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Succinate therapy in rheumatic fever
SELECTED
ciated
The brain shares in equal with hypertension.
measure
153
ABSTRACTS
the generalized
increase
in vascular
tone
which
is assoWAIFE.
Quinn,
R. Fever, J. Clin.
W.: Antihyaluronidase Streptococcal Infections Investigation 27:471 (July),
Studies , and 1948.
of Sera Miscellaneous
From
Patients With Non-Streptececcal
Rheumatic Diseases.
The author determined antihyaluronidase titers of sera from patients with rheumatic fever, other streptococcal infections, and miscellaneous diseases. The technique used was a mucin-clot prevention test in which the serum rather than the enzyme is the variable factor. The highest mean antihyaluronidase titers were found in patients with active acute rheuThe next highest titers were matic fever, all of whom, incidentally, were receiving salicylates. found in patients with subsiding rheumatic fever. The titers were lower in normal subjects or patients with miscellaneous diseases, such as tuberculosis, pneumonia, and urethritis, or with other hemolytic streptococcal infections. WAIFS. Wegria, R., Fischel, E. E., and Wilson, New England J. Med. 239:117 (July
P. E.: Succinate 22), 1948.
Therapy
in
Rheumatic
Fever.
Case histories of ten patients with acute rheumatic fever are presented. Each was given Subenon (a succinic acid derivative) in doses of 3.4 to 7.2 Gm. daily for fifteen to forty-six days. None of the analgesic or antipyretic properties of salicylate were observed. It did not prevent, as salicylate usually does, the involvement of additional points. Evidences of pericarditis and myocarditis were observed to progress during the therapy. The authors considered the results sufficiently unsatisfactory so that further trial of the drug was abandoned. KAY. Ludden, T. E., and Edwards, J. E.: Carditis in gation of 35 Cases and Review of the Literature. (Aug. 4), 1948.
Poliomyelitis: Proc.
Staff
An Anatomic Meet., Mayo
Clin.
Investi23~379
In addition to a review of the literature, this investigation consisted of the histologic study of six sections taken from each of thirty-five hearts obtained at necropsies performed between 1925 and 1946. Myocarditis was demonstrated in fourteen of the thirty-five cases. Lesions were described as severe (six cases), moderately severe (four cases), minimal (three cases), and healed (one case). Three of these cases also presented unusual lesions, including perforation of the myocardium of the right atrium, vegetative mitral endocarditis, and vegetative endarteritis of a patent ductus arteriosus. To these investigators it seems probable that the lesions observed were caused by the same virus which caused the poliomyelitis. Disregarding this assumption, it is still apparent that myocarditis, as well as other significant cardiovascular lesions, may occur frequently in cases of poliomyelitis. ARKLESS. Leighton, R. S.: Calcification Radiology 51:257 (Aug.),
of the
Ascending
Aorta
as a Sign
of Syphilitic
Aortitis.
1948.
The object of this study was to correlate the association of syphilitic aortitis and calcification of the aorta and to evaluate its significance. The author divided his material into three groups. Group I consisted of all cases of syphilitic aortitis, proved at autopsy, in which chest roentgenograms were available. Of the eighteen cases studied, nine (50 per cent) showed calcification of the ascending aorta ($0 per cent had a positive Wassermann). In the series of Jackson and Leibert in which a similar correlation was made, 22.7 per cent (fifteen of fifty-one cases) showed calcification of the ascending aorta. Group II consisted of all cases of clinically diagnosed syphilitic aortitis with available chest reontgeno-
ciated
The brain shares in equal with hypertension.
measure
153
ABSTRACTS
the generalized
increase
in vascular
tone
which
is assoWAIFE.
Quinn,
R. Fever, J. Clin.
W.: Antihyaluronidase Streptococcal Infections Investigation 27:471 (July),
Studies , and 1948.
of Sera Miscellaneous
From
Patients With Non-Streptececcal
Rheumatic Diseases.
The author determined antihyaluronidase titers of sera from patients with rheumatic fever, other streptococcal infections, and miscellaneous diseases. The technique used was a mucin-clot prevention test in which the serum rather than the enzyme is the variable factor. The highest mean antihyaluronidase titers were found in patients with active acute rheuThe next highest titers were matic fever, all of whom, incidentally, were receiving salicylates. found in patients with subsiding rheumatic fever. The titers were lower in normal subjects or patients with miscellaneous diseases, such as tuberculosis, pneumonia, and urethritis, or with other hemolytic streptococcal infections. WAIFS. Wegria, R., Fischel, E. E., and Wilson, New England J. Med. 239:117 (July
P. E.: Succinate 22), 1948.
Therapy
in
Rheumatic
Fever.
Case histories of ten patients with acute rheumatic fever are presented. Each was given Subenon (a succinic acid derivative) in doses of 3.4 to 7.2 Gm. daily for fifteen to forty-six days. None of the analgesic or antipyretic properties of salicylate were observed. It did not prevent, as salicylate usually does, the involvement of additional points. Evidences of pericarditis and myocarditis were observed to progress during the therapy. The authors considered the results sufficiently unsatisfactory so that further trial of the drug was abandoned. KAY. Ludden, T. E., and Edwards, J. E.: Carditis in gation of 35 Cases and Review of the Literature. (Aug. 4), 1948.
Poliomyelitis: Proc.
Staff
An Anatomic Meet., Mayo
Clin.
Investi23~379
In addition to a review of the literature, this investigation consisted of the histologic study of six sections taken from each of thirty-five hearts obtained at necropsies performed between 1925 and 1946. Myocarditis was demonstrated in fourteen of the thirty-five cases. Lesions were described as severe (six cases), moderately severe (four cases), minimal (three cases), and healed (one case). Three of these cases also presented unusual lesions, including perforation of the myocardium of the right atrium, vegetative mitral endocarditis, and vegetative endarteritis of a patent ductus arteriosus. To these investigators it seems probable that the lesions observed were caused by the same virus which caused the poliomyelitis. Disregarding this assumption, it is still apparent that myocarditis, as well as other significant cardiovascular lesions, may occur frequently in cases of poliomyelitis. ARKLESS. Leighton, R. S.: Calcification Radiology 51:257 (Aug.),
of the
Ascending
Aorta
as a Sign
of Syphilitic
Aortitis.
1948.
The object of this study was to correlate the association of syphilitic aortitis and calcification of the aorta and to evaluate its significance. The author divided his material into three groups. Group I consisted of all cases of syphilitic aortitis, proved at autopsy, in which chest roentgenograms were available. Of the eighteen cases studied, nine (50 per cent) showed calcification of the ascending aorta ($0 per cent had a positive Wassermann). In the series of Jackson and Leibert in which a similar correlation was made, 22.7 per cent (fifteen of fifty-one cases) showed calcification of the ascending aorta. Group II consisted of all cases of clinically diagnosed syphilitic aortitis with available chest reontgeno-