SULPHAMETHAZINE CLINICAL TRIALS IN CHILDREN

308

" XBD=2407 XBD=2510XHG=885 XBD=1425 XBD=1498 XBD=1611 XBD=1693 XBD=1784 XBD=1911 XBD=1983 XBD=2018 XBD=2129 XBD=2220 XBD=2300 XHG=1336 XHG=1439 XHG=1512 XHG=1625 XHG=1708 XHG=1800 XHG=1924 XHG=1998 XHG=2036 XHG=2145 XHG=2235 XHG=2314 XHG=2420 YBD=211 YBD=218 YBD=217 YBD=209 YBD=216 YBD=210 YHG=181>dose YHG=181>for YHG=181>their YHG=190>age YHG=190>was YHG=180>given YHG=180>for YHG=182>7 YHG=180>days YHG=180>and YHG=180>the YHG=180>drug YHG=179>level XBD=200 XBD=428 XBD=568 XBD=642 XBD=764 XBD=847 XBD=976 XBD=1177 XBD=1272 XHG=83 XHG=229 XHG=458 XHG=599 XHG=669 XHG=792 XHG=1006 XHG=1206 YBD=211 YBD=219 YBD=211 YBD=218 YHG=182>wider YHG=183>biological YHG=183>point YHG=182>of YHG=183>view YHG=191>we YHG=191>may YHG=181>consider YHG=181>the " XBD=2510 XBD=313 XHG=638 XBD=377 XBD=612 XBD=798 XBD=913 XBD=1272 XHG=819 XHG=83 XHG=334 XHG=401 XHG=934 YBD=250 YBD=257 YBD=250 YBD=257 YHG=221>association YHG=221>of YHG=221>pernicious YHG=221>anaemia YHG=221>with YHG=220>hypopituitarism XBD=1410 XBD=1630 XBD=1761 XBD=1931 XBD=2023 XBD=2293 XHG=1334 XHG=1427 XHG=1647 XHG=1813 XHG=1946 XHG=2041 XHG=2308 YBD=257 YBD=249 YBD=250 YHG=220>estimated YHG=220>daily. YHG=220>There YHG=229>was YHG=219>considerable YHG=218>individual " " " " " " "

XBD=127 XHG=719 XBD=319 XBD=523 XBD=596 XBD=690 XBD=935 XBD=1083 XBD=1274 XHG=84 XHG=159 XHG=352 XHG=553 XHG=625 XHG=970 XHG=1113 YBD=287 YBD=288 YBD=287 YBD=295 YBD=288 YBD=295 YHG=267>as YHG=260>another YHG=259>example YHG=259>of YHG=259>the YHG=259>precocious YHG=259>senile YHG=259>changes XBD=2510 XBD=1536 XBD=1666 XBD=1822 XBD=1963 XBD=2169 XBD=2269 XBD=2315 XBD=2413 XHG=1335 XHG=1588 XHG=1691 XHG=1846 XHG=1988 XHG=2193 XHG=2295 XHG=2341 XHG=2439 YBD=296 YBD=289 YBD=294 YBD=288 YHG=259>variation. YHG=259>The YHG=259>lowest YHG=259>figure YHG=259>obtained YHG=268>was YHG=259>3 YHG=267>mg. YHG=259>and XBD=126 XBD=279 XBD=374 XBD=555 XBD=677 XBD=893 XBD=1067 XBD=1127 XBD=1273 XHG=83 XHG=155 XHG=308 XHG=404 XHG=583 XHG=923 XHG=1096 XHG=1149 YBD=326 YBD=327 YBD=326 YBD=333 YBD=326 YBD=327 YBD=328 YHG=297>to YHG=297>which YHG=298>the YHG=297>patient YHG=297>with YHG=297>pituitary YHG=296>disease YHG=298>is YHG=298>liable. XBD=1401XHG=706 XBD=1567 XBD=1757 XBD=1841 XBD=1926 XBD=2051 XBD=2219 XBD=2310 XBD=2350 XBD=2511 XHG=1335 XHG=1417 XHG=1682 XHG=1775 XHG=1860 XHG=1945 XHG=2102 XHG=2235 XHG=2327 XHG=2365 YBD=335 YHG=298>the YHG=298>highest YHG=307>mg. YHG=307>per YHG=298>100 YHG=306>c.cm. YHG=298>There YHG=306>was YHG=307>a YHG=297>notable XBD=197 XHG=697 XBD=281 XBD=403 XBD=680 XBD=880 XBD=1007 XBD=1068 XBD=1178 XBD=1226 XBD=1275 XHG=83 XHG=216 XHG=299 XHG=420 XHG=897 XHG=1025 XHG=1081 XHG=1194 XHG=1243 YBD=364 YBD=364 YBD=372 YBD=372 YBD=365 YHG=335>From YHG=336>the YHG=344>more YHG=335>immediately YHG=336>practical YHG=336>point YHG=336>of YHG=337>view YHG=337>it YHG=337>is XBD=1495 XBD=1556 XBD=1634 XBD=1745 XBD=1804 XBD=1915 XBD=2054 XBD=2164 XBD=2285 XBD=2341 XBD=2420 XBD=2512 XHG=1336 XHG=1513 XHG=1569 XHG=1652 XHG=1763 XHG=1819 XHG=1931 XHG=2071 XHG=2180 XHG=2301 XHG=2357 XHG=2437 YBD=367 YBD=374 YBD=366 YHG=337>absence YHG=338>of YHG=337>the YHG=337>drop YHG=337>level YHG=337>which YHG=337>took YHG=337>place YHG=337>in YHG=336>the YHG=336>sick XBD=207 XHG=762 XBD=261 XBD=483 XBD=582 XBD=697 XBD=753 XBD=828 XBD=1010 XBD=1100 XBD=1274 XHG=84 XHG=220 XHG=274 XHG=495 XHG=594 XHG=711 XHG=840 XHG=1024 XHG=1112 YBD=403 YBD=404 YBD=403 YBD=411 YBD=404 YHG=375>useful YHG=375>to YHG=374>remember YHG=375>that YHG=383>some YHG=375>of YHG=374>the YHG=374>physical YHG=375>and YHG=384>nervous XBD=1437 XBD=1496 XBD=1560 XBD=1774 XBD=1989 XHG=1336 XHG=1454 XHG=1512 XHG=1576 XHG=1792 YBD=406 YBD=405 YBD=413 YHG=376>child YHG=386>as YHG=377>he YHG=376>improved YHG=376>clinically. XBD=298 XBD=376 XBD=594 XBD=771 XBD=897 XBD=977 XBD=1085 XBD=1159 XBD=1274 XHG=85 XHG=333 XHG=406 XHG=629 XHG=806 XHG=1012 XHG=1119 XHG=1193 YBD=449 YBD=444 YBD=449 YBD=442 YBD=443 YBD=444 YBD=445 YHG=413>symptoms YHG=413>of YHG=413>pituitary YHG=413>disease YHG=422>may YHG=413>be YHG=414>due YHG=414>in YHG=424>rare XBD=1740XHG=930 XBD=1832 XBD=1931 XBD=2133 XBD=2203 XBD=2268 XBD=2510 XHG=1384 XHG=1756 XHG=1848 XHG=1948 XHG=2149 XHG=2218 XHG=2284 YBD=451 YBD=452 YHG=415>Sulphamethazine YHG=424>was YHG=416>well YHG=415>tolerated YHG=414>by YHG=415>all YHG=423>age-groups. an associated XBD=1531XHG=628 XBD=1800 XBD=1862 XBD=1948 XBD=2063 XBD=2148 XBD=2236 XBD=2365 XBD=2422 XBD=2512 XHG=1335 XHG=1550 XHG=1820 XHG=1883 XHG=1969 XHG=2083 XHG=2168 XHG=2256 XHG=2383 XHG=2441 YBD=490 YBD=483 YHG=453>Vomiting YHG=454>attributable YHG=453>to YHG=454>the YHG=454>drug YHG=454>did YHG=454>not YHG=462>occur YHG=454>in YHG=463>any XBD=275 XBD=328 XBD=839 XBD=1015 XBD=1108 XBD=1213 XBD=1275 XHG=85 XHG=287 XHG=855 XHG=1033 XHG=1123 XHG=1228 YBD=480 YBD=480 YBD=488 YBD=481 YBD=482 YBD=491 YBD=484 YHG=451>instances YHG=452>to YHG=451>pernicious YHG=452>anaemia YHG=453>and YHG=463>may YHG=454>be XBD=248 XHG=671 XBD=318 XBD=544 XBD=655 XBD=776 XHG=85 XHG=266 XHG=336 XHG=560 YBD=519 YBD=527 YBD=520 YBD=519 YHG=489>relieved YHG=490>by YHG=491>treatment YHG=490>with YHG=490>liver. XBD=1378 XBD=1454 XBD=1548 XBD=1740 XBD=1942 XBD=2032 XBD=2260 XBD=2335 XBD=2415 XBD=2512 XHG=1336 XHG=1388 XHG=1467 XHG=1562 XHG=1791 XHG=1955 XHG=2046 XHG=2273 XHG=2348 XHG=2428 YBD=522 YBD=528 YBD=521 YBD=529 YHG=493>of YHG=493>the YHG=492>sick YHG=492>children. YHG=492>Nausea YHG=493>and YHG=492>depression YHG=501>are YHG=493>not YHG=501>easy

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" XBD=2514 XBD=1377 XHG=2411 XBD=1526 XBD=1594 XBD=1792 XBD=1895 XBD=1986 XBD=2084 XBD=2264 XBD=2384 XHG=1326 YBD=561 XHG=1407 XHG=1554 XHG=1623 XHG=1818 XHG=1923 XHG=2015 XHG=2111 XHG=2291 YBD=570 YHG=531>other YBD=560 YHG=531>to YHG=540>assess YHG=532>in YHG=531>children YHG=531>and YHG=540>are YHG=531>not YHG=531>notable YHG=531>with

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XBD=2513 XHG=2492 XBD=1654 XBD=1748 XBD=1801 XBD=1890 XBD=2007 XBD=2229 XBD=2337 XBD=2472 XHG=1335 YBD=601 XHG=1676 XHG=1768 XHG=1821 XHG=1910 XHG=2028 XHG=2250 XHG=2357 YBD=608 YHG=580>a YBD=600 YBD=599 YHG=570>sulphonamides, YHG=570>but YHG=570>it YHG=570>has YHG=570>been YHG=570>estimated YHG=570>that YHG=570>about SULPHAMETHAZINE XBD=1439 XHG=2358 XBD=1510 XBD=1634 XBD=1829 XBD=1998 XBD=2332 XBD=2513 XHG=1335 XHG=1467 XHG=1533 XHG=1661 XHG=1856 XHG=2024 YBD=639 YHG=609>therapy YBD=638 YBD=645 YBD=646 YBD=647 YHG=609>third YHG=610>of YHG=609>child YHG=609>patients YHG=609>having YHG=609>sulphapyridine XBD=1459 CLINICAL XBD=1518 XBD=1560 XBD=1697 XBD=1842 XBD=2101 XBD=2152 XBD=2233 XBD=2513 XHG=1338 YBD=678 XHG=1477 XHG=1537 XHG=1578 XHG=1714 XHG=1855 XHG=2111 XHG=2168 XHG=2259 YBD=677 YBD=681 YBD=684 YBD=676 YHG=648>vomit YHG=657>as YHG=657>a YHG=648>direct YHG=648>result, YHG=648>particularly YHG=648>in YHG=647>the TRIALSYHG=648>intermediate IN CHILDREN XBD=1459 XHG=2436 XBD=1519 XBD=1750 XBD=1919 XBD=2012 XBD=2077 XBD=2266 XBD=2357 XBD=2420 XBD=2514 XHG=1335 YBD=724 XHG=1476 XHG=1532 XHG=1801 XHG=1935 XHG=2028 XHG=2095 XHG=2282 XHG=2373 YBD=716 YHG=686>sign YBD=718 YBD=723 YBD=715 YHG=687>stages YHG=687>of YHG=687>treatment. YHG=686>There YHG=695>was YHG=686>cyanosis YHG=686>and YHG=695>no

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H M D BELF, D C H XBD=2513 M XHG=2467 XBD=1379 XBD=1497 XBD=1652 XBD=1746 XBD=1864 XBD=2060 XBD=2286 XBD=2450 XHG=1336 XHG=1394 XHG=1517 XHG=1670 XHG=1764 XHG=1882 XHG=2078 XHG=2303 YBD=800 YBD=801 YBD=793 YHG=764>of YHG=773>cases YHG=764>during YHG=764>and YHG=764>after YHG=764>stopping YHG=763>treatment YHG=763>showed YHG=773>no B N U I, D PYBD=794 DEPUTY MEDICAL SUPERINTENDENT XBD=1514 XBD=1590 XBD=1835 XBD=1910 XBD=2184 XBD=2388 XBD=2514 XHG=1336 XHG=1547 XHG=1619 XHG=1867 XHG=1938 XHG=2216 XHG=2439 YBD=840 YHG=803>One YBD=832 YBD=839 YBD=833 YHG=803>evidence YHG=802>depression YHG=803>of YHG=802>leucopoietic YHG=802>activity. MEDICAL SUPERINTENDENT XBD=1463 XBD=1531 XBD=1575 XBD=1755 XBD=1865 XBD=1968 XBD=2017 XBD=2142 XBD=2347 XBD=2414 XBD=2454 XBD=2513 XHG=1337 YBD=879 XHG=1489 XHG=1554 XHG=1601 XHG=1781 XHG=1891 XHG=1993 XHG=2042 XHG=2168 XHG=2372 XHG=2435 XHG=2481 YBD=872 YHG=851>g. YBD=878 YBD=870 YBD=871 YHG=842>infant YHG=842>of YHG=842>5 YHG=842>months YHG=842>who YHG=841>had YHG=850>a YHG=841>total YHG=841>quantity YHG=841>of YHG=843>7 BOOTH HALL CHILDREN’S HOSPITAL, MANCHESTER XBD=1685 XBD=1792 XBD=1826 XBD=2048 XBD=2286 XBD=2341 XHG=1336 YBD=918 XHG=1697 XHG=1804 XHG=1837 XHG=2060 XHG=2298 YBD=917 YHG=890>mg. YBD=910 YBD=909 YHG=880>sulphamethazine YHG=880>with YHG=889>a YHG=880>maximum YHG=880>blood-level YHG=880>of XBD=2513 XHG=2442 XBD=1406 XBD=1489 XBD=1611 XBD=1835 XBD=1873 XBD=2150 XBD=2262 XBD=2387 XBD=2443 XBD=2514 XHG=1339 XHG=1423 XHG=1505 XHG=1629 XHG=1849 XHG=1886 XHG=2164 XHG=2300 XHG=2403 XHG=2453 YBD=956 YBD=949 YBD=948 YBD=950 YHG=928>per YHG=919>100 YHG=928>c.cm. YHG=919>developed YHG=929>a YHG=918>morbilliform YHG=919>rash. YHG=919>Two YHG=920>of YHG=920>the XBD=227 XBD=468 XBD=709 XBD=806 XBD=983 XBD=1170 XBD=1276 XHG=138 XHG=248 XHG=489 XHG=730 XHG=827 XHG=1002 XHG=1183 YBD=965 YBD=974 YBD=975 YBD=967 YBD=973 YBD=975 YBD=967 YHG=935>OUR YHG=935>colleagues, YHG=935>Macartney YHG=938>and YHG=937>others,l YHG=938>recently YHG=937>used XBD=1496 XBD=1692 XBD=1813 XBD=1860 XBD=1979 XBD=2081 XBD=2153 XBD=2289 XBD=2515 XHG=1337 XHG=1523 XHG=1718 XHG=1841 XHG=1888 XHG=2005 XHG=2111 XHG=2180 XHG=2316 YBD=994 YBD=987 YBD=995 YHG=958>healthy YHG=958>children YHG=958>aged YHG=958>1 YHG=967>year YHG=958>and YHG=959>10 YHG=967>years YHG=958>developed XBD=440 XBD=504 XBD=591 XBD=823 XBD=889 XBD=953 XBD=1080 XBD=1149 XBD=1276 XHG=89 XHG=462 XHG=525 XHG=614 XHG=846 XHG=909 XHG=979 XHG=1106 XHG=1169 YBD=1013 YBD=1008 YBD=1007 YBD=1006 YBD=1007 YBD=1007 YBD=1006 YHG=976>sulphamethazine YHG=976>in YHG=977>the YHG=978>treatment YHG=977>of YHG=977>73 YHG=986>cases YHG=977>of YHG=977>lobar XBD=1464 XBD=1583 XBD=1744 XBD=1810 XBD=1866 XBD=1965 XBD=2031 XBD=2087 XBD=2380 XBD=2515 XHG=1336 XHG=1484 XHG=1602 XHG=1764 XHG=1831 XHG=1888 XHG=1986 XHG=2053 XHG=2109 XHG=2415 YBD=1026 YBD=1033 YBD=1034 YBD=1027 YHG=997>rashes YHG=997>after YHG=997>having YHG=996>23 YHG=997>and YHG=996>53 YHG=1006>g. YHG=997>respectively YHG=998>there ; XBD=319 XHG=875 XBD=381 XBD=536 XBD=642 XBD=846 XBD=925 XBD=1002 XBD=1124 XBD=1276 XHG=89 XHG=340 XHG=409 XHG=565 XHG=670 XHG=953 XHG=1032 XHG=1152 YBD=1053 YBD=1045 YBD=1047 YBD=1054 YBD=1046 YBD=1046 YBD=1053 YBD=1046 YHG=1015>pneumonia YHG=1015>in YHG=1016>adults YHG=1017>and YHG=1017>reported YHG=1025>on YHG=1016>its YHG=1016>high YHG=1016>theraXBD=1413 XBD=1502 XBD=1651 XBD=1901 XBD=2231 XBD=2513 XHG=1336 XHG=1452 XHG=1541 XHG=1689 XHG=1941 XHG=2269 YBD=1065 YBD=1066 YHG=1045>was YHG=1045>no YHG=1036>other YHG=1036>detectable YHG=1036>constitutional YHG=1036>disturbance. XBD=218 XBD=463 XBD=572 XBD=685 XBD=911 XBD=993 XBD=1165 XBD=1276 XHG=90 XHG=260 XHG=507 XHG=613 XHG=719 XHG=950 XHG=1024 XHG=1200 YBD=1093 YBD=1094 YBD=1086 YBD=1085 YBD=1085 YBD=1084 YHG=1056>peutic YHG=1055>efficiency, YHG=1057>the YHG=1057>low YHG=1056>incidence YHG=1056>of YHG=1064>nausea YHG=1054>and XBD=1457 XBD=1652 XBD=1732 XBD=1862 XBD=2025 XBD=2136 XBD=2260 XBD=2445 XBD=2516 XHG=1338 XHG=1474 XHG=1669 XHG=1747 XHG=1879 XHG=2041 XHG=2152 XHG=2277 XHG=2460 YBD=1104 YBD=1105 YBD=1112 YBD=1106 YHG=1075>These YHG=1075>amounts YHG=1084>are YHG=1075>much YHG=1076>greater YHG=1075>than YHG=1076>those YHG=1075>required YHG=1076>for XBD=281 XBD=497 XBD=601 XBD=931 XBD=1024 XBD=1104 XBD=1276 XHG=92 XHG=295 XHG=507 XHG=610 XHG=948 XHG=1039 XHG=1117 YBD=1133 YBD=1133 YBD=1126 YBD=1132 YBD=1125 YBD=1124 YHG=1095>vomiting YHG=1096>compared YHG=1096>with YHG=1095>sulphapyridine, YHG=1095>and YHG=1095>the YHG=1095>absence XBD=1379 XBD=1564 XBD=1622 XBD=1699 XBD=1817 XBD=2067 XHG=1339 XHG=1395 XHG=1579 XHG=1633 XHG=1715 XHG=1832 YBD=1143 YBD=1144 YBD=1152 YHG=1115>ill YHG=1114>children YHG=1114>of YHG=1114>the YHG=1123>same YHG=1123>age-groups. XBD=135 XHG=762 XBD=339 XBD=496 XBD=736 XBD=867 XBD=1180 XBD=1276 XHG=90 XHG=154 XHG=390 XHG=518 XHG=896 XHG=1207 YBD=1165 YBD=1172 YBD=1173 YBD=1165 YBD=1164 YBD=1172 YBD=1163 YHG=1135>of YHG=1135>cyanosis. YHG=1135>They YHG=1135>considered YHG=1135>renal YHG=1134>complications YHG=1142>unXBD=1949 XBD=2100 XHG=1764 XHG=1973 YBD=1212 YHG=1189>CLINICAL YHG=1189>NOTES XBD=207 XHG=803 XBD=272 XBD=391 XBD=463 XBD=553 XBD=777 XBD=895 XBD=1117 XBD=1188 XBD=1276 XHG=91 XHG=231 XHG=295 XHG=420 XHG=487 XHG=578 XHG=922 XHG=1144 XHG=1210 YBD=1212 YBD=1204 YBD=1205 YBD=1212 YBD=1211 YBD=1203 YHG=1175>likely YHG=1175>in YHG=1175>view YHG=1175>of YHG=1175>the YHG=1174>relatively YHG=1174>high YHG=1174>solubility YHG=1173>of YHG=1173>the XBD=318 XHG=93 YBD=1252 YHG=1215>compound. XBD=2034 XBD=2129 XBD=2261 XBD=2320 XBD=2384 XBD=2517 XHG=1939 XHG=2052 XHG=2150 XHG=2280 XHG=2344 XHG=2407 YBD=1268 YBD=1261 YBD=1269 YBD=1262 YHG=1232>drug YHG=1241>was YHG=1232>given YHG=1232>to YHG=1232>11 YHG=1232>child- BfOMCopMCMMMa.―The XBD=228 XBD=367 XBD=492 XBD=607 XBD=695 XBD=783 XBD=848 XBD=1215 XBD=1277 XHG=138 XHG=249 XHG=389 XHG=513 XHG=629 XHG=716 XHG=805 XHG=866 XHG=1237 YBD=1292 YBD=1284 YBD=1283 YBD=1290 YBD=1281 YHG=1254>This YHG=1263>paper YHG=1254>deals YHG=1253>with YHG=1253>the YHG=1262>use YHG=1253>of YHG=1252>sulphamethazine YHG=1251>in XBD=1407 XBD=1523 XBD=1956 XBD=2026 XBD=2169 XBD=2214 XBD=2335 XBD=2473 XBD=2515 XHG=1340 XHG=1429 XHG=1547 XHG=1982 XHG=2044 XHG=2194 XHG=2240 XHG=2357 XHG=2495 YBD=1309 YBD=1301 YBD=1302 YHG=1280>ren YHG=1272>with YHG=1271>bronchopneumonia, YHG=1272>of YHG=1271>whom YHG=1272>9 YHG=1280>were YHG=1272>under YHG=1273>2 XBD=260 XBD=352 XBD=524 XBD=588 XBD=758 XBD=816 XBD=908 XBD=947 XBD=1132 XHG=92 XHG=277 XHG=368 XHG=544 XHG=607 XHG=775 XHG=832 XHG=925 XHG=964 YBD=1324 YBD=1324 YBD=1329 YBD=1330 YBD=1323 YBD=1322 YBD=1330 YHG=1294>children YHG=1294>and YHG=1293>infants, YHG=1293>32 YHG=1293>acutely YHG=1292>ill YHG=1293>and YHG=1293>6 YHG=1292>healthy. XBD=1463 XHG=2379 XBD=1593 XBD=1735 XBD=1869 XBD=2069 XBD=2265 XBD=2346 XBD=2518 XHG=1342 YBD=1342 XHG=1516 XHG=1633 XHG=1773 XHG=1906 XHG=2106 XHG=2303 YBD=1349 YHG=1311>clinical YBD=1341 YBD=1340 YHG=1319>years. YHG=1310>The YHG=1319>cases YHG=1320>were YHG=1311>selected YHG=1311>because YHG=1311>of XBD=1516 XBD=1646 XBD=1850 XBD=1941 XBD=2160 XBD=2227 XBD=2316 XBD=2516 XHG=1339 XHG=1568 XHG=1661 XHG=1864 XHG=1956 XHG=2173 XHG=2241 XHG=2332 YBD=1387 YBD=1380 YBD=1381 YHG=1351>severity. YHG=1351>The YHG=1350>diagnosis YHG=1359>was YHG=1350>confirmed YHG=1350>by YHG=1351>two YHG=1350>observers XBD=324 XHG=866 XBD=483 XBD=840 XBD=949 XBD=1209 XHG=156 XHG=350 XHG=976YBD=1397 YBD=1403 YBD=1396YHG=1374>AND YHG=1374>DOSAGE, YHG=1375>BLOOD YHG=1374>CONCENTRATION YHG=1373>TOLERANCE XBD=1417XHG=510 XBD=1481 XBD=1556 XBD=1653 XBD=1698 XBD=1829 XBD=1930 XBD=2163 XBD=2240 XBD=2517 XHG=1340 XHG=1440 XHG=1506 XHG=1581 XHG=1677 XHG=1726 XHG=1853 XHG=1955 XHG=2187 XHG=2265 YBD=1419 YBD=1418 YBD=1420 YBD=1426 YBD=1427 YHG=1389>and YHG=1390>in YHG=1389>all YHG=1390>but YHG=1390>2 YHG=1399>cases YHG=1399>was YHG=1390>supported YHG=1389>by YHG=1389>radiographic XBD=218 XHG=699 XBD=341 XBD=468 XBD=535 XBD=685 XBD=820 XHG=140 XHG=233 XHG=356 XHG=482 XHG=549 YBD=1451 YBD=1459 YBD=1452 YHG=1422>The YHG=1422>doses YHG=1422>given YHG=1421>by YHG=1422>mouth YHG=1431>were : XBD=1529 XBD=1641 XBD=1824 XBD=2050 XBD=2199 XBD=2259 XBD=2388 XBD=2445 XBD=2517 XHG=1340 XHG=1580 XHG=1656 XHG=1839 XHG=2064 XHG=2214 XHG=2276 XHG=2404 XHG=2456 YBD=1460 YBD=1467 YBD=1466 YBD=1458 YBD=1459 YHG=1429>evidence. YHG=1429>All YHG=1429>patients YHG=1429>responded YHG=1429>within YHG=1429>36 YHG=1430>hours YHG=1430>of YHG=1430>the

