three conjugated double bonds. although the) po\usuzd four double bonds in total). Se\crsl leukotriene\ have now been identitird. and difference\ in structure arc rctlectrd m the spectrum of their biological effects; some of thebe compounds hate potentialI\ important actions in inllammation ar well in\ inducing a characteristic 40% contraction of smooth murle. The contributions in thi\ volume include several chapten dcscribiny the \>nthrG of leukotrienes. an account oi their biological properties and pharmacolug~. a comparison of the acti\itie> of puritiell SRS and synthetic leukotriene\. and dchcriptions of the effects of inhibitors of the :ipos) pnax pathway. There dre also three introductoq articles in a bmzdly Gmilar \t!le: a long\h preface by Piper. introducory remArk\ by Pike and an outlinr hirtt>c h! Bnrklehurst. L’nfortunatrl~. &hough rhi\ volume hab been pubhhhcd rclati\cl> rdpidlj, leukotrirne hiolosy 1~\uch 3 f~rrmoving field th+r many of the contributlon~ uave already been l persed~ul by more detailed papn publi&ed in \clentilic jaurn;d\ after the Symposium, often u ith the timeauthors. which rhoulJ lx \ second. Iation to the oreaniren, uho were demonstrably succes& in ar~mblm$ man! at’ the acknowledged authorities in this field. There are, however. \ome gems that are not duplicatti elsewhere, including Pike’~ re>earchcs on the etymolop of ‘Ieukctriene’. which provide revealing comment> on the Greek @de35 ’ . hot knoun :I> the havour of Odyw*us* .md on it tribe of pointed-mouth crabs Apart from luch ewlteric offerings. thi3 booL’\ m;tin valu.: I* that it gives the int :rr%ted reader an .ucotmt of how this active tx\cxcJ. c1re.i\tc~rcJ in miJ- I%K&..
This volume represents the proczedingsof a Symposium held at the Royal College of Surgeons. London, in September 1980. II has been published with commendable speed, although the presentation inevitably loses something because the book is in camera-ready format. The term ‘SRS’ (for ‘4ow-reacting \ub stance’) was coined over 40 yeun ago when it was dixovered that the action of cobra verom on guinea pig lungs caused the release of a substance that induced a slow contraction of intestinal muscle; ‘SRS-A’ u a Gapplied to the xubstance released during anaphylaxis. Later evidence suggested thst it was a metaboliteof arachidonic acid, and in 1979-l9M) a family of compounds wit\ discovered that was produced from ardchidonate by the action of lipo\ygensses;oneofthese(5-(S)-hydroxy-6(R)Lysteinylglycinyl - 7.9, I 1. II eicosdtetraenoic acid) was identified by Morris and
Well balanced
The rdpld e\pan\ltm m p’pttdr rcwarch ha, reached the pomt at which .m! anempt IO produce a cclmplete. hut c’lmcr\c rc$Icu III the ticld i\ prohabl) an impGhlc ta4. even when the rcopc IC \llghtl> re\trictcJ to pcptidez actitc in the CM ;IS m ‘The Role of Peptide\ In Seuronal Functton’. Hamg xcepted that dilemma. htrucler. thir c,~llcction of papers make\ 3 valiant ;Ittempt 1,~ rcvie& both the more c*ttihh\hcd r&3 III peptide\ in the h~p,.nai.lrnlc-pitult.l~ dv* and the putarite prptide ncurotr.m~m:tter* more resentI) f~run~loutzide thi* ,~a. The book ma\ tc &r&d n!ushl) mra three panr; the iir*t piut being concerned maInI> u ith peptidc hicb) rtheyrc .md hiretion. the recond u th ~!sctn,ph?,ioloElcai otner\ation> anJ I&Z tlnrd uith put.tttr\c neurotran’rmmen.
I‘he rrm.unmg papcrc. aciountm~ ior appro\imatel> half rhc lxxrb. m\czt+te .i num&r of in&\ iJual pcpndcx pdrticuldrl~ ;1s putati\c neurotr~n~rnittcn in thr OS Perhaps the nro~t &taiieJ 2~1drrh~ t* prcsent4 b> Phillip> for .m+tenGn II .I\ d ncurotmnvtlitter in the h> polha!.ullU\ .UIL! concerned u ith ~atcr hlance Other SINK! neurotran\mmrr candidate3 conrldercJ .ire neurotenhm ~ncl huh\tance P. pamcularl~ in thou hrdm and >pinal .IWL concemcll N ilh pain, and VIP and carnorins with their az~mmettic distnbuliom in the bmin. hul u ith no clearly dettrfined rolr. Lebx con\ incing candidate% presented are cholcc)s!:i Cinin and bradykinin. A number of ‘rcleil~ ing hormones’ also make good candidates as neurotmnsmitten quite apan fmm their hormone releasing prop&es. Prptidrb
thetopics
I Y82
and authors fnr the scctionsdeal-
ing with the basic electmphysiology of the heatt. The chapters by Gettes on the involvemen of ions in dirlurhdncer ot
chapter should help to nrach a wider rcader\hlp. My oVerall impn%iWI after readinp thi\
rhythm is one of the best in the book. Simi-
volume ir that it i\ a *orthy addition to the Encyclopaedia and one which wdl urve as
larly it was a splendid idea to invite Krinsky
a useful btx~h IO many different t)pe\of
IO contribute a chapter on mathematical models of cardiac arrhythmias. The lauer
enlists over the next few years.
worker has made an important contribution toour understanding of the subject but most of the material was pKviously published in Russian. Consequently it has not been as widely known as it deserve* to be. This
A
wi-
J \~HTltO~tt?
