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Subject Index for Volume 27
Bioorganic Chemistry 27, 489–493 (1999) Article ID bioo.1999.1160, available online at http://www.idealibrary.com on
Subject Index for Volume 27 A
Aminoglycoside antibiotics modification by kanamycin nucleotidyltransferase from Staphylococcus aureus, kinetic mechanism, 395 2-Amino-6-mercapto-7-methylpurine ribonucleoside phosphate-independent hydrolysis by purine nucleoside phosphorylase, 307 (S)-2-Amino-4-phosphonobutyric acid analogues, selective modulation of metabotropic glutamate receptors, 20 Aphthovirus 2A protein cleavage mechanism, 55 Aureolic acid antibiotics biosynthesis, 41 Azabicycloalkanes tropane-related, versatile synthesis and reactivity, 91
Acetylation hydroxymethylated phenolic compounds, chemoselective enzyme-catalyzed reactions, 119 Acetylcholinesterase erythrocyte, kinetic inhibition by tacrine and tacrine derivatives (human), 197 Active sites yeast OMP decarboxylase, probing with UMP, thiosubstituted UMP analogues, and CMP-6-carboxylate, 297 [v-(Adenosin-58-O-yl)alkyl]cobalamins inhibitory properties toward ribonucleotide triphosphate reductase from Lactobacillus leichmannii, kinetic evaluation, 451 Advanced glycation end products formation from low molecular weight model comB pounds, 443 Aeromonas hydrophila AE036 Beauveria bassiana metallo-b-lactamase, hydroxamate inhibitors of, 35 biohydroxylation reactions with, 81 Alcohol dehydrogenase (RS)-N-Benzoylalanine hydroxamate + native and single-point mutants, catalysis of NAD inhibition of Aeromonas hydrophila AE036 metalloreduction by PhCH2OH, log(kcat/Km) for, linear b-lactamase, 35 dependence on distance between reactants, 289 (RS)-N-Benzoyl-O-benzylalanine hydroxamate 5-Alkenyl-1-pyrroline 1-oxide-5-carboxylic esters inhibition of Aeromonas hydrophila AE036 metalloreactions leading to synthesis of tropanes and related b-lactamase, 35 azabicycloalkanes, 91 Benzyl alcohol sec-Alkyl 2-methyl-3-oxobutyrate reduction of NAD+ with horse liver alcohol dehydroreduction with yeast keto ester reductase: construcgenase and mutants, log(kcat/Km) for, linear tion of plural stereocenters remote from reacdependence on distance between reactants, 289 tion center, 3 (RS)-O-Benzyl-N-phenoxyacetylalanine hydroxamate Alkylpiperidines inhibition of Aeromonas hydrophila AE036 metalloincubation with Beauveria bassiana, hydroxylation b-lactamase, 35 products of, 81 (RS)-O-Benzyl-N-phenoxyacetylphenylalanine hyAmino acids droxamate acetylated, low molecular weight model compounds inhibition of Aeromonas hydrophila AE036 metallowith, formation of advanced glycation end b-lactamase, 35 products, 443 Biohydroxylation side chains, effects on peptide conformation, modelreactions catalyzed by enzymes and whole-cell sysing, 434 tems, 81 1-Aminocyclopentane-1,3-dicarboxylic acid Bis-[48-azido-2,28:68,28-terpyridine platinum(II)] analogues, selective modulation of metabotropic complexes glutamate receptors, 20 with rigid and extended linkers, design and synthesis 489 0045-2068/99 $30.00 Copyright q 1999 by Academic Press All rights of reproduction in any form reserved.
