- Email: [email protected]
Studies on the immune response of the rheumatic subject and its relationship to activity of the rheumatic process: The determination of antistreptolysin titer
1122
THE
AMERICAN
HEART
JOURNAL
recorded arterial pulse waves) ; it is probable that the gradient of rise of pressure is the most important factor. It has thus far not been determined what structure or structures contribute the main sound vibrations in response to the application of force initiated by the contraction of the ventricular muscle upon the ventricular contents.
Resnik, Harry, Jr., and Friedman, Ben: Studies creased Oxygen Consumption in Patients With vestigation
14:
551,
on the Mechanism Cardiac
Disease,
of the InJ.
Clin.
In
1935.
1. The basal metabolic rate is elevated in many persons with congestive car,diae failure and declines as improvement occurs. The degree of elevation (and decline) tends to parallel the severity of congestive failure (and the extent of improvement). 2. The above observations indicate that the increased work of the respiratory muscles associated with cardiac dyspnea adds another load to an already overburdened heart. This factor of respiratory effort assumes greater importance a8 cardiac failure becomes worse, for the ventilation ten,ds to rise and the vital capacity Ventilation in geometric PrOpOrtiOnS. Proto fall, thus increasing the ratio, Vital capacity ’ cedures which tend to reduce the ventilation (rest, morphine, venesection, paracentesis) are beneficial in part through reduction of the work of breathing.
Flaxman, 396,
Nathan:
Variability
of Murmurs
in Mitral
Stenosis, Am. J. M. Se. 190,
1935.
1. The variability of the murmurs in 237 cases of mitral stenosis is reported. 2. Auricular fibrillation was present in 46.6 per cent; it had no effect on the character or type of murmurs audible. 3. Double murmurs were found in 79 per cent. 4. Systolic murmurs alone were present in 15.2 per cent. 5. The murmurs of mitral stenosis were readily recognized by the characteristic rasping sound without resort to isolating the murmurs definitely in the cardiac cycle by timing.
Cobum, Alvin F., and Pauli, Ruth H.: Studies on the Immune Response of the Rheumatic Subject and Its Relationship to Activity of the Rheumatic Process: The Determination of Antistreptolysin Titer, J. Exper. Med. 62: 129, 1935. 1. A method for determining 2. The natural human level proximately 50 units.
the antistreptolysin of antistreptolysin
titer is #described determined in this
in detail. way is ap-
Coburn, A. V., and Pauli, R. H.: Studies on the Immune Response of the Rheumatic Subject and Its Relationship to Activity of the Rheumatic Process: Observations on an Epidemic of Influenza Followed by Hemolytic Streptococcus Infections in a Rheumatic Colony, J. Exper. Med. 62: 137, 1935. The observation8 presented in this paper may be summarized as follows: A study has been made on an isolated group of children with heart disease. All of these individuals, with one exception, were rheumatic subjects. Many of them carried a strain of hemolytic streptococcus in the throat flora during the winter of 1934. The organism produced no detectable toxin and was not associated with respiratory disease. Four patients contracted chickenpox during the winter months. None developed rheumatic reerudescences.
THE
AMERICAN
HEART
JOURNAL
recorded arterial pulse waves) ; it is probable that the gradient of rise of pressure is the most important factor. It has thus far not been determined what structure or structures contribute the main sound vibrations in response to the application of force initiated by the contraction of the ventricular muscle upon the ventricular contents.
Resnik, Harry, Jr., and Friedman, Ben: Studies creased Oxygen Consumption in Patients With vestigation
14:
551,
on the Mechanism Cardiac
Disease,
of the InJ.
Clin.
In
1935.
1. The basal metabolic rate is elevated in many persons with congestive car,diae failure and declines as improvement occurs. The degree of elevation (and decline) tends to parallel the severity of congestive failure (and the extent of improvement). 2. The above observations indicate that the increased work of the respiratory muscles associated with cardiac dyspnea adds another load to an already overburdened heart. This factor of respiratory effort assumes greater importance a8 cardiac failure becomes worse, for the ventilation ten,ds to rise and the vital capacity Ventilation in geometric PrOpOrtiOnS. Proto fall, thus increasing the ratio, Vital capacity ’ cedures which tend to reduce the ventilation (rest, morphine, venesection, paracentesis) are beneficial in part through reduction of the work of breathing.
Flaxman, 396,
Nathan:
Variability
of Murmurs
in Mitral
Stenosis, Am. J. M. Se. 190,
1935.
1. The variability of the murmurs in 237 cases of mitral stenosis is reported. 2. Auricular fibrillation was present in 46.6 per cent; it had no effect on the character or type of murmurs audible. 3. Double murmurs were found in 79 per cent. 4. Systolic murmurs alone were present in 15.2 per cent. 5. The murmurs of mitral stenosis were readily recognized by the characteristic rasping sound without resort to isolating the murmurs definitely in the cardiac cycle by timing.
Cobum, Alvin F., and Pauli, Ruth H.: Studies on the Immune Response of the Rheumatic Subject and Its Relationship to Activity of the Rheumatic Process: The Determination of Antistreptolysin Titer, J. Exper. Med. 62: 129, 1935. 1. A method for determining 2. The natural human level proximately 50 units.
the antistreptolysin of antistreptolysin
titer is #described determined in this
in detail. way is ap-
Coburn, A. V., and Pauli, R. H.: Studies on the Immune Response of the Rheumatic Subject and Its Relationship to Activity of the Rheumatic Process: Observations on an Epidemic of Influenza Followed by Hemolytic Streptococcus Infections in a Rheumatic Colony, J. Exper. Med. 62: 137, 1935. The observation8 presented in this paper may be summarized as follows: A study has been made on an isolated group of children with heart disease. All of these individuals, with one exception, were rheumatic subjects. Many of them carried a strain of hemolytic streptococcus in the throat flora during the winter of 1934. The organism produced no detectable toxin and was not associated with respiratory disease. Four patients contracted chickenpox during the winter months. None developed rheumatic reerudescences.