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Study of cytomegalovirus infection in renal transplant recipients
International Congress Series 1255 (2003) 215 – 216
Study of cytomegalovirus infection in renal transplant recipients Yiman Meng *, Yongfeng Liu General Surgery and Organ Transplant Unit, First Clinical University Hospital, China Medical University, 155 North Nanjing Street, Shenyang, Liaoning 110001, China Received 27 February 2003; accepted 28 March 2003
Abstract Background: The purpose of the study was to detect the incidence of active cytomegalovirus (CMV) infection in the population of different immune status and to observe the effect of prophylactic usage of the anti-CMV drug acyclovir. Methods: All patients were divided into postrenal transplantation group (P), fever group (F) and normal group (N). The P group was subdivided into P1 group (less than 6 months) and P2 group (more than 6 months). Results: The incidence of P group was higher than that of N group ( p < 0.01), and no significant difference was noted between the incidence of N group and F group ( p>0.05). The average antigen-positive (Ag+) cell number per 5 104 leukocytes was 13.5, and 55 in active CMV infection and CMV disease. Conclusions: The result of the study reveals that the incidence of active CMV infection correlates with the population immune status, the small dose of acyclovir in the first 3 months following renal transplantation has prophylactic effect, LSAB method can make rapid and early diagnosis of active CMV infection and CMV disease, the Ag+ number correlates with the severity of infection. D 2003 Elsevier B.V. All rights reserved. Keywords: Cytomegalovirus (CMV); Renal transplantation; Acyclovir
1. Background The purpose of the study was to detect the incidence of active cytomegalovirus (CMV) infection in the population of different immune status and to observe the effect of prophylactic usage of anti-CMV drug acyclovir.
* Corresponding author. Tel.: +86-24-2325-6666-6235; fax: +86-24-2326-5539. 0531-5131/03 D 2003 Elsevier B.V. All rights reserved. doi:10.1016/S0531-5131(03)00662-9
216
Y. Meng, Y. Liu / International Congress Series 1255 (2003) 215–216
2. Methods All patients were divided into post-renal transplantation group (P), fever group (F) and normal group (N). The P group was subdivided into P1 group (less than 6 months) and P2 group (more than 6 months). LSAB method was utilized to detect incidence of active CMV infection and CMV disease, renal function (blood creatine) was also detected in P group.
3. Results Table 1 showed that the incidence of active CMV infection of P, F, N groups were 21.4%, 3.7%, 0%, respectively. The incidence of P group was higher than that of N group ( p < 0.01), and no significant difference was noted between the incidence of N group and F group ( p>0.05). Table 2 shows that no significant difference was noted between P1 Table 1 Incidence of active CMV infection in N and P group Case N P F
25 28 27
Positive
CMV disease
Incidence (%)
0 6 1
0 2 0
0 21.4* 3.7**
* p < 0.01. ** p>0.05 compared with N group.
group (29.4%) and P2 group (9.1%) ( p>0.05). The average antigen-positive (Ag+) cell number per 5 104 leukocytes was 13.5 and 55 in active CMV infection and CMV disease.
4. Conclusions The result of the study reveals that the incidence of active CMV infection correlates with the population immune status, the small dose of acyclovir in the first 3 months following renal transplantation has prophylactic effect, LSAB method can make rapid and early diagnosis of active CMV infection and CMV disease, the Ag+ number correlates with the severity of infection.
Table 2 Incidence of active CMV infection post-Tx
Post-Tx < 6 months Post-Tx>6 months p>0.05.
Case
Positive
Incidence (%)
11 17
1 5
9.1 29.4
Study of cytomegalovirus infection in renal transplant recipients Yiman Meng *, Yongfeng Liu General Surgery and Organ Transplant Unit, First Clinical University Hospital, China Medical University, 155 North Nanjing Street, Shenyang, Liaoning 110001, China Received 27 February 2003; accepted 28 March 2003
Abstract Background: The purpose of the study was to detect the incidence of active cytomegalovirus (CMV) infection in the population of different immune status and to observe the effect of prophylactic usage of the anti-CMV drug acyclovir. Methods: All patients were divided into postrenal transplantation group (P), fever group (F) and normal group (N). The P group was subdivided into P1 group (less than 6 months) and P2 group (more than 6 months). Results: The incidence of P group was higher than that of N group ( p < 0.01), and no significant difference was noted between the incidence of N group and F group ( p>0.05). The average antigen-positive (Ag+) cell number per 5 104 leukocytes was 13.5, and 55 in active CMV infection and CMV disease. Conclusions: The result of the study reveals that the incidence of active CMV infection correlates with the population immune status, the small dose of acyclovir in the first 3 months following renal transplantation has prophylactic effect, LSAB method can make rapid and early diagnosis of active CMV infection and CMV disease, the Ag+ number correlates with the severity of infection. D 2003 Elsevier B.V. All rights reserved. Keywords: Cytomegalovirus (CMV); Renal transplantation; Acyclovir
1. Background The purpose of the study was to detect the incidence of active cytomegalovirus (CMV) infection in the population of different immune status and to observe the effect of prophylactic usage of anti-CMV drug acyclovir.
* Corresponding author. Tel.: +86-24-2325-6666-6235; fax: +86-24-2326-5539. 0531-5131/03 D 2003 Elsevier B.V. All rights reserved. doi:10.1016/S0531-5131(03)00662-9
216
Y. Meng, Y. Liu / International Congress Series 1255 (2003) 215–216
2. Methods All patients were divided into post-renal transplantation group (P), fever group (F) and normal group (N). The P group was subdivided into P1 group (less than 6 months) and P2 group (more than 6 months). LSAB method was utilized to detect incidence of active CMV infection and CMV disease, renal function (blood creatine) was also detected in P group.
3. Results Table 1 showed that the incidence of active CMV infection of P, F, N groups were 21.4%, 3.7%, 0%, respectively. The incidence of P group was higher than that of N group ( p < 0.01), and no significant difference was noted between the incidence of N group and F group ( p>0.05). Table 2 shows that no significant difference was noted between P1 Table 1 Incidence of active CMV infection in N and P group Case N P F
25 28 27
Positive
CMV disease
Incidence (%)
0 6 1
0 2 0
0 21.4* 3.7**
* p < 0.01. ** p>0.05 compared with N group.
group (29.4%) and P2 group (9.1%) ( p>0.05). The average antigen-positive (Ag+) cell number per 5 104 leukocytes was 13.5 and 55 in active CMV infection and CMV disease.
4. Conclusions The result of the study reveals that the incidence of active CMV infection correlates with the population immune status, the small dose of acyclovir in the first 3 months following renal transplantation has prophylactic effect, LSAB method can make rapid and early diagnosis of active CMV infection and CMV disease, the Ag+ number correlates with the severity of infection.
Table 2 Incidence of active CMV infection post-Tx
Post-Tx < 6 months Post-Tx>6 months p>0.05.
Case
Positive
Incidence (%)
11 17
1 5
9.1 29.4