490
SUBJECT INDEX
for study of DNA topology by photoaffinity labeling, 477 Bis(benzoxazole) metabolite UK-1 produced by Streptomyces, Mg2+dependent binding to DNA and inhibition of human topoisomerase II, 326 Bleomycin biosynthesis in Streptomyces verticillus: model of hybrid peptide and polyketide biosynthesis, 155 Blood parameters in albino mice, effects of products of electrochemical oxidation of 4-hydroxyindole, 239 Breast cancer triphenylethylene dimers for treatment of, synthesis and cytotoxic activity in vitro, 27, 383
synthesis of tropanes and related azabicycloalkanes, 91 Cyclohexene retinal chromophore moiety in rhodopsin, role in pigment bioactivity, 372 16a,17a-Cyclohex-38-eno-progesterone 3 H-labeled, synthesis as probe for steroid–receptor binding studies, 207 Cytidine 58-monophosphate-6-carboxylate in probing of yeast OMP decarboxylase active sites, 297 Cytochrome P450cam monooxygenase isolated Y96A mutant, biohydroxylation reactions with, 81 D
C C1027 biosynthesis, 172 Calicheamicin biosynthetic cascade, 172 Candida rugosa lipase catalysis of chemoselective transesterification reactions on hydroxymethylated phenolic compounds, 119 Carbohydrates low molecular weight model compounds with, formation of advanced glycation end products, 443 L-2-(Carboxycyclopropyl)glycine analogues, selective modulation of metabotropic glutamate receptors, 20 Chelation cobalt in biosynthesis of vitamin B12 corrin ring component, 100 Chromoprotein enediynes biosynthesis, 172 Cobalamin corrin ring component, biosynthesis, 100 Cobalt chelation in biosynthesis of vitamin B12 corrin ring component, 100 Co–C bond homolysis, intermediate formed by, adenosylcobalamin competitive inhibibitors mimicking, kinetic evaluation, 451 Conformation peptides, effects of amino acid side chains, modeling, 434 Crosslinking photoinduced, by dibenzoyldiazomethane–oligodeoxynucleotide conjugate, mechanistic study, 227 Cycloaddition substitution effects in 2 + 2 reaction of phenylpropanoids, 339
Deacetylation hydroxymethylated phenolic compounds, chemoselective enzyme-catalyzed reactions, 119 N-Deoxyribosyltransferases glycosyl transfer reactions catalyzed by, 135 Dibenzoyldiazomethane–oligodeoxynucleotide conjugate photoinduced crosslinking and cleavage at guanine by, mechanistic study, 227 Diterpenoid resins classification by solid state NMR, 409 DNA Mg2+-dependent binding to UK-1, 326 operator sequences with isoteric base-pair analogues, in analysis of trp repressor–operator complex interface, 215 topology, analysis by photoaffinity labeling, bisintercalators with rigid and extended linkers for, design and synthesis, 477 DNA topoisomerase II inhibition by UK-1 (human), 326 E Electrochemical oxidation 4-hydroxyindole, products of, effects on blood parameters of albino mice, 239 Enediyne biosynthesis and self-resistance, 172 N-Eptyl-tacrine kinetic inhibition of acetylcholinesterase from human erythrocytes, 197 Erythrocytes acetylcholinesterase, kinetic inhibition by tacrine and tacrine derivatives (human), 197 Estrogen receptor triphenylethylene dimers inhibiting, synthesis and cytotoxicity in vitro, 27, 383
491