" XBD=2514 XBD=1381 XBD=1501 XBD=1680 XBD=1945 XBD=2100 XBD=2231 XBD=2301 XBD=2343 XHG=1338 XHG=1397 XHG=1521 XHG=1731 XHG=1966 XHG=2120 XHG=2251 XHG=2320 YBD=754 YHG=734>a YBD=755 YHG=725>number YHG=725>of YHG=726>renal YHG=725>trouble. YHG=725>White-cell YHG=725>counts YHG=724>made YHG=734>on P.XHG=2362 A. JENNINGS W. H. PATTERSON

13-8

" XBD=1438 XBD=1503 XBD=1729 XBD=1826 XBD=1898 XBD=2129 XBD=2262 XBD=2383 XBD=2477 XBD=2518 XHG=1340 XHG=1460 XHG=1521 XHG=1749 XHG=1847 XHG=1918 XHG=2182 XHG=2283 XHG=2403 XHG=2496 YBD=1498 YBD=1499 YHG=1469>start YHG=1469>of YHG=1468>treatment YHG=1469>and YHG=1469>all YHG=1468>recovered. YHG=1468>One YHG=1468>child YHG=1469>had YHG=1478>a |>" " XBD=319 XBD=409 XBD=682 XBD=771 XBD=842 XBD=1212 XBD=1280 XBD=1123 XHG=253 XHG=336 XHG=573 XHG=696 XHG=787 XHG=1137 XHG=1225 XHG=939 YBD=1514 YBD=1512 YBD=1511 YBD=1516 YBD=1511 YBD=1515 YBD=1515 YHG=1486>Age YHG=1487>(yr.) YHG=1485>Initial YHG=1486>dose YHG=1487>(g.) YHG=1486>dose YHG=1484>(g.) YHG=1486>Six-hourly

