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Subject index to volume 39
Medical Hypotheses I
I
Mdcai Hypotiwsc~(1992) 39.391-396 olmngmmGrovpuKLtd1992
Subject Index to Volume 39
I
A Acute lymphoblastic leukaemia, therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with, 384 Ageing. information theory and, 291 AIDS (Acquired Immunodeficiency Syndrome) blood group antigen-related glycoepitopes as key structural determinants in immunogenesis and the pathogenesis of, 212 hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manoeuvre, 49 Kaposi’s sarcoma as the result of prolonged and repeated exposure to nitrites and/or semen, 22 preexisting chronic infraepithelial trichomonas invasion with consecutive immuncdepression enables progression of HIV, 22.5 Toxoplasma gondii as cofactor in, 140 Alpha-fetoprotein gene: derivation of a basic mechanism of control for embryonic genes as a specific subset, 258 Aluminium, Alzheimer’s disease and, 123 Alzheimer’s disease diet as one of the causal factors of, 123 extra-pyramidal symptoms in, 3 16 Amyloid, Alzheimer’s disease and, 123 Anaemia: protective mechanism of the sickle cell trait, 284 Arachidonic acid and ameliorative effect of ginger in rheumatism and musculoskelefal disorders, 342 and free radical induction of coronary vasospasm and acute myocardial infarction, 90 Arthritis, ameliorative effects of ginger on, 342 Ascorbate status and xerostomia, 53 Attention, inside-out theory of, 295 Autohaemotherapy for viral diseases and immunodeficiencies: a hypothesis, 30 Autoimmune disease cytokines play a central role in the pathogenesis of systemic lupus erythematosus. 356 nitric oxide-mediated neuronal injury in multiple sclerosis, 143 possible role of histamine in patbogenesis of, 349
B
Bacteria Escherichia coii and Sudden Infant Death Syndrome, 127 Helicobacter pyfori as the major causal factor in chronic hypochlorhydria, 367, 375 periodontal disease activity is triggered by a localized absence of interleukin-4, 319 plant bacteria spores as an aetiological factor in carcinogenesis. 95, 323 Blind, total eye transplantation for, 201 Blood group antigen-related glycoepitopes as key sttucturaf determinants in immunogenesis and AIDS pathogenesis. Blood ozonimtiat for the therapy of immuncdeficiencies and viral diseases, 30 Bone marrow: the origin and spread of human leukaemia, 110 Borderline personality disorder, deterministic nonlinear chaos in brain function and, 67 Brain calcium intake and the protein composition of mouse brain: relevance to multiple sclerosis, 275 deterministic nonlinear chaos in brain function and borderline psychopathological phenomena, 67 diet as one of the causal factors of Alxheimer’s disease, 123 extra-pyramidal symptoms in Alzheimer’s disease, 3 16 inside-out theory of attention, 295 turnours, explanation for the rarity of extra-axial metastases in, 88
1
C
Calcium evidence for Randall’s plaques to be. the origin of primary renal stones, 360 intake and the protein composition of mouse brain: relevance to multiple sclerosis, 275 Campylobacfer pylori as the major causal factor in chronic hypochlorhydria. 367.375 Cancer
391
I
392 activation of oncogenes and/or inactivation of anti-oncogenes by reactive oxygen species, 267 anaerobic metabolism of malignant cells, 95, 323 anticancer activity of indomethacin, proposed mechanism for, 265 bacterial spores as an aetiological factor in carcino-genesis, 95, 323 brain tumours. explanation for the rarity of extra-axial metastases in, 88 colon epithelial cell glutathione S-transferase inhibition is a factor in the increased risk of colorectal cancer due to ingestion of animal fat, 119 convergent magnetic ionizing radiation and, 175 detachment cascade during metastasis, 364 discontinuity in the competitive interaction of tumour cell with the tumour-bearing host: a hypothesis, 73 hormonal therapy for stomach cancer, 137 hypothyroid induced hypanetabolic state as a possible diagnostic and therapeutic manoeuvre, 49 immune destruction of tumours caused by certain enveloped viruses using modified viral antigens, 17 Kaposi’s sarcoma and HIV, 22 models of cell population in tumours: possibility of their application to optimization of radiotherapy, 182 Na+/H+ antiporter in cncology in the light of the spontaneous regression of cancer and cell metabolism, 229 origin and spread of human leukaemia. 110 as physiological phenomenon rather than pathological misfortune, 41 therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukaemia, 384 Cardicmyopathy, degenerative, relationship of dietary fatty acid and selenium to, 58 Cell(s) anaerobic metabolism in malignant cells and the role of bacterial spores in the aetiology of carcinogenesis, 95. 323 detachment cascade during metastasis, 364 energetic potential, hypotensive drugs and, 130 hypothyroid induced hypcmetabolic state as a possible diagnostic and therapeutic manoeuvre, 49 models of cell population in turnours: possibility of their application to optimization of radiotherapy, 182 Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism, 229 precipitous stem cell differentiation and I/f noise, 191 Chaos theory: deterministic nonlinear chaos in brain function and borderline psychopathological phenomena, 67 Cholecystokinin: and anticancer activity of indomethacin, 265 Cholesterol and other risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334 Chratic~fatigue syndrome: new thoughts and reinterpretation of previous data, 185 Circadian rhythms of serotonin and melatonin. infant colic and, 164 Coagulation, bioregulation by fibrin/fibrinogen of, 152 Colic, infant: effect of serotonin and melatonin circadian rhythms on intestinal smooth muscle, 164 Colorectal cancer, inhibition of colon epithelial cell glutathione S-transferase is a factor in the increased risk due to dietary animal fat of, 119 Copper: and fatigue syndromes, 185 Coronary heart disease risk factors: synthesis of a new hyporhesis through adaptation, 334
