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Study of the QT interval corrected for heart rate in patents with type 2 dibetes mellitus
Poster Session 2
$286
Before treatment
After2 weeks
After 12 weeks
Controls
Fructosamine 1.95:0.4** 2.05:0.6** 2.05:0.3** 1.14-0.2 (mmol/I) HbAlc (%) 8.25:1.7"* 7.94-1.3"* 4.84-0.4 MDA (/xmol/l) 2.454-0.32* 2.424-0.60* 2.584-0.50* 2.14-0.33 SOD (U) 1.124-0.19" 1.134-0.15" 1.144-0.18" 1.314-0.13 fS-NAG(U/I) 24.0(15.4-36.0)** 23.5(14.l-39.0)** 23.8(14.6-38.0)** 17.2(12.3-23.5) tPA (ng/ml) 6.7 (2.4-18.9) 5.4 (2.4-I2.0)z 6.2 (2.4-16.2) 5.8 (2.5-9.6) PAI-I (ng/ml) 182(67-496)** 142 (58-346)**z 122 (38-389)*z 56(24-128) Significantdifferencesas comparedto healthypersons: *p<0.01, **p<0.001, and to baseline values:Zp<0.01. therapy remained comparable with baseline values. Plasma PAI-1 levels were not changed in healthy subjects after vitamin administration. Conclusion: Impaired fibrinolysis in obese Type 2 diabetic patients my be improved both in acute and in chronic phase of combined vitamin C and E treatment. No changes apparent in the oxidative stress measured by plasma MDA concentration induce a hypothesis that combined vitamin C and E administration may influence fibrinolysis still by another mechanism than by oxidative stress alone. Further randomised, placebo controlled and more extended study will be necessary.
Pl168 Diabetes Mellitus and Cardiovascular Risk Factors lnpost-Menopausal Women ZULEMA Z.S. STOLARZA, Nestor N.S. Siseles, Pamela P.G. Gutierrez, Mirta M.L. Lemer, Clandio C.G. Gonzalez, Julio J.S. Szuster. Climateric,
Hospital Frances, Buenos Aires, Capital, Argentina; Nutrition, Hospital Frances, Buenos Aires, Capital, Argentina Objectives: To assess the main anthropometric characteristics and the frequency of Diabetes Mellitus and different cardiovascular risk factors, as the first stage of a mid-term tracking program in post-menopausal women who attended the Nutrition and Climacteric Services. Methods: 102 post-menopausal women in all, 42-74 y (media = 56.7 -I6.4 y), were included in the study. BMI values, waist, blood pressure, total cholesterolemia and LDL-c, HDL-c, Trygliceridemia, uricemia, glycemia and fibrinogenemia (Clauss method) were determined. Personal and familiar antecedents as regards cardiovascular and/or metabolic diseases were asked for and a general and gynecogical physical exam was carries out. Statistical Analysis: procedures of descriptive statistics were carried out, Chi square, non-parametric correlation (Spearman) and multiple logistic regression (method quasi-Newton; maximum likelihood). Results: Taking a B M I > = 30 as the limit, the 28.4% of women showed obesity; the BMI of the total sample was 28.2 4- 4.9 kg/m2. Smoking habit was stated by 29.4% of women. A 59.8% of them, were classified as hypertensive (higher values than the JNC limits). The arterial blood pressure values were: SBP: 130.3 4- 20.1 mmHg; DBP: 85.7 4- 10.9 mmHg. 9.8% of the women turned out to be diabetic. 13.1% of the hypertensive women were diabetic and 80% of the diabetic, hypertensive. LDL levels found in the sample were high (156.7 4- 38.7 mg/dl); the median fibrinogenemia was 320 mg/dl. In the Spearman model, the presence of Hypertension was significantly associated with the age, BMI and uricemia. In the multivariate model, age and BMI were highly associated with hypertension. Conclusion: Arterial hypertension is very frequent in this group of patients, not always appropriately controlled with the treatment. Furthermore, the association: diabetes-hypertension, especially in obese women, is relevant. The systematic search for control of modifiable factors, seems specially recommended in this sector of population.