Some gems
hr* colleagues a\ SRS-A. The name Icukcb tnene wa\ coined by Samuel\um BYdcuxdu
SRS-A and Leukotrienes
Ihe= compound%, becaux leuhcr)te* acre uwd a5 the original source and the product\ were trienes (that IX they contained three conjugated double bonds. although the) po\usuzd four double bonds in total). Se\crsl leukotriene\ have now been identitird. and difference\ in structure arc rctlectrd m the spectrum of their biological effects; some of thebe compounds hate potentialI\ important actions in inllammation ar well in\ inducing a characteristic 40% contraction of smooth murle. The contributions in thi\ volume include several chapten dcscribiny the \>nthrG of leukotrienes. an account oi their biological properties and pharmacolug~. a comparison of the acti\itie> of puritiell SRS and synthetic leukotriene\. and dchcriptions of the effects of inhibitors of the :ipos) pnax pathway. There dre also three introductoq articles in a bmzdly Gmilar \t!le: a long\h preface by Piper. introducory remArk\ by Pike and an outlinr hirtt>c h! Bnrklehurst. L’nfortunatrl~. &hough rhi\ volume hab been pubhhhcd rclati\cl> rdpidlj, leukotrirne hiolosy 1~\uch 3 f~rrmoving field th+r many of the contributlon~ uave already been l persed~ul by more detailed papn publi&ed in \clentilic jaurn;d\ after the Symposium, often u ith the timeauthors. which rhoulJ lx \ second. Iation to the oreaniren, uho were demonstrably succes& in ar~mblm$ man! at’ the acknowledged authorities in this field. There are, however. \ome gems that are not duplicatti elsewhere, including Pike’~ re>earchcs on the etymolop of ‘Ieukctriene’. which provide revealing comment> on the Greek @de35 ’ . hot knoun :I> the havour of Odyw*us* .md on it tribe of pointed-mouth crabs Apart from luch ewlteric offerings. thi3 booL’\ m;tin valu.: I* that it gives the int :rr%ted reader an .ucotmt of how this active tx\cxcJ. c1re.i\tc~rcJ in miJ- I%K&..
This volume represents the proczedingsof a Symposium held at the Royal College of Surgeons. London, in September 1980. II has been published with commendable speed, although the presentation inevitably loses something because the book is in camera-ready format. The term ‘SRS’ (for ‘4ow-reacting \ub stance’) was coined over 40 yeun ago when it was dixovered that the action of cobra verom on guinea pig lungs caused the release of a substance that induced a slow contraction of intestinal muscle; ‘SRS-A’ u a Gapplied to the xubstance released during anaphylaxis. Later evidence suggested thst it was a metaboliteof arachidonic acid, and in 1979-l9M) a family of compounds wit\ discovered that was produced from ardchidonate by the action of lipo\ygensses;oneofthese(5-(S)-hydroxy-6(R)Lysteinylglycinyl - 7.9, I 1. II eicosdtetraenoic acid) was identified by Morris and
Well balanced
The rdpld e\pan\ltm m p’pttdr rcwarch ha, reached the pomt at which .m! anempt IO produce a cclmplete. hut c’lmcr\c rc$Icu III the ticld i\ prohabl) an impGhlc ta4. even when the rcopc IC \llghtl> re\trictcJ to pcptidez actitc in the CM ;IS m ‘The Role of Peptide\ In Seuronal Functton’. Hamg xcepted that dilemma. htrucler. thir c,~llcction of papers make\ 3 valiant ;Ittempt 1,~ rcvie& both the more c*ttihh\hcd r&3 III peptide\ in the h~p,.nai.lrnlc-pitult.l~ dv* and the putarite prptide ncurotr.m~m:tter* more resentI) f~run~loutzide thi* ,~a. The book ma\ tc &r&d n!ushl) mra three panr; the iir*t piut being concerned maInI> u ith peptidc hicb) rtheyrc .md hiretion. the recond u th ~!sctn,ph?,ioloElcai otner\ation> anJ I&Z tlnrd uith put.tttr\c neurotran’rmmen.
I‘he rrm.unmg papcrc. aciountm~ ior appro\imatel> half rhc lxxrb. m\czt+te .i num&r of in&\ iJual pcpndcx pdrticuldrl~ ;1s putati\c neurotr~n~rnittcn in thr OS Perhaps the nro~t &taiieJ 2~1drrh~ t* prcsent4 b> Phillip> for .m+tenGn II .I\ d ncurotmnvtlitter in the h> polha!.ullU\ .UIL! concerned u ith ~atcr hlance Other SINK! neurotran\mmrr candidate3 conrldercJ .ire neurotenhm ~ncl huh\tance P. pamcularl~ in thou hrdm and >pinal .IWL concemcll N ilh pain, and VIP and carnorins with their az~mmettic distnbuliom in the bmin. hul u ith no clearly dettrfined rolr. Lebx con\ incing candidate% presented are cholcc)s!:i Cinin and bradykinin. A number of ‘rcleil~ ing hormones’ also make good candidates as neurotmnsmitten quite apan fmm their hormone releasing prop&es. Prptidrb