- Email: [email protected]
SULPHONAMIDE RESISTANCE
596
" XBD=2622 XBD=1636 XHG=2464 XBD=1839 XBD=1909 XBD=2056 XBD=2155 XBD=2286 XBD=2445 XHG=1428 YBD=295 XHG=1661 XHG=1862 XHG=1930 XHG=2077 XHG=2176 XHG=2338 YBD=292 YBD=297 YBD=287 YHG=255>Overbeek, YHG=255>Gaillard, YHG=256>de YHG=256>Jongh YHG=257>and YHG=257>Yam. YHG=255>They YHG=255>planted Annotations " XBD=2621 XBD=1492 XHG=2599 XBD=1620 XBD=1844 XBD=1901 XBD=2192 XBD=2306 XBD=2388 XBD=2529 XBD=2583 XHG=1425 YBD=330 XHG=1510 XHG=1636 XHG=1862 XHG=1916 XHG=2207 XHG=2323 XHG=2405 XHG=2545 YBD=339 YHG=309>a YBD=331 YBD=329 YHG=301>out YHG=299>small YHG=300>fragments YHG=300>of YHG=300>bone-marrow YHG=301>from YHG=299>the YHG=300>femur YHG=299>of " XBD=2620 XBD=1627 XHG=2506 XBD=1737 XBD=1790 XBD=1985 XBD=2055 XBD=2285 XBD=2474 XHG=1423 XHG=1656 XHG=1769 XHG=1822 XHG=2017 XHG=2084 XHG=2313 YBD=374 YHG=342>saline YBD=375 YBD=384 YBD=383 YBD=373 YHG=343>guineapig YHG=343>into YHG=351>a YHG=344>mixture YHG=344>of YHG=344>guineapig YHG=343>plasma, RESISTANCE SULPHONAMIDE " XBD=2617 XBD=1501 XHG=2601 XBD=1697 XBD=1749 XBD=1857 XBD=2039 XBD=2212 XBD=2325 XBD=2360 XBD=2418 XBD=2529 XBD=2584 XHG=1425 YBD=417 XHG=1514 XHG=1710 XHG=1763 XHG=1872 XHG=2054 XHG=2226 XHG=2345 XHG=2379 XHG=2436 XHG=2545 YBD=428 YHG=388>1 YBD=418 YBD=416 YHG=386>and YHG=385>dilutions YHG=387>of YHG=387>liver YHG=389>extracts YHG=388>ranging YHG=388>from YHG=389>1 YHG=387>in YHG=388>5000 YHG=388>to " XBD=293 XBD=372 XBD=621 XBD=675 XBD=976 XBD=1151 XHG=211 XHG=306 XHG=385 XHG=634 XHG=987 XHG=1164 YBD=448 YBD=449 YBD=460 YBD=450 YBD=460 YBD=461 YHG=422>ALL YHG=422>the YHG=422>advantages YHG=422>of YHG=422>therapy YHG=422>disappear " XBD=1365 XBD=1464XHG=687 XBD=1647 XBD=1813 XBD=1933 XBD=2122 XBD=2358 XBD=2413 XBD=2514 XBD=2619 XHG=1423YBD=459 XHG=1481 XHG=1699 XHG=1827 XHG=1947 XHG=2137 XHG=2374 XHG=2427 XHG=2529 YBD=467YHG=422>sulphonamide YBD=471 YBD=472 YBD=461 YBD=462 YHG=431>in YHG=431>150,000. YHG=431>From YHG=430>these YHG=431>explants YHG=431>migrations YHG=431>of YHG=430>cells YHG=430>took XBD=274 XHG=821 XBD=336 XBD=554 XBD=783 XBD=853 XBD=1158 XBD=1275 XBD=1364 XHG=163 XHG=313 XHG=372 XHG=593 XHG=891YBD=494 XHG=1198 XHG=1314 YBD=493 YBD=503 YBD=501 YBD=495YHG=463>is YHG=461>when YHG=471>a YHG=462>resistant YHG=463>organism YHG=464>encountered, YHG=464>and YHG=474>an "" XBD=2617 XBD=1531 XBD=1619 XBD=1731 XBD=1791 XBD=2164 XBD=2242 XBD=2343 XBD=2393 XBD=2473 XHG=1423 XHG=1542 XHG=1633 XHG=1749 