Pl169 Study of the QT Interval Corrected for Heart Rate in Patents with Type 2 Dibetes Mellitus EUGENII I. SOKOLOV, Andrey L. Davydov, Ninella T. Starkova. Dpt of
Endocrinology, Moscow Medical Stomatology Institute, Moscow, Russian Federation The objective of the study was to monitor the QT interval corrected for heart rate (QTc) in patents with type 2 diabetes mellitus. 42 patients with type 2 diabetes mellitus aged between 35-55 years with compensated carbohydrate metabolism (Hb A l e < 8,0 %), including 21 patients with signs of diabetic neuropathy (DN) were studied. The QTc interval was calculated according to Bazett's formula with monitoring of electrocardiogram. During the investigation it was found that the patients with type 2 diabetes mellitus and the DN had a prolonged QTc interval at rest that correlated with pulse rate (r=0.84; p<0.001), see the table below #
Groups of patients
HR, beatsdmin
QTc, s
1 2 3
Type 2 diabeteswith DN; n = 21 Type 2 diabetes;n=21 Healthypeople,n=25
87.25:1.13* 70.2 4-1.14 69.85:1.12
0.4304-0.004* 0.3974-0.004 0.3915:0.003
*p
Conclusion: Based on the results obtained we recommend the QT interval monitoring as a complimentary specific test for diagnosis of diabetic vegetative (autonomic) cardiac neuropathy.
Pl170
Tei-Index Is Useful in E v a l u a t i n g Subclinical Cardiac Dysfunction in Diabetic Patients SHUICHI TOHYO 1, Nobuhiko S aito 2. l Department of Internal Medicine Division of Metabolism and Endocrinology, St.Marianna Univ.of School of Medicine, Kawasaki-shi, Kanagawa, Japan; 2Department of Internal Medicine Division of Metabolism and Endocrinology, St.Marianna Univ.of Sehool of Medicine, Kawasaki-shi, Kanagawa, Japan
Purpose: Regarding cardiac function in patients with diabetic cardiomyopathy, systolic and diastolic functions have been evaluated separately. Using Doppler echocardiography, Tel et al. proposed a novel index that facilitates simultaneous evaluation of systolic and diastolic functions. That is, a total ejection isovolume (Tei)-index: T = [isovolumic relaxation time ((IRT) + isovolumic contraction time (ICT)/ejection time (ET)]. Using the Tel-index(T), we evaluated the presence or absence of subclinical cardiac dysfunction in diabetic patients. Subjects: The subjects consisted of 42 healthy volunteers (Group C: 20 males and 22 females, mean age: 48.9 4- 10.5 years) and 42 diabetics (Group D: 20 males and 22 females, mean age: 50.31 4- 11.43 years). Patients with ischemic heart disease and hypertension were excluded. Methods: Using left ventricular(V) Doppler echoeardiography, T, ejection fraction (EF), fractional shortening (FS), V-end-diastolic dimension (Dd), V-end-systolic dimension (Ds), inter-V-septum-thickness-diameter diastole (IVSthd), and inter-V-septum-thickness-diameter systole (IVSths) were determined. Moreover, age and BMI were determined. In Group D, coefficients of variation were evaluated to investigate the correlations between T and the duration of diabetes and HbAlc. Statistical analysis was performed using unpaired t-test to evaluate the T between the two groups. The correlation between the two groups was evaluated using Fisher's PLSD. Results: The following T were obtained for the two groups: 0.231 ± 0.006 in Group C vs. 0.400 -4- 0.007 in Group D (p < 0.001 ). Percentages for EF were as follows: 78.52 -I- 1.32% in Group C vs. 74.66 4- 1.592% in Group D (p = 0.066). There were no significant differences among other parameters of cardiac functions. In Group C, T did not correlate with any
$286
Before treatment
