- Email: [email protected]
Sulfanilamide eruption. A study of patients with the morbilliform rash and of their subsequent reactions
310
THE
JOURNATr
O’F
AI~IIERGY
Nine of the 14 developed eye lesions, taneously into the cornea and into the skin. whereas none of the group developed skin lesions. In a group of 15 control animals all developed both eye and skin lesions. In a third experiment 1s immune and 1S Of the irncontrol animals were reinoculated in the anterior chambrr of the eye. mnne group 12 showed reactions, as compared to 15 reactors in the control group. The eye lesions which developed in the animals of the immune group had a longer average incubation period than those of the control. The authors roncalnde that the eye does not participate as much as other tissues in the development of resistance to syphilis and that there is “no need and indeed no ground for invoking a state of allergy to explain [these] findings in rabbits. ” Sulfanilamide Eruption. A Study of Patients Their Subsequent. Reactions. Schlesinger, .T. IXs. Chiltl. 56: 1256, 1928.
With E. R.,
the Morbilliform ant1 Rlit~hell,
Rash and of %‘. T>,., Jr.: Am.
The ant,hors report, in detail 10 cases of morbilliform eruption from the administration of sulfanilamide, together with studies of the reactions of these patients to The eruption appearrcl within five to subsequent administration of the drug. seventeen days after the start of snlfanilamide and was oc~c*:tsionally preceded by transient lencopenia. In all eases there was a prodromal periotl of fever (three to The eruption was accomseventy-two hours before the appearance of the eruption). panied by fever and a normal or slightly elevated white count. Three of the patients showed palpable enlargement of the spleen, which lasted not more than two weeks after the onset of the eruption. The rash lasted from one and one-half to four days. Tn several cases there was a transient leucopenia as the rash was fading. Later administration of the drug produced a rharactrristio scarlatiniform eruption with fever and leucocytosis. Occasionally increased capillary fragility and arthritis were observed. Repeated administration of gradually increasing doses has been sncc,essful in decreasing or abolishing the patients’ reactions to the drug. sickne
Re-examination E.:
Schweiz.
of Eczemat,ous Individuals. med.
Wehnschr.
68:
691.
CTomez-Orbnneda, 1938.
J., an(l
The authors re-examined 106 individuals who had had occupational dermatitis one to three and one-half years previously. Patch tests which were positive at the time of the dermatitis (for the most part caused by turpentine) were repeated. When the patient had been successful in eliminating the cansat,ive agent of his dermatitis, the patch test reaction was found to be eit,her greatly reduced in degree or entirely negative. When the causative agent had not been eliminated, the patient’s hypersensitivity was for the most part unchanged. Check-up Examination Wehnschr. 68: i83,
of Eczematous 1938.
Patients.
Patch tests of 903 patients with eczema per cent. Follow-up of 86 patients of this plete cure of 91 per cent of the patients in was discontinued. On the other hand, when tliscontinned there was a cure in only 26 per
l\liescher,
G. :
Schweiz.
med.
revealed positive reactions in about 50 group of 903 patients revealed a comwhom contact with the causative agent contact with the causative agent was not, rent.
THE
JOURNATr
O’F
AI~IIERGY
Nine of the 14 developed eye lesions, taneously into the cornea and into the skin. whereas none of the group developed skin lesions. In a group of 15 control animals all developed both eye and skin lesions. In a third experiment 1s immune and 1S Of the irncontrol animals were reinoculated in the anterior chambrr of the eye. mnne group 12 showed reactions, as compared to 15 reactors in the control group. The eye lesions which developed in the animals of the immune group had a longer average incubation period than those of the control. The authors roncalnde that the eye does not participate as much as other tissues in the development of resistance to syphilis and that there is “no need and indeed no ground for invoking a state of allergy to explain [these] findings in rabbits. ” Sulfanilamide Eruption. A Study of Patients Their Subsequent. Reactions. Schlesinger, .T. IXs. Chiltl. 56: 1256, 1928.
With E. R.,
the Morbilliform ant1 Rlit~hell,
Rash and of %‘. T>,., Jr.: Am.
The ant,hors report, in detail 10 cases of morbilliform eruption from the administration of sulfanilamide, together with studies of the reactions of these patients to The eruption appearrcl within five to subsequent administration of the drug. seventeen days after the start of snlfanilamide and was oc~c*:tsionally preceded by transient lencopenia. In all eases there was a prodromal periotl of fever (three to The eruption was accomseventy-two hours before the appearance of the eruption). panied by fever and a normal or slightly elevated white count. Three of the patients showed palpable enlargement of the spleen, which lasted not more than two weeks after the onset of the eruption. The rash lasted from one and one-half to four days. Tn several cases there was a transient leucopenia as the rash was fading. Later administration of the drug produced a rharactrristio scarlatiniform eruption with fever and leucocytosis. Occasionally increased capillary fragility and arthritis were observed. Repeated administration of gradually increasing doses has been sncc,essful in decreasing or abolishing the patients’ reactions to the drug. sickne
Re-examination E.:
Schweiz.
of Eczemat,ous Individuals. med.
Wehnschr.
68:
691.
CTomez-Orbnneda, 1938.
J., an(l
The authors re-examined 106 individuals who had had occupational dermatitis one to three and one-half years previously. Patch tests which were positive at the time of the dermatitis (for the most part caused by turpentine) were repeated. When the patient had been successful in eliminating the cansat,ive agent of his dermatitis, the patch test reaction was found to be eit,her greatly reduced in degree or entirely negative. When the causative agent had not been eliminated, the patient’s hypersensitivity was for the most part unchanged. Check-up Examination Wehnschr. 68: i83,
of Eczematous 1938.
Patients.
Patch tests of 903 patients with eczema per cent. Follow-up of 86 patients of this plete cure of 91 per cent of the patients in was discontinued. On the other hand, when tliscontinned there was a cure in only 26 per
l\liescher,
G. :
Schweiz.
med.
revealed positive reactions in about 50 group of 903 patients revealed a comwhom contact with the causative agent contact with the causative agent was not, rent.