SUBJECT INDEX F Fluorescent sensors construction by template polymerization, 463 Foot-and-mouth disease virus 2A protein cleavage mechanism, 55 G Genes blm, cloning and characterization, 155 L-Glutamate conformationally constrained analogues, subtypeselective modulation of metabotropic glutamate receptors, 20 Glutamate receptor metabotropic, subtype-selective modulation by conformationally constrained L-glutamate analogues, 20 Glycation low molecular weight model compounds, 443 Glycosyl transferring enzymes nucleoside synthesis mediated by, 135 Guanine oligodeoxynucleotide cleavage at, by dibenzoyldiazomethane–oligodeoxynucleotide conjugate, mechanistic study, 227 H Hydrogenolysis 1-pyrroline 1-oxide cycloadducts in synthesis of tropanes and related azabicycloalkanes, 91 Hydrolysis phosphate-independent, 2-amino-6-mercapto-7methylpurine ribonucleoside by purine nucleoside phosphorylase, 307 5-Hydroperoxyisourate intermediate in urate oxidase reaction, theoretical study, 351 Hydroxamates inhibitors of Aeromonas hydrophila AE036 metallob-lactamase, 35 4-Hydroxyindole electrochemical oxidation, products of, effects on blood parameters of albino mice, 239 Hydroxylation biohydroxylation reactions catalyzed by enzymes and whole-cell systems, 81 Hydroxymethylated phenols enzyme-catalyzed chemoselective transesterification reactions on, 119 I Isomerization photoinduced, retinal chromophore in rhodopsin, role of cyclohexene moiety, 372
K Kanamycin nucleotidyltransferase from Staphylococcus aureus, kinetic mechanism, 395 Keto ester reductase yeast, reduction of b-keto esters: construction of plural stereocenters remote from reaction center, 3 L Lactobacillus leichmannii ribonucleotide triphosphate reductase, adenosylcobalamin competitive inhibitors of, kinetic evaluation, 451 Lipase from Candida rugosa or pancreas, chemoselective transesterification reactions on hydroxymethylated phenolic compounds, 119 Lysyl tyrosylquinone model studies, overview, 253 M Magnesium UK-1 binding to DNA dependent on, analysis, 326 Metallo-b-lactamase Aeromonas hydrophila AE036, hydroxamate inhibitors of, 35 a-Methyl b-keto esters reduction with yeast keto ester reductase: construction of plural stereocenters remote from reaction center, 3 Methyltransferases in biosynthesis of vitamin B12 corrin ring component, 100 6-Metoxy-tacrine kinetic inhibition of acetylcholinesterase from human erythrocytes, 197 Mithramycin biosynthetic studies, 41 Molecular imprinting enantioselective Tro¨ger’s base receptor preparation, 363 fluorescent sensor preparation, 463 N +
NAD reduction by PhCH2OH with horse liver alcohol dehydrogenase and mutants, log(kcat/Km) for, linear dependence on distance between reactants, 289 Nuclear magnetic resonance solid state, classification of modern resins, 409
492
SUBJECT INDEX
Nucleoside phosphorylases glycosyl transfer reactions catalyzed by, 135 Nucleosides synthesis mediated by glycosyl transferring enzymes, 135 O Oligodeoxynucleotides photoinduced crosslinking and cleavage at guanine by dibenzoyldiazomethane– oligodeoxynucleotide conjugate, mechanistic study, 227 Orotidine-58-monophosphate decarboxylase yeast, active site probing with UMP, thio-substituted UMP analogues, and CMP-6-carboxylate, 297 Oxidation electrochemical, 4-hydroxyindole, products of, effects on blood parameters of albino mice, 239 P Pancreatic lipase catalysis of chemoselective transesterification reactions on hydroxymethylated phenolic compounds, 119 Peptides conformation, effects of amino acid side chains, modeling, 434 low molecular weight model compounds with, formation of advanced glycation end products, 443 and polyketides, hybrid biosynthesis, bleomycin biosynthesis in Streptomyces verticillus as model of, 155 synthetic, differential reactivity with protein kinases A and C, 189 Phenols hydroxymethylated, enzyme-catalyzed chemoselective transesterification reactions on, 119 (RS)-N-Phenoxyacetylalanine hydroxamate inhibition of Aeromonas hydrophila AE036 metallob-lactamase, 35 (RS)-N-Phenoxyacetylphenylalanine hydroxamate inhibition of Aeromonas hydrophila AE036 metallob-lactamase, 35 Phenylglycine analogues, selective modulation of metabotropic glutamate receptors, 20 Phenylpropanoids 2 + 2 cycloaddition reaction, effects of substitution, 339 Phosphopento-mutase coupled with nucleoside phosphorylase, glycosyl transfer reactions catalyzed by, 135 Photoaffinity labeling