MEDICAL HYPOTHESES
Coronary vasospasm and acute myocardial infarction, induction by free radicals of, 90 Cranial irradiation of children with acute lymphoblastic leukaemia, prophylactic, therapeutic gain with hyperfractionation in, 384 Cryonic suspension, technical feasibility of, 6 Cytokine(s) central role in the pathogenesis of systemic lupus erythematosus of, 356 localized absence of interleukin-4 triggers periodontal disease activity, 3 19 macrophage-T-lymphocyte theory of schizophrenia, 248 theory of headache, 168
Degenerative cardiomyopathy. relationship of dietary fatty acid and selenium to. 58 Dementia see Alzheimer’s disease Depression chronic low self-esteem as the cause of eating disorders, 311 Helicobacfer pylori-induced chronic hypochlorhydria and, 375 Diet(ary) and Alzheimer’s disease, 123 animal fat: a factor in the increased risk of colorectal cancer is inhibition of colon epithelial cell glutathione S-transferase, 119 calcium intake and the protein composition of mouse brain: relevance to multiple sclerosis, 275 and cytokine theory of headache, 168 fatty acid, relationship to degenerative cardiomyopathy of selenium and, 58 ginger: in rheumatism and musculoskeletal disorders, 342 risk factors for coronary heart disease: synthesis of a new hypothesis through adaptatiat, 334 and role of lipid peroxidation in McArdle’s disease, 147 and Sudden Infant Death Syndrome, 127, 286 threshold effect: consequences of change in the frequency of food intake in the presence of a functional threhold, 302 see also Eating disorders Disseminated intravascular coagulation: and Sudden Infant Death Syndrome, 127 Dry mouth, ascorbate status and, 53
Eating disorders, chronic low self-esteem as a cause of, 311 Electrolytes: hypotensive drugs and the cellular energetic potential, 130 Electromagnetics: an overview of the effects of convergent magnetic ionizing radiation on biological function. 175 Embryonic genes, derivation of a basic mechanism of control for, 258 Epistemology: a metaphysical basis for clinical practice, 63 Escherichia coli: and Sudden Infant Death Syndrome, 127 Evolution: cancer as a physiological phenemenon rather than a pathological misfortune. 41 Extracellular matrix and detachment cascade during metastasis, 364 and rarity of extra-axial metastasis in brain tumours. 88 Extra-pyramidal symtoms in Alzheimer’s disease, 316 Eye transplantation, total: a challenge for the future, 201
SUBJECT INDEX
I
393 F
Fat, dietary animal: a factor in the increased risk of colorectal cancer is inhibition of colon epithelial cell glutathione S-transferase, 119 Fatigue syndromes: new thoughts and reinterpretation of previous data, 185 Fatty acids, dietary Alzheimer’s disease and, 123 cytokine theory of headache and, 168 relationship to degenerative cardiomyopathy of selenium and, 58 Fibrir&ibrinogen, bioregulation of blood coagulatiat by, 152 Fluoridation of water: are most of its promotors neurotics?, 199 Free radicals activation of oncogenes and/or inactivation of anti-oncogenes by, 261 induction of coronary vasospasm and acute myocardial infarction by, 90 lipid peroxidation in McArdle’s disease, 147 multiple sclerosis and, 271 nitric oxide-mediated neuronal injury in multiple sclerosis, 143 and relationship between dietary fatty acids and selenium and degenerative cardiomyopathy, 58 understanding the role of oxyradicals in general and in toxic hepatic damage can help safer drug design, 133
CL; Gastrin: and anticancer activity of indomethacin, 265 Gastritis, chronic: Helicobacter pylori as the major causal factor in chronic hypochlorhydria, 367. 375 Gene(s) activation of oncogenes and/or inactivation of anti-cncogenes by reactive oxygen species, 267 and cancer as a physiological phenomenon rather than a pathological misfortune, 41 derivation of a basic mechanism of control for embryonic genes as a specific subset, 258 and hormonal therapy for stomach cancer, 137 proteaive mechanism of the sickle cell trait, 284 Turner syndrome as a candidate pseudoautosanal disorder, 156 Ginger: in rheumatism and musculoskeletal disorders, 156 Glut&none S-transferase, colon epithelial cell, dietary fat-related increased risk of colorectal cancer is due to inhibition of, 119 Gonadotropin: and sexual orientation in men, 85
1
H
Haem pathway: and fatigue syndromes, 185 Haemorrhagic Shock Encephalopathy Syndrome: and Sudden Infant Death Syndrcme, 127 Headache, cytokine theory of, 168 1lean estimating left ventrical work by gated blood pool ventriculogram, 195 free radical induction of coronary vasospasm and acute myocardial infarction, 90 relationship of dietary fatty acid and selenium to degenerative cardiomyopathy, 58 risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334
1
Helicobucter pylori as the major causal factor in chronic hypochlorhydria, 367, 375 Histamine and pathogenesis of autoimmune diseases: implications for immunotherapy with histamine-2 receptor antagonists, 349 and role of human placental mast cells in pre-eclampsia, 281 Homosexuals anatomical and functional basis for sexual orientation in males, 85 Kaposi’s sarcoma as a result of prolonged and repeated exposure to nitrites and/or semen, 22 Hormones anatomical and functional basis for sexual orientation in males, 85 endocrine therapy for stomach cancer, 137 hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manoeuvre, 49 Human immunodeficiency virus (HIV) see AIDS llydrogen: the Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism, 229 Ilypertension hypotensive drugs and the cellular energetic potential, 130 and other risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334 Hypochlorhydria, chronic, Helicobacter pylori as the major causal factor in, 367, 375 Hyporhalamus: anatomical and functional basis for sexual orientation in males, 85 Hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manceuvre, 49