XHG=1805 XHG=2176 XHG=2257 XHG=2354 XHG=2407 XHG=2486 YBD=506 YBD=505 YBD=514 YHG=473>place YHG=474>and YHG=474>after YHG=476>15 YHG=475>hours’ YHG=475>the YHG=484>area YHG=474>of YHG=474>the YHG=474>migraincubation " XBD=1363 XBD=395 XBD=525 XBD=587 XBD=679 XBD=737 XBD=820 XBD=1145 XBD=1194 XHG=161 XHG=410 XHG=545 XHG=607 XHG=697 XHG=838 XHG=1163 XHG=1212 YBD=546 YBD=538 YBD=547 YBD=540 YBD=548 YHG=506>organism YHG=506>fast YHG=508>to YHG=516>one YHG=508>of YHG=507>the YHG=507>sulphonamides YHG=508>is YHG=508>usually &dquo; &dquo; XBD=1505XHG=752 XBD=1608 XBD=1698 XBD=1920 XBD=2010 XBD=2100 XBD=2232 XBD=2333 XBD=2440 XBD=2618 XHG=1423 XHG=1518 XHG=1619 XHG=1712 XHG=1972 XHG=2022 XHG=2112 XHG=2245 XHG=2345 XHG=2453 YBD=550 YBD=549 YHG=519>tion YHG=517>field YHG=525>was YHG=518>measured. YHG=519>It YHG=528>was YHG=518>found YHG=519>that YHG=517>liver YHG=519>extracts "" XBD=1361 XBD=239 XBD=310 XBD=392 XBD=489 XBD=739 XBD=862 XBD=1007 XBD=1078 XBD=1184 XHG=159 XHG=269 XHG=343 XHG=422 XHG=520 XHG=768 XHG=893 XHG=1038 XHG=1106 XHG=1213 YBD=580 YBD=581 YBD=591 YBD=583 YBD=592 YBD=583 YBD=592 YHG=550>fast YHG=551>to YHG=550>all YHG=551>the YHG=551>commonly YHG=552>used YHG=552>drugs YHG=552>of YHG=552>this YHG=561>group ; XBD=1648 XHG=2460 XBD=1861 XBD=1949 XBD=2046 XBD=2163 XBD=2250 XBD=2284 XBD=2449 XBD=2618 XHG=1424 YBD=601 XHG=1659 XHG=1873 XHG=1959 XHG=2056 XHG=2172 XHG=2262 XHG=2295 YBD=602 YHG=561>optimal YBD=594 YBD=592 YBD=593 YHG=561>stimulated YHG=562>migration YHG=562>and YHG=562>that YHG=562>there YHG=571>was YHG=570>a YHG=562>definite XBD=229 XHG=907 XBD=427 XBD=554 XBD=672 XBD=762 XBD=884 XBD=957 XBD=1362 XHG=161 XHG=253 XHG=449 XHG=577 XHG=694 XHG=784 XHG=986YBD=627 YBD=625 YBD=626 YBD=636 YHG=593>the YHG=594>clinician YHG=596>must YHG=595>then YHG=595>fall YHG=595>back YHG=595>pre-sulphonamide "" XBD=2615 XBD=1588 XBD=1640 XBD=1774 XBD=1849 XBD=1998 XBD=2212 XBD=2310 XBD=2397 XHG=1424 XHG=1599 XHG=1650 XHG=1784 XHG=1859 XHG=2010 XHG=2221 XHG=2320 XHG=2408 YBD=637YHG=605>on YBD=645 YBD=636 YBD=646 YHG=606>dilution YHG=607>at YHG=606>which YHG=606>the YHG=605>largest YHG=605>migration YHG=605>field YHG=614>was YHG=606>produced; " XBD=1360 XBD=294 XBD=409 XBD=471 XBD=713 XBD=810 XBD=973 XBD=1122 XHG=160 XHG=316 XHG=430 XHG=493 XHG=733 XHG=992 XHG=1174 YBD=679 YBD=669 YBD=670 YBD=671 YBD=680 YBD=671 YBD=680 YHG=639>agents YHG=638>such YHG=648>as YHG=639>acriflavine YHG=640>and YHG=639>crystal