DNA topological analysis with, bis-intercalators with rigid and extended linkers for, design and synthesis, 477 Photochemistry crosslinking and cleavage at guanine by dibenzoyldiazomethane–oligodeoxynucleotide conjugate, mechanistic study, 227 Photoisomerization retinal chromophore in rhodopsin, role of cyclohexene moiety, 372 Polyketides and peptides, hybrid biosynthesis, bleomycin biosynthesis in Streptomyces verticillus as model of, 155 Polyketide synthase role in biosynthesis of aureolic acid group antibiotics, 41 Polymerization template, construction of fluorescent sensors by, 463 Progesterone receptor binding studies, 3H-labeled 16a,17a-cyclohex-38eno-progesterone as probe for, synthesis, 207 Protein kinase A and protein kinase C, differential specificity in reaction with synthetic peptides, 189 Protein kinase C and protein kinase A, differential specificity in reaction with synthetic peptides, 189 Proteins nonstoichiometric cotranslational scission in eukaryotic ribosomes, model, 55 Purine nucleoside phosphorylase catalysis of phosphate-independent hydrolysis of 2amino-6-mercapto-7-methylpurine ribonucleoside, 307 Q Quantitative structure–activity relationships peptides: effects of amino acid side chains on conformation, 434 Quinocofactors modeling, overview, 253 R Reduction b-keto esters with yeast keto ester reductase: construction of plural stereocenters remote from reaction center, 3 NAD+ by PhCH2OH with horse liver alcohol dehydrogenase and mutants, log(kcat/Km) for, linear dependence on distance between reactants, 289 Resins classification by solid state NMR, 409
493
SUBJECT INDEX Retinal sterically modified, visual pigments with, bioactivity, 372 Rhodococcus sp. biohydroxylation reactions with, 81 Rhodopsin with sterically modified retinal analogs, bioactivity, 372 Ribonucleotide triphosphate reductase from Lactobacillus leichmannii, adenosylcobalamin competitive inhibitors of, kinetic evaluation, 451 Ribosomes eukaryotic, nonstoichiometric cotranslational protein scission in, model, 55 S Stereochemistry b-keto ester reduction with yeast keto ester reductase: construction of plural stereocenters remote from reaction center, 3 Steroids binding to receptors, 3H-labeled 16a,17a-cyclohex38-eno-progesterone for study of, synthesis, 207 Strain energy role in amino acid side chain effects on peptide conformation, 434 Streptomyces verticillus bleomycin biosynthesis: model of hybrid peptide and polyketide biosynthesis, 155 Symposium-in-print, 1 T Tacrine and derivatives, kinetic inhibition of acetylcholinesterase from human erythrocytes, 197 Tamoxifen cytotoxicity in breast cancer cells in vitro, comparison with triphenylethylene dimers, 383 Terpyridine platinum(II) complexes bis-intercalators with rigid and extended linkers for analysis of DNA topology by photoaffinity labeling, design and synthesis, 477