After2 weeks
After 12 weeks
Controls
Fructosamine 1.95:0.4** 2.05:0.6** 2.05:0.3** 1.14-0.2 (mmol/I) HbAlc (%) 8.25:1.7"* 7.94-1.3"* 4.84-0.4 MDA (/xmol/l) 2.454-0.32* 2.424-0.60* 2.584-0.50* 2.14-0.33 SOD (U) 1.124-0.19" 1.134-0.15" 1.144-0.18" 1.314-0.13 fS-NAG(U/I) 24.0(15.4-36.0)** 23.5(14.l-39.0)** 23.8(14.6-38.0)** 17.2(12.3-23.5) tPA (ng/ml) 6.7 (2.4-18.9) 5.4 (2.4-I2.0)z 6.2 (2.4-16.2) 5.8 (2.5-9.6) PAI-I (ng/ml) 182(67-496)** 142 (58-346)**z 122 (38-389)*z 56(24-128) Significantdifferencesas comparedto healthypersons: *p<0.01, **p<0.001, and to baseline values:Zp<0.01. therapy remained comparable with baseline values. Plasma PAI-1 levels were not changed in healthy subjects after vitamin administration. Conclusion: Impaired fibrinolysis in obese Type 2 diabetic patients my be improved both in acute and in chronic phase of combined vitamin C and E treatment. No changes apparent in the oxidative stress measured by plasma MDA concentration induce a hypothesis that combined vitamin C and E administration may influence fibrinolysis still by another mechanism than by oxidative stress alone. Further randomised, placebo controlled and more extended study will be necessary.
Pl168 Diabetes Mellitus and Cardiovascular Risk Factors lnpost-Menopausal Women ZULEMA Z.S. STOLARZA, Nestor N.S. Siseles, Pamela P.G. Gutierrez, Mirta M.L. Lemer, Clandio C.G. Gonzalez, Julio J.S. Szuster. Climateric,
Hospital Frances, Buenos Aires, Capital, Argentina; Nutrition, Hospital Frances, Buenos Aires, Capital, Argentina Objectives: To assess the main anthropometric characteristics and the frequency of Diabetes Mellitus and different cardiovascular risk factors, as the first stage of a mid-term tracking program in post-menopausal women who attended the Nutrition and Climacteric Services. Methods: 102 post-menopausal women in all, 42-74 y (media = 56.7 -I6.4 y), were included in the study. BMI values, waist, blood pressure, total cholesterolemia and LDL-c, HDL-c, Trygliceridemia, uricemia, glycemia and fibrinogenemia (Clauss method) were determined. Personal and familiar antecedents as regards cardiovascular and/or metabolic diseases were asked for and a general and gynecogical physical exam was carries out. Statistical Analysis: procedures of descriptive statistics were carried out, Chi square, non-parametric correlation (Spearman) and multiple logistic regression (method quasi-Newton; maximum likelihood). Results: Taking a B M I > = 30 as the limit, the 28.4% of women showed obesity; the BMI of the total sample was 28.2 4- 4.9 kg/m2. Smoking habit was stated by 29.4% of women. A 59.8% of them, were classified as hypertensive (higher values than the JNC limits). The arterial blood pressure values were: SBP: 130.3 4- 20.1 mmHg; DBP: 85.7 4- 10.9 mmHg. 9.8% of the women turned out to be diabetic. 13.1% of the hypertensive women were diabetic and 80% of the diabetic, hypertensive. LDL levels found in the sample were high (156.7 4- 38.7 mg/dl); the median fibrinogenemia was 320 mg/dl. In the Spearman model, the presence of Hypertension was significantly associated with the age, BMI and uricemia. In the multivariate model, age and BMI were highly associated with hypertension. Conclusion: Arterial hypertension is very frequent in this group of patients, not always appropriately controlled with the treatment. Furthermore, the association: diabetes-hypertension, especially in obese women, is relevant. The systematic search for control of modifiable factors, seems specially recommended in this sector of population.