YHG=639>violet. YHG=639>DevelopXBD=1584XHG=831 XBD=1670 XBD=1833 XBD=2011 XBD=2081 XBD=2248 XBD=2305 XBD=2447 XBD=2506 XBD=2615 XHG=1421 XHG=1603 XHG=1687 XHG=1848 XHG=2032 XHG=2098 XHG=2265 XHG=2330 XHG=2467 XHG=2525 YBD=686 YBD=681 YHG=650>further, YHG=650>the YHG=649>more YHG=650>active YHG=658>an YHG=651>extract YHG=650>in YHG=651>terms YHG=649>of YHG=649>USP &dquo; &dquo; "" XBD=1361 XBD=265 XBD=323 XBD=629 XBD=850 XBD=1010 XBD=1093 XBD=1213 XHG=159 XHG=282 XHG=339 XHG=644 XHG=865 XHG=1026 XHG=1109 XHG=1230 YBD=714 YBD=724 YBD=716 YBD=719 YBD=715 YHG=683>ment YHG=682>of YHG=682>sulphonamide YHG=684>resistance YHG=684>follows YHG=683>the YHG=693>same YHG=693>course XBD=1526 XBD=1617 XBD=1793 XBD=1886 XBD=2078 XBD=2252 XBD=2317 XBD=2514 XBD=2615 XHG=1421 XHG=1551 XHG=1644 XHG=1820 XHG=1916 XHG=2107 XHG=2275 XHG=2346 XHG=2543 YBD=726 YBD=735 YBD=724 YBD=733 YBD=725 YHG=695>units YHG=694>the YHG=696>greater YHG=693>the YHG=693>dilution YHG=694>needed YHG=696>to YHG=694>produce YHG=693>this " XBD=201 XBD=418 XBD=472 XBD=598 XBD=877 XBD=1123 XBD=1214 XBD=1300 XHG=158 XHG=213 XHG=430 XHG=488 XHG=890 XHG=1176 XHG=1228 XHG=1312 YBD=759 YBD=759 YBD=759 YHG=736>as YHG=726>resistance YHG=729>to YHG=728>other YHG=728>substances. YHG=729>It YHG=737>can YHG=728>be " XBD=1361 XBD=1584XHG=611 XBD=1817 XBD=2001 XBD=2113 XBD=2209 XBD=2304 XBD=2526 XBD=2611 XHG=1422YBD=760 XHG=1602 XHG=1862 XHG=2020 XHG=2130 XHG=2227 XHG=2322 XHG=2548 YBD=774YHG=728>antibacterial YBD=778 YBD=769 YBD=777 YBD=771 YHG=738>optimal YHG=738>migration. YHG=738>Hence, YHG=737>they YHG=747>say, YHG=738>this YHG=738>technique YHG=747>can " XBD=1360 XBD=354 XBD=696 XBD=815 XBD=879 XBD=991 XBD=1094 XBD=1157 XBD=1282 XHG=158 XHG=377 XHG=718 XHG=838 XHG=902 XHG=1017 XHG=1116 XHG=1181 XHG=1306 YBD=812 YBD=813 YBD=803 YBD=811 YBD=802 YBD=803 YBD=813 YHG=772>produced YHG=772>experimentally YHG=773>both YHG=773>in YHG=772>vivo YHG=772>and YHG=772>in YHG=772>vitro XBD=1469 XHG=2459 XBD=1574 XBD=1624 XBD=1843 XBD=1916 XBD=2086 XBD=2130 XBD=2452 XBD=2615 XHG=1411 YBD=812 XHG=1478 XHG=1584 XHG=1636 XHG=1850 XHG=1923 XHG=2093 XHG=2141 YBD=821 YHG=772>by YHG=779>be YHG=782>used YHG=781>to YHG=782>determine YHG=782>the YHG=781>activity YHG=782>of YHG=782>anti-pernicious YHG=782>anaemia, " XBD=1357 XBD=378 XBD=596 XBD=652 XBD=931 XBD=968 XBD=1210 XHG=157 XHG=391 XHG=610 XHG=667 XHG=946 XHG=983 XHG=1226 YBD=848 YBD=857 YBD=847 YBD=856 YBD=857 YHG=816>repeatedly YHG=816>passaging YHG=826>or