2-Thiouridine 58-monophosphate in probing of yeast OMP decarboxylase active sites, 297 4-Thiouridine 58-monophosphate in probing of yeast OMP decarboxylase active sites, 297 Topaquinone model studies, overview, 253 Transesterification enzyme-catalyzed chemoselective reactions on hydroxymethylated phenolic compounds, 119 Triphenylethylene dimers synthesis and cytotoxic activity in vitro, 27, 383 Tro¨ger’s base enantioselective synthetic receptors for, preparation, 363 Tropanes and related azabicycloalkanes, versatile synthesis and reactivity, 91 trp repressor–operator complex interface of, probing with operator sequences containing isoteric base-pair analogues, 215 Truxillic acid formation via light-catalyzed 2 + 2 cycloaddition, 339 L-Tryptophan fluorescent sensor for, preparation, 463 Tryptophan tryptophylquinone model studies, overview, 253 U UK-1 Mg2+-dependent binding to DNA and inhibition of human DNA topoisomerase II, 326 Urate oxidase intermediates in reaction of, theoretical study, 351 Uridine 58-monophosphate and thiosubstituted analogues, in probing of yeast OMP decarboxylase active sites, 297 V Vitamin B12 corrin ring component, biosynthesis, 100
Subject Index for Volume 27 A
Aminoglycoside antibiotics modification by kanamycin nucleotidyltransferase from Staphylococcus aureus, kinetic mechanism, 395 2-Amino-6-mercapto-7-methylpurine ribonucleoside phosphate-independent hydrolysis by purine nucleoside phosphorylase, 307 (S)-2-Amino-4-phosphonobutyric acid analogues, selective modulation of metabotropic glutamate receptors, 20 Aphthovirus 2A protein cleavage mechanism, 55 Aureolic acid antibiotics biosynthesis, 41 Azabicycloalkanes tropane-related, versatile synthesis and reactivity, 91
Acetylation hydroxymethylated phenolic compounds, chemoselective enzyme-catalyzed reactions, 119 Acetylcholinesterase erythrocyte, kinetic inhibition by tacrine and tacrine derivatives (human), 197 Active sites yeast OMP decarboxylase, probing with UMP, thiosubstituted UMP analogues, and CMP-6-carboxylate, 297 [v-(Adenosin-58-O-yl)alkyl]cobalamins inhibitory properties toward ribonucleotide triphosphate reductase from Lactobacillus leichmannii, kinetic evaluation, 451 Advanced glycation end products formation from low molecular weight model comB pounds, 443 Aeromonas hydrophila AE036 Beauveria bassiana metallo-b-lactamase, hydroxamate inhibitors of, 35 biohydroxylation reactions with, 81 Alcohol dehydrogenase (RS)-N-Benzoylalanine hydroxamate + native and single-point mutants, catalysis of NAD inhibition of Aeromonas hydrophila AE036 metalloreduction by PhCH2OH, log(kcat/Km) for, linear b-lactamase, 35 dependence on distance between reactants, 289 (RS)-N-Benzoyl-O-benzylalanine hydroxamate 5-Alkenyl-1-pyrroline 1-oxide-5-carboxylic esters inhibition of Aeromonas hydrophila AE036 metalloreactions leading to synthesis of tropanes and related b-lactamase, 35 azabicycloalkanes, 91 Benzyl alcohol sec-Alkyl 2-methyl-3-oxobutyrate reduction of NAD+ with horse liver alcohol dehydroreduction with yeast keto ester reductase: construcgenase and mutants, log(kcat/Km) for, linear tion of plural stereocenters remote from reacdependence on distance between reactants, 289 tion center, 3 (RS)-O-Benzyl-N-phenoxyacetylalanine hydroxamate Alkylpiperidines inhibition of Aeromonas hydrophila AE036 metalloincubation with Beauveria bassiana, hydroxylation b-lactamase, 35 products of, 81 (RS)-O-Benzyl-N-phenoxyacetylphenylalanine hyAmino acids droxamate acetylated, low molecular weight model compounds inhibition of Aeromonas hydrophila AE036 metallowith, formation of advanced glycation end b-lactamase, 35 products, 443 Biohydroxylation side chains, effects on peptide conformation, modelreactions catalyzed by enzymes and whole-cell sysing, 434 tems, 81 1-Aminocyclopentane-1,3-dicarboxylic acid Bis-[48-azido-2,28:68,28-terpyridine platinum(II)] analogues, selective modulation of metabotropic complexes glutamate receptors, 20 with rigid and extended linkers, design and synthesis 489 0045-2068/99 $30.00 Copyright q 1999 by Academic Press All rights of reproduction in any form reserved.