Immune system blood group antigen-related glycoepitopes as key structural determinants in immunogenesis and AIDS pathogenesis. 212 cytokine theory of headache, 168 cytokines play a central role in the pathogenesis of systemic lupus erythematosus, 356 hypothesis for immune destruction of tumours caused by certain enveloped viruses using modified viral antigens, 17 localized absence of interleukin-4 triggers periodontal disease activity, 3 19 macrophage-T-lymphocyte theory of schizophrenia, 248 ozoniration of blood for the therapy of viral diseases and immunodeficiencies, 30 possible role of histamine in pathogenesis of autoimmune diseases, 349 Sudden Infant Death Syndrome and, 127 see also AIDS Indomethacin, proposed mechanism for the anticancer activity of, 265 Inflammation ginger in rheumatism and musculoskeletal disorders, 342 human placental mast cells in pre-eclampsia, 281 Information theory: and ageing, 291 Interleukins (ILs) localized absence of IL-4 triggers periodontal disease activity, 319 in macrophage-T-lymphocyte theory of schizophrenia. 248
394
MEDICAL HYPO’IRESES
I Kaposi’s sarcoma is the result of prolonged and repeated exposure to nitrites and/or semen, 22 Kidney stones, evidence for Randall’s plaques to be the origin of, 360
Left sided neglect: an inside-out theory of attention, 295 Leukaemia origin and spread of human leukaemia, 110 therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukaemia. 384 Lipid peroxidation, role in McArdle’s disease of, 147 Lipopolysaccharides: monoclonal antibody therapy in the treatment of Reye’s Syndrome, 238 Lithocholic acid: a factor in the increased risk of colorectal cancer due to ingestion of animal fat is inhibition of colon epithelial cell glutathione S-transferase, 119 Lithofibrin: evidence for Randall’s plaques to be the origin of primary renal stones, 360 Liver hepatic porphyria: new thoughts and reinterpretation of previous data, 185 monoclonal antibody therapy in the treatment of Reye’s Syndrome, 238 understanding the role of oxyradicals in general and in toxic hepatic damage can helpsafer drug design, 133
I
infant colic and the effect of serotonin and melatonin circadian rhythms on intestinal smooth muscle, 164 postural reflexes in Parkinson’s disease: a reverse hypothesis, 243 see also Myopathy Myocardial infarction, free radical induction of coronary vasospasm and. 90 Myopathy lipid peroxidation in McArdles’s disease, 147 relationship of dietary fatty acid and selenium to degenerative cardiomyopathy, 58
I
N
Neglect, clinical: an inside-out theory of attention, 295 Nervous system anatomical and functional basis for sexual orientation in males, 85 extra-pyramidal symptoms in Alrheimer’s disease, 316 nitric oxide-mediated neuronal injury in multiple sclerosis, 143 postural reflexes in Parkinson’s disease: a reverse hypothesis, 243 rarity of extra-axial metastases in brain turnours, 88 relapsing neurosyphilis following penicillin treatment, 35 role of reactive oxygen species in the pathogenesis of multiple sclerosis, 271 see also Brain Nitric oxide-mediated neuronal injury in multiple sclerosis, 143 Nitrites, Kaposi’s sarcoma as the result of prolonged and repeated exposure to semen and/or, 22 Noise, precipitous stem cell differentiation and, 191
M
McArdle’s disease, role of lipid peroxidaticn in, 147 Macrophage-T-lymphocyte theory of schizophrenia, 248 Magnetic fields: an overview of the effects of convergent magnetic ionizing radiation at biological function, 175 Maharishi Ayurveda. model for the extraction of toxins using a procedure from, 1 Malabsorption, Helicobacter pyfori-induced chronic hypcchlorhydria and. 375 Male sexual orientation, anatomical and functional basis for, 85 Mast cells, human placental, role in pre-eclampsia of, 281 Medical science: metaphysics as a basis for clinical practice, 63 MelatotGtt anticancer activity of indomethacin and, 265 circadian rhythms. infant colic and, 164 Metaphysics as a basis for clinical practice, 63 Monoclonal antibody therapy in the treatment of Reye’s Syndrome, 238 Mortality rates, information theory and, 291 Mouth ascorbate status and xerostania, 53 localized absence of interleukin-4 triggers periodontal disease activity, 319 Multiple sclerosis and calcium intake during adolescence, 275 fatigue syndromes: new thoughts and reinterpretation of previous data, 185 nitric oxide-mediated neuronal injuty in, 143 role of reactive oxygen species in pathogenesis of, 271 Muscle(s) estimating left vuttricular work by gated blood pool venniculogram, 195 ginger in rheumatism and musculoskeletal disorders, 342
Oestrogen therapy for stomach cancer, 137 Oncogene(s) activation of oncogenes and/or inactivation of anti-oncogenes by reactive oxygen species, 267 and hormonal therapy for stomach cancer, 137 Optic nerve: in total eye transplantation, 201 Ozonimtion of blood for the therapy of viral diseases and immunodeficiencies: a hypothesis, 30
Paralytic
polio: new thoughts and reinterpretation of previous data, 185 Parkinson’s disease, reverse hypothesis of altered postural reflexes in, 243 Penicillin treatment of syphilis, presence of treponemes following, 35 Periodontal disease activity is triggered by a localized absence of interleukin-4, 3 19 Pharmaceutical design: and a better understanding of the role of oxyradicals, 133 Phosphate: hypotensive drugs and the cellular energetic potential, 130 Placental mast cells, human, role in preeclampsia of, 281 Plant bacterial spores as an aetiological factor in carcinogenesis. 95, 323 Porphyria, hepatic: new thoughts and reinterpretation of previous data, 185 Positivism as a basis for clinical practice, 63 Postural reflexes in Parkinson’s disease: a reverse hypothesis.