YHG=816>subculturing YHG=826>a YHG=815>susceptible XBD=1514 XHG=2472 XBD=1702 XBD=1761 XBD=1888 XBD=1983 XBD=2093 XBD=2224 XBD=2328 XBD=2374 XBD=2456 XBD=2615 XHG=1419 YBD=866 XHG=1533 XHG=1721 XHG=1775 XHG=1907 XHG=1999 XHG=2103 XHG=2240 XHG=2344 XHG=2389 YBD=858 YHG=826>organYBD=862 YHG=826>liver YHG=827>extracts YHG=826>in YHG=826>vitro, YHG=825>and YHG=825>they YHG=825>found YHG=826>that YHG=826>if YHG=826>the YHG=825>clinical XBD=230 XHG=695 XBD=298 XBD=392 XBD=598 XBD=668 XBD=905 XBD=1238 XBD=1308 XBD=1359 XHG=157 XHG=257 XHG=326 XHG=420 XHG=628 XHG=934YBD=902 XHG=1268 XHG=1336 YBD=892 YBD=901 YBD=893 YBD=892 YBD=892YHG=861>increasing YBD=891 YHG=861>ism YHG=861>in YHG=861>the YHG=870>presence YHG=861>of YHG=860>concentrations YHG=861>of YHG=870>a " XBD=2615 XBD=1588 XBD=1644 XBD=1715 XBD=1880 XBD=1974 XBD=2313 XBD=2383 XBD=2543 XHG=1419 XHG=1604 XHG=1665 XHG=1731 XHG=1896 XHG=1993 XHG=2330 XHG=2400 XHG=2559 YBD=902 YBD=911 YBD=910 YBD=901 YHG=872>potency YHG=871>of YHG=880>an YHG=872>extract YHG=879>was YHG=870>destroyed-say YHG=870>by YHG=870>boiling YHG=870>for " XBD=1358 XBD=460 XBD=736 XBD=945 XBD=1168 XBD=1268 XHG=145 XHG=514 XHG=968 XHG=1191 XHG=1292 YBD=946 YBD=938 YBD=946 YBD=936 YHG=905>,sulphonamide. YHG=906>Resistance YHG=905>gradually YHG=905>and YHG=905>the XBD=1469XHG=759 XBD=1590 XBD=1707 XBD=1800 XBD=2017 XBD=2240 XBD=2612 XHG=1420YBD=937 XHG=1491 XHG=1611 XHG=1731 XHG=1825 XHG=2040 XHG=2264 YBD=947YHG=905>increases YBD=948 YBD=955 YBD=946 YBD=956 YHG=925>an YHG=916>hour YHG=915>with YHG=915>2% YHG=914>sulphuric YHG=914>acid-the YHG=915>migration-stimu" XBD=1356 XBD=250 XBD=396 XBD=474 XBD=562 XBD=771 XBD=1099 XBD=1169 XHG=157 XHG=276 XHG=423 XHG=501 XHG=586 XHG=798 XHG=1126 XHG=1194 YBD=982 YBD=985 YBD=981 YBD=988 YBD=991 YBD=981 YBD=990 YHG=950>final YHG=950>strain YHG=950>of, YHG=950>for YHG=950>instance, YHG=959>pneumococcus YHG=959>or XBD=1541 XHG=2541 XBD=1777 XBD=1901 XBD=2006 XBD=2250 XBD=2421 XBD=2512 XBD=2614 XHG=1418 YBD=991 XHG=1567 XHG=1803 XHG=1928 XHG=2036 XHG=2301 XHG=2448 YBD=1001YHG=951>streptoYBD=992 YBD=1000 YHG=969>were YHG=959>also YHG=959>There YHG=968>are YHG=959>still YHG=960>lating YHG=960>properties YHG=959>destroyed. " XBD=2613 XBD=290 XHG=738 XBD=404 XBD=474 XBD=717 XBD=780 XBD=1001 XBD=1207 XBD=1270 XBD=1358 XHG=156 XHG=313 XHG=425 XHG=494 XHG=803YBD=1027 XHG=1023 XHG=1231 XHG=1291 YBD=1028 YBD=1035 YBD=1026 YBD=1027 YBD=1026YHG=996>to YHG=1004>coccus YHG=1005>may YHG=995>be