490
SUBJECT INDEX
for study of DNA topology by photoaffinity labeling, 477 Bis(benzoxazole) metabolite UK-1 produced by Streptomyces, Mg2+dependent binding to DNA and inhibition of human topoisomerase II, 326 Bleomycin biosynthesis in Streptomyces verticillus: model of hybrid peptide and polyketide biosynthesis, 155 Blood parameters in albino mice, effects of products of electrochemical oxidation of 4-hydroxyindole, 239 Breast cancer triphenylethylene dimers for treatment of, synthesis and cytotoxic activity in vitro, 27, 383
synthesis of tropanes and related azabicycloalkanes, 91 Cyclohexene retinal chromophore moiety in rhodopsin, role in pigment bioactivity, 372 16a,17a-Cyclohex-38-eno-progesterone 3 H-labeled, synthesis as probe for steroid–receptor binding studies, 207 Cytidine 58-monophosphate-6-carboxylate in probing of yeast OMP decarboxylase active sites, 297 Cytochrome P450cam monooxygenase isolated Y96A mutant, biohydroxylation reactions with, 81 D
C C1027 biosynthesis, 172 Calicheamicin biosynthetic cascade, 172 Candida rugosa lipase catalysis of chemoselective transesterification reactions on hydroxymethylated phenolic compounds, 119 Carbohydrates low molecular weight model compounds with, formation of advanced glycation end products, 443 L-2-(Carboxycyclopropyl)glycine analogues, selective modulation of metabotropic glutamate receptors, 20 Chelation cobalt in biosynthesis of vitamin B12 corrin ring component, 100 Chromoprotein enediynes biosynthesis, 172 Cobalamin corrin ring component, biosynthesis, 100 Cobalt chelation in biosynthesis of vitamin B12 corrin ring component, 100 Co–C bond homolysis, intermediate formed by, adenosylcobalamin competitive inhibibitors mimicking, kinetic evaluation, 451 Conformation peptides, effects of amino acid side chains, modeling, 434 Crosslinking photoinduced, by dibenzoyldiazomethane–oligodeoxynucleotide conjugate, mechanistic study, 227 Cycloaddition substitution effects in 2 + 2 reaction of phenylpropanoids, 339
Deacetylation hydroxymethylated phenolic compounds, chemoselective enzyme-catalyzed reactions, 119 N-Deoxyribosyltransferases glycosyl transfer reactions catalyzed by, 135 Dibenzoyldiazomethane–oligodeoxynucleotide conjugate photoinduced crosslinking and cleavage at guanine by, mechanistic study, 227 Diterpenoid resins classification by solid state NMR, 409 DNA Mg2+-dependent binding to UK-1, 326 operator sequences with isoteric base-pair analogues, in analysis of trp repressor–operator complex interface, 215 topology, analysis by photoaffinity labeling, bisintercalators with rigid and extended linkers for, design and synthesis, 477 DNA topoisomerase II inhibition by UK-1 (human), 326 E Electrochemical oxidation 4-hydroxyindole, products of, effects on blood parameters of albino mice, 239 Enediyne biosynthesis and self-resistance, 172 N-Eptyl-tacrine kinetic inhibition of acetylcholinesterase from human erythrocytes, 197 Erythrocytes acetylcholinesterase, kinetic inhibition by tacrine and tacrine derivatives (human), 197 Estrogen receptor triphenylethylene dimers inhibiting, synthesis and cytotoxicity in vitro, 27, 383
491
SUBJECT INDEX F Fluorescent sensors construction by template polymerization, 463 Foot-and-mouth disease virus 2A protein cleavage mechanism, 55 G Genes blm, cloning and characterization, 155 L-Glutamate conformationally constrained analogues, subtypeselective modulation of metabotropic glutamate receptors, 20 Glutamate receptor metabotropic, subtype-selective modulation by conformationally constrained L-glutamate analogues, 20 Glycation low molecular weight model compounds, 443 Glycosyl transferring enzymes nucleoside synthesis mediated by, 135 Guanine oligodeoxynucleotide cleavage at, by dibenzoyldiazomethane–oligodeoxynucleotide conjugate, mechanistic study, 227 H Hydrogenolysis 1-pyrroline 1-oxide cycloadducts