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Steroid Sulfatase Promotes Invasion and is a Useful Marker for Predicting the Progression of Bladder Cancer
Annals of Oncology 25 (Supplement 4): iv564–iv573, 2014 doi:10.1093/annonc/mdu359.10
tumour biology and pathology 1638P
STEROID SULFATASE PROMOTES INVASION AND IS A USEFUL MARKER FOR PREDICTING THE PROGRESSION OF BLADDER CANCER
abstracts
Objectives: To assess the clinical and functional significance of steroid sulfatase (STS) in bladder cancer. STS is steroid sulfates activation enzyme and is considered one of the key enzymes in androgen signaling pathway. Androgen signal is recently suggested to be involved in the growth of bladder cancer. However, the role of STS in bladder cancer has not been elucidated.
© European Society for Medical Oncology 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_4/iv567/2242316 by guest on 26 October 2019
S. Eri, M. Kato, M. Wei, S. Yamano, M. Fujioka, H. Wanibuchi Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, JAPAN
Methods: STS expression was measured in 170 bladder cancer tissues by immunohistochemistry. The effect of STS knockdown on cell proliferation, migration and invasion capacity was evaluated using bladder cancer cell line (T24). Results: The incidences of STS positive cancers were 21.3% and 41.2% in non-muscle invasive and muscle invasive bladder cancers, respectively ( p = 0.0262). STS positive cancers showed shorter recurrence-free survival and cancer specific survival (CSS) (p = 0.0083, 0.0014, respectively). By multivariate analysis, STS expression level was identified as an independent prognostic factor for CSS (p = 0.043). Furthermore, in vitro knockdown of STS significantly reduced cell migration and invasion capacities of bladder cancer cells accompanied by up-regulation of E-cadherin and down-regulation of vimentin. However, the expression of androgen receptor (AR) was not correlated with that of STS, pathological stage or survival of patients with bladder cancer, suggesting that AR is not likely to play an important role in the progression of bladder cancer. Conclusions: The present study demonstrates that STS promotes the invasion capability of bladder cancer and is a useful marker for predicting the progression of bladder cancers. Disclosure: All authors have declared no conflicts of interest.
tumour biology and pathology 1638P
STEROID SULFATASE PROMOTES INVASION AND IS A USEFUL MARKER FOR PREDICTING THE PROGRESSION OF BLADDER CANCER
abstracts
Objectives: To assess the clinical and functional significance of steroid sulfatase (STS) in bladder cancer. STS is steroid sulfates activation enzyme and is considered one of the key enzymes in androgen signaling pathway. Androgen signal is recently suggested to be involved in the growth of bladder cancer. However, the role of STS in bladder cancer has not been elucidated.
© European Society for Medical Oncology 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_4/iv567/2242316 by guest on 26 October 2019
S. Eri, M. Kato, M. Wei, S. Yamano, M. Fujioka, H. Wanibuchi Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, JAPAN
Methods: STS expression was measured in 170 bladder cancer tissues by immunohistochemistry. The effect of STS knockdown on cell proliferation, migration and invasion capacity was evaluated using bladder cancer cell line (T24). Results: The incidences of STS positive cancers were 21.3% and 41.2% in non-muscle invasive and muscle invasive bladder cancers, respectively ( p = 0.0262). STS positive cancers showed shorter recurrence-free survival and cancer specific survival (CSS) (p = 0.0083, 0.0014, respectively). By multivariate analysis, STS expression level was identified as an independent prognostic factor for CSS (p = 0.043). Furthermore, in vitro knockdown of STS significantly reduced cell migration and invasion capacities of bladder cancer cells accompanied by up-regulation of E-cadherin and down-regulation of vimentin. However, the expression of androgen receptor (AR) was not correlated with that of STS, pathological stage or survival of patients with bladder cancer, suggesting that AR is not likely to play an important role in the progression of bladder cancer. Conclusions: The present study demonstrates that STS promotes the invasion capability of bladder cancer and is a useful marker for predicting the progression of bladder cancers. Disclosure: All authors have declared no conflicts of interest.