I
suBEcr
395
INDEX
acid secretion: Helicobacter pylori as the major causal factor in chronic hypochlorhydria, 367. 375 cancer, hormonal therapy for, 137 Sudden Infant Death Syndrome immune response and, 127 vitamin E/selenium and, 127, 286 Syphilis: as an incurable disease, 35 Systemic lupus erythematosus, central role of cytokines in pathogenesis of, 356
243 Pregnancy protective mechanism of the sickle cell trait, 284 role of human placental mast cells in pre-eclampsia, 281 Prolific productivity of praninent scientists, 159 Prostaglandins and ameliorative effect of ginger in rheumatism and musculoskeletal disorders, 342 and role of human placental mast cells in preeclampsia. 281 Psoriasis: possible role of histamine in the pathogenesis of autoimmune diseases, 349 Psychopathological phenomena, borderline, deterministic nonlinear chaos in brain function and, 67 Publications: clues to prolific productivity among prominent scientists, 159
R
1
Radiation convergent magnetic ionizing, effects on biological function of. 175 models of cell population in tumours: possibility of their application to optimization of radiotherapy, 182 therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukaemia, 384 Randall’s plaques as the origin of primary renal stones, 360 Reactive oxygen species see Free radicals Renal stones, evidence for Randall’s plaques to be the origin of, 360 Reye’s Syndrome, monoclonal antibody therapy in, 238 Rheumatism, ginger and, 342 Risk factor intervention in coronary heart disease; synthesis of a new hypothesis through adaptation, 334
Tamoxifen therapy for stomach cancer, 137 Testosterone: and sexual orientation in males, 85 Threshold effect: consequences of change in the frequency of food intake in the presence of a functional threshold, 302 Thrombosis: and bioregulatory roles for fibrin/fibrinogen on blood coagulation, 152 Thromboxane and anticancer activity of indomethacin, 265 and relationship of dietary fatty acid and selenium to degenerative cardiomyopathy, 58 Thyroid hormone: hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manoeuvre. 49 T-lymphocyte-macrophage theory of schizophrenia, 248 Toxin extraction using a procedure from Maharishi Ayurveda. 1 Toxoplama godii: an AIDS-enhancing cofactor, 140 Treponemes: syphilis as an incurable disease, 35 Trichomonas: pre-existing chronic infraepithelial invasion with consecutive immunodepression enables progression of HlV, 225 Turner syndrome as a candidate pseudoautosomal disorder, I56
V S Salivary glands: ascorbate status and xerostomia, 53 Schizophrenia, macrophage-T-lymphocyte theory of, 248 Scientists. prominent, prolific productivity of, 159 Selenium relationship to degenerative cardiomyopathy of dietary fatty acid and, 58 Sudden Infant Death Syndrome and, 127, 286 Self-esteem, chronic low: as cause of eating disorders, 311 Semen, Kaposi’s sarcoma as the result of prolonged and repeated exposure to nitrites and/or, 22 Serotonin circadian rhythms, infant colic and, 164 Sudden infant Death Syndrome and, 127 Seven: as fundamental dimensionless biological constant, 291 Sexual orientation in males, anatomical and functional basis for, 85 Sickle cell trait, protective mechanisms for, 284 Skin cytokines play a central role in the pathogenesis of systemic lupus erythematosus, 356 role of histamine in the pathogenesis of psoriasis, 349 Sodium: the Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism, 229 Stem cell differentiation and I/f noise, 191 Stomach
I
Vascular system bioregulatory roles for tibrin/librinogen on blood coagulation, 152 blood group antigen-related glycoepitopes as key structural determinants in immunogenesis and AIDS pathogenesrs. 212 degenerative cardiomyopathy, relationship of dietary fatty acid and selenium to, 58 estimating left ventricular work by gated blood pool ventriculogram. 195 free radical induction of coronary vasospasm and acute myocardial infarcticm, 90 hypotensive drugs and the cellular energetic potential, 130 origin and spread of human leukaemia, 110 ozonization of blood for the therapy of viral diseases and immunodeficiencies. 30 pre-eclampsia, role of human placental mast cells in, 2X1 protective mechanism of the sickle cell trait, 284 risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334 Sudden Infant Death Syndrome and, 127 Viruses hypolhesis for the immune destruction of tumours caused by certain enveloped viruses using modified viral antigens. 17 ozonization of blood for the therapy of viral diseases and immunodeticiencies. 30 Vitamm(s)
1
396
MEDICAL HYPOTHESES
ascorbate status and xerostania, 53 vitamin E and Sudden Infant Death Syndrome,
I
X 127, 286
W
Water fluoridation: are most of its promotors neurotics?, 199 Work: clues to prolific productivity among prominent scienlists, 159
Xerostomia,
ascorbic
status and, 53
I
Mdcai Hypotiwsc~(1992) 39.391-396 olmngmmGrovpuKLtd1992
Subject Index to Volume 39
I