in synthesis of tropanes and related azabicycloalkanes, 91 Hydrolysis phosphate-independent, 2-amino-6-mercapto-7methylpurine ribonucleoside by purine nucleoside phosphorylase, 307 5-Hydroperoxyisourate intermediate in urate oxidase reaction, theoretical study, 351 Hydroxamates inhibitors of Aeromonas hydrophila AE036 metallob-lactamase, 35 4-Hydroxyindole electrochemical oxidation, products of, effects on blood parameters of albino mice, 239 Hydroxylation biohydroxylation reactions catalyzed by enzymes and whole-cell systems, 81 Hydroxymethylated phenols enzyme-catalyzed chemoselective transesterification reactions on, 119 I Isomerization photoinduced, retinal chromophore in rhodopsin, role of cyclohexene moiety, 372
K Kanamycin nucleotidyltransferase from Staphylococcus aureus, kinetic mechanism, 395 Keto ester reductase yeast, reduction of b-keto esters: construction of plural stereocenters remote from reaction center, 3 L Lactobacillus leichmannii ribonucleotide triphosphate reductase, adenosylcobalamin competitive inhibitors of, kinetic evaluation, 451 Lipase from Candida rugosa or pancreas, chemoselective transesterification reactions on hydroxymethylated phenolic compounds, 119 Lysyl tyrosylquinone model studies, overview, 253 M Magnesium UK-1 binding to DNA dependent on, analysis, 326 Metallo-b-lactamase Aeromonas hydrophila AE036, hydroxamate inhibitors of, 35 a-Methyl b-keto esters reduction with yeast keto ester reductase: construction of plural stereocenters remote from reaction center, 3 Methyltransferases in biosynthesis of vitamin B12 corrin ring component, 100 6-Metoxy-tacrine kinetic inhibition of acetylcholinesterase from human erythrocytes, 197 Mithramycin biosynthetic studies, 41 Molecular imprinting enantioselective Tro¨ger’s base receptor preparation, 363 fluorescent sensor preparation, 463 N +
NAD reduction by PhCH2OH with horse liver alcohol dehydrogenase and mutants, log(kcat/Km) for, linear dependence on distance between reactants, 289 Nuclear magnetic resonance solid state, classification of modern resins, 409
492
SUBJECT INDEX
Nucleoside phosphorylases glycosyl transfer reactions catalyzed by, 135 Nucleosides synthesis mediated by glycosyl transferring enzymes, 135 O Oligodeoxynucleotides photoinduced crosslinking and cleavage at guanine by dibenzoyldiazomethane– oligodeoxynucleotide conjugate, mechanistic study, 227 Orotidine-58-monophosphate decarboxylase yeast, active site probing with UMP, thio-substituted UMP analogues, and CMP-6-carboxylate, 297 Oxidation electrochemical, 4-hydroxyindole, products of, effects on blood parameters of albino mice, 239 P Pancreatic lipase catalysis of chemoselective transesterification reactions on hydroxymethylated phenolic compounds, 119 Peptides conformation, effects of amino acid side chains, modeling, 434 low molecular weight model compounds with, formation of advanced glycation end products, 443 and polyketides, hybrid biosynthesis, bleomycin biosynthesis in Streptomyces verticillus as model of, 155 synthetic, differential reactivity with protein kinases A and C, 189 Phenols hydroxymethylated, enzyme-catalyzed chemoselective transesterification reactions on, 119 (RS)-N-Phenoxyacetylalanine hydroxamate inhibition of Aeromonas hydrophila AE036 metallob-lactamase, 35 (RS)-N-Phenoxyacetylphenylalanine hydroxamate inhibition of Aeromonas hydrophila AE036 metallob-lactamase, 35 Phenylglycine analogues, selective modulation of metabotropic glutamate receptors, 20 Phenylpropanoids 2 + 2 cycloaddition reaction, effects of substitution, 339 Phosphopento-mutase coupled with nucleoside phosphorylase, glycosyl transfer reactions catalyzed by, 135 Photoaffinity labeling
