- Email: [email protected]
Stem cell mobilization and collection from patients and healthy donors
ARTICLE IN PRESS Transfusion and Apheresis Science ■■ (2015) ■■–■■
Contents lists available at ScienceDirect
Transfusion and Apheresis Science j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / t r a n s c i
Guest Editorial
Stem cell mobilization and collection from patients and healthy donors
This theme embodies the following six topics: - Stem cell mobilization strategies and stem cell mobilization failure - Stem cell mobilization and collection from healthy donors - Peripheral blood stem cell mobilization and collection from elderly patients and elderly healthy donors - Stem cell mobilization and collection from pediatric patients and pediatric healthy donors - Optimizing mobilization strategies in difficult-to-mobilize patients: The role of plerixafor - The role of nurses and technicians for stem cell mobilization and collection
This Issue has been suggested to me two years ago by the Transfusion and Apheresis Science Editor-in Chief, Gail Rock. I have included significant articles by contributors who specialize in transfusion and apheresis science. Over many decades, I have been collaborating with these investigators to advance the field of Bone Marrow Transplantation and Stem Cell Apheresis. Six authors, Leylagül Kaynar, Güray Saydam, Osman İlhan, Musa Karakükcü, Hakan Göker, and Aysen Timuragaoglu, review the consensus regarding both the stem cell mobilization and the collection from young, adult and elderly patients as well as healthy donors. These authors review also the causes of the mobilization failure, new strategies for poor stem cell mobilization together with the recent literature on the subject and the latest treatment methods.
Kaynar et al., Kayseri, Turkey, deal with stem cell mobilization strategies and stem cell mobilization failure. They aim to summarize the reasons for peripheral stem cell mobilization failure. İlhan et al. focus on the issue of optimization of peripheral blood stem cell mobilization and collection from elderly patients and elderly healthy donors. They aim to revise these data about stem cell mobilization in both elderly patients and healthy donors. Saydam et al. review aspects of stem cell mobilization and collection from healthy donors. They explain that the most frequently used grafts of hematopoietic stem cells (HSCs) for allogeneic transplantation are peripheral blood stem cells (PBSCs). Karakukcu et al. analyze the stem cell mobilization and collection from pediatric patients and healthy donors. Goker et al. focus on optimizing mobilization strategies in difficult-to-mobilize patients: The role of plerixafor. They describe the risk factors that were related with poor mobilization. They mention about methods to make better stem cell collection yields and hence reduce the risk of mobilization failure, and include careful donor selection and improving the apheresis procedure. In a final article, Aysen Timuragaoglu focuses on the role of technicians for stem cell mobilization and collection. She summarizes the central role of nurses and technicians. SCT
http://dx.doi.org/10.1016/j.transci.2015.05.005 1473-0502/© 2015 Elsevier Ltd. All rights reserved.
Please cite this article in press as: Ali Unal, Transfusion and Apheresis Science (2015), doi: 10.1016/j.transci.2015.05.005
ARTICLE IN PRESS 2
■■/Transfusion and Apheresis Science ■■ (2015) ■■–■■
process needs a multidisciplinary coordinated team to become successful. Hematology/Oncology/BMT team consists of medical director, physicians, nurses, patient care assistants, transplant coordinators, pharmacists, therapists, and dietitians. Throughout their reviews, the authors provide a model for determination of stem cell mobilization and collection: - the use of cytokines alone or in combination with chemotherapy (Chemo mobilization) is the most common strategy applied to mobilize and collect PBSCs; - the causes of mobilization failure; - new strategies for poor mobilization; - the major problem in a transplant eligible elderly patient is stem cell mobilization failure; - factors affecting stem cell mobilization have been revised as previous use of alkylating agents or radiotherapy, marrow involvement and bone marrow fibrosis;
- the characteristic features, potential side effects and main topics in peripheral blood stem cell mobilization from healthy donors; - the risk factors associated with mobilization failure. In conclusion, I am very appreciative to Gail Rock for her administrative support. She facilitates the sharing of the latest developments in blood science with the broader readership of Transfusion and Apheresis Science. Ali Unal * Medical School Bone Marrow Transplantation Center, Erciyes University, Kayseri TR 38039, Turkey * Tel.: +90 532 4111163; fax: +90 352 4373698. E-mail address: [email protected].