Pl169 Study of the QT Interval Corrected for Heart Rate in Patents with Type 2 Dibetes Mellitus EUGENII I. SOKOLOV, Andrey L. Davydov, Ninella T. Starkova. Dpt of
Endocrinology, Moscow Medical Stomatology Institute, Moscow, Russian Federation The objective of the study was to monitor the QT interval corrected for heart rate (QTc) in patents with type 2 diabetes mellitus. 42 patients with type 2 diabetes mellitus aged between 35-55 years with compensated carbohydrate metabolism (Hb A l e < 8,0 %), including 21 patients with signs of diabetic neuropathy (DN) were studied. The QTc interval was calculated according to Bazett's formula with monitoring of electrocardiogram. During the investigation it was found that the patients with type 2 diabetes mellitus and the DN had a prolonged QTc interval at rest that correlated with pulse rate (r=0.84; p<0.001), see the table below #
Groups of patients
HR, beatsdmin
QTc, s
1 2 3
Type 2 diabeteswith DN; n = 21 Type 2 diabetes;n=21 Healthypeople,n=25
87.25:1.13* 70.2 4-1.14 69.85:1.12
0.4304-0.004* 0.3974-0.004 0.3915:0.003
*p
Conclusion: Based on the results obtained we recommend the QT interval monitoring as a complimentary specific test for diagnosis of diabetic vegetative (autonomic) cardiac neuropathy.
Pl170
Tei-Index Is Useful in E v a l u a t i n g Subclinical Cardiac Dysfunction in Diabetic Patients SHUICHI TOHYO 1, Nobuhiko S aito 2. l Department of Internal Medicine Division of Metabolism and Endocrinology, St.Marianna Univ.of School of Medicine, Kawasaki-shi, Kanagawa, Japan; 2Department of Internal Medicine Division of Metabolism and Endocrinology, St.Marianna Univ.of Sehool of Medicine, Kawasaki-shi, Kanagawa, Japan
Purpose: Regarding cardiac function in patients with diabetic cardiomyopathy, systolic and diastolic functions have been evaluated separately. Using Doppler echocardiography, Tel et al. proposed a novel index that facilitates simultaneous evaluation of systolic and diastolic functions. That is, a total ejection isovolume (Tei)-index: T = [isovolumic relaxation time ((IRT) + isovolumic contraction time (ICT)/ejection time (ET)]. Using the Tel-index(T), we evaluated the presence or absence of subclinical cardiac dysfunction in diabetic patients. Subjects: The subjects consisted of 42 healthy volunteers (Group C: 20 males and 22 females, mean age: 48.9 4- 10.5 years) and 42 diabetics (Group D: 20 males and 22 females, mean age: 50.31 4- 11.43 years). Patients with ischemic heart disease and hypertension were excluded. Methods: Using left ventricular(V) Doppler echoeardiography, T, ejection fraction (EF), fractional shortening (FS), V-end-diastolic dimension (Dd), V-end-systolic dimension (Ds), inter-V-septum-thickness-diameter diastole (IVSthd), and inter-V-septum-thickness-diameter systole (IVSths) were determined. Moreover, age and BMI were determined. In Group D, coefficients of variation were evaluated to investigate the correlations between T and the duration of diabetes and HbAlc. Statistical analysis was performed using unpaired t-test to evaluate the T between the two groups. The correlation between the two groups was evaluated using Fisher's PLSD. Results: The following T were obtained for the two groups: 0.231 ± 0.006 in Group C vs. 0.400 -4- 0.007 in Group D (p < 0.001 ). Percentages for EF were as follows: 78.52 -I- 1.32% in Group C vs. 74.66 4- 1.592% in Group D (p = 0.066). There were no significant differences among other parameters of cardiac functions. In Group C, T did not correlate with any