" XBD=1484 XBD=1524 XBD=1645 XBD=1760 XBD=1984 XBD=2076 XBD=2280 XBD=2360 XHG=1340 XHG=1501 XHG=1540 XHG=1660 XHG=1776 XHG=1999 XHG=2092 XHG=2311 XHG=2378 YBD=1546 YBD=1538 YBD=1539 YHG=1509>relapse YHG=1518>a YHG=1509>week YHG=1509>after YHG=1508>treatment YHG=1518>was YHG=1508>stopped YHG=1517>no YHG=1509>chemo; " XBD=2517 XBD=562 XHG=890 XBD=748 XBD=918 XBD=1103 XHG=534 XHG=695 XHG=1049 o-t YBD=1553 YBD=1554 YBD=1554 YHG=1547>.. YHG=1526>1-0 YHG=1548>.. YHG=1526>0-5 " XBD=2518 XBD=1505 XBD=1598 XBD=1729 XBD=1804 XBD=1843 XBD=1957 XBD=2051 XBD=2162 XHG=1342 XHG=1521 XHG=1617 XHG=1744 XHG=1822 XHG=1863 XHG=1975 XHG=2068 XHG=2178 YBD=1577 YBD=1578 YBD=1586 YHG=1548>therapy YHG=1558>was YHG=1549>given YHG=1548>for YHG=1548>4 YHG=1548>days YHG=1548>and YHG=1548>then YHG=1548>sulphamethazine " XBD=562 XHG=891 XBD=748 XBD=918 XBD=1126 XHG=534 XHG=695 XHG=1050 s-2 YBD=1593 YBD=1594 YBD=1594 YHG=1587>.. YHG=1565>1-5 YHG=1588>.. YHG=1565>0-75 " XBD=1418 XBD=1620 XBD=1730 XBD=1988 XHG=1340 XHG=1433 XHG=1636 XHG=1744 XHG=2003 YBD=1618 YBD=1625 YBD=1624 YHG=1597>was YHG=1588>restarted YHG=1588>with YHG=1587>satisfactory YHG=1596>response. " XBD=2190 XBD=354 XHG=890 XBD=562 XBD=748 XBD=918 XBD=1104 XHG=291 XHG=534 XHG=693 XHG=1052 YBD=1632 YBD=1633 YBD=1633 YHG=1605>2-5 YHG=1627>.. YHG=1605>2-0 YHG=1628>.. YHG=1605>1’0 " XBD=1682 XBD=1950 XBD=2014 XBD=2104 XBD=2316 XBD=2454 XHG=1390 XHG=1728 XHG=1965 XHG=2026 XHG=2149 XHG=2362 XHG=2498 YBD=1648 YBD=1657 YBD=1664 YBD=1665 YBD=1656 YHG=1627>Meningococcal YHG=1627>meningitis. YHG=1643>YHG=1627>Ten YHG=1626>patients YHG=1627>aged YHG=1627>2 2-5 " XBD=2517 XBD=377 XHG=890 XBD=560 XBD=917 XBD=1103 XHG=291 XHG=532 XHG=1051 YBD=1672 YBD=1673 YHG=1645>5-10 YHG=1666>.. YHG=1667>.. YHG=1645>1.5 " XBD=1498 XBD=1582 XBD=1670 XBD=1823 XBD=2045 XBD=2185 XHG=1343 XHG=1540 XHG=1628 XHG=1714 XHG=1866 XHG=2086 XHG=2226 YBD=1697 YBD=1705 YBD=1704 YBD=1696 YBD=1703 YHG=1667>months YHG=1668>to YHG=1668>10 YHG=1676>years YHG=1666>suffering YHG=1666>from YHG=1666>meningococcal " XBD=2519 XBD=375 XHG=889 XBD=561 XBD=747 XBD=917 XBD=1103 XHG=271 XHG=532 XHG=691 XHG=1049 YBD=1712 YBD=1713 YHG=1684>10-15 YHG=1683>3’0 YHG=1706>.. YHG=1684>2-0 " XBD=2519 XBD=1559 XHG=2505 XBD=1704 XBD=1868 XBD=2276 XBD=2458 XHG=1340 YBD=1735 XHG=1608 XHG=1755 XHG=1916 XHG=2334 YBD=1737 YHG=1713>I YBD=1744 YBD=1743 YHG=1706>meningitis YHG=1715>were YHG=1706>given YHG=1706>sulphamethazine. YHG=1706>Group " XBD=2518 XBD=1650 XBD=1746 XBD=1925 XBD=2042 XBD=2082 XBD=2206 XBD=2302 XBD=2341 XBD=2405 XHG=1340 XHG=1668 XHG=1764 XHG=1943 XHG=2060 XHG=2103 XHG=2225 XHG=2321 XHG=2362 XHG=2419 YBD=1784 YBD=1777 YBD=1775 YBD=1776 YHG=1747>meningococcus YHG=1756>was YHG=1746>isolated YHG=1746>from YHG=1746>8 YHG=1755>cases YHG=1746>and YHG=1747>7 YHG=1746>of YHG=1746>these XBD=213 XHG=925 XBD=399 XBD=538 XBD=578 XBD=707 XBD=792 XBD=908 XBD=958 XBD=1062 XBD=1280 XHG=139 XHG=231 XHG=418 XHG=558 XHG=598 XHG=727 XHG=813 XHG=977YBD=1782 XHG=1081 YBD=1781 YBD=1790 YBD=1782 YBD=1790 YHG=1753>For YHG=1752>patients YHG=1752>under YHG=1751>5 YHG=1761>years YHG=1752>the YHG=1752>drug YHG=1752>is YHG=1752>best YHG=1752>dispensed " XBD=1551 XBD=1681 XBD=1796 XBD=1898 XBD=1991 XBD=2050 XBD=2117 XBD=2259 XBD=2319 XBD=2353 XHG=1340 XHG=1602 XHG=1698 XHG=1813 XHG=1915 XHG=2008 XHG=2066 XHG=2132 XHG=2276 XHG=2332 XHG=2371 YBD=1817 YBD=1815 YBD=1816 YHG=1787>recovered. YHG=1786>The YHG=1786>fatal YHG=1795>case YHG=1795>was YHG=1786>in YHG=1795>an YHG=1786>infant YHG=1786>of YHG=1786>2 YHG=1786>months " XBD=2518 XBD=134 XHG=873 XBD=318 XBD=395 XBD=607 XBD=703 XBD=793 XBD=856 XBD=986 XBD=1042 XBD=1281 XHG=92 XHG=149 XHG=335 XHG=412 XHG=627 XHG=721 XHG=808 XHG=1001 XHG=1058 YBD=1822 YBD=1829 YBD=1821 YBD=1822 YBD=1830 YBD=1822 YBD=1830 YHG=1792>in YHG=1792>powders YHG=1792>for YHG=1801>accuracy, YHG=1792>and YHG=1801>can YHG=1792>be YHG=1793>given YHG=1792>in YHG=1792>suspension " XBD=2517 XBD=1530 XBD=1587 XBD=1773 XBD=1845 XBD=1931 XBD=2014 XBD=2106 XBD=2164 XBD=2345 XBD=2413 XHG=1341 XHG=1544 XHG=1606 XHG=1796 XHG=1865 XHG=1948 XHG=2028 XHG=2120 XHG=2181 XHG=2365 XHG=2434 YBD=1864 YBD=1863 YBD=1860 YBD=1855 YBD=1856 YHG=1825>admitted YHG=1827>to YHG=1826>hospital YHG=1835>on YHG=1825>the YHG=1825>5th YHG=1825>day YHG=1825>of YHG=1825>disease; YHG=1825>he YHG=1826>died XBD=135 XHG=938 XBD=242 XBD=298 XBD=406 XBD=535 XBD=666 XBD=835 XBD=924 XBD=982 XBD=1279 XHG=92 XHG=147 XHG=256 XHG=311 XHG=425 XHG=587 XHG=686 XHG=849 XHG=997 YBD=1861 YBD=1869 YBD=1861 YBD=1862 YBD=1869 YHG=1832>in YHG=1832>milk YHG=1841>or YHG=1831>fruit YHG=1831>juice. YHG=1831>The YHG=1831>sodium YHG=1832>salt YHG=1832>of YHG=1832>sulphametha" XBD=2517 XBD=1386 XBD=1515 XBD=1628 XBD=1844 XBD=1996 XBD=2086 XBD=2124 XBD=2236 XBD=2387 XBD=2442 XBD=2472 XHG=1343 XHG=1402 XHG=1529 XHG=1639 XHG=1854 XHG=2009 XHG=2100 XHG=2137 XHG=2251 XHG=2401 XHG=2452 XHG=2485 YBD=1896 YBD=1895 YBD=1902 YHG=1866>18 YHG=1866>hours YHG=1865>after YHG=1865>admission YHG=1865>having YHG=1865>had YHG=1875>a YHG=1865>total YHG=1865>dosage YHG=1865>of YHG=1865>2 YHG=1874>g. XBD=179 XHG=708 XBD=276 XBD=602 XBD=673 XBD=954 XBD=1175 XBD=1279 XHG=94 XHG=216 XHG=311 XHG=631 XHG=990 XHG=1201 YBD=1901 YBD=1900 YBD=1901 YBD=1909 YHG=1871>zine YHG=1871>for YHG=1871>intramuscular YHG=1880>or YHG=1871>intravenous YHG=1871>injection YHG=1880>was " XBD=2517 XBD=1517 XBD=1564 XBD=1887 XBD=1977 XBD=2151 XBD=2264 XBD=2350 XHG=1390 XHG=1532 XHG=1577 XHG=1901 XHG=1991 XHG=2166 XHG=2280 XHG=2362 YBD=1942 YBD=1934 YBD=1935 YBD=1941 YHG=1905>Group YHG=1913>II YHG=1905>meningococcus YHG=1914>was YHG=1905>isolated YHG=1905>from YHG=1914>one YHG=1905>patient. XBD=266 XHG=758 XBD=318 XBD=523 XBD=579 XBD=609 XBD=744 XBD=851 XBD=1082 XBD=1114 XBD=1163 XBD=1219 XBD=1279 XHG=91 XHG=278 XHG=330 XHG=536 XHG=589 XHG=624 XHG=864 XHG=1097 XHG=1130 XHG=1178 XHG=1232 YBD=1948 YBD=1947 YBD=1939 YBD=1946 YBD=1940 YBD=1948 YBD=1948 YBD=1940 YHG=1910>supplied YHG=1910>in YHG=1910>ampoules YHG=1911>of YHG=1910>3 YHG=1919>c.cm., YHG=1910>each YHG=1910>containing YHG=1911>1 YHG=1920>g. YHG=1911>to YHG=1910>be XBD=237 XHG=745 XBD=294 XBD=355 XBD=478 XBD=590 XBD=729 XBD=910 XBD=1043 XBD=1184 XBD=1277 XHG=90 XHG=252 XHG=312 XHG=372 XHG=495 XHG=603 XHG=924 XHG=1056 XHG=1199 YBD=1980 YBD=1979 YBD=1980 YBD=1980 YHG=1950>diluted YHG=1950>to YHG=1950>10 YHG=1958>c.cm. YHG=1950>with YHG=1950>sterile YHG=1950>distilled YHG=1950>water YHG=1951>before YHG=1959>use. " XBD=2519 XBD=1430 XBD=1603 XBD=1732 XBD=1786 XBD=1986 XBD=2111 XBD=2241 XBD=2449 XHG=1340 XHG=1465 XHG=1637 XHG=1765 XHG=1820 XHG=2024 XHG=2142 XHG=2357 XHG=2482 YBD=1980 YBD=1979 YBD=1974 YBD=1982 YBD=1973 YHG=1944>This YHG=1943>infant, YHG=1945>aged YHG=1945>8 YHG=1944>months, YHG=1944>died YHG=1944>after YHG=1944>days YHG=1944>in 0-05 " XBD=2519 XBD=1517 XBD=1711 XBD=1813 XBD=1931 XBD=2006 XBD=2111 XBD=2280 XBD=2351 XHG=1340 XHG=1565 XHG=1736 XHG=1838 XHG=1958 XHG=2034 XHG=2246 XHG=2308 XHG=2374 YBD=2022 YBD=2014 YBD=2021 YHG=1984>hospital. YHG=1985>During YHG=1984>this YHG=1984>time YHG=1984>he YHG=1984>had YHG=1993>g. YHG=1984>of YHG=1984>sulphaXBD=171 XHG=865 XBD=274 XBD=330 XBD=415 XBD=541 XBD=628 XBD=772 XBD=853 XBD=995 XBD=1277 XHG=93 XHG=185 XHG=287 XHG=338 XHG=429 XHG=551 XHG=738 XHG=786 XHG=1006 YBD=2019 YBD=2026 YBD=2020 YBD=2027 YBD=2028 YHG=1990>The YHG=1989>dose YHG=1989>of YHG=1989>this YHG=1989>given YHG=1999>was YHG=1999>g. YHG=1999>per YHG=1990>pound YHG=1990>body-weight. " XBD=2518 XBD=1564 XBD=1694 XBD=1819 XBD=1891 XBD=1984 XBD=2087 XBD=2216 XBD=2288 XBD=2384 XHG=1339 XHG=1615 XHG=1722 XHG=1847 XHG=1919 XHG=2010 XHG=2121 XHG=2247 XHG=2320 XHG=2410 YBD=2055 YBD=2061 YBD=2054 YBD=2053 YHG=2024>methazine. YHG=2024>The YHG=2024>level YHG=2024>of YHG=2024>free YHG=2024>drug YHG=2024>in YHG=2024>the YHG=2024>blood XBD=169 XHG=847 XBD=411 XBD=505 XBD=640 XBD=701 XBD=830 XBD=989 XBD=1030 XBD=1137 XBD=1199 XBD=1278 XHG=90 XHG=187 XHG=427 XHG=522 XHG=658 XHG=715 XHG=1006 XHG=1049 XHG=1155 XHG=1213 YBD=2059 YBD=2059 YBD=2060 YBD=2067 YBD=2060 YBD=2059 YHG=2029>The YHG=2029>precaution YHG=2038>was YHG=2029>taken YHG=2029>of YHG=2038>never YHG=2029>adding YHG=2039>a YHG=2030>dose YHG=2030>of YHG=2030>the " XBD=2517 XBD=1391 XBD=1472 XBD=1570 XBD=1662 XBD=1721 XBD=1945 XBD=2040 XBD=2210 XBD=2297 XBD=2382 XHG=1340 XHG=1406 XHG=1487 XHG=1586 XHG=1677 XHG=1737 XHG=1962 XHG=2135 XHG=2230 XHG=2317 XHG=2403 YBD=2094 YBD=2100 YBD=2101 YBD=2093 YBD=2099 YHG=2073>on YHG=2064>the YHG=2064>first YHG=2063>day YHG=2063>of YHG=2064>treatment YHG=2073>was YHG=2073>mg. YHG=2073>per YHG=2064>100 YHG=2073>c.cm., XBD=240 XHG=916 XBD=335 XBD=396 XBD=652 XBD=782 XBD=897 XBD=958 XBD=1108 XBD=1279 XHG=90 XHG=260 XHG=355 XHG=417 XHG=670 XHG=803 XHG=979 XHG=1130 YBD=2098 YBD=2098 YBD=2099 YBD=2104 YBD=2106 YHG=2069>sodium YHG=2069>salt YHG=2069>to YHG=2069>transfusion YHG=2069>fluids YHG=2069>such YHG=2078>as YHG=2069>saline, YHG=2070>glucose " XBD=2516 XBD=1417 XBD=1476 XBD=1572 XBD=1639 XBD=1742 XBD=1821 XBD=1906 XBD=2071 XBD=2182 XBD=2351 XBD=2443 XHG=1340 XHG=1443 XHG=1496 XHG=1596 XHG=1667 XHG=1771 XHG=1840 XHG=1933 XHG=2094 XHG=2233 XHG=2369 XHG=2470 YBD=2140 YBD=2133 YBD=2132 YHG=2103>and YHG=2104>it YHG=2102>15 YHG=2112>mg. YHG=2113>on YHG=2103>the YHG=2103>second YHG=2103>day. YHG=2103>There YHG=2112>was YHG=2112>no XBD=134 XHG=938 XBD=274 XBD=444 XBD=537 XBD=645 XBD=731 XBD=923 XBD=980 XBD=1063 XBD=1145 XBD=1277 XHG=90 XHG=148 XHG=325 XHG=459 XHG=554 XHG=661 XHG=749 XHG=996 XHG=1079 XHG=1161 YBD=2137 YBD=2146 YBD=2138 YBD=2137 YBD=2138 YBD=2138 YHG=2117>or YHG=2108>blood. YHG=2108>There YHG=2117>was YHG=2109>only YHG=2117>one YHG=2108>occasion YHG=2109>to YHG=2117>use YHG=2109>the YHG=2108>intra" XBD=2518 XBD=1518 XBD=1582 XBD=1875 XBD=1996 XBD=2182 XBD=2245 XBD=2327 XHG=1340 XHG=1539 XHG=1592 XHG=1897 XHG=2017 XHG=2202 XHG=2262 XHG=2342 YBD=2180 YBD=2172 YBD=2173 YHG=2142>evidence YHG=2142>-improvement YHG=2142>after YHG=2143>increase YHG=2142>of YHG=2143>the YHG=2142>standard XBD=234 XHG=590 XBD=380 XBD=478 XBD=567 XBD=883 XBD=1014 XBD=1115 XBD=1231 XBD=1279 XHG=91 XHG=259 XHG=405 XHG=502 XHG=906 XHG=1038 XHG=1138 XHG=1255 YBD=2178 YBD=2184 YBD=2186 YBD=2177 YBD=2178 YBD=2178 YBD=2178 YHG=2157>venous YHG=2148>route, YHG=2147>but YHG=2147>the YHG=2148>intramuscular YHG=2148>route YHG=2157>was YHG=2148>used YHG=2158>a " XBD=2517 XBD=1441 XBD=1545 XBD=1733 XBD=1821 XBD=1933 XBD=2036 XBD=2140 XBD=2295 XBD=2397 XHG=1340 XHG=1493 XHG=1568 XHG=1754 XHG=1847 XHG=1959 XHG=2062 XHG=2166 XHG=2322 XHG=2417 YBD=2211 YBD=2220 YBD=2213 YBD=2212 YHG=2182>dose. YHG=2182>At YHG=2182>autopsy YHG=2183>the YHG=2182>CSF YHG=2191>was YHG=2183>still YHG=2182>turbid YHG=2182>and YHG=2183>there XBD=250 XHG=842 XBD=302 XBD=426 XBD=514 XBD=571 XBD=636 XBD=737 XBD=825 XBD=948 XBD=1037 XBD=1092 XBD=1220 XBD=1279 XHG=91 XHG=260 XHG=313 XHG=438 XHG=530 XHG=587 XHG=654 XHG=749 XHG=961 XHG=1053 XHG=1110 XHG=1236 YBD=2217 YBD=2218 YBD=2217 YBD=2226 YBD=2218 YHG=2188>number YHG=2187>of YHG=2188>times YHG=2187>and YHG=2188>in YHG=2197>no YHG=2196>case YHG=2197>was YHG=2187>there YHG=2197>any YHG=2188>ill YHG=2187>effect YHG=2189>at " XBD=2518 XBD=1416 XBD=1452 XBD=1645 XBD=1822 XBD=1874 XBD=1952 XBD=2056 XBD=2114 XBD=2189 XBD=2318 XHG=1338 XHG=1429 XHG=1463 XHG=1658 XHG=1831 XHG=1887 XHG=1966 XHG=2070 XHG=2124 XHG=2198 XHG=2355 YBD=2251 YBD=2252 YBD=2260 YHG=2231>was YHG=2232>a YHG=2222>fibrinous YHG=2222>exudate YHG=2223>at YHG=2222>base YHG=2222>of YHG=2222>the YHG=2222>brain. YHG=2222>Samples XBD=157 XHG=315 XBD=246 XBD=304 XBD=510 XHG=92 XHG=174 XHG=262 YBD=2258 YBD=2258 YBD=2257 YBD=2264 YHG=2228>the YHG=2227>site YHG=2227>of YHG=2227>injection. " XBD=2519 XBD=1456 XBD=1520 XBD=1700 XBD=1814 XBD=1902 XBD=2115 XBD=2249 XBD=2314 XBD=2407 XHG=1339 XHG=1478 XHG=1534 XHG=1720 XHG=1836 XHG=1923 XHG=2134 XHG=2272 XHG=2331 XHG=2429 YBD=2291 YBD=2300 YBD=2299 YBD=2292 YBD=2298 YHG=2261>taken YHG=2262>at YHG=2262>autopsy YHG=2271>gave YHG=2262>the YHG=2261>following YHG=2262>levels YHG=2263>of YHG=2262>free YHG=2262>drug XBD=217 XHG=805 XBD=327 XBD=384 XBD=459 XBD=549 XBD=660 XBD=712 XBD=791 XBD=919 XBD=1008 XBD=1225 XBD=1279 XHG=140 XHG=230 XHG=341 XHG=394 XHG=472 XHG=565 XHG=672 XHG=726 XHG=932YBD=2297 XHG=1023 XHG=1238 YBD=2304 YBD=2296 YBD=2297 YBD=2297 YHG=2267>The YHG=2268>level YHG=2268>of YHG=2268>free YHG=2267>drug YHG=2267>in YHG=2267>the YHG=2267>blood YHG=2277>was YHG=2267>estimated YHG=2267>in " XBD=2518 XBD=1405 XBD=1503 XBD=1660 XBD=1937 XBD=2159 XBD=2402 XHG=1338 XHG=1436 XHG=1527 XHG=1697 XHG=2069 XHG=2182 XHG=2430 YBD=2338 YBD=2331 YBD=2339 YBD=2330 YHG=2310>per YHG=2302>100 YHG=2310>c.cm. YHG=2301>heart-blood YHG=2311>mg., YHG=2302>pericardial YHG=2301>fluid : XBD=155 XHG=832 XBD=254 XBD=320 XBD=445 XBD=505 XBD=725 XBD=816 XBD=935 XBD=1166 XBD=1277 XHG=88 XHG=170 XHG=269 XHG=331 XHG=461 XHG=517 XHG=740 XHG=951 XHG=1218 YBD=2336 YBD=2337 YBD=2336 YBD=2344 YBD=2336 YBD=2337 YHG=2307>the YHG=2307>first YHG=2302>24 YHG=2307>hours YHG=2307>of YHG=2307>treatment YHG=2307>and YHG=2307>daily YHG=2307>thereafter. YHG=2307>No 31-8 XBD=1537 XBD=1704 XBD=1774 XHG=1448 XHG=1563 XHG=1732 XHG=1799 YBD=2371 YBD=2370 YBD=2377 YHG=2349>mg., YHG=2341>muscle YHG=2341>18 YHG=2350>mg. " XBD=1874 XBD=259 XHG=858 XBD=350 XBD=478 XBD=536 XBD=648 XBD=731 XBD=842 XBD=994 XBD=1278 XHG=90 XHG=274 XHG=366 XHG=495 XHG=552 XHG=665 XHG=747 XHG=1008 YBD=2383 YBD=2384 YBD=2376 YBD=2375 YBD=2383 YHG=2347>attempt YHG=2356>was YHG=2347>made YHG=2347>to YHG=2346>keep YHG=2347>the YHG=2346>level YHG=2346>within YHG=2346>preconceived " XBD=2519 XBD=1466 XBD=1691 XBD=1868 XBD=1909 XBD=1995 XBD=2054 XBD=2087 XBD=2227 XBD=2320 XHG=1387 XHG=1483 XHG=1707 XHG=1887 XHG=1926 XHG=2012 XHG=2067 XHG=2106 XHG=2245 XHG=2338 YBD=2417 YBD=2409 YBD=2418 YBD=2410 YHG=2379>The YHG=2380>remaining YHG=2380>patient, YHG=2389>a YHG=2380>girl YHG=2380>of YHG=2380>7 YHG=2389>years, YHG=2389>was YHG=2379>admitted XBD=233 XHG=863 XBD=338 XBD=586 XBD=843 XBD=959 XBD=1208 XBD=1278 XHG=90 XHG=272 XHG=358 XHG=606 XHG=978 XHG=1228 YBD=2422 YBD=2417 YBD=2416 YBD=2415 YBD=2415 YBD=2415 YHG=2386>limits YHG=2386>184 YHG=2386>blood-level YHG=2386>estimations YHG=2394>were YHG=2385>made-138 YHG=2395>on ; XBD=1378 XBD=1458 XBD=1577 XBD=1695 XBD=1752 XBD=1978 XBD=2134 XBD=2244 XHG=1337 XHG=1392 XHG=1473 XHG=1590 XHG=1709 XHG=1761 XHG=1992 XHG=2148 XHG=2257 YBD=2448 YBD=2449 YBD=2457 YBD=2456 YBD=2450 YBD=2458 YHG=2418>in YHG=2419>the YHG=2419>third YHG=2419>week YHG=2420>of YHG=2420>meningitis YHG=2419>having YHG=2420>been YHG=2419>inadequately " XBD=2520 XBD=135 XHG=686 XBD=232 XBD=415 XBD=506 XBD=567 XBD=633 XBD=670 XBD=843 XBD=1037 XBD=1166 XBD=1277 XHG=90 XHG=152 XHG=247 XHG=430 XHG=522 XHG=584 XHG=650 XHG=858 XHG=1088 XHG=1181 YBD=2455 YBD=2455 YBD=2456 YBD=2463 YBD=2455 YBD=2455 YHG=2425>32 YHG=2426>sick YHG=2426>children