Please cite this article in press as: Ali Unal, Transfusion and Apheresis Science (2015), doi: 10.1016/j.transci.2015.05.005
Contents lists available at ScienceDirect
Transfusion and Apheresis Science j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / t r a n s c i
Guest Editorial
Stem cell mobilization and collection from patients and healthy donors
This theme embodies the following six topics: - Stem cell mobilization strategies and stem cell mobilization failure - Stem cell mobilization and collection from healthy donors - Peripheral blood stem cell mobilization and collection from elderly patients and elderly healthy donors - Stem cell mobilization and collection from pediatric patients and pediatric healthy donors - Optimizing mobilization strategies in difficult-to-mobilize patients: The role of plerixafor - The role of nurses and technicians for stem cell mobilization and collection
This Issue has been suggested to me two years ago by the Transfusion and Apheresis Science Editor-in Chief, Gail Rock. I have included significant articles by contributors who specialize in transfusion and apheresis science. Over many decades, I have been collaborating with these investigators to advance the field of Bone Marrow Transplantation and Stem Cell Apheresis. Six authors, Leylagül Kaynar, Güray Saydam, Osman İlhan, Musa Karakükcü, Hakan Göker, and Aysen Timuragaoglu, review the consensus regarding both the stem cell mobilization and the collection from young, adult and elderly patients as well as healthy donors. These authors review also the causes of the mobilization failure, new strategies for poor stem cell mobilization together with the recent literature on the subject and the latest treatment methods.
Kaynar et al., Kayseri, Turkey, deal with stem cell mobilization strategies and stem cell mobilization failure. They aim to summarize the reasons for peripheral stem cell mobilization failure. İlhan et al. focus on the issue of optimization of peripheral blood stem cell mobilization and collection from elderly patients and elderly healthy donors. They aim to revise these data about stem cell mobilization in both elderly patients and healthy donors. Saydam et al. review aspects of stem cell mobilization and collection from healthy donors. They explain that the most frequently used grafts of hematopoietic stem cells (HSCs) for allogeneic transplantation are peripheral blood stem cells (PBSCs). Karakukcu et al. analyze the stem cell mobilization and collection from pediatric patients and healthy donors. Goker et al. focus on optimizing mobilization strategies in difficult-to-mobilize patients: The role of plerixafor. They describe the risk factors that were related with poor mobilization. They mention about methods to make better stem cell collection yields and hence reduce the risk of mobilization failure, and include careful donor selection and improving the apheresis procedure. In a final article, Aysen Timuragaoglu focuses on the role of technicians for stem cell mobilization and collection. She summarizes the central role of nurses and technicians. SCT
http://dx.doi.org/10.1016/j.transci.2015.05.005 1473-0502/© 2015 Elsevier Ltd. All rights reserved.
Please cite this article in press as: Ali Unal, Transfusion and Apheresis Science (2015), doi: 10.1016/j.transci.2015.05.005
ARTICLE IN PRESS 2
■■/Transfusion and Apheresis Science ■■ (2015) ■■–■■
process needs a multidisciplinary coordinated team to become successful. Hematology/Oncology/BMT team consists of medical director, physicians, nurses, patient care assistants, transplant coordinators, pharmacists, therapists, and dietitians. Throughout their reviews, the authors provide a model for determination of stem cell mobilization and collection: - the use of cytokines alone or in combination with chemotherapy (Chemo mobilization) is the most common strategy applied to mobilize and collect PBSCs; - the causes of mobilization failure; - new strategies for poor mobilization; - the major problem in a transplant eligible elderly patient is stem cell mobilization failure; - factors affecting stem cell mobilization have been revised as previous use of alkylating agents or radiotherapy, marrow involvement and bone marrow fibrosis;
- the characteristic features, potential side effects and main topics in peripheral blood stem cell mobilization from healthy donors; - the risk factors associated with mobilization failure. In conclusion, I am very appreciative to Gail Rock for her administrative support. She facilitates the sharing of the latest developments in blood science with the broader readership of Transfusion and Apheresis Science. Ali Unal * Medical School Bone Marrow Transplantation Center, Erciyes University, Kayseri TR 38039, Turkey * Tel.: +90 532 4111163; fax: +90 352 4373698. E-mail address: [email protected].
Please cite this article in press as: Ali Unal, Transfusion and Apheresis Science (2015), doi: 10.1016/j.transci.2015.05.005