YHG=995>insensitive YHG=995>saturated YHG=994>solutions YHG=995>of YHG=995>the XBD=1537 XBD=1689 XBD=1754 XBD=1826 XBD=2060 XBD=2187 XBD=2392 XBD=2517 XHG=1420 XHG=1560 XHG=1713 XHG=1778 XHG=1848 XHG=2112 XHG=2208 XHG=2417 XHG=2541 YBD=1045 YBD=1041 YBD=1035 YBD=1036 YHG=1014>many YHG=1005>points YHG=1006>to YHG=1005>be YHG=1003>explained. YHG=1005>For YHG=1005>instance, YHG=1004>Pace YHG=1004>and " XBD=1355 XBD=283 XBD=547 XBD=661 XBD=884 XBD=944 XBD=1082 XBD=1211 XHG=157 XHG=337 XHG=566 XHG=679 XHG=965 XHG=1101 XHG=1230 YBD=1081 YBD=1080 YBD=1072 YBD=1071 YBD=1080 YBD=1070 YBD=1080 YHG=1040>drugs. YHG=1040>Compared YHG=1040>with YHG=1040>resistance YHG=1049>many YHG=1039>other YHG=1039>drugs, XBD=1551XHG=903 XBD=1620 XBD=1709 XBD=1900 XBD=1986 XBD=2141 XBD=2200 XBD=2286 XBD=2510 XBD=2613 XHG=1419YBD=1070 XHG=1572 XHG=1640 XHG=1731 XHG=1919 XHG=2005 XHG=2162 XHG=2218 XHG=2306 XHG=2530 YBD=1081YHG=1041>to YBD=1089 YHG=1049>Fisher YHG=1049>do YHG=1050>not YHG=1049>mention YHG=1050>nature YHG=1049>of YHG=1049>the YHG=1049>migrating YHG=1049>cells " XBD=1357 XBD=446 XBD=671 XBD=723 XBD=833 XBD=893 XBD=1131 XBD=1183 XHG=156 XHG=465 XHG=690 XHG=742 XHG=852 XHG=913 XHG=1150 XHG=1203 YBD=1125 YBD=1116 YBD=1116 YBD=1116 YHG=1084>sulphonamide YHG=1084>resistance YHG=1084>is YHG=1094>easy YHG=1086>to YHG=1083>induce-it YHG=1084>is XBD=1612 XHG=2504 XBD=1742 XBD=1834 XBD=1989 XBD=2100 XBD=2217 XBD=2306 XBD=2480 XBD=2611 XHG=1420 YBD=1125 XHG=1636 XHG=1764 XHG=1858 XHG=2014 XHG=2124 XHG=2242 XHG=2330 YBD=1126 YHG=1084>evident YBD=1134 YBD=1133 YHG=1094>(previous YHG=1094>work YHG=1093>has YHG=1094>shown YHG=1094>that YHG=1093>they YHG=1103>are YHG=1093>usually YHG=1093>fibroXBD=197 XHG=898 XBD=307 XBD=415 XBD=515 XBD=591 XBD=803 XBD=869 XBD=967 XBD=1247 XBD=1356 XHG=155 XHG=225 XHG=338 XHG=443 XHG=542 XHG=619 XHG=830 XHG=998YBD=1166 XHG=1300 YBD=1161 YBD=1160 YBD=1160 YBD=1159 YHG=1130>in YHG=1139>one, YHG=1129>and YHG=1138>can YHG=1129>be YHG=1129>maximal YHG=1129>in YHG=1129>six, YHG=1129>subcultures. YHG=1129>Its "" XBD=2612 XBD=1539 XBD=1647 XBD=2082 XBD=2366 XBD=2482 XHG=1419 XHG=1571 XHG=1676 XHG=2109 XHG=2412 XHG=2510 YBD=1179 YBD=1169 YBD=1170 YHG=1138>blasts YHG=1139>and YHG=1138>polymorphonuclear YHG=1138>leucocytes) YHG=1147>nor YHG=1138>what ; "" XBD=1355 XBD=379 XBD=551 XBD=874 XBD=1070 XBD=1133 XHG=154 XHG=414 XHG=906 XHG=1101 XHG=1166 YBD=1206 YBD=1214 YBD=1205 YHG=1183>occurrence YHG=1173>during YHG=1173>therapy