YHG=2426>and YHG=2426>46 YHG=2435>on YHG=2426>6 YHG=2426>healthy YHG=2425>children. YHG=2425>The YHG=2425>level " XBD=2518 XBD=1488 XBD=1597 XBD=1934 XBD=2059 XBD=2150 XBD=2374 XHG=1338 XHG=1504 XHG=1613 XHG=1986 XHG=2074 XHG=2168 XHG=2390 YBD=2488 YBD=2496 YBD=2497 YBD=2489 YHG=2459>treated YHG=2459>with YHG=2459>sulphapyridine. YHG=2459>She YHG=2468>was YHG=2460>extremely YHG=2459>emaciXBD=131 XHG=941 XBD=213 XBD=506 XBD=615 XBD=708 XBD=923 XBD=991 XBD=1054 XBD=1275 XHG=88 XHG=147 XHG=232 XHG=522 XHG=632 XHG=726 XHG=1010 XHG=1073 YBD=2494 YBD=2503 YBD=2495 YBD=2494 YBD=2494 YBD=2495 YHG=2465>in YHG=2466>the YHG=2465>cerebrospinal YHG=2465>fluid YHG=2475>was YHG=2465>measured YHG=2474>on YHG=2465>17 YHG=2465>occasions. " XBD=2520 XBD=1428 XBD=1521 XBD=1615 XBD=1858 XBD=2041 XBD=2254 XHG=1338 XHG=1445 XHG=1538 XHG=1631 XHG=1876 XHG=2056 XHG=2305 YBD=2527 YBD=2535 YBD=2528 YHG=2498>ated YHG=2499>and YHG=2499>had YHG=2499>intractable YHG=2498>cerebral YHG=2499>vomiting. YHG=2499>Treatment 2! XBD=169 XHG=803 XBD=358 XBD=418 XBD=546 XBD=603 XBD=642 XBD=782 XBD=944 XBD=1004 XBD=1091 XBD=1210 XHG=91 XHG=191 XHG=377 XHG=438 XHG=564 XHG=620 XHG=665 XHG=964 XHG=1024 XHG=1112 YBD=2534 YBD=2535 YBD=2534 YBD=2517 YBD=2542 YBD=2541 YBD=2533 YBD=2541 YBD=2533 YHG=2504>The YHG=2506>children YHG=2506>in YHG=2505>the YHG=2505>ill YHG=2505>&dquo; YHG=2514>group YHG=2504>ranged YHG=2504>in YHG=2514>age YHG=2504>from &dquo; " XBD=2520 XBD=1527 XBD=1587 XBD=1649 XBD=1787 XBD=2047 XBD=2244 XBD=2302 XBD=2335 XBD=2387 XBD=2446 XHG=1338 XHG=1544 XHG=1598 XHG=1663 XHG=1802 XHG=2062 XHG=2260 XHG=2314 XHG=2354 XHG=2405 XHG=2458 YBD=2575 YBD=2567 YBD=2568 YHG=2538>consisted YHG=2547>an YHG=2538>initial YHG=2538>intravenous YHG=2537>injection YHG=2538>2 YHG=2547>g. YHG=2538>of YHG=2538>the XBD=244 XHG=801 XBD=303 XBD=368 XBD=507 XBD=603 XBD=661 XBD=783 XBD=867 XBD=1044 XBD=1221 XBD=1282 XHG=90 XHG=263 XHG=325 XHG=387 XHG=527 XHG=620 XHG=677 XHG=886 XHG=1062 XHG=1238 YBD=2574 YBD=2582 YBD=2574 YBD=2581 YBD=2574 YBD=2573 YHG=2545>months YHG=2545>to YHG=2545>13 YHG=2553>years, YHG=2544>and YHG=2544>in YHG=2544>these YHG=2544>the YHG=2553>average YHG=2544>amount YHG=2544>of " XBD=2518 XBD=1488 XBD=1587 XBD=1656 XBD=2025 XBD=2223 XBD=2300 XHG=1338 XHG=1513 XHG=1612 XHG=1675 XHG=2049 XHG=2247 XHG=2323 YBD=2608 YBD=2615 YBD=2607 YHG=2577>sodium YHG=2578>salt YHG=2577>of YHG=2577>sulphamethazine YHG=2577>followed YHG=2577>by YHG=2578>intramusXBD=439 XHG=844 XBD=574 XBD=634 XBD=720 XBD=824 XBD=891 XBD=1026 XBD=1124 XBD=1204 XBD=1276 XHG=90 XHG=461 XHG=593 XHG=655 XHG=741 XHG=912 XHG=1048 XHG=1146 XHG=1227 YBD=2621 YBD=2622 YBD=2614 YBD=2613 YBD=2613 YBD=2613 YBD=2620 YHG=2584>sulphamethazine YHG=2584>given YHG=2584>in YHG=2584>the YHG=2584>first YHG=2583>24 YHG=2584>hours YHG=2593>was YHG=2583>4-2 YHG=2593>g., " XBD=2518 XBD=1442 XBD=1662 XBD=1726 XBD=1762 XBD=1818 XBD=1954 XBD=1995 XBD=2141 XBD=2240 XBD=2321 XBD=2388 XHG=1339 XHG=1461 XHG=1682 XHG=1741 XHG=1784 XHG=1840 XHG=1975 XHG=2016 XHG=2193 XHG=2260 XHG=2343 XHG=2408 YBD=2654 YBD=2655 YBD=2652 YBD=2646 YBD=2647 YHG=2617>cular YHG=2617>injections YHG=2617>of YHG=2617>2 YHG=2626>g. YHG=2626>every YHG=2617>6 YHG=2617>hours. YHG=2618>In YHG=2618>all, YHG=2617>23 YHG=2617>intraXBD=219 XHG=919 XBD=264 XBD=395 XBD=528 XBD=837 XBD=900 XBD=999 XBD=1095 XBD=1186 XBD=1275 XHG=90 XHG=240 XHG=283 XHG=415 XHG=551 XHG=857 XHG=1021 XHG=1119 XHG=1209 YBD=2661 YBD=2654 YBD=2653 YBD=2660 YHG=2624>giving YHG=2633>a YHG=2633>mean YHG=2624>blood YHG=2624>concentration YHG=2624>of YHG=2623>16-5 YHG=2632>mg. YHG=2632>per YHG=2623>100 " XBD=2520 XBD=1528 XBD=1746 XBD=1861 XBD=1993 XBD=2088 XBD=2248 XHG=1337 XHG=1546 XHG=1765 XHG=1882 XHG=2012 XHG=2108 XHG=2268 lowest, YBD=2693 YBD=2686 YHG=2657>muscular YHG=2657>injections YHG=2666>were YHG=2657>given YHG=2657>and YHG=2657>careful YHG=2657>examination XBD=197 XHG=922 XBD=327 XBD=796 XBD=896 XBD=981 XBD=1081 XBD=1186 XBD=1277 XHG=91 XHG=249 XHG=510 XHG=819 XHG=1007 XHG=1110 XHG=1211 YBD=2692 YBD=2693 YBD=2692 YBD=2699 YBD=2692 YHG=2672>c.cm. YHG=2663>The YHG=2664>concentration YHG=2672>was YHG=2663>3-8 YHG=2672>mg. YHG=2663>and YHG=2662>the " XBD=2518 XBD=1381 XBD=1459 XBD=1658 XBD=1761 XBD=1929 XBD=1993 XBD=2093 XBD=2151 XBD=2341 XBD=2442 XHG=1338 XHG=1393 XHG=1474 XHG=1671 XHG=1777 XHG=1945 XHG=2009 XHG=2108 XHG=2162 XHG=2391 XHG=2457 YBD=2732 YBD=2733 YBD=2726 YBD=2725 YHG=2690>of YHG=2695>injection YHG=2696>sites YHG=2696>showed YHG=2705>no YHG=2696>sign YHG=2696>of YHG=2696>reaction. YHG=2697>At YHG=2696>the XBD=240 XHG=796 XBD=343 XBD=439 XBD=528 XBD=617 XBD=745 XBD=875 XBD=1045 XBD=1181 XBD=1277 XHG=90 XHG=261 XHG=364 XHG=460 XHG=550 XHG=639 XHG=895YBD=2739 XHG=1064 XHG=1200 YBD=2739 YBD=2732 YBD=2739 YBD=2739 YBD=2731 YHG=2702>highest YHG=2702>29-8 YHG=2712>mg. YHG=2712>per YHG=2703>100 YHG=2712>c.cm. YHG=2702>The YHG=2702>highest YHG=2702>figure YHG=2697>was " XBD=2519 XBD=1431 XBD=1491 XBD=1653 XBD=1760 XBD=2019 XBD=2204 XBD=2288 XBD=2399 XHG=1337 XHG=1447 XHG=1501 XHG=1667 XHG=1775 XHG=2034 XHG=2219 XHG=2304 XHG=2413 YBD=2773 YBD=2772 YBD=2765 YBD=2764 YHG=2735>time YHG=2735>of YHG=2735>writing YHG=2744>very YHG=2735>satisfactory YHG=2744>progress YHG=2735>has YHG=2735>been YHG=2735>made 2t XBD=272 XHG=921 XBD=330 XBD=398 XBD=541 XBD=653 XBD=901 XBD=997 XBD=1047 XBD=1140 XBD=1277 XHG=90 XHG=289 XHG=347 XHG=414 XHG=557 XHG=735 XHG=1014 XHG=1063 XHG=1156 YBD=2772 YBD=2779 YBD=2778 YBD=2771 YBD=2771 YHG=2742>obtained YHG=2742>in YHG=2751>an YHG=2742>infant YHG=2742>aged YHG=2742>months, YHG=2742>and YHG=2742>it YHG=2750>was YHG=2741>found " XBD=2518 XBD=1391 XBD=1476 XBD=1646 XBD=1736 XBD=1820 XBD=2016 XBD=2078 XBD=2279 XBD=2472 XHG=1338 XHG=1410 XHG=1495 XHG=1664 XHG=1755 XHG=1840 XHG=2035 XHG=2094 XHG=2297 XHG=2490 YBD=2811 YBD=2805 YBD=2803 YBD=2812 YBD=2804 YHG=2774>by YHG=2775>patient YHG=2775>but YHG=2775>the YHG=2774>question YHG=2774>of YHG=2774>complete YHG=2783>recovery YHG=2775>is XBD=179 XHG=764 XBD=259 XBD=353 XBD=567 XBD=735 XBD=830 XBD=1009 XBD=1152 XBD=1277 XHG=91 XHG=209 XHG=288 XHG=383 XHG=597 XHG=859 XHG=1038 XHG=1181 YBD=2812 YBD=2810 YBD=2818 YBD=2811 YBD=2818 YBD=2810 YHG=2782>that YHG=2791>on YHG=2780>standard YHG=2781>dosage YHG=2781>the YHG=2781>highest YHG=2781>levels YHG=2789>were " XBD=1417 XHG=1338 XHG=1435 YBD=2843 YBD=2844 YHG=2814>still YHG=2814>doubtful. " XBD=1624 XBD=272 XHG=952 XBD=323 XBD=503 XBD=634 XBD=667 XBD=800 XBD=941 XBD=984 XBD=1062 XBD=1277 XHG=91 XHG=283 XHG=336 XHG=514 XHG=646 XHG=679 XHG=851 XHG=996 XHG=1073 YBD=2851 YBD=2857 YBD=2850 YBD=2850 YBD=2858 YHG=2821>obtained YHG=2821>in YHG=2820>children YHG=2820>under YHG=2821>3 YHG=2830>years. YHG=2820>This YHG=2821>is YHG=2820>the YHG=2827>age-group XBD=1505 XBD=2083 XBD=2208 XBD=2258 XBD=2379 XBD=2446 XHG=1388 XHG=1915 XHG=2113 XHG=2240 XHG=2288 XHG=2407 XHG=2478 YBD=2889 YBD=2882 YBD=2890 YBD=2883 YHG=2853>Lobar YHG=2853>patients YHG=2853>aged YHG=2854>1 YHG=2862>year YHG=2855>to YHG=2853>13 " XBD=2517 XBD=266 XHG=676 XBD=433 XBD=604 XBD=661 XBD=772 XBD=1185 XBD=1278 XHG=90 XHG=283 XHG=448 XHG=619 XHG=788YBD=2891 XHG=1202 YBD=2896 YBD=2889 YBD=2897 YHG=2854>with YHG=2860>highest YHG=2859>fatality YHG=2860>in YHG=2860>both YHG=2860>bronchopneumonia YHG=2859>and’the " XBD=2519 XBD=1447 XBD=1679 XBD=1782 XBD=1844 XBD=2226 XBD=2355 XHG=1338 XHG=1468 XHG=1699 XHG=1803 XHG=1866 XHG=2278 XHG=2376 YBD=2923 YBD=2929 YBD=2922 YBD=2930 YHG=2901>years YHG=2892>responded YHG=2892>well YHG=2893>to YHG=2892>sulphamethazine. YHG=2893>The YHG=2893>patient XBD=392 XHG=854 XBD=634 XBD=737 XBD=828 XBD=958 XBD=1214 XBD=1283 XHG=89 XHG=416 XHG=660 XHG=761 XHG=983 XHG=1239 YBD=2937 YBD=2935 YBD=2929 YBD=2936 YBD=2929 YBD=2928 YHG=2899>meningococcal YHG=2899>meningitis YHG=2899>and YHG=2900>the YHG=2899>early YHG=2899>attainment YHG=2898>of " XBD=2517 XBD=1382 XBD=1443 XBD=1572 XBD=1799 XBD=1841 XBD=1952 XBD=1986 XBD=2295 XHG=1340 XHG=1401 XHG=1463 XHG=1592 XHG=1818 XHG=1859 XHG=1971 XHG=2004 XHG=2314 YBD=2962 YBD=2961 YBD=2969 YBD=2970 YHG=2932>of YHG=2932>13 YHG=2941>years YHG=2932>developed YHG=2942>a YHG=2933>type YHG=2939>I YHG=2933>pneumococcal YHG=2941>empyema. principle.’ XBD=179 XHG=905 XBD=304 XBD=348 XBD=384 XBD=516 XHG=87 XHG=190 XHG=316 XHG=360 XHG=395 YBD=2977 YBD=2970 YHG=2940>high YHG=2940>levels YHG=2938>is YHG=2948>a YHG=2938>sound XBD=832 XBD=894 XBD=971 XBD=1022 XBD=1201 XBD=1279 XHG=785 XHG=843 XHG=982 XHG=1034 XHG=1213 YBD=2969 YBD=2968 YBD=2968 YBD=2977 YBD=2968 YHG=2939>In YHG=2939>all YHG=2939>the YHG=2939>ill YHG=2939>patients YHG=2939>the " XBD=1399 XHG=1337 XHG=1417 YBD=3002 YBD=3001 YHG=2972>All YHG=2971>recovered. " XBD=1627 XBD=258 XHG=810 XBD=497 XBD=697 XBD=781 XBD=903 XBD=1015 XBD=1279 XHG=91 XHG=269 XHG=524 XHG=728 XHG=931 XHG=1045 YBD=3016 YBD=3008 YBD=3015 YBD=3007 YBD=3008 YBD=3015 YHG=2979>highest YHG=2978>blood-level YHG=2977>attained YHG=2978>by YHG=2978>each YHG=2987>case YHG=2978>throughout " XBD=2519 XBD=1422 XBD=1726 XBD=1869 XBD=1944 XBD=1991 XBD=2062 XBD=2383 XHG=1386 XHG=1453 XHG=1755 XHG=1900 XHG=1970 XHG=2022 XHG=2289 XHG=2413 YBD=3048 YBD=3040 YBD=3041 YBD=3049 YHG=3011>A YHG=3011>miscellaneous YHG=3020>group YHG=3010>of YHG=3010>5 YHG=3010>ill YHG=3020>were YHG=3012>given XBD=299 XHG=936 XBD=393 XBD=570 XBD=722 XBD=785 XBD=917 XBD=980 XBD=1059 XBD=1279 XHG=91 XHG=316 XHG=411 XHG=587 XHG=741 XHG=803 XHG=993 XHG=1075 YBD=3051 YBD=3048 YBD=3047 YBD=3048 YBD=3055 YHG=3019>treatment YHG=3027>was YHG=3017>reached YHG=3018>within YHG=3018>48 YHG=3018>hours YHG=3018>of YHG=3018>the YHG=3017>beginning " XBD=2520 XBD=1689 XBD=1789 XBD=1875 XBD=2072 XBD=2135 XBD=2222 XBD=2344 XHG=1339 XHG=1712 XHG=1811 XHG=1896 XHG=2095 XHG=2157 XHG=2245 XHG=2366 YBD=3087 YBD=3079 YBD=3080 YHG=3050>sulphamethazine YHG=3050>and YHG=3060>are YHG=3050>included YHG=3050>in YHG=3050>the YHG=3050>total YHG=3051>number XBD=137 XHG=776 XBD=228 XBD=421 XBD=528 XBD=598 XBD=745 XBD=879 XBD=1045 XBD=1121 XBD=1277 XHG=92 XHG=163 XHG=259 XHG=451 XHG=558 XHG=628 XHG=909 XHG=1074 XHG=1151 YBD=3087 YBD=3095 YBD=3086 YBD=3094 YBD=3087 YBD=3086 YHG=3058>of YHG=3058>the YHG=3058>therapy YHG=3057>and YHG=3057>in YHG=3066>many YHG=3066>cases YHG=3057>within YHG=3057>24 YHG=3058>hours. " XBD=2519 XBD=1498 XBD=1619 XBD=1741 XBD=1865 XBD=2158 XBD=2259 XBD=2351 XHG=1303 XHG=1526 XHG=1646 XHG=1768 XHG=1892 XHG=2187 XHG=2286 XHG=2379 YBD=3122 YBD=3127 YBD=3126 YBD=3119 YHG=3090>because YHG=3090>they YHG=3099>were YHG=3089>fully YHG=3089>investigated, YHG=3089>but YHG=3090>the YHG=3088>clinical XBD=310 XHG=761 XBD=397 XBD=514 XBD=676 XBD=739 XBD=855 XBD=1149 XBD=1307 XHG=91 XHG=332 XHG=418 XHG=535 XHG=697 XHG=878 XHG=1201 YBD=3126 YBD=3126 YBD=3125 YBD=3133 YBD=3133 YBD=3125 YHG=3097>Thereafter YHG=3097>the YHG=3096>level YHG=3095>tended YHG=3096>to YHG=3096>drop YHG=3096>considerably. YHG=3096>The " XBD=2361 XBD=1528 XBD=1579 XBD=1667 XBD=1857 XBD=1915 XBD=1999 XBD=2171 XHG=1339 XHG=1547 XHG=1598 XHG=1686 XHG=1876 XHG=1934 XHG=2018 XHG=2189 YBD=3165 YBD=3166 YBD=3158 YHG=3129>diagnosis YHG=3129>is YHG=3129>not YHG=3128>relevant YHG=3128>in YHG=3129>the YHG=3130>present YHG=3129>account. 4t XBD=250 XHG=838 XBD=449 XBD=511 XBD=821 XBD=915 XHG=91 XHG=271 XHG=467 XHG=525 YBD=3172 YBD=3172 YBD=3165 YHG=3144>average YHG=3135>duration YHG=3136>of YHG=3134>chemotherapy YHG=3144>was XBD=1120 XBD=1185 XBD=1280 XHG=1000 XHG=1153 XHG=1202 YBD=3171 YHG=3135>days YHG=3136>it YHG=3144>was ; " XBD=212 XBD=491 XBD=687 XBD=743 XBD=920 XBD=1043 XBD=1152 XBD=1280 XHG=91 XHG=227 XHG=506 XHG=702 XHG=757 XHG=935 XHG=1058 XHG=1168 YBD=3203 YBD=3204 YBD=3211 YBD=3202 YBD=3203 YBD=3203 YBD=3203 YBD=3211 YHG=3174>either YHG=3174>discontinued YHG=3174>abruptly YHG=3182>or YHG=3174>reduced YHG=3174>doses YHG=3183>were YHG=3174>given |>" XBD=1516 XHG=1504 YBD=3209 YHG=3207>" XBD=1279 XBD=150 XHG=679 XBD=209 XBD=336 XBD=426 XBD=471 XBD=560 XBD=667 XBD=852 XBD=1154 XHG=89 XHG=163 XHG=222 XHG=350 XHG=439 XHG=483 XHG=574 XHG=904 XHG=1167 YBD=3242 YBD=3242 YBD=3244 YBD=3243 YBD=3249 YBD=3243 YBD=3243 YHG=3213>for YHG=3213>24 YHG=3213>hours YHG=3213>and YHG=3213>it YHG=3223>was YHG=3213>then YHG=3212>stopped. YHG=3213>Estimations YHG=3213>made " XBD=2521 XBD=1422 XBD=1685 XBD=1795 XBD=1860 XBD=2225 XBD=2286 XBD=2471 XHG=1387 XHG=1442 XHG=1708 XHG=1817 XHG=1877 XHG=2246 XHG=2308 XHG=2491 YBD=3283 YBD=3275 YBD=3284 YBD=3276 YHG=3246>A YHG=3246>preliminary YHG=3245>trial YHG=3245>of YHG=3246>sulphamethazine YHG=3246>in YHG=3246>children YHG=3246>is XBD=157 XHG=927 XBD=251 XBD=366 XBD=691 XBD=804 XBD=911 XBD=951 XBD=1070 XBD=1130 XBD=1169 XBD=1280 XHG=91 XHG=175 XHG=268 XHG=383 XHG=709 XHG=821 XHG=968 XHG=1088 XHG=1147 XHG=1187 YBD=3282 YBD=3283 YBD=3289 YBD=3282 YBD=3282 YBD=3282 YBD=3290 YHG=3252>the YHG=3253>day YHG=3252>after YHG=3252>discontinuance YHG=3261>gave YHG=3252>only YHG=3262>a YHG=3253>trace YHG=3262>or YHG=3262>a YHG=3262>very " XBD=1526 XHG=1339 YBD=3323 YHG=3285>reported. XBD=162 XHG=884 XBD=475 XBD=542 XBD=629 XBD=759 XBD=859 XBD=905 XBD=1088 XBD=1280 XHG=91 XHG=190 XHG=500 XHG=563 XHG=655 XHG=812 XHG=930 XHG=1113 YBD=3322 YBD=3322 YBD=3328 YBD=3320 YBD=3321 YBD=3329 YBD=3322 YHG=3292>low YHG=3292>concentration YHG=3293>of YHG=3293>the YHG=3292>drug. YHG=3291>In YHG=3292>6 YHG=3292>healthy YHG=3292>children " XBD=2520 XBD=1492 XBD=1635 XBD=1968 XBD=2041 XBD=2130 XBD=2255 XBD=2376 XHG=1388 XHG=1520 XHG=1664 XHG=1997 XHG=2065 XHG=2160 XHG=2283 XHG=2406 YBD=3361 YBD=3353 YBD=3354 YBD=3355 YBD=3362 YHG=3325>High YHG=3324>blood YHG=3324>concentrations YHG=3325>of YHG=3325>the YHG=3325>drug YHG=3334>were YHG=3325>safely XBD=264 XHG=876 XBD=352 XBD=461 XBD=529 XBD=568 XBD=685 XBD=783 XBD=851 XBD=985 XBD=1073 XBD=1280 XHG=92 XHG=287 XHG=375 XHG=486 XHG=551 XHG=594 XHG=707 XHG=810 XHG=1007 XHG=1096 YBD=3361 YBD=3368 YBD=3361 YBD=3369 YBD=3360 YBD=3359 YBD=3367 YBD=3360 YHG=3331>between YHG=3331>the YHG=3340>ages YHG=3332>of YHG=3332>1 YHG=3341>year YHG=3331>and YHG=3330>12 YHG=3339>years YHG=3331>the YHG=3332>standard " XBD=2520 XBD=1521 XBD=1638 XBD=1725 XBD=2019 XBD=2178 XBD=2303 XBD=2393 XBD=2443 XHG=1339 XHG=1543 XHG=1659 XHG=1747 XHG=2042 XHG=2200 XHG=2355 XHG=2414 XHG=2465 YBD=3397 YBD=3392 YBD=3399 YBD=3401 YBD=3394 YBD=3393 YHG=3363>obtained YHG=3364>with YHG=3363>the YHG=3358>experimental YHG=3364>dosage YHG=3364>used. YHG=3364>It YHG=3364>is YHG=3364>for 1. Macartney, D. W., Luxton, R. W., Smith, G. S. and Ramsay, " XBD=2521 XBD=1486 XBD=1774 XBD=1831 XBD=2056 XBD=2139 XBD=2342 XBD=2416 XHG=1338 XHG=1503 XHG=1790 XHG=1850 XHG=2074 XHG=2157 XHG=2358 YBD=3439 YBD=3431 YBD=3433 YBD=3440 YBD=3432 YHG=3403>further YHG=3402>investigation YHG=3403>to YHG=3402>determine YHG=3403>the YHG=3404>necessity YHG=3403>for YHG=3402>such W. A.XHG=2432 Lancet, 1942, i, 639. |>" 2. XBD=1515 YBD=3473 YHG=3442>levels. ’ L. Ibid, p. 760. Colebrook,XHG=1339