A Acute lymphoblastic leukaemia, therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with, 384 Ageing. information theory and, 291 AIDS (Acquired Immunodeficiency Syndrome) blood group antigen-related glycoepitopes as key structural determinants in immunogenesis and the pathogenesis of, 212 hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manoeuvre, 49 Kaposi’s sarcoma as the result of prolonged and repeated exposure to nitrites and/or semen, 22 preexisting chronic infraepithelial trichomonas invasion with consecutive immuncdepression enables progression of HIV, 22.5 Toxoplasma gondii as cofactor in, 140 Alpha-fetoprotein gene: derivation of a basic mechanism of control for embryonic genes as a specific subset, 258 Aluminium, Alzheimer’s disease and, 123 Alzheimer’s disease diet as one of the causal factors of, 123 extra-pyramidal symptoms in, 3 16 Amyloid, Alzheimer’s disease and, 123 Anaemia: protective mechanism of the sickle cell trait, 284 Arachidonic acid and ameliorative effect of ginger in rheumatism and musculoskelefal disorders, 342 and free radical induction of coronary vasospasm and acute myocardial infarction, 90 Arthritis, ameliorative effects of ginger on, 342 Ascorbate status and xerostomia, 53 Attention, inside-out theory of, 295 Autohaemotherapy for viral diseases and immunodeficiencies: a hypothesis, 30 Autoimmune disease cytokines play a central role in the pathogenesis of systemic lupus erythematosus. 356 nitric oxide-mediated neuronal injury in multiple sclerosis, 143 possible role of histamine in patbogenesis of, 349
B
Bacteria Escherichia coii and Sudden Infant Death Syndrome, 127 Helicobacter pyfori as the major causal factor in chronic hypochlorhydria, 367, 375 periodontal disease activity is triggered by a localized absence of interleukin-4, 319 plant bacteria spores as an aetiological factor in carcinogenesis. 95, 323 Blind, total eye transplantation for, 201 Blood group antigen-related glycoepitopes as key sttucturaf determinants in immunogenesis and AIDS pathogenesis. Blood ozonimtiat for the therapy of immuncdeficiencies and viral diseases, 30 Bone marrow: the origin and spread of human leukaemia, 110 Borderline personality disorder, deterministic nonlinear chaos in brain function and, 67 Brain calcium intake and the protein composition of mouse brain: relevance to multiple sclerosis, 275 deterministic nonlinear chaos in brain function and borderline psychopathological phenomena, 67 diet as one of the causal factors of Alxheimer’s disease, 123 extra-pyramidal symptoms in Alzheimer’s disease, 3 16 inside-out theory of attention, 295 turnours, explanation for the rarity of extra-axial metastases in, 88
1
C
Calcium evidence for Randall’s plaques to be. the origin of primary renal stones, 360 intake and the protein composition of mouse brain: relevance to multiple sclerosis, 275 Campylobacfer pylori as the major causal factor in chronic hypochlorhydria. 367.375 Cancer
391
I
392 activation of oncogenes and/or inactivation of anti-oncogenes by reactive oxygen species, 267 anaerobic metabolism of malignant cells, 95, 323 anticancer activity of indomethacin, proposed mechanism for, 265 bacterial spores as an aetiological factor in carcino-genesis, 95, 323 brain tumours. explanation for the rarity of extra-axial metastases in, 88 colon epithelial cell glutathione S-transferase inhibition is a factor in the increased risk of colorectal cancer due to ingestion of animal fat, 119 convergent magnetic ionizing radiation and, 175 detachment cascade during metastasis, 364 discontinuity in the competitive interaction of tumour cell with the tumour-bearing host: a hypothesis, 73 hormonal therapy for stomach cancer, 137 hypothyroid induced hypanetabolic state as a possible diagnostic and therapeutic manoeuvre, 49 immune destruction of tumours caused by certain enveloped viruses using modified viral antigens, 17 Kaposi’s sarcoma and HIV, 22 models of cell population in tumours: possibility of their application to optimization of radiotherapy, 182 Na+/H+ antiporter in cncology in the light of the spontaneous regression of cancer and cell metabolism, 229 origin and spread of human leukaemia. 110 as physiological phenomenon rather than pathological misfortune, 41 therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukaemia, 384 Cardicmyopathy, degenerative, relationship of dietary fatty acid and selenium to, 58 Cell(s) anaerobic metabolism in malignant cells and the role of bacterial spores in the aetiology of carcinogenesis, 95. 323 detachment cascade during metastasis, 364 energetic potential, hypotensive drugs and, 130 hypothyroid induced hypcmetabolic state as a possible diagnostic and therapeutic manoeuvre, 49 models of cell population in turnours: possibility of their application to optimization of radiotherapy, 182 Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism, 229 precipitous stem cell differentiation and I/f noise, 191 Chaos theory: deterministic nonlinear chaos in brain function and borderline psychopathological phenomena, 67 Cholecystokinin: and anticancer activity of indomethacin, 265 Cholesterol and other risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334 Chratic~fatigue syndrome: new thoughts and reinterpretation of previous data, 185 Circadian rhythms of serotonin and melatonin. infant colic and, 164 Coagulation, bioregulation by fibrin/fibrinogen of, 152 Colic, infant: effect of serotonin and melatonin circadian rhythms on intestinal smooth muscle, 164 Colorectal cancer, inhibition of colon epithelial cell glutathione S-transferase is a factor in the increased risk due to dietary animal fat of, 119 Copper: and fatigue syndromes, 185 Coronary heart disease risk factors: synthesis of a new hyporhesis through adaptation, 334
MEDICAL HYPOTHESES
Coronary vasospasm and acute myocardial infarction, induction by free radicals of, 90 Cranial irradiation of children with acute lymphoblastic leukaemia, prophylactic, therapeutic gain with hyperfractionation in, 384 Cryonic suspension, technical feasibility of, 6 Cytokine(s) central role in the pathogenesis of systemic lupus erythematosus of, 356 localized absence of interleukin-4 triggers periodontal disease activity, 3 19 macrophage-T-lymphocyte theory of schizophrenia, 248 theory of headache, 168