DNA topological analysis with, bis-intercalators with rigid and extended linkers for, design and synthesis, 477 Photochemistry crosslinking and cleavage at guanine by dibenzoyldiazomethane–oligodeoxynucleotide conjugate, mechanistic study, 227 Photoisomerization retinal chromophore in rhodopsin, role of cyclohexene moiety, 372 Polyketides and peptides, hybrid biosynthesis, bleomycin biosynthesis in Streptomyces verticillus as model of, 155 Polyketide synthase role in biosynthesis of aureolic acid group antibiotics, 41 Polymerization template, construction of fluorescent sensors by, 463 Progesterone receptor binding studies, 3H-labeled 16a,17a-cyclohex-38eno-progesterone as probe for, synthesis, 207 Protein kinase A and protein kinase C, differential specificity in reaction with synthetic peptides, 189 Protein kinase C and protein kinase A, differential specificity in reaction with synthetic peptides, 189 Proteins nonstoichiometric cotranslational scission in eukaryotic ribosomes, model, 55 Purine nucleoside phosphorylase catalysis of phosphate-independent hydrolysis of 2amino-6-mercapto-7-methylpurine ribonucleoside, 307 Q Quantitative structure–activity relationships peptides: effects of amino acid side chains on conformation, 434 Quinocofactors modeling, overview, 253 R Reduction b-keto esters with yeast keto ester reductase: construction of plural stereocenters remote from reaction center, 3 NAD+ by PhCH2OH with horse liver alcohol dehydrogenase and mutants, log(kcat/Km) for, linear dependence on distance between reactants, 289 Resins classification by solid state NMR, 409
493
SUBJECT INDEX Retinal sterically modified, visual pigments with, bioactivity, 372 Rhodococcus sp. biohydroxylation reactions with, 81 Rhodopsin with sterically modified retinal analogs, bioactivity, 372 Ribonucleotide triphosphate reductase from Lactobacillus leichmannii, adenosylcobalamin competitive inhibitors of, kinetic evaluation, 451 Ribosomes eukaryotic, nonstoichiometric cotranslational protein scission in, model, 55 S Stereochemistry b-keto ester reduction with yeast keto ester reductase: construction of plural stereocenters remote from reaction center, 3 Steroids binding to receptors, 3H-labeled 16a,17a-cyclohex38-eno-progesterone for study of, synthesis, 207 Strain energy role in amino acid side chain effects on peptide conformation, 434 Streptomyces verticillus bleomycin biosynthesis: model of hybrid peptide and polyketide biosynthesis, 155 Symposium-in-print, 1 T Tacrine and derivatives, kinetic inhibition of acetylcholinesterase from human erythrocytes, 197 Tamoxifen cytotoxicity in breast cancer cells in vitro, comparison with triphenylethylene dimers, 383 Terpyridine platinum(II) complexes bis-intercalators with rigid and extended linkers for analysis of DNA topology by photoaffinity labeling, design and synthesis, 477
2-Thiouridine 58-monophosphate in probing of yeast OMP decarboxylase active sites, 297 4-Thiouridine 58-monophosphate in probing of yeast OMP decarboxylase active sites, 297 Topaquinone model studies, overview, 253 Transesterification enzyme-catalyzed chemoselective reactions on hydroxymethylated phenolic compounds, 119 Triphenylethylene dimers synthesis and cytotoxic activity in vitro, 27, 383 Tro¨ger’s base enantioselective synthetic receptors for, preparation, 363 Tropanes and related azabicycloalkanes, versatile synthesis and reactivity, 91 trp repressor–operator complex interface of, probing with operator sequences containing isoteric base-pair analogues, 215 Truxillic acid formation via light-catalyzed 2 + 2 cycloaddition, 339 L-Tryptophan fluorescent sensor for, preparation, 463 Tryptophan tryptophylquinone model studies, overview, 253 U UK-1 Mg2+-dependent binding to DNA and inhibition of human DNA topoisomerase II, 326 Urate oxidase intermediates in reaction of, theoretical study, 351 Uridine 58-monophosphate and thiosubstituted analogues, in probing of yeast OMP decarboxylase active sites, 297 V Vitamin B12 corrin ring component, biosynthesis, 100