3 9-75 8-8

33-8

pneumonia.-Six

patients

SUMMARY

.

^

309 The therapeutic of sulphamethazine in a " XBD=2528 XBD=1397 XBD=1618 XBD=1793 XBD=1866 XBD=1986 XBD=2197 XBD=2322 XBD=2420 XHG=1347 YBD=206 XHG=1429 XHG=1650 XHG=1825 XHG=1900 XHG=2018 XHG=2230 XHG=2355 XHG=2453 YBD=205 YBD=214 YBD=213 YHG=186>an YHG=177>analgesia YHG=177>similar YHG=177>to YHG=177>that YHG=177>obtained YHG=177>with YHG=186>gas efficiencyYHG=177>and of casesYBD=245 of bronchopneumonia and meningosmall series " XBD=2529 XBD=1506 XBD=1677 XBD=1908 XBD=1964 XBD=2058 XBD=2185 XBD=2241 XBD=2380 XHG=1348 XHG=1560 XHG=1693 XHG=1925 XHG=1982 XHG=2075 XHG=2202 XHG=2258 XHG=2397 YBD=246 YBD=253 YBD=244 YHG=225>oxygen. YHG=216>Other YHG=215>operations YHG=216>in YHG=216>this YHG=216>series YHG=215>in YHG=214>which YHG=215>trilene coccal meningitis " XBD=2529 XBD=1415 XBD=1527 XBD=1661 XBD=1778 XBD=2034 XBD=2147 XBD=2282 XHG=1348was XHG=1432 XHG=1542 XHG=1677 XHG=1793 XHG=2051 XHG=2164 XHG=2315 YBD=285 YBD=292 YBD=284 YBD=283 YBD=291 YHG=255>has : YHG=255>been YHG=254>found YHG=255>most YHG=255>satisfactory YHG=255>have YHG=254>been YHG=254>operations encouraging. in adults was oblow toxicity The same " XBD=2530 XBD=1398 XBD=1488 XBD=1612 XBD=1730 XBD=1797 XBD=2021 XBD=2228 XBD=2336 XHG=1349 XHG=1425 XHG=1515 XHG=1638 XHG=1756 XHG=1824 XHG=2046 XHG=2259 XHG=2362 YBD=324 reported YBD=330 YBD=323 YBD=328 YBD=329 YHG=303>on YHG=294>the YHG=294>skull YHG=295>such YHG=303>as YHG=294>depressed YHG=294>fractures YHG=293>(the YHG=292>patients and infants. Other advantages over children YBD=367 served in " XBD=2528 XBD=1443 XBD=1547 XBD=1653 XBD=1796 XBD=1897 XBD=2019 XBD=2096 XBD=2282 XHG=1349 XHG=1472 XHG=1576 XHG=1683 XHG=1827 XHG=1926 XHG=2049 XHG=2126 XHG=2309 YBD=363 YBD=362 YBD=369 YHG=342>were YHG=333>bad YHG=333>risk YHG=342>cases, YHG=332>but YHG=341>gave YHG=341>no YHG=332>anxiety YHG=332>whatever), are YBD=408 easier oralYHG=370>operations. administration with longer " XBD=2528 XBD=1564 XBD=1628 XBD=1706 XBD=1809 XBD=1899 XBD=2054 XBD=2145 XBD=2288 XHG=1349 XHG=1578 XHG=1642 XHG=1721 XHG=1824 XHG=1913 XHG=2071 XHG=2160 XHG=2302 YBD=409 YBD=402 YBD=407 YBD=401 YHG=372>operations YHG=381>on YHG=372>the YHG=381>nose YHG=371>and YHG=371>throat, YHG=372>and YHG=371>dental sulphapyridine much less likelihood of between YBD=440 intervalsXHG=2489 doses, and " XBD=2530 XBD=1494 XBD=1622 XBD=1796 XBD=2030 XBD=2097 XBD=2183 XBD=2281 XBD=2463 XHG=1350 XHG=1520 XHG=1648 XHG=1820 XHG=2055 XHG=2118 XHG=2208 XHG=2305 YBD=441 YBD=448 YBD=443 YHG=411>Trilene YHG=412>gives YHG=411>enough YHG=411>relaxation YHG=411>of YHG=411>the YHG=411>jaw YHG=410>muscles YHG=411>to of intramuscular at the site YBD=481 trouble XHG=2395 " XBD=2531 XBD=1481 XBD=1532 XBD=1656 XBD=1753 XBD=1819 XBD=1891 XBD=2081 XBD=2164 XBD=2305 XHG=1350 XHG=1508 XHG=1555 XHG=1682 XHG=1778 XHG=1845 XHG=1917 XHG=2105 XHG=2190 YBD=488 YBD=480 YHG=451>enable YHG=460>a YHG=451>large YHG=460>gag YHG=451>to YHG=450>be YHG=450>inserted YHG=451>for YHG=450>tonsil YHG=450>mouth injection when the is used.YBD=520 sodium salt " XBD=2531 XBD=1575 XBD=1666 XBD=1718 XBD=1764 XBD=1891 XBD=2074 XBD=2136 XBD=2253 XBD=2434 XHG=1350 XHG=1628 XHG=1687 XHG=1741 XHG=1786 XHG=1913 XHG=2095 XHG=2159 XHG=2275 XHG=2455 YBD=519 YHG=490>and YBD=527 YHG=491>operations. YHG=490>It YHG=491>is YHG=500>a YHG=490>great YHG=490>comfort YHG=489>to YHG=490>both YHG=484>surgeon " XBD=2531 XBD=1588 XBD=1646 XBD=1767 XBD=1877 XBD=1918 XBD=2280 XHG=1350 XHG=1605 XHG=1663 XHG=1783 XHG=1894 XHG=1934 XHG=2298 YBD=560 YBD=559 YBD=565 YBD=566 YHG=529>anaesthetist YHG=530>to YHG=529>work YHG=529>with YHG=539>a YHG=529>non-innammable YHG=530>anaathetic, the advice of our colleagues in the We are grateful for " XBD=2531 XBD=1473 XBD=1581 XBD=1709 XBD=1820 XBD=1904 XBD=2001 XBD=2062 XBD=2142 XBD=2203 XBD=2416 XHG=1351 XHG=1493 XHG=1601 XHG=1727 XHG=1840 XHG=1923 XHG=2019 XHG=2077 XHG=2162 XHG=2223 XHG=2434 YBD=600 YBD=607 YBD=606 YBD=599 YHG=569>which YHG=569>does YHG=578>away YHG=569>with YHG=569>the YHG=569>risk YHG=569>of YHG=570>fire YHG=578>or YHG=569>explosion YHG=570>from where all the bacteriological Crumpsall Hospital Laboratory, " XBD=2536 XBD=1477 XBD=1681 XBD=1744 XBD=1926 XBD=2143 XBD=2207 XBD=2272 XBD=2473 XHG=1351 XHG=1500 XHG=1703 XHG=1765 XHG=1977 XHG=2164 XHG=2222 XHG=2293 XHG=2493 YBD=639 YHG=609>of YBD=646 YBD=638 YHG=608>lights, YHG=608>cauteries YHG=618>or YHG=609>suckers. YHG=609>Because YHG=609>its YHG=609>property and we thank were made ; and biochemical investigations " XBD=2531 XBD=1420 XBD=1640 XBD=1905 XBD=2048 XBD=2168 XBD=2393 XBD=2455 XHG=1352 XHG=1432 XHG=1651 XHG=1917 XHG=2058 XHG=2180 XHG=2406 XHG=2467 YBD=684 YBD=685 YBD=686 YBD=677 YBD=678 YHG=648>not YHG=648>increasing YHG=648>haemorrhage YHG=648>trilene YHG=649>made YHG=647>operations YHG=657>on YHG=648>the Chemical Ltd. for supplying us (Pharmaceuticals) Imperial " XBD=2532 XBD=1505 XBD=1655 XBD=1754 XBD=1841 XBD=2021 XBD=2087 XBD=2291 XHG=1352 YBD=718 XHG=1528 XHG=1679 XHG=1777 XHG=1864 XHG=2044 XHG=2104 XHG=2312 YBD=723 YHG=687>afterwards YBD=717 YBD=725 YHG=687>thyroid YHG=686>easier, YHG=687>and YHG=687>the YHG=687>absence YHG=688>of YHG=688>vomiting with sulphamethazine.

or

" XBD=2532 XBD=1428 XHG=2437 XBD=1476 XBD=1660 XBD=1726 XBD=1816 XBD=2019 XBD=2130 XBD=2321 XBD=2413 XHG=1352 YBD=757 XHG=1452 XHG=1500 XHG=1686 XHG=1752 XHG=1841 XHG=2071 XHG=2154 XHG=2344 YBD=756 YHG=727>been YBD=765 YBD=758 YHG=736>was YHG=736>a YHG=726>comfort YHG=727>to YHG=727>the YHG=727>patients. YHG=728>No YHG=728>attempt YHG=727>has " XBD=2533 XBD=1462 XHG=2501 XBD=1520 XBD=1601 XBD=1749 XBD=1823 XBD=2104 XBD=2286 XBD=2486 XHG=1352 YBD=797 XHG=1479 XHG=1536 XHG=1618 XHG=1765 XHG=1838 XHG=2121 XHG=2303 YBD=796 YHG=767>it YBD=798 YBD=805 YBD=804 YHG=766>made YHG=766>to YHG=775>use YHG=766>trilene YHG=767>for YHG=766>intrathoracic YHG=776>surgery, YHG=767>although " XBD=2531 XBD=1419 XBD=1529 XBD=1740 XBD=1812 XBD=1982 XBD=2071 XBD=2257 XBD=2312 XHG=1351 YBD=844 XHG=1433 XHG=1539 XHG=1753 XHG=1821 XHG=1995 XHG=2081 XHG=2270 XHG=2321 YBD=836 YHG=816>empyema. YBD=837 YHG=807>has YHG=806>been YHG=806>successful YHG=806>for YHG=807>opening YHG=807>and YHG=807>drainage YHG=807>of TRICHLORETHYLENE ANESTHESIA |>" " XBD=1391 XBD=1439 XBD=1596 XBD=1772 XBD=1829 XBD=2154 XBD=2367 XBD=2534 XBD=2087 XHG=1353 XHG=1408 XHG=1457 XHG=1613 XHG=1789 XHG=2104 XHG=2169 XHG=2384 XHG=1847 YBD=875 YBD=876 YBD=884 YBD=877 YHG=846>It YHG=846>is YHG=846>always YHG=845>difficult YHG=846>to YHG=856>an YHG=856>empyema YHG=847>patient YHG=847>anaesthetise " XBD=2533 XBD=1445 XHG=2353 XBD=1710 XBD=1845 XBD=2005 XBD=2086 XBD=2189 XBD=2318 XHG=1351 XHG=1479 XHG=1744 XHG=1881 XHG=2039 XHG=2120 XHG=2223 YBD=923 YBD=915 YBD=916 YHG=885>with YHG=894>gas-oxygen YHG=886>only, YHG=886>unless YHG=886>he YHG=886>has YHG=886>been JOHNYBD=924 A CAMB, M R C S ELAM, BYHG=886>carefully " XBD=2533 XBD=1642 XBD=1754 XBD=1856 XBD=1919 XBD=2058 XBD=2205 XBD=2279 XBD=2395 XHG=1352 XHG=1677 XHG=1786 XHG=1888 XHG=1952 XHG=2089 XHG=2238 XHG=2312 YBD=955 YBD=963 YBD=956 YHG=924>premedicated, YHG=924>and YHG=934>one YHG=925>is YHG=926>often YHG=925>asked YHG=926>to YHG=925>give ANÆSTHETIST TO THE YHG=926>these WELLHOUSE HOSPITAL, BARNET VISITINGXHG=2429 " XBD=2534 XBD=1591 XHG=2405 XBD=1660 XBD=1738 XBD=1996 XBD=2120 XBD=2377 XHG=1353 YBD=1003 XHG=1618 XHG=1688 XHG=1766 XHG=2047 XHG=2148 YBD=995 YHG=965>For YBD=994 YBD=1002 YHG=965>anaesthetics YHG=974>as YHG=974>an YHG=974>emergency. YHG=965>orthopaedic YHG=974>opera194:1, |>" XBD=213 XBD=353 XBD=661 XBD=770 XBD=1295 XBD=1007 XHG=170 XHG=246 XHG=527 XHG=694 XHG=1272 XHG=803 YBD=1039 YBD=1033 YBD=1033 YHG=1004>IN YHG=1004>June, YHG=1004>Hewer YHG=1003>and YHG=1013>a YHG=1003>Hadfield published " XBD=1465 XBD=1699 XBD=1782 XBD=1910 XBD=2217 XBD=2434 XBD=2534 XHG=1352 XHG=1501 XHG=1733 XHG=1816 XHG=1943 XHG=2251 XHG=2469 YBD=1040 YBD=1042 YBD=1041 YBD=1034 YHG=1005>tions, YHG=1004>especially YHG=1014>on YHG=1004>aged YHG=1004>subjects-for YHG=1005>example, YHG=1004>the " XBD=2535 XBD=1534 XBD=1596 XBD=1635 XBD=1972 XBD=2484 XHG=1352 XHG=1553 XHG=1611 XHG=1653 XHG=1991 XHG=2503 YBD=1081 YBD=1074 YHG=1044>insertion YHG=1044>of YHG=1054>a YHG=1044>Smith-Petersen YHG=1044>pin-gas-oxygen-trilene YHG=1044>is XBD=354 XHG=827 XBD=501 XBD=572 XBD=658 XBD=745 XBD=809 XBD=850 XBD=1029 XBD=1148 XBD=1212 XBD=1294 XHG=126 XHG=375 XHG=523 XHG=593 XHG=680 XHG=767 XHG=871YBD=1073 XHG=1050 XHG=1170 XHG=1230 YBD=1082 YBD=1080 YBD=1072 YBD=1080 YBD=1073 YHG=1043>preliminary YHG=1044>report YHG=1053>on YHG=1043>the YHG=1052>use YHG=1043>of YHG=1053>a YHG=1043>purified YHG=1043>form YHG=1043>triTrilene ’ XBD=389 XHG=948 XBD=541 XBD=625 XBD=932 XBD=989 XBD=1057 XBD=1294 XHG=126 XHG=404 XHG=560 XHG=834 XHG=1007 XHG=1074 YBD=1120 YBD=1119 YBD=1113 YBD=1113 YHG=1083>chlorethylene YHG=1083>known YHG=1082>as YHG=1083>(ICI) YHG=1093>as YHG=1093>an YHG=1083>anaesthetic " XBD=1788 XBD=1597 XHG=1353 XHG=1615 YBD=1121 YBD=1114 YHG=1084>particularly YHG=1084>suitable. " XBD=2536 XBD=252 XHG=838 XBD=390 XBD=676 XBD=816 XBD=902 XBD=1018 XBD=1293 XBD=1507 XBD=1594 XBD=1767 XBD=1996 XBD=2058 XBD=2145 XBD=2210 XBD=2332 XHG=126 XHG=288 XHG=411 XHG=697 XHG=925YBD=1152 XHG=1039 XHG=1401 XHG=1530 XHG=1617 XHG=1790 XHG=2017 XHG=2079 XHG=2168 XHG=2231 XHG=2354 YBD=1161 YBD=1160 YBD=1153 YBD=1160 YBD=1161 YBD=1152 YBD=1153 YBD=1160 YHG=1123>agent; YHG=1123>these YHG=1123>investigators YHG=1122>found YHG=1123>the YHG=1123>drug YHG=1123>satisfactory. YHG=1123>With YHG=1124>the YHG=1123>Boyle’s YHG=1123>apparatus YHG=1122>in YHG=1132>use YHG=1122>at YHG=1123>most YHG=1122>hospitals " XBD=2535 XBD=157 XHG=813 XBD=311 XBD=453 XBD=545 XBD=652 XBD=712 XBD=794 XBD=936 XBD=1104 XBD=1164 XBD=1293 XBD=1472 XBD=1526 XBD=1578 XBD=1760 XBD=1822 XBD=1928 XBD=2042 XBD=2130 XBD=2228 XBD=2398 XHG=127 XHG=173 XHG=327 XHG=469 XHG=563 XHG=671 XHG=730 XHG=954YBD=1199 XHG=1122 XHG=1178 XHG=1354 XHG=1494 XHG=1546 XHG=1601 XHG=1781 XHG=1845 XHG=1950 XHG=2066 XHG=2152 XHG=2250 XHG=2420 YBD=1193 YBD=1200 YBD=1192 YBD=1199 YBD=1193 YBD=1200 YBD=1199 YBD=1192 YHG=1164>A YHG=1163>further YHG=1163>report YHG=1172>was YHG=1162>read YHG=1163>at YHG=1162>the YHG=1163>Royal YHG=1162>Society YHG=1162>of YHG=1163>MediYHG=1163>today YHG=1163>it YHG=1163>is YHG=1163>difficult YHG=1164>to YHG=1163>give YHG=1172>pure YHG=1172>gas YHG=1162>and YHG=1171>oxygen YHG=1172>anaes" XBD=1295 XBD=199 XBD=262 XBD=401 XBD=451 XBD=570 XBD=639 XBD=815 XBD=972 XBD=1054 XBD=1152 XHG=127 XHG=216 XHG=274 XHG=418 XHG=468 XHG=587 XHG=654 XHG=989 XHG=1070 XHG=1168 YBD=1233 YBD=1238 YBD=1239 YBD=1232 YBD=1232 YBD=1232 YBD=1239 YHG=1204>cine YHG=1212>on YHG=1203>March YHG=1203>6, YHG=1202>1942, YHG=1202>by YHG=1202>Hewer.2 YHG=1202>Since YHG=1203>the YHG=1202>first YHG=1202>report XBD=1475XHG=864 XBD=1538 XBD=1626 XBD=1826 XBD=1996 XBD=2092 XBD=2155 XBD=2271 XBD=2372 XBD=2418 XBD=2536 XHG=1354 XHG=1498 XHG=1561 XHG=1648 XHG=1847 XHG=2017 XHG=2114 XHG=2177 XHG=2293 XHG=2394 XHG=2440 YBD=1233 YBD=1231 YHG=1202>thesia YHG=1202>the YHG=1202>resistant YHG=1202>patient YHG=1202>and YHG=1203>to YHG=1202>keep YHG=1201>him YHG=1212>a YHG=1201>good XBD=144 XHG=899 XBD=261 XBD=379 XBD=552 XBD=624 XBD=871 XBD=949 XBD=1056 XBD=1126 XBD=1244 XBD=1295 XHG=128 XHG=171 XHG=289 XHG=408 XHG=583 XHG=653 XHG=978YBD=1272 XHG=1086 XHG=1154 XHG=1271 YBD=1277 YBD=1279 YBD=1278 YHG=1244>I YHG=1242>have YHG=1242>used YHG=1242>trilene, YHG=1251>or YHG=1241>supervised YHG=1242>its YHG=1251>use, YHG=1242>in YHG=1251>over YHG=1251>a " XBD=2537 XBD=1491 XBD=1615 XBD=1810 XBD=1874 XBD=2024 XBD=2089 XBD=2180 XBD=2265 XBD=2365 XHG=1355 XHG=1537 XHG=1637 XHG=1832 XHG=1894 XHG=2049 XHG=2115 XHG=2201 XHG=2289 XHG=2389 YBD=1272 YBD=1271 YBD=1279 YHG=1242>colour. YHG=1242>The YHG=1242>addition YHG=1242>of YHG=1242>trilene YHG=1243>to YHG=1242>the YHG=1251>gas YHG=1241>and YHG=1251>oxygen XBD=303 XHG=839 XBD=431 XBD=627 XBD=675 XBD=715 XBD=824 XBD=964 XBD=1110 XBD=1295 XHG=128 XHG=320 XHG=483 XHG=644 XHG=693 XHG=732 XHG=979YBD=1319 XHG=1129 YBD=1312 YBD=1311 YBD=1319 YHG=1282>thousand YHG=1291>cases. YHG=1282>Trilene YHG=1281>is YHG=1292>a YHG=1291>very YHG=1282>heavy YHG=1281>liquid, YHG=1281>vaporis" XBD=2536 XBD=1482 XBD=1576 XBD=1654 XBD=1840 XBD=2052 XBD=2143 XBD=2245 XBD=2328 XBD=2482 XHG=1353 XHG=1497 XHG=1590 XHG=1669 XHG=1855 XHG=2067 XHG=2157 XHG=2260 XHG=2342 XHG=2495 YBD=1319 YBD=1312 YBD=1318 YBD=1311 YHG=1282>makes YHG=1281>just YHG=1282>the YHG=1281>required YHG=1282>difference YHG=1282>and YHG=1282>does YHG=1282>not YHG=1290>appear YHG=1282>to XBD=185 XHG=726 XBD=313 XBD=435 XBD=586 XBD=704 XBD=950 XBD=1014 XBD=1152 XBD=1243 XBD=1295 XHG=129 XHG=205 XHG=335 XHG=458 XHG=609 XHG=973YBD=1351 XHG=1036 XHG=1204 XHG=1263 YBD=1359 YBD=1351 YHG=1322>ing YHG=1322>much YHG=1331>more YHG=1322>slowly YHG=1322>than YHG=1321>chloroform YHG=1331>or YHG=1322>ether. YHG=1322>It YHG=1321>is " XBD=2538 XBD=1465 XBD=1545 XBD=1721 XBD=1890 XBD=1968 XBD=2076 XBD=2167 XBD=2340 XBD=2395 XHG=1355 XHG=1480 XHG=1561 XHG=1774 XHG=1906 XHG=1985 XHG=2091 XHG=2183 XHG=2356 XHG=2410 YBD=1351 YBD=1359 YBD=1350 YBD=1358 YHG=1322>upset YHG=1322>the YHG=1321>patient. YHG=1321>There YHG=1331>are YHG=1331>very YHG=1322>real YHG=1321>dangers YHG=1321>in YHG=1321>trying XBD=395 XHG=917 XBD=490 XBD=883 XBD=949 XBD=1037 XBD=1082 XBD=1208 XBD=1296 XHG=128 XHG=415 XHG=511 XHG=970YBD=1391 XHG=1059 XHG=1103 XHG=1228 YBD=1399 YBD=1397 YBD=1391 YBD=1392 YHG=1362>non-irritating YHG=1362>and YHG=1361>non-inflammable; YHG=1362>it YHG=1362>has YHG=1371>a YHG=1361>smell YHG=1361>not " XBD=2537 XBD=1395 XBD=1475 XBD=1572 XBD=1717 XBD=1841 XBD=1936 XBD=2042 XBD=2233 XBD=2306 XHG=1355 XHG=1428 XHG=1507 XHG=1603 XHG=1747 XHG=1871 XHG=1967 XHG=2074 XHG=2266 XHG=2337 YBD=1398 YBD=1390 YBD=1399 YBD=1391 YHG=1362>to YHG=1361>do YHG=1362>too YHG=1361>much YHG=1361>with YHG=1370>gas YHG=1362>and YHG=1370>oxygen, YHG=1371>as YHG=1361>American