Degenerative cardiomyopathy. relationship of dietary fatty acid and selenium to. 58 Dementia see Alzheimer’s disease Depression chronic low self-esteem as the cause of eating disorders, 311 Helicobacfer pylori-induced chronic hypochlorhydria and, 375 Diet(ary) and Alzheimer’s disease, 123 animal fat: a factor in the increased risk of colorectal cancer is inhibition of colon epithelial cell glutathione S-transferase, 119 calcium intake and the protein composition of mouse brain: relevance to multiple sclerosis, 275 and cytokine theory of headache, 168 fatty acid, relationship to degenerative cardiomyopathy of selenium and, 58 ginger: in rheumatism and musculoskeletal disorders, 342 risk factors for coronary heart disease: synthesis of a new hypothesis through adaptatiat, 334 and role of lipid peroxidation in McArdle’s disease, 147 and Sudden Infant Death Syndrome, 127, 286 threshold effect: consequences of change in the frequency of food intake in the presence of a functional threhold, 302 see also Eating disorders Disseminated intravascular coagulation: and Sudden Infant Death Syndrome, 127 Dry mouth, ascorbate status and, 53
Eating disorders, chronic low self-esteem as a cause of, 311 Electrolytes: hypotensive drugs and the cellular energetic potential, 130 Electromagnetics: an overview of the effects of convergent magnetic ionizing radiation on biological function. 175 Embryonic genes, derivation of a basic mechanism of control for, 258 Epistemology: a metaphysical basis for clinical practice, 63 Escherichia coli: and Sudden Infant Death Syndrome, 127 Evolution: cancer as a physiological phenemenon rather than a pathological misfortune. 41 Extracellular matrix and detachment cascade during metastasis, 364 and rarity of extra-axial metastasis in brain tumours. 88 Extra-pyramidal symtoms in Alzheimer’s disease, 316 Eye transplantation, total: a challenge for the future, 201
SUBJECT INDEX
I
393 F
Fat, dietary animal: a factor in the increased risk of colorectal cancer is inhibition of colon epithelial cell glutathione S-transferase, 119 Fatigue syndromes: new thoughts and reinterpretation of previous data, 185 Fatty acids, dietary Alzheimer’s disease and, 123 cytokine theory of headache and, 168 relationship to degenerative cardiomyopathy of selenium and, 58 Fibrir&ibrinogen, bioregulation of blood coagulatiat by, 152 Fluoridation of water: are most of its promotors neurotics?, 199 Free radicals activation of oncogenes and/or inactivation of anti-oncogenes by, 261 induction of coronary vasospasm and acute myocardial infarction by, 90 lipid peroxidation in McArdle’s disease, 147 multiple sclerosis and, 271 nitric oxide-mediated neuronal injury in multiple sclerosis, 143 and relationship between dietary fatty acids and selenium and degenerative cardiomyopathy, 58 understanding the role of oxyradicals in general and in toxic hepatic damage can help safer drug design, 133
CL; Gastrin: and anticancer activity of indomethacin, 265 Gastritis, chronic: Helicobacter pylori as the major causal factor in chronic hypochlorhydria, 367. 375 Gene(s) activation of oncogenes and/or inactivation of anti-cncogenes by reactive oxygen species, 267 and cancer as a physiological phenomenon rather than a pathological misfortune, 41 derivation of a basic mechanism of control for embryonic genes as a specific subset, 258 and hormonal therapy for stomach cancer, 137 proteaive mechanism of the sickle cell trait, 284 Turner syndrome as a candidate pseudoautosanal disorder, 156 Ginger: in rheumatism and musculoskeletal disorders, 156 Glut&none S-transferase, colon epithelial cell, dietary fat-related increased risk of colorectal cancer is due to inhibition of, 119 Gonadotropin: and sexual orientation in men, 85
1
H
Haem pathway: and fatigue syndromes, 185 Haemorrhagic Shock Encephalopathy Syndrome: and Sudden Infant Death Syndrcme, 127 Headache, cytokine theory of, 168 1lean estimating left ventrical work by gated blood pool ventriculogram, 195 free radical induction of coronary vasospasm and acute myocardial infarction, 90 relationship of dietary fatty acid and selenium to degenerative cardiomyopathy, 58 risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334
1
Helicobucter pylori as the major causal factor in chronic hypochlorhydria, 367, 375 Histamine and pathogenesis of autoimmune diseases: implications for immunotherapy with histamine-2 receptor antagonists, 349 and role of human placental mast cells in pre-eclampsia, 281 Homosexuals anatomical and functional basis for sexual orientation in males, 85 Kaposi’s sarcoma as a result of prolonged and repeated exposure to nitrites and/or semen, 22 Hormones anatomical and functional basis for sexual orientation in males, 85 endocrine therapy for stomach cancer, 137 hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manoeuvre, 49 Human immunodeficiency virus (HIV) see AIDS llydrogen: the Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism, 229 Ilypertension hypotensive drugs and the cellular energetic potential, 130 and other risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334 Hypochlorhydria, chronic, Helicobacter pylori as the major causal factor in, 367, 375 Hyporhalamus: anatomical and functional basis for sexual orientation in males, 85 Hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manceuvre, 49