YHG=1173>is YHG=1173>therefore XBD=1582XHG=584 XBD=1700 XBD=1925 XBD=2041 XBD=2101 XBD=2191 XBD=2473 XBD=2609 XHG=1419YBD=1214 XHG=1600 XHG=1715 XHG=1942 XHG=2060 XHG=2122 XHG=2207 XHG=2492 YBD=1215YHG=1173>sulphonamide YBD=1214 YBD=1224 YBD=1223 YHG=1183>relation YHG=1183>their YHG=1184>properties YHG=1183>have YHG=1184>to YHG=1183>the YHG=1181>pathology-of YHG=1184>perni" XBD=1355 XBD=275 XBD=557 XBD=725 XBD=829 XBD=1004 XBD=1265 XHG=156 XHG=311 XHG=608 XHG=865 XHG=1039 XHG=1303 YBD=1259 YBD=1250 YBD=1250 YBD=1259 YBD=1257 YHG=1218>easily YHG=1218>understood. YHG=1218>From YHG=1218>known YHG=1219>procedures YHG=1217>by XBD=1522XHG=761 XBD=1722 XBD=1847 XBD=2006 XBD=2361 XBD=2473 XBD=2608 XHG=1419YBD=1249 XHG=1536 XHG=1748 XHG=1859 XHG=2019 XHG=2373 XHG=2486 YBD=1266YHG=1218>the YBD=1268 YBD=1260 YHG=1227>cious ; also YHG=1228>anaemia YHG=1227>their YHG=1228>control YHG=1228>experiments YHG=1231>seem YHG=1228>inadeXBD=278 XHG=644 XBD=333 XBD=387 XBD=621 XBD=958 XBD=1054 XBD=1188 XBD=1355 XHG=153 XHG=301 XHG=355 XHG=412 XHG=982YBD=1304 XHG=1076 XHG=1211 YBD=1296 YBD=1295 YBD=1294 YBD=1294YHG=1263>experimentally YHG=1263>which YHG=1263>it YHG=1264>is YHG=1262>developed YHG=1273>one YHG=1263>could YHG=1262>deduce " XBD=2606 XBD=1547 XBD=1678 XBD=1769 XBD=1951 XBD=2048 XBD=2256 XBD=2379 XHG=1418 XHG=1599 XHG=1702 XHG=1793 XHG=1972 XHG=2072 XHG=2278 XHG=2402 YBD=1312 YBD=1304 YBD=1305 YBD=1313 YHG=1274>quate. YHG=1273>But YHG=1273>the YHG=1272>method YHG=1272>will YHG=1272>certainly YHG=1272>have YHG=1272>important "" XBD=1354 XBD=244 XBD=476 XBD=632 XBD=710 XBD=840 XBD=984 XBD=1055 XBD=1132 XHG=153 XHG=270 XHG=504 XHG=661 XHG=740 XHG=1013 XHG=1085 XHG=1161 YBD=1340 YBD=1339 YBD=1339 YBD=1348 YHG=1309>that YHG=1308>resistance YHG=1307>would YHG=1308>be YHG=1309>most YHG=1309>to YHG=1307>be YHG=1307>produced XBD=1670XHG=868 XBD=1723 XBD=1894 XBD=2022 XBD=2168 XBD=2222 XBD=2288 XBD=2361 XBD=2607 XHG=1417YBD=1348 XHG=1693 XHG=1746 XHG=1916 XHG=2046 XHG=2191 XHG=2247 XHG=2313 XHG=2386 YBD=1358YHG=1307>likely YBD=1348 YBD=1349 YBD=1359 YHG=1312>applications YHG=1317>if YHG=1317>further YHG=1317>work YHG=1316>shows YHG=1317>it YHG=1318>to YHG=1317>be YHG=1318>sufficiently " XBD=1353 XBD=263 XBD=307 XBD=482 XBD=578 XBD=682 XBD=816 XBD=947 XBD=1075 XBD=1137 XBD=1224 XHG=152 XHG=284 XHG=328 XHG=499 XHG=597 XHG=702 XHG=837 XHG=968 XHG=1098 XHG=1157 XHG=1246 YBD=1385 YBD=1394 YBD=1388 YBD=1393 YBD=1384 YBD=1384 YBD=1384 YBD=1393 YHG=1353>when