·

" XBD=244 XBD=350 XBD=415 XBD=671 XBD=762 XBD=815 XBD=923 XBD=1120 XBD=1231 XHG=128 XHG=266 XHG=374 XHG=435 XHG=724 XHG=784 XHG=947 XHG=1144 XHG=1255 YBD=1431 YBD=1431 YBD=1430 YBD=1431 YHG=1401>unlike YHG=1402>that YHG=1401>of YHG=1401>chloroform. YHG=1401>It YHG=1401>is YHG=1410>now YHG=1401>coloured YHG=1401>blue YHG=1402>to " XBD=1295 XBD=1609XHG=839 XBD=1717 XBD=1873 XBD=1961 XBD=2107 XBD=2239 XBD=2295 XBD=2354 XBD=2431 XBD=2538 XHG=1354 XHG=1621 XHG=1732 XHG=1887 XHG=1976 XHG=2122 XHG=2254 XHG=2308 XHG=2366 XHG=2443 YBD=1436 YBD=1430 YBD=1431 YBD=1438 YHG=1401>anaesthetists YHG=1401>have YHG=1401>shown, YHG=1401>and YHG=1401>trilene YHG=1410>seems YHG=1401>to YHG=1401>be YHG=1401>the YHG=1401>drug

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XBD=2537XHG=939 XBD=1409 XBD=1531 XBD=1651 XBD=1827 XBD=1909 XBD=1973 XBD=2130 XBD=2199 XBD=2265 XBD=2405 XHG=1354 XHG=1433 XHG=1556 XHG=1675 XHG=1850 XHG=1933 XHG=2000 XHG=2155 XHG=2225 XHG=2291 XHG=2431 YBD=1477 YBD=1470 YBD=1471 YHG=1450>we YHG=1441>have YHG=1440>been YHG=1440>looking YHG=1440>for YHG=1441>enable YHG=1450>us YHG=1441>to YHG=1441>avoid YHG=1441>these XBD=340 XBD=393 XBD=512 XBD=771 XBD=917 XBD=969 XBD=1099 XBD=1296 XHG=128 XHG=361 XHG=414 XHG=535 XHG=795 XHG=993YBD=1471 XHG=1122 YBD=1479 YBD=1470 YBD=1477 YBD=1471 YHG=1441>distinguish YHG=1441>it YHG=1441>from YHG=1441>chloroform, YHG=1441>which YHG=1441>is YHG=1441>often YHG=1440>coloured XBD=197 YBD=1511 YHG=1481>red. XBD=1591XHG=129 XHG=1355 YBD=1518 YHG=1480>dangers. ’ XBD=313 XHG=882 XBD=563 XBD=727 XBD=852 XBD=998 XBD=1130 XBD=1296 XBD=1665 XBD=1848 XBD=1910 XBD=2148 XBD=2308 XBD=2385 XBD=2540 XHG=172 XHG=340 XHG=594 XHG=755 XHG=1024 XHG=1159 XHG=1402 XHG=1679 XHG=1862 XHG=1925 XHG=2163 XHG=2321 XHG=2400 YBD=1558 YBD=1551 YBD=1550 YBD=1549 YBD=1555 YBD=1557 YBD=1550 YBD=1558 YHG=1520>Certain YHG=1521>mysterious YHG=1520>deaths YHG=1521>have YHG=1520>taken YHG=1521>place YHG=1529>among YHG=1520>Manufacture YHG=1520>presents YHG=1529>no YHG=1519>difficulties, YHG=1520>though YHG=1520>the YHG=1521>supply XBD=313 XHG=768 XBD=486 XBD=584 XBD=697 XBD=753 XBD=833 XBD=1202 XBD=1250 XBD=1295 XBD=1384 XBD=1559 XBD=1628 XBD=1806 XBD=1990 XBD=2109 XBD=2236 XBD=2470 XBD=2541 XHG=129 XHG=327 XHG=501 XHG=600 XHG=713 XHG=848YBD=1591 XHG=1218 XHG=1264 XHG=1353 XHG=1412 XHG=1586 XHG=1654 XHG=1832 XHG=2018 XHG=2136 XHG=2264 XHG=2499 YBD=1590 YBD=1597 YBD=1591 YBD=1589 YBD=1597 YBD=1590 YHG=1561>industrial YHG=1561>workers YHG=1560>who YHG=1561>have YHG=1561>to YHG=1570>use YHG=1560>trichlorethylene YHG=1560>it YHG=1560>is YHG=1560>limited YHG=1560>at YHG=1560>present YHG=1559>because YHG=1560>such YHG=1560>large YHG=1560>quantities YHG=1560>of ; XBD=279 XHG=754 XBD=387 XBD=514 XBD=632 XBD=730 XBD=794 XBD=1039 XBD=1170 XBD=1294 XBD=1685 XBD=1763 XBD=1890 XBD=1995 XBD=2049 XBD=2247 XHG=130 XHG=302 XHG=410 XHG=538 XHG=657 XHG=818YBD=1630 XHG=1091 XHG=1192 XHG=1355 XHG=1700 XHG=1777 XHG=1903 XHG=2009 XHG=2062 YBD=1638 YBD=1631 YBD=1637 YBD=1630 YBD=1637 YBD=1629 YBD=1638 YHG=1600>thought YHG=1601>that YHG=1601>these YHG=1609>were YHG=1601>due YHG=1601>to YHG=1600>impurities. YHG=1600>The YHG=1600>postYHG=1600>trichlorethylene YHG=1609>are YHG=1599>being YHG=1599>used YHG=1599>in YHG=1599>industry. XBD=277 XBD=444 XBD=511 XBD=606 XBD=759 XBD=915 XBD=979 XBD=1177 XBD=1296 XHG=130 XHG=300 XHG=468 XHG=531 XHG=630 XHG=782 XHG=939 XHG=1002 XHG=1200 YBD=1678 YBD=1671 YBD=1670 YBD=1678 YBD=1670 YHG=1640>mortem YHG=1641>reports YHG=1641>of YHG=1641>two YHG=1641>recent YHG=1640>deaths YHG=1641>in YHG=1640>industry YHG=1649>were XBD=2045 XHG=1849 YBD=1699 YHG=1676>SUMMARY ’

XBD=1298XHG=673 XBD=409 XBD=499 XBD=565 XBD=655 XBD=918 XBD=1004 XBD=1131 XBD=1185 XHG=130 XHG=424 XHG=518 XHG=578 XHG=928YBD=1718 XHG=1019 XHG=1142 XHG=1198 YBD=1710 YBD=1711 YBD=1717 YBD=1710 YHG=1680>unsatisfactory YHG=1681>and YHG=1689>no YHG=1681>real YHG=1680>explanation YHG=1690>was YHG=1680>given YHG=1680>of YHG=1679>their XBD=240 XHG=651 XBD=397 XBD=575 XBD=633 XBD=980 XBD=1061 XBD=1296 XBD=1758 XBD=1817 XBD=1977 XBD=2063 XBD=2174 XBD=2282 XBD=2339 XBD=2406 XBD=2537 XHG=131 XHG=289 XHG=414 XHG=594 XHG=998YBD=1757 XHG=1080 XHG=1404 XHG=1776 XHG=1834 XHG=1995 XHG=2080 XHG=2190 XHG=2299 XHG=2357 XHG=2423 YBD=1750 YBD=1749 YBD=1750 YBD=1757 YBD=1755 YBD=1749 YBD=1750 YHG=1729>cause. YHG=1720>Some YHG=1720>workers YHG=1720>in YHG=1720>trichlorethylene YHG=1730>are YHG=1719>considered YHG=1719>Trichlorethylene, YHG=1728>or YHG=1719>trilene, YHG=1719>has YHG=1719>been YHG=1719>used YHG=1729>as YHG=1728>an YHG=1729>anwsXBD=1474 XBD=1537 XBD=1649 XBD=1764 XBD=1902 XBD=2072 XBD=2191 XBD=2309 XBD=2379 XBD=2537 XHG=1356 XHG=1497 XHG=1559 XHG=1674 XHG=1789 XHG=1954 XHG=2094 XHG=2214 XHG=2331 XHG=2403 YBD=1789 YBD=1790 ansemia. YHG=1760>thetic YHG=1760>in YHG=1769>over YHG=1760>1000 YHG=1769>cases. YHG=1759>There YHG=1759>have YHG=1759>been YHG=1769>no YHG=1760>deaths XBD=166 XHG=426 XBD=226 XBD=349 XBD=407 XBD=583 XBD=1026 XBD=1108 XBD=1239 XBD=1301 XHG=131 XHG=183 XHG=242 XHG=367 XHG=822YBD=1798 XHG=1043 XHG=1129 XHG=1257 YBD=1791 YBD=1789 YBD=1790 YBD=1790 YBD=1790 YBD=1789 YHG=1761>to YHG=1760>be YHG=1760>liable YHG=1760>to YHG=1760>aplastic YHG=1760>Whatever YHG=1760>the YHG=1769>cause YHG=1759>of XBD=1477 XBD=1610 XBD=1678 XBD=1913 XBD=1975 XBD=2064 XBD=2316 XBD=2424 XBD=2537 XHG=1355 XHG=1500 XHG=1632 XHG=1700 XHG=1935 XHG=1999 XHG=2086 XHG=2368 XHG=2447 YBD=1829 YBD=1830 YHG=1799>which YHG=1800>could YHG=1800>be YHG=1799>attributed YHG=1800>to YHG=1799>the YHG=1799>anaesthetic. YHG=1800>Its YHG=1809>nonXBD=293 XHG=877 XBD=462 XBD=552 XBD=719 XBD=784 XBD=850 XBD=941 XBD=1147 XBD=1297 XHG=131 XHG=319 XHG=488 XHG=562 XHG=744 XHG=810 XHG=966YBD=1829 XHG=1172 YBD=1835 YBD=1837 YBD=1830 YBD=1837 YBD=1837 YHG=1799>recorded YHG=1800>deaths, YHG=1809>no YHG=1800>anxiety YHG=1810>as YHG=1800>to YHG=1800>the YHG=1800>patient’s YHG=1799>safety XBD=191 XHG=723 XBD=299 XBD=557 XBD=617 XBD=700 XBD=813 XBD=1158 XBD=1297 XHG=132 XHG=209 XHG=317 XHG=577 XHG=636 XHG=834YBD=1869 XHG=1178 YBD=1877 YBD=1870 YBD=1870 YHG=1840>has YHG=1840>been YHG=1839>experienced YHG=1840>in YHG=1840>the YHG=1840>1000 YHG=1839>administrations YHG=1839>under XBD=1672 XBD=1783 XBD=1851 XBD=2182 XBD=2287 XBD=2474 XBD=2543 XHG=1354 XHG=1699 XHG=1808 XHG=1876 XHG=2211 XHG=2316 XHG=2500 YBD=1877 YBD=1870 YBD=1869 YHG=1839>inflammability, YHG=1849>ease YHG=1840>of YHG=1839>administration YHG=1839>and YHG=1840>absence YHG=1839>of XBD=267 YBD=1910 YHG=1880>review. XBD=1663XHG=135 XBD=1880 XBD=2022 XBD=2078 XBD=2132 XBD=2398 XHG=1355 XHG=1693 XHG=1911 XHG=2046 XHG=2109 XHG=2156 YBD=1909 YBD=1917 YHG=1880>postanaesthetic YHG=1879>vomiting YHG=1879>make YHG=1879>it YHG=1889>a YHG=1879>satisfactory XBD=310 XHG=812 XBD=504 XBD=582 XBD=660 XBD=785 XBD=921 XBD=1036 XBD=1133 XBD=1245 XBD=1296 XHG=175 XHG=338 XHG=533 XHG=610 XHG=688 XHG=949YBD=1949 XHG=1065 XHG=1161 XHG=1273 YBD=1957 YBD=1950 YBD=1956 YHG=1919>Trilene YHG=1919>dropped YHG=1929>on YHG=1929>an YHG=1929>open YHG=1919>mask YHG=1919>does YHG=1919>not YHG=1919>give YHG=1928>a XBD=1474 XBD=1602 XBD=1688 XBD=1924 XBD=2152 XBD=2200 XBD=2288 XBD=2489 XHG=1355 XHG=1493 XHG=1619 XHG=1706 XHG=1942 XHG=2169 XHG=2219 XHG=2305 YBD=1950 YBD=1951 YBD=1949 YBD=1958 YHG=1919>thetic YHG=1919>when YHG=1920>full YHG=1919>abdominal YHG=1919>relaxation YHG=1919>is YHG=1920>not YHG=1919>required. XBD=357 XHG=802 XBD=601 XBD=780 XBD=833 XBD=1044 XBD=1131 XBD=1295 XHG=132 XHG=379 XHG=622 XHG=855YBD=1989 XHG=1067 XHG=1154 YBD=1996 YBD=1997 YHG=1959>satisfactory YHG=1959>anaesthesia YHG=1959>because YHG=1959>it YHG=1959>vaporises YHG=1960>too YHG=1959>slowly, XBD=1443 XBD=1497 XBD=1644 XBD=1707 XBD=1977 XBD=2093 XBD=2182 XBD=2283 XBD=2457 XBD=2539 XHG=1404 XHG=1466 XHG=1522 XHG=1668 XHG=1733 XHG=2001 XHG=2118 XHG=2208 XHG=2308 XHG=2480 YBD=1990 YBD=1996 YBD=1997 YBD=1989 YHG=1960>It YHG=1959>is YHG=1960>useful YHG=1959>in YHG=1959>conjunction YHG=1959>with YHG=1968>gas YHG=1959>and YHG=1968>oxygen YHG=1960>for XBD=1564 XBD=1644 XBD=1778 XBD=1836 XBD=2081 XHG=1355 XHG=1579 XHG=1660 XHG=1794 XHG=1848 YBD=2030 YBD=2037 YBD=2033 YBD=2029 YHG=1999>increasing YHG=1999>the YHG=1999>depth YHG=1999>of YHG=1999>anaesthesia. XBD=196 XHG=656 XBD=244 XBD=288 XBD=337 XBD=489 XBD=549 XBD=634 XBD=880 XBD=1022 XBD=1085 XBD=1126 XBD=1296 XHG=133 XHG=213 XHG=259 XHG=308 XHG=358 XHG=510 XHG=569 XHG=901YBD=2029 XHG=1043 XHG=1102 XHG=1145 YBD=2036 YBD=2028 YBD=2029 YHG=1999>but YHG=1999>if YHG=1999>it YHG=1999>is YHG=1999>placed YHG=1999>in YHG=2000>the YHG=1999>chloroform YHG=1999>bottle YHG=2009>a YHG=1998>Boyle’s XBD=289 XBD=378 XBD=504 XBD=558 XBD=818 XBD=924 XBD=1004 XBD=1095 XBD=1259 XBD=1297 XHG=133 XHG=304 XHG=394 XHG=518 XHG=573 XHG=831 XHG=940 XHG=1019 XHG=1111 XHG=1273 YBD=2068 YBD=2076 YBD=2069 YBD=2076 YBD=2076 YBD=2069 YHG=2039>machine YHG=2039>and YHG=2039>given YHG=2039>in YHG=2039>conjunction YHG=2039>with YHG=2048>gas YHG=2039>and YHG=2048>oxygen YHG=2048>a XBD=1519 XBD=1619 XBD=1697 XBD=1815 XBD=1874 XBD=1966 XBD=2092 XBD=2201 XBD=2469 XBD=2539 XHG=1400 XHG=1542 XHG=1637 XHG=1722 XHG=1837 XHG=1896 XHG=1989 XHG=2113 XHG=2223 XHG=2492 YBD=2083 YBD=2084 YBD=2092 YHG=2055>About YHG=2055>half YHG=2055>the YHG=2064>cases YHG=2055>in YHG=2055>this YHG=2055>series YHG=2064>were YHG=2054>anaesthetised YHG=2055>by XBD=357 XHG=755 XBD=479 XBD=729 XBD=786 XBD=1005 XBD=1226 XBD=1297 XHG=135 XHG=384 XHG=506 XHG=814YBD=2109 XHG=1056 XHG=1254 YBD=2116 YBD=2115 YBD=2109 YBD=2114 YBD=2109 YHG=2079>satisfactory YHG=2079>light YHG=2079>anaesthesia YHG=2079>is YHG=2079>obtained. YHG=2079>Marrett, YHG=2079>at