Immune system blood group antigen-related glycoepitopes as key structural determinants in immunogenesis and AIDS pathogenesis. 212 cytokine theory of headache, 168 cytokines play a central role in the pathogenesis of systemic lupus erythematosus, 356 hypothesis for immune destruction of tumours caused by certain enveloped viruses using modified viral antigens, 17 localized absence of interleukin-4 triggers periodontal disease activity, 3 19 macrophage-T-lymphocyte theory of schizophrenia, 248 ozoniration of blood for the therapy of viral diseases and immunodeficiencies, 30 possible role of histamine in pathogenesis of autoimmune diseases, 349 Sudden Infant Death Syndrome and, 127 see also AIDS Indomethacin, proposed mechanism for the anticancer activity of, 265 Inflammation ginger in rheumatism and musculoskeletal disorders, 342 human placental mast cells in pre-eclampsia, 281 Information theory: and ageing, 291 Interleukins (ILs) localized absence of IL-4 triggers periodontal disease activity, 319 in macrophage-T-lymphocyte theory of schizophrenia. 248
394
MEDICAL HYPO’IRESES
I Kaposi’s sarcoma is the result of prolonged and repeated exposure to nitrites and/or semen, 22 Kidney stones, evidence for Randall’s plaques to be the origin of, 360
Left sided neglect: an inside-out theory of attention, 295 Leukaemia origin and spread of human leukaemia, 110 therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukaemia. 384 Lipid peroxidation, role in McArdle’s disease of, 147 Lipopolysaccharides: monoclonal antibody therapy in the treatment of Reye’s Syndrome, 238 Lithocholic acid: a factor in the increased risk of colorectal cancer due to ingestion of animal fat is inhibition of colon epithelial cell glutathione S-transferase, 119 Lithofibrin: evidence for Randall’s plaques to be the origin of primary renal stones, 360 Liver hepatic porphyria: new thoughts and reinterpretation of previous data, 185 monoclonal antibody therapy in the treatment of Reye’s Syndrome, 238 understanding the role of oxyradicals in general and in toxic hepatic damage can helpsafer drug design, 133
I
infant colic and the effect of serotonin and melatonin circadian rhythms on intestinal smooth muscle, 164 postural reflexes in Parkinson’s disease: a reverse hypothesis, 243 see also Myopathy Myocardial infarction, free radical induction of coronary vasospasm and. 90 Myopathy lipid peroxidation in McArdles’s disease, 147 relationship of dietary fatty acid and selenium to degenerative cardiomyopathy, 58
I
N
Neglect, clinical: an inside-out theory of attention, 295 Nervous system anatomical and functional basis for sexual orientation in males, 85 extra-pyramidal symptoms in Alrheimer’s disease, 316 nitric oxide-mediated neuronal injury in multiple sclerosis, 143 postural reflexes in Parkinson’s disease: a reverse hypothesis, 243 rarity of extra-axial metastases in brain turnours, 88 relapsing neurosyphilis following penicillin treatment, 35 role of reactive oxygen species in the pathogenesis of multiple sclerosis, 271 see also Brain Nitric oxide-mediated neuronal injury in multiple sclerosis, 143 Nitrites, Kaposi’s sarcoma as the result of prolonged and repeated exposure to semen and/or, 22 Noise, precipitous stem cell differentiation and, 191
M
McArdle’s disease, role of lipid peroxidaticn in, 147 Macrophage-T-lymphocyte theory of schizophrenia, 248 Magnetic fields: an overview of the effects of convergent magnetic ionizing radiation at biological function, 175 Maharishi Ayurveda. model for the extraction of toxins using a procedure from, 1 Malabsorption, Helicobacter pyfori-induced chronic hypcchlorhydria and. 375 Male sexual orientation, anatomical and functional basis for, 85 Mast cells, human placental, role in pre-eclampsia of, 281 Medical science: metaphysics as a basis for clinical practice, 63 MelatotGtt anticancer activity of indomethacin and, 265 circadian rhythms. infant colic and, 164 Metaphysics as a basis for clinical practice, 63 Monoclonal antibody therapy in the treatment of Reye’s Syndrome, 238 Mortality rates, information theory and, 291 Mouth ascorbate status and xerostania, 53 localized absence of interleukin-4 triggers periodontal disease activity, 319 Multiple sclerosis and calcium intake during adolescence, 275 fatigue syndromes: new thoughts and reinterpretation of previous data, 185 nitric oxide-mediated neuronal injuty in, 143 role of reactive oxygen species in pathogenesis of, 271 Muscle(s) estimating left vuttricular work by gated blood pool venniculogram, 195 ginger in rheumatism and musculoskeletal disorders, 342
Oestrogen therapy for stomach cancer, 137 Oncogene(s) activation of oncogenes and/or inactivation of anti-oncogenes by reactive oxygen species, 267 and hormonal therapy for stomach cancer, 137 Optic nerve: in total eye transplantation, 201 Ozonimtion of blood for the therapy of viral diseases and immunodeficiencies: a hypothesis, 30
Paralytic
polio: new thoughts and reinterpretation of previous data, 185 Parkinson’s disease, reverse hypothesis of altered postural reflexes in, 243 Penicillin treatment of syphilis, presence of treponemes following, 35 Periodontal disease activity is triggered by a localized absence of interleukin-4, 3 19 Pharmaceutical design: and a better understanding of the role of oxyradicals, 133 Phosphate: hypotensive drugs and the cellular energetic potential, 130 Placental mast cells, human, role in preeclampsia of, 281 Plant bacterial spores as an aetiological factor in carcinogenesis. 95, 323 Porphyria, hepatic: new thoughts and reinterpretation of previous data, 185 Positivism as a basis for clinical practice, 63 Postural reflexes in Parkinson’s disease: a reverse hypothesis.