anas-

" XBD=2450 XBD=1501 XHG=2359 XBD=1690 XBD=1746 XBD=1877 XBD=1911 XBD=1986 XBD=2168 XBD=2237 XBD=2344 XHG=1355 YBD=2128 XHG=1518 XHG=1708 XHG=1763 XHG=1893 XHG=1927 XHG=2000 XHG=2183 XHG=2252 YBD=2124 YHG=2095>help. YBD=2123 YHG=2094>medical YHG=2095>students, YHG=2097>to YHG=2095>whom YHG=2095>I YHG=2104>am YHG=2095>indebted YHG=2095>for YHG=2094>their

" XBD=1296 XBD=192 XHG=827 XBD=312 XBD=378 XBD=544 XBD=725 XBD=801 XBD=971 XBD=1120 XBD=1192 XHG=136 XHG=216 XHG=338 XHG=403 XHG=573 XHG=752 XHG=997YBD=2148 XHG=1146 XHG=1220 YBD=2149 YBD=2154 YBD=2148 YBD=2148 YHG=2119>the YHG=2119>RSM YHG=2119>in YHG=2118>March, YHG=2119>showed YHG=2128>an YHG=2119>inhaler YHG=2119>which YHG=2119>he YHG=2118>had

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XBD=1297XHG=888 XBD=271 XBD=335 XBD=469 XBD=538 XBD=625 XBD=809 XBD=874 XBD=953 XBD=1120 XHG=139 XHG=284 XHG=348 XHG=482 XHG=550 XHG=646 XHG=823 XHG=971YBD=2188 XHG=1133 YBD=2195 YBD=2189 YBD=2196 YBD=2196 YBD=2195 YHG=2158>devised YHG=2158>by YHG=2158>which YHG=2158>air YHG=2168>was YHG=2158>inspired YHG=2159>by YHG=2159>the YHG=2159>patient YHG=2158>through XBD=159 XHG=905 XBD=283 XBD=522 XBD=687 XBD=883 XBD=995 XBD=1094 XBD=1164 XBD=1298 XHG=138 XHG=176 XHG=306 XHG=544 XHG=738 XHG=1016 XHG=1117 XHG=1186 YBD=2229 YBD=2228 YBD=2235 YBD=2229 YBD=2228 YBD=2236 YHG=2208>a YHG=2198>bottle YHG=2198>containing YHG=2198>trilene. YHG=2198>Trilene YHG=2208>may YHG=2199>also YHG=2198>be YHG=2198>given XBD=221 XHG=734 XBD=257 XBD=447 XBD=682 XBD=811 XBD=1051 XBD=1248 XBD=1297 XHG=136 XHG=237 XHG=273 XHG=465 XHG=829YBD=2268 XHG=1069 XHG=1265 YBD=2276 YBD=2275 YBD=2268 YBD=2269 YHG=2238>from YHG=2248>a YHG=2238>Shipway YHG=2238>apparatus. YHG=2238>The YHG=2238>anaesthesia YHG=2238>obtained YHG=2238>is chloroform, XBD=170 XHG=797 XBD=275 XBD=392 XBD=481 XBD=585 XBD=781 XBD=890 XBD=1296 XHG=135 XHG=183 XHG=292 XHG=408 XHG=498 XHG=602 XHG=1162 YBD=2316 YBD=2308 YBD=2309 YBD=2317 YHG=2278>in YHG=2288>some YHG=2288>ways YHG=2278>like YHG=2278>that YHG=2278>obtained YHG=2279>with YHG=2279>except XBD=1555 XBD=1720 XHG=1358 XHG=1578 YBD=2329 YHG=2300>Victorian YHG=2301>Doctor

Reviews of Books

" XBD=1031 XBD=211 XHG=774 XBD=288 XBD=488 XBD=713 XBD=759 XBD=842 XHG=135 XHG=224 XHG=303 XHG=503 XHG=727 XHG=856YBD=2348 YBD=2349 YBD=2349YHG=2320>not YHG=2318>that YHG=2319>full YHG=2319>muscular YHG=2319>relaxation YHG=2319>is YHG=2319>uniform.

" XBD=1471 XBD=1566 XBD=1628 XBD=1697 XBD=1868 XBD=2002 XBD=2087 XBD=2145 XBD=2322 XBD=2415 XHG=1401 XHG=1493 XHG=1589 XHG=1645 XHG=1717 XHG=1882 XHG=2052 XHG=2107 XHG=2161 XHG=2339 XHG=2434 YBD=2379 YBD=2384 YBD=2383 YBD=2378 YHG=2350>The YHG=2349>Life YHG=2351>of YHG=2350>Sir YHG=2350>William YHG=2350>Wilde. YHG=2351>T. YHG=2351>G. YHG=2350>WiLSON, YHG=2350>MB, YHG=2350>LittD " XBD=2541 XBD=246 XHG=672 XBD=398 XBD=660 XBD=714 XBD=1054 XBD=1142 XBD=1295 XHG=176 XHG=261 XHG=411 XHG=726YBD=2388 XHG=1066 XHG=1154 YBD=2396 YBD=2396 YBD=2388 YHG=2358>The YHG=2359>similar YHG=2358>composition YHG=2359>of YHG=2359>trichlorethylene YHG=2358>and YHG=2358>chloro-

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XBD=2255 XBD=1503 XBD=1718 XBD=1929 XBD=2039 XBD=2137 XHG=1400 XHG=1553 XHG=1755 XHG=1981 XHG=2065 XHG=2191 YBD=2427 YBD=2419 YBD=2418 YHG=2390>Dubl. YHG=2391>London: YHG=2390>Methuen. YHG=2391>Pp. YHG=2391>338. YHG=2391>15s. XBD=219 XHG=803 XBD=288 XBD=341 XBD=420 XBD=514 XBD=614 XBD=693 XBD=788 XBD=897 XBD=1031 XBD=1142 XBD=1298 XHG=133 XHG=232 XHG=303 XHG=356 XHG=435 XHG=528 XHG=628 XHG=707 XHG=910YBD=2435 XHG=1045 XHG=1155 YBD=2428 YBD=2436 YBD=2428 YBD=2429 YHG=2398>form YHG=2399>led YHG=2399>to YHG=2399>the YHG=2399>fear YHG=2398>that YHG=2398>the YHG=2408>new YHG=2399>drug YHG=2398>might YHG=2398>have YHG=2399>similar XBD=288 XHG=872 XBD=372 XBD=425 XBD=497 XBD=587 XBD=668 XBD=751 XBD=859 XBD=936 XBD=1045 XBD=1214 XBD=1297 XHG=134 XHG=303 XHG=386 XHG=439 XHG=512 XHG=601 XHG=683 XHG=764 XHG=951YBD=2468 XHG=1097 XHG=1228 YBD=2475 YBD=2468 YHG=2437>dangers, YHG=2439>but YHG=2448>so YHG=2438>far YHG=2438>this YHG=2438>has YHG=2439>not YHG=2438>been YHG=2439>the YHG=2448>case. YHG=2438>There YHG=2438>has XBD=1459 XBD=1554 XBD=1636 XBD=1822 XBD=1966 XBD=2012 XBD=2229 XBD=2384 XBD=2541 XHG=1404 XHG=1484 XHG=1577 XHG=1658 XHG=1845 XHG=1988 XHG=2033 XHG=2252 XHG=2406 YBD=2470 YBD=2469 YBD=2468 YBD=2476 YHG=2440>To YHG=2440>call YHG=2440>Sir YHG=2440>William YHG=2440>Wilde YHG=2440>a YHG=2440>Victorian YHG=2440>doctor YHG=2440>hardly XBD=217 XHG=712 XBD=275 XBD=464 XBD=521 XBD=697 XBD=857 XBD=1005 XBD=1154 XBD=1296 XHG=133 XHG=231 XHG=290 XHG=478 XHG=530 XHG=872YBD=2508 XHG=1019 XHG=1167 YBD=2507 YBD=2515 YBD=2507 YBD=2515 YBD=2507 YHG=2478>been YHG=2487>no YHG=2478>evidence YHG=2478>of YHG=2478>primary YHG=2478>cardiac YHG=2478>failure YHG=2478>during YHG=2478>inducXBD=1443 XBD=1603 XBD=1668 XBD=1758 XBD=1861 XBD=1925 XBD=2034 XBD=2102 XBD=2227 XBD=2336 XBD=2451 XBD=2540 XHG=1355 XHG=1467 XHG=1628 XHG=1692 XHG=1781 XHG=1882 XHG=1944 XHG=2055 XHG=2126 XHG=2264 XHG=2357 XHG=2475 YBD=2516 YBD=2509 YBD=2511 YBD=2514 YBD=2508 YHG=2479>does YHG=2478>justice YHG=2479>to YHG=2479>the YHG=2479>sort YHG=2478>of YHG=2488>man YHG=2478>he YHG=2488>was YHG=2478>but YHG=2479>then YHG=2478>Dr. ; trilene,YBD=2548 XBD=1530 XBD=1679 XBD=1736 XBD=1812 XBD=2039 XBD=2180 XBD=2219 XBD=2330 XBD=2430 XBD=2542 XHG=1355 XHG=1544 XHG=1694 XHG=1746 XHG=1826 XHG=2055 XHG=2196 XHG=2233 XHG=2346 XHG=2443 YBD=2550 YBD=2547 YBD=2555 YBD=2549 YBD=2548 YHG=2519>Wilson’s YHG=2518>notion YHG=2519>of YHG=2519>the YHG=2518>Victorians YHG=2518>differs YHG=2527>a YHG=2518>good YHG=2517>deal YHG=2518>from XBD=592 XBD=768 XBD=826 XBD=890 XBD=956 XBD=1115 XBD=1229 XBD=1296 XHG=487 XHG=610 XHG=785 XHG=844 XHG=976 XHG=1131 XHG=1246 YBD=2555 YBD=2547 YBD=2555 YHG=2518>there YHG=2527>appears YHG=2518>to YHG=2518>be YHG=2527>no YHG=2518>danger YHG=2518>its XBD=206 XHG=908 XBD=309 XHG=132 XHG=221 YHG=2518>tion YHG=2518>with XBD=472 XHG=845 XBD=580 XBD=716 XBD=814 XBD=940 XBD=1018 XBD=1227 XBD=1300 XBD=1419 XBD=1702 XBD=1800 XBD=1952 XBD=2016 XBD=2169 XBD=2330 XBD=2407 XBD=2543 XHG=133 XHG=505 XHG=612 XHG=746 XHG=970YBD=2587 XHG=1035 XHG=1257 XHG=1354 XHG=1437 XHG=1719 XHG=1852 XHG=1969 XHG=2032 XHG=2189 XHG=2346 XHG=2420 YBD=2593 YBD=2588 YBD=2588 YBD=2593 YBD=2589 YHG=2557>readministration, YHG=2558>and YHG=2558>there YHG=2558>has YHG=2557>been YHG=2566>no YHG=2558>’evidence YHG=2557>of YHG=2559>the YHG=2556>conventional YHG=2567>one. YHG=2557>Thus YHG=2558>he YHG=2558>writes, YHG=2557>&dquo; YHG=2558>all, YHG=2558>Wilde After XBD=277 XHG=441 XBD=423 XBD=648 XHG=133 XHG=294 YBD=2634 YBD=2627 YBD=2635 YHG=2597>delayed YHG=2598>trilene YHG=2597>poisoning. XBD=1431 XBD=1538 XBD=1630 XBD=1789 XBD=1880 XBD=1973 XBD=2137 XBD=2228 XBD=2303 XBD=2540 XHG=1355 XHG=1449 XHG=1555 XHG=1648 XHG=1822 XHG=1897 XHG=1991 XHG=2153 XHG=2245 XHG=2320 YBD=2636 YBD=2627 YBD=2635 YBD=2628 YBD=2629 YHG=2599>had YHG=2599>only YHG=2599>two YHG=2598>faults YHG=2598>bad YHG=2598>temper YHG=2597>and YHG=2598>his YHG=2598>mistresses. : XBD=247 XHG=848 XBD=370 XBD=555 XBD=622 XBD=707 XBD=826 XBD=945 XBD=1204 XBD=1296 XHG=175 XHG=269 XHG=392 XHG=580 XHG=641 XHG=731 XHG=969YBD=2667 XHG=1258 YBD=2674 YBD=2668 YHG=2637>The YHG=2638>main YHG=2638>features YHG=2638>of YHG=2637>the YHG=2637>drug YHG=2637>have YHG=2637>been YHG=2637>It these. XBD=1402 XBD=1675 XBD=1742 XBD=1868 XBD=1947 XBD=2062 XBD=2197 XBD=2279 XBD=2420 XBD=2543 XHG=1356 XHG=1427 XHG=1699 XHG=1762 XHG=1892 XHG=1971 XHG=2085 XHG=2221 XHG=2303 XHG=2446 YBD=2667 YBD=2668 YBD=2676 YBD=2675 YHG=2639>In YHG=2638>extenuation YHG=2637>of YHG=2638>these YHG=2647>we YHG=2647>may YHG=2637>plead YHG=2638>his YHG=2648>many YHG=2638>good XBD=159 XHG=756 XBD=258 XBD=359 XBD=414 XBD=651 XBD=741 XBD=787 XBD=1047 XBD=1223 XBD=1297 XHG=131 XHG=173 XHG=273 XHG=375 XHG=431 XHG=666 XHG=803YBD=2707 XHG=1063 XHG=1238 YBD=2714 YBD=2714 YHG=2676>is YHG=2686>very YHG=2687>easy YHG=2678>to YHG=2677>administer YHG=2677>and YHG=2677>is YHG=2677>particularly YHG=2677>suitable YHG=2677>for XBD=1483 XBD=1579 XBD=1807 XBD=1915 XBD=1982 XBD=2103 XBD=2164 XBD=2234 XBD=2427 XBD=2541 XHG=1356 XHG=1504 XHG=1600 XHG=1828 XHG=1934 XHG=2002 XHG=2123 XHG=2184 XHG=2253 XHG=2448 YBD=2716 YBD=2706 YBD=2707 YBD=2708 YBD=2715 YHG=2678>points YHG=2678>and YHG=2677>remember YHG=2677>that YHG=2677>he YHG=2677>lived YHG=2677>in YHG=2687>an YHG=2678>immoral YHG=2687>age ; XBD=525 XHG=723 XBD=671 XBD=779 XBD=1119 XBD=1241 XBD=1298 XHG=131 XHG=557 XHG=813YBD=2746 XHG=1152 XHG=1274 YBD=2754 YBD=2746 YHG=2717>general-practitioner YHG=2717>work. YHG=2717>Its YHG=2716>administration YHG=2725>over YHG=2726>a XBD=1414 XBD=1489 XBD=1581 XBD=1822 XBD=1944 XBD=2039 XBD=2163 XBD=2243 XBD=2346 XBD=2540 XHG=1354 XHG=1440 XHG=1517 XHG=1608 XHG=1849 XHG=1970 XHG=2067 XHG=2190 XHG=2270 XHG=2372 YBD=2748 YBD=2746 YBD=2754 YBD=2755 YBD=2747 YHG=2718>for YHG=2718>all YHG=2718>the YHG=2717>Victorians YHG=2726>were YHG=2718>not YHG=2717>good YHG=2717>by YHG=2727>any YHG=2717>means.&dquo; XBD=1414 XBD=1582 XBD=1691 XBD=1906 XBD=2070 XBD=2166 XBD=2228 XBD=2426 XBD=2543 XHG=1356 XHG=1437 XHG=1610 XHG=1710 XHG=1927 XHG=2089 XHG=2187 XHG=2251 XHG=2445 YBD=2792 YBD=2786 YBD=2787 YHG=2758>No YHG=2757>doubt YHG=2756>but YHG=2757>Victorian YHG=2757>Dublin YHG=2766>was YHG=2767>so YHG=2756>different YHG=2757>from XBD=209 XHG=856 XBD=355 XBD=564 XBD=628 XBD=762 XBD=832 XBD=982 XBD=1128 XBD=1297 XHG=131 XHG=231 XHG=378 XHG=587 XHG=652 XHG=784 XHG=1037 XHG=1151 YBD=2793 YBD=2794 YBD=2785 YBD=2786 YBD=2793 YHG=2756>long YHG=2756>period YHG=2756>appeared YHG=2757>to YHG=2766>cause YHG=2765>no YHG=2756>shock. YHG=2756>(The ; YHG=2756>longest XBD=423 XBD=488 XBD=590 XBD=728 XBD=830 XBD=1071 XBD=1240 XBD=1297 XHG=131 XHG=449 XHG=515 XHG=618 XHG=929 XHG=1122 XHG=1265 YBD=2826 YBD=2825 YBD=2832 YBD=2825 YBD=2826 YHG=2796>administration YHG=2797>in YHG=2797>this YHG=2796>series YHG=2805>was YHG=2795>hours.) YHG=2796>There YHG=2796>is 4 XBD=1549XHG=755 XBD=1731 XBD=1787 XBD=1875 XBD=1980 XBD=2081 XBD=2158 XBD=2360 XBD=2543 XHG=1354 XHG=1562 XHG=1746 XHG=1799 XHG=1887 XHG=1995 XHG=2093 XHG=2170 XHG=2371 YBD=2832 YBD=2834 YBD=2827 YHG=2797>Victorian YHG=2796>London, YHG=2797>at YHG=2805>any YHG=2797>rate, YHG=2797>that YHG=2797>the YHG=2797>adjective YHG=2798>becomes XBD=1420XHG=755 XBD=1616 XBD=1708 XBD=1763 XBD=2008 XBD=2074 XBD=2244 XBD=2334 XBD=2479 XBD=2547 XHG=1356 XHG=1446 XHG=1670 XHG=1733 XHG=1791 XHG=2033 XHG=2100 XHG=2269 XHG=2361 XHG=2505 YBD=2867 YBD=2874 YBD=2866 YHG=2838>too YHG=2837>protean. YHG=2836>It YHG=2836>is YHG=2836>customary YHG=2837>to YHG=2837>lament YHG=2838>the YHG=2837>decay YHG=2836>of XBD=214 XBD=321 XBD=520 XBD=628 XBD=741 XBD=842 XBD=1172 XBD=1298 XHG=132 XHG=227 XHG=336 XHG=535 XHG=643 XHG=856 XHG=1223 YBD=2873 YBD=2874 YBD=2866 YBD=2865 YBD=2872 YBD=2865 YBD=2865 YHG=2844>very YHG=2836>little YHG=2836>vomiting YHG=2846>even YHG=2836>after YHG=2836>long YHG=2835>administration. YHG=2835>For XBD=1377 XBD=1609 XBD=1742 XBD=2006 XBD=2096 XBD=2223 XBD=2356 XBD=2544 XHG=1357 XHG=1396 XHG=1627 XHG=1778 XHG=2020 XHG=2136 XHG=2262 XHG=2395 YBD=2889 YBD=2905 YBD=2906 YBD=2907 YBD=2913 YHG=2877>&dquo; YHG=2877>characters YHG=2875>&dquo;-of YHG=2876>eccentrics YHG=2876>and YHG=2886>men YHG=2877>with YHG=2876>enough XBD=332 XHG=885 XBD=451 XBD=520 XBD=791 XBD=861 XBD=950 XBD=1105 XBD=1238 XBD=1297 XHG=131 XHG=360 XHG=479 XHG=548 XHG=819 XHG=978YBD=2904 XHG=1133 XHG=1265 YBD=2912 YBD=2905 YBD=2906 YBD=2913 YBD=2905 YHG=2876>operations YHG=2876>such YHG=2886>as YHG=2876>amputation YHG=2875>of YHG=2875>the YHG=2875>breast YHG=2875>there YHG=2875>is XBD=1575XHG=880 XBD=1690 XBD=2009 XBD=2090 XBD=2171 XBD=2252 XBD=2384 XBD=2542 XHG=1357 XHG=1614 XHG=1729 XHG=2050 XHG=2123 XHG=2211 XHG=2293 XHG=2416 YBD=2947 YBD=2946 YBD=2953 YHG=2916>originality YHG=2915>and YHG=2915>independence YHG=2917>to YHG=2917>do YHG=2926>as YHG=2917>they YHG=2916>liked : XBD=235 XBD=326 XBD=604 XBD=723 XBD=855 XBD=984 XBD=1038 XBD=1167 XBD=1297 XHG=132 XHG=258 XHG=350 XHG=628 XHG=746 XHG=1008 XHG=1064 XHG=1218 YBD=2953 YBD=2945 YBD=2944 YBD=2945 YBD=2944 YHG=2915>much YHG=2916>less YHG=2915>haemorrhage YHG=2916>than YHG=2915>when YHG=2915>ether YHG=2915>is YHG=2915>used. YHG=2914>The XBD=437 XHG=659 XBD=638 XBD=918 XBD=1034 XBD=1118 XBD=1297 XHG=131 XHG=457 XHG=937YBD=2992 XHG=1054 XHG=1139 YBD=2991 YBD=2985 YBD=2984 YHG=2954>respiration-rate YHG=2956>increases YHG=2954>considerably YHG=2955>after YHG=2955>the YHG=2954>adminiXBD=1524 XBD=1613 XBD=1658 XBD=1696 XBD=1875 XBD=2012 XBD=2068 XBD=2160 XBD=2312 XBD=2433 XBD=2544 XHG=1356 XHG=1538 XHG=1627 XHG=1673 XHG=1709 XHG=1890 XHG=2026 XHG=2081 XHG=2176 XHG=2322 XHG=2446 YBD=2984 YBD=2993 YBD=2992 YBD=2986 YBD=2985 YHG=2956>whether YHG=2955>this YHG=2955>is YHG=2965>a YHG=2955>needless YHG=2956>regret YHG=2966>or YHG=2958>not, YHG=2966>no-one YHG=2955>could YHG=2956>have

" XBD=2544 XBD=1432 XBD=1621 XBD=1678 XBD=1766 XBD=1813 XBD=1912 XBD=2028 XBD=2083 XBD=2294 XBD=2452 XHG=1355 XHG=1448 XHG=1637 XHG=1694 XHG=1781 XHG=1828 XHG=1928 XHG=2044 XHG=2098 XHG=2310 XHG=2468 YBD=3026 YBD=3024 YBD=3025 YHG=2996>had YHG=2995>occasion YHG=2995>to YHG=2995>feel YHG=2995>it YHG=2996>who YHG=2996>lived YHG=2996>in YHG=2995>Victorian YHG=2995>Dublin YHG=2995>and XBD=280 XHG=856 XBD=378 XBD=503 XBD=572 XBD=772 XBD=828 XBD=928 XBD=1135 XBD=1239 XBD=1302 XHG=131 XHG=312 XHG=408 XHG=534 XHG=604 XHG=804 XHG=958YBD=3024 XHG=1167 XHG=1268 YBD=3023 YBD=3025 YBD=3032 YBD=3029 YBD=3023 YHG=2994>stration YHG=2995>has YHG=2994>been YHG=2995>in YHG=3004>progress YHG=3003>a YHG=2995>few YHG=2994>minutes, YHG=2994>but YHG=2993>if

" " " "

XBD=291 XHG=847 XBD=351 XBD=392 XBD=645 XBD=696 XBD=828 XBD=887 XBD=1202 XBD=1298 XHG=130 XHG=311 XHG=370 XHG=411 XHG=665 XHG=717 XHG=907YBD=3064 XHG=1221 YBD=3063 YBD=3071 YBD=3071 YBD=3063 YHG=3034>morphia YHG=3043>or YHG=3044>a YHG=3034>barbiturate YHG=3035>is YHG=3034>given YHG=3044>as YHG=3034>premedication YHG=3033>this XBD=2546 XBD=1431 XBD=1609 XBD=1714 XBD=1792 XBD=1933 XBD=1987 XBD=2120 XBD=2254 XBD=2343 XHG=1355 XHG=1445 XHG=1620 XHG=1728 XHG=1807 XHG=1946 XHG=1999 XHG=2133 XHG=2268 XHG=2357 YBD=3067 YBD=3066 YBD=3065 YBD=3072 YHG=3045>was YHG=3035>familiar YHG=3035>with YHG=3035>the YHG=3035>circles YHG=3036>in YHG=3036>which YHG=3036>Wilde YHG=3034>and YHG=3035>Speranza XBD=1505 XBD=1714 XBD=1853 XBD=1940 XBD=2016 XBD=2117 XBD=2305 XBD=2364 XBD=2543 XHG=1356 XHG=1557 XHG=1732 XHG=1872 XHG=1957 XHG=2033 XHG=2137 XHG=2324 XHG=2383 YBD=3106 YBD=3105 YBD=3104 YHG=3075>moved. YHG=3075>Neither YHG=3075>Wilde YHG=3085>nor YHG=3076>his YHG=3075>wife YHG=3075>deferred YHG=3075>to YHG=3084>convenXBD=194 XHG=835 XBD=248 XBD=341 XBD=406 XBD=642 XBD=744 XBD=810 XBD=952 XBD=1080 XBD=1137 XBD=1299 XHG=131 XHG=219 XHG=274 XHG=366 XHG=432 XHG=669 XHG=771 XHG=978YBD=3111 XHG=1105 XHG=1163 YBD=3103 YBD=3103 YBD=3103 YHG=3072>rise YHG=3073>is YHG=3074>not YHG=3083>so YHG=3074>noticeable YHG=3074>and YHG=3074>in YHG=3083>many YHG=3083>cases YHG=3073>is YHG=3073>absent XBD=1462 XBD=1574 XBD=1658 XBD=1824 XBD=2151 XBD=2213 XBD=2285 XBD=2403 XBD=2543 XHG=1356 XHG=1497 XHG=1593 XHG=1676 XHG=1844 XHG=2170 XHG=2227 XHG=2304 XHG=2423 YBD=3146 YBD=3144 YBD=3145 YHG=3115>tion : YHG=3114>and YHG=3115>the YHG=3115>famous YHG=3115>trial-ominous YHG=3115>of YHG=3114>his YHG=3114>son’s YHG=3115>catasXBD=338 XHG=131 YBD=3149 YHG=3112>altogether. XBD=243 XHG=854 XBD=375 XBD=607 XBD=837 XBD=986 XBD=1109 XBD=1214 XBD=1298 XHG=174 XHG=256 XHG=390 XHG=623 XHG=1002 XHG=1125 XHG=1230 YBD=3181 YBD=3188 YBD=3190 YBD=3182 YBD=3182 YBD=3181 YHG=3152>For YHG=3152>major YHG=3152>abdominal YHG=3153>operations YHG=3153>trilene YHG=3152>alone YHG=3152>does YHG=3151>not XBD=1666 XBD=1782 XBD=1898 XBD=2015 XBD=2141 XBD=2200 XBD=2241 XBD=2363 XBD=2543 XHG=1357 XHG=1685 XHG=1801 XHG=1916 XHG=2032 XHG=2159 XHG=2219 XHG=2259 XHG=2381 YBD=3191 YBD=3185 YBD=3186 YBD=3184 YBD=3183 YBD=3192 YHG=3154>trophe-would YHG=3155>have YHG=3155>done YHG=3156>little YHG=3156>harm YHG=3155>to YHG=3163>a YHG=3163>more YHG=3155>respect-

" " " " " "

XBD=2544XHG=494 XBD=1379 XBD=1513 XBD=1689 XBD=1956 XBD=2060 XBD=2177 XBD=2445 XHG=1359 XHG=1398 XHG=1538 XHG=1715 XHG=1986 XHG=2084 XHG=2199 XHG=2469 YBD=3247 YBD=3271 YBD=3272 YBD=3264 YBD=3270 YBD=3263 YHG=3234>&dquo; YHG=3234>dirty, YHG=3235>untidy, YHG=3234>daring... YHG=3242>very YHG=3233>imaginative YHG=3233>and XBD=166 XBD=250 XBD=469 XBD=635 XBD=1180 XBD=1298 XHG=130 XHG=188 XHG=274 XHG=1069YBD=3268 XHG=1205 YBD=3258 YBD=3259 YBD=3260 YBD=3268 YBD=3261 gas-oxygen-trilene YHG=3229>in YHG=3230>the YHG=3225>induction YHG=3231>period, YHG=3231>being YHG=3230>used XBD=199 XHG=771 XBD=318 XBD=458 XBD=517 XBD=670 XBD=753 XBD=943 XBD=1183 XHG=131 XHG=217 XHG=336 XHG=477 XHG=537 XHG=688 XHG=961YBD=3308 YBD=3298 YBD=3299 YBD=3300 YBD=3300 YHG=3269>and YHG=3269>ether YHG=3269>added YHG=3270>to YHG=3270>obtain YHG=3271>the YHG=3271>required YHG=3271>relaxation. XBD=1547 XBD=1665 XBD=1882 XBD=2174 XBD=2403 XBD=2545 XHG=1357 XHG=1600 XHG=1705 XHG=1921 XHG=2212 XHG=2443 YBD=3304 YBD=3305 YBD=3303 YBD=3310 YHG=3274>learned.&dquo; YHG=3275>Dr. YHG=3272>Wilson’s YHG=3273>entertaining YHG=3274>narrative YHG=3273>gives XBD=190 XBD=324 XBD=534 XBD=617 XBD=825 XBD=879 XBD=942 XBD=1021 XBD=1076 XBD=1300 XHG=174 XHG=205 XHG=338 XHG=549 XHG=633 XHG=839 XHG=956 XHG=1035 XHG=1088 YBD=3337 YBD=3345 YBD=3338 YBD=3339 YBD=3339 YBD=3339 YBD=3347 YHG=3308>I YHG=3308>would YHG=3309>especially YHG=3310>call YHG=3310>attention YHG=3311>to YHG=3310>its YHG=3319>use YHG=3310>in YHG=3309>midwifery XBD=1462XHG=893 XBD=1527 XBD=1657 XBD=1902 XBD=2003 XBD=2191 XBD=2238 XBD=2353 XBD=2419 XBD=2546 XHG=1358 XHG=1485 XHG=1551 XHG=1682 XHG=1928 XHG=2027 XHG=2216 XHG=2262 XHG=2377 XHG=2440 YBD=3344 YBD=3351 YBD=3343 YBD=3350 YBD=3342 YBD=3349 YHG=3313>body YHG=3314>to YHG=3314>these YHG=3314>adjectives, YHG=3314>and YHG=3313>pictures YHG=3322>a YHG=3322>man YHG=3313>of YHG=3313>great little XBD=183 XHG=859 XBD=235 XBD=411 XBD=475 XBD=597 XBD=713 XHG=130 XHG=204 XHG=257 XHG=435 XHG=499 XHG=621 YBD=3383 YBD=3376 YBD=3377 YBD=3385 YHG=3346>for YHG=3347>it YHG=3356>appears YHG=3348>to YHG=3348>have YHG=3358>very XBD=969 XBD=1042 XBD=1130 XBD=1299 XHG=993YBD=3378 XHG=1066 XHG=1153 YBD=3378 YBD=3378 YHG=3349>effect YHG=3358>on YHG=3349>the YHG=3349>uterine XBD=1494 XBD=1594 XBD=1759 XBD=1833 XBD=1964 XBD=2080 XBD=2256 XBD=2472 XBD=2546 XHG=1359 XHG=1519 XHG=1620 XHG=1790 XHG=1859 XHG=1997 XHG=2105 XHG=2282 XHG=2504 YBD=3390 YBD=3391 YBD=3383 YBD=3382 YBD=3389 YBD=3381 YHG=3353>ability YHG=3354>and YHG=3363>energy YHG=3354>of YHG=3353>mind YHG=3353>who YHG=3352>worked YHG=3352>fruitfully YHG=3353>at XBD=272 XHG=798 XBD=367 XBD=409 XBD=535 XBD=718 XBD=781 XBD=930 XBD=1025 XBD=1101 XBD=1193 XBD=1300 XHG=131 XHG=293 XHG=387 XHG=428 XHG=553 XHG=739 XHG=951YBD=3417 XHG=1046 XHG=1120 XHG=1216 YBD=3420 YBD=3414 YBD=3415 YBD=3416 YBD=3417 YBD=3417 YBD=3424 YHG=3386>muscle, YHG=3386>and YHG=3395>a YHG=3386>weak YHG=3387>mixture YHG=3387>of YHG=3388>trilene YHG=3388>and YHG=3388>air YHG=3388>will YHG=3388>give XBD=1718 XBD=1929 XBD=2021 XBD=2094 XBD=2320 XBD=2379 XBD=2546 XHG=1622 XHG=1733 XHG=1946 XHG=2036 XHG=2110 XHG=2336 XHG=2392 YBD=3423 YBD=3427 YBD=3421 YBD=3420 YBD=3428 YHG=3393>vital YHG=3393>statistics, YHG=3385>and YHG=3391>his YHG=3392>specialties YHG=3391>of YHG=3392>otology XBD=1435 XBD=1777 XBD=1868 XBD=2022 XBD=2120 XBD=2162 XBD=2326 XBD=2388 XBD=2547 XHG=1358 XHG=1454 XHG=1830 XHG=1887 XHG=2042 XHG=2140 XHG=2181 XHG=2347 XHG=2404 YBD=3469 YBD=3461 YBD=3468 YBD=3460 YHG=3432>and YHG=3432>ophthalmology. YHG=3431>It YHG=3431>evokes YHG=3431>also YHG=3440>a YHG=3431>picture YHG=3430>of YHG=3430>Dublin C. L. and 1. Hewer, F. Brit. med. J. 1941, i, 924. Hadfield, C.

" XBD=2545 XBD=1441 XBD=1573 XBD=1683 XBD=1762 XBD=1915 XBD=2029 XBD=2148 XBD=2245 XBD=2417 XHG=1357 XHG=1472 XHG=1625 XHG=1718 XHG=1796 XHG=1947 XHG=2062 XHG=2180 XHG=2277 XHG=2450 YBD=3226 YBD=3225 YBD=3223 YBD=3224 YHG=3194>able YHG=3204>man. YHG=3195>W. YHG=3195>B. YHG=3195>Yeats YHG=3195>said YHG=3194>that YHG=3194>the YHG=3194>Wildes YHG=3203>were XBD=206 XHG=964 XBD=405 XBD=612 XBD=853 XBD=945 XBD=995 XBD=1045 XBD=1157 XBD=1299 XHG=131 XHG=226 XHG=424 XHG=631 XHG=875 XHG=1013YBD=3222 XHG=1066 XHG=1175 YBD=3226 YBD=3221 YBD=3227 YBD=3229YHG=3192>it YBD=3221 YHG=3189>give YHG=3191>sufficient YHG=3192>muscular YHG=3192>relaxation, YHG=3192>but YHG=3192>is YHG=3201>very YHG=3191>useful .

C. L. Proc 2. Hewer, R. Soc. Med. 1942, 35, 463. " XBD=2547 XBD=1579 XBD=1739 XBD=1802 XBD=1882 XBD=1976 XBD=2166 XBD=2308 XBD=2456 XHG=1514 XHG=1598 XHG=1760 XHG=1818 XHG=1902 XHG=1996 XHG=2186 XHG=2327 XHG=2476 YBD=3504 YBD=3502 YBD=3501 YBD=3507 YBD=3500 YHG=3472>middle YHG=3471>of YHG=3471>the YHG=3470>last YHG=3471>century, YHG=3470>which YHG=3470>makes YHG=3480>one

" XBD=1999 XHG=1942 YBD=3556 YHG=3527>3

archaeology,

during