I
suBEcr
395
INDEX
acid secretion: Helicobacter pylori as the major causal factor in chronic hypochlorhydria, 367. 375 cancer, hormonal therapy for, 137 Sudden Infant Death Syndrome immune response and, 127 vitamin E/selenium and, 127, 286 Syphilis: as an incurable disease, 35 Systemic lupus erythematosus, central role of cytokines in pathogenesis of, 356
243 Pregnancy protective mechanism of the sickle cell trait, 284 role of human placental mast cells in pre-eclampsia, 281 Prolific productivity of praninent scientists, 159 Prostaglandins and ameliorative effect of ginger in rheumatism and musculoskeletal disorders, 342 and role of human placental mast cells in preeclampsia. 281 Psoriasis: possible role of histamine in the pathogenesis of autoimmune diseases, 349 Psychopathological phenomena, borderline, deterministic nonlinear chaos in brain function and, 67 Publications: clues to prolific productivity among prominent scientists, 159
R
1
Radiation convergent magnetic ionizing, effects on biological function of. 175 models of cell population in tumours: possibility of their application to optimization of radiotherapy, 182 therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukaemia, 384 Randall’s plaques as the origin of primary renal stones, 360 Reactive oxygen species see Free radicals Renal stones, evidence for Randall’s plaques to be the origin of, 360 Reye’s Syndrome, monoclonal antibody therapy in, 238 Rheumatism, ginger and, 342 Risk factor intervention in coronary heart disease; synthesis of a new hypothesis through adaptation, 334
Tamoxifen therapy for stomach cancer, 137 Testosterone: and sexual orientation in males, 85 Threshold effect: consequences of change in the frequency of food intake in the presence of a functional threshold, 302 Thrombosis: and bioregulatory roles for fibrin/fibrinogen on blood coagulation, 152 Thromboxane and anticancer activity of indomethacin, 265 and relationship of dietary fatty acid and selenium to degenerative cardiomyopathy, 58 Thyroid hormone: hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic manoeuvre. 49 T-lymphocyte-macrophage theory of schizophrenia, 248 Toxin extraction using a procedure from Maharishi Ayurveda. 1 Toxoplama godii: an AIDS-enhancing cofactor, 140 Treponemes: syphilis as an incurable disease, 35 Trichomonas: pre-existing chronic infraepithelial invasion with consecutive immunodepression enables progression of HlV, 225 Turner syndrome as a candidate pseudoautosomal disorder, I56
V S Salivary glands: ascorbate status and xerostomia, 53 Schizophrenia, macrophage-T-lymphocyte theory of, 248 Scientists. prominent, prolific productivity of, 159 Selenium relationship to degenerative cardiomyopathy of dietary fatty acid and, 58 Sudden Infant Death Syndrome and, 127, 286 Self-esteem, chronic low: as cause of eating disorders, 311 Semen, Kaposi’s sarcoma as the result of prolonged and repeated exposure to nitrites and/or, 22 Serotonin circadian rhythms, infant colic and, 164 Sudden infant Death Syndrome and, 127 Seven: as fundamental dimensionless biological constant, 291 Sexual orientation in males, anatomical and functional basis for, 85 Sickle cell trait, protective mechanisms for, 284 Skin cytokines play a central role in the pathogenesis of systemic lupus erythematosus, 356 role of histamine in the pathogenesis of psoriasis, 349 Sodium: the Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism, 229 Stem cell differentiation and I/f noise, 191 Stomach
I
Vascular system bioregulatory roles for tibrin/librinogen on blood coagulation, 152 blood group antigen-related glycoepitopes as key structural determinants in immunogenesis and AIDS pathogenesrs. 212 degenerative cardiomyopathy, relationship of dietary fatty acid and selenium to, 58 estimating left ventricular work by gated blood pool ventriculogram. 195 free radical induction of coronary vasospasm and acute myocardial infarcticm, 90 hypotensive drugs and the cellular energetic potential, 130 origin and spread of human leukaemia, 110 ozonization of blood for the therapy of viral diseases and immunodeficiencies. 30 pre-eclampsia, role of human placental mast cells in, 2X1 protective mechanism of the sickle cell trait, 284 risk factors for coronary heart disease: synthesis of a new hypothesis through adaptation, 334 Sudden Infant Death Syndrome and, 127 Viruses hypolhesis for the immune destruction of tumours caused by certain enveloped viruses using modified viral antigens. 17 ozonization of blood for the therapy of viral diseases and immunodeticiencies. 30 Vitamm(s)
1
396
MEDICAL HYPOTHESES
ascorbate status and xerostania, 53 vitamin E and Sudden Infant Death Syndrome,
I
X 127, 286
W
Water fluoridation: are most of its promotors neurotics?, 199 Work: clues to prolific productivity among prominent scienlists, 159
Xerostomia,
ascorbic
status and, 53