YHG=1362>a YHG=1353>patient YHG=1361>was YHG=1353>first YHG=1352>given YHG=1352>small YHG=1352>doses YHG=1353>of YHG=1353>the XBD=1596 XHG=2525 XBD=1702 XBD=1945 XBD=2045 XBD=2195 XBD=2260 XBD=2433 XBD=2502 XBD=2608 XHG=1416 YBD=1394 XHG=1634 XHG=1725 XHG=1968 XHG=2070 XHG=2218 XHG=2284 XHG=2456 YBD=1401 YHG=1352>drug, YBD=1397 YBD=1395 YHG=1361>reliable; YHG=1362>the YHG=1361>Weil-Felix YHG=1362>test YHG=1370>serves YHG=1363>to YHG=1362>remind YHG=1372>us YHG=1362>that XBD=329 XHG=879 XBD=409 XBD=459 XBD=645 XBD=850 XBD=956 XBD=1076 XBD=1134 XBD=1228 XBD=1352 XHG=152 XHG=355 XHG=436 XHG=485 XHG=671 XHG=984YBD=1429 XHG=1103 XHG=1162 XHG=1255 YBD=1430 YBD=1439 YBD=1438 YBD=1434 YBD=1429 YBD=1429YHG=1397>and YBD=1428 YHG=1397>followed YHG=1397>by YHG=1407>a YHG=1397>gradual YHG=1397>increase, YHG=1397>such YHG=1397>is YHG=1397>the YHG=1406>case. " XBD=2608 XBD=1540 XBD=1649 XBD=1754 XBD=1811 XBD=1945 XBD=1998 XBD=2111 XBD=2293 XHG=1415 XHG=1553 XHG=1664 XHG=1764 XHG=1824 XHG=1957 XHG=2012 XHG=2123 XHG=2306 YBD=1439 YBD=1447 YBD=1438 YBD=1437 YBD=1448 YBD=1440 YHG=1407>useful YHG=1408>tests YHG=1416>may YHG=1406>be YHG=1406>found YHG=1407>in YHG=1408>most YHG=1406>unlikely YHG=1407>circumstances. " XBD=1353 XBD=285 XHG=848 XBD=374 XBD=566 XBD=825 XBD=887 XBD=1072 XBD=1233 XHG=156 XHG=306 XHG=396 XHG=586 XHG=909YBD=1473 XHG=1095 XHG=1254 YBD=1474 YBD=1482 YBD=1474 YBD=1483YHG=1442>of YBD=1473 YHG=1442>Hence YHG=1443>the YHG=1443>extreme YHG=1442>importance YHG=1442>massive YHG=1442>dosage YHG=1442>from CIRCUMSTANTIAL EVIDENCE " XBD=1351 XBD=111 XHG=477 XBD=222 XBD=378 XBD=447 XBD=788 XBD=1000 XBD=1147 XHG=108 XHG=153 XHG=250 XHG=407 XHG=840YBD=1527 XHG=1030 XHG=1175 YBD=1525 YBD=1523 YBD=1519 YBD=1528 YBD=1528YHG=1487>chemotherapy. YBD=1523 YHG=1521>, YHG=1488>the YHG=1488>outset YHG=1488>in YHG=1487>Though YHG=1487>easily YHG=1486>induced, STARLING " XBD=1352 XBD=357 XHG=915 XBD=431 XBD=776 XBD=881 XBD=963 XBD=1089 XHG=151 XHG=390 XHG=466 XHG=810 XHG=995YBD=1563 XHG=1120 YBD=1564 YBD=1572 YBD=1572 YBD=1572YHG=1532>be YHG=1532>resistance YHG=1534>to YHG=1532>sulphonamides YHG=1541>can YHG=1542>very YHG=1533>persistent; XBD=177 XHG=601 XBD=341 XBD=531 XBD=581 XBD=641 XBD=1066 XBD=1354 XHG=152 XHG=195 XHG=358 XHG=549 XHG=660YBD=1607 XHG=1084 YBD=1617 YBD=1608 YBD=1617 YHG=1587>a YHG=1576>typical YHG=1576>instance YHG=1576>is YHG=1576>sulphapyridine-fast YHG=1576>pneumococci " XBD=2609 XBD=1511 XBD=1560 XBD=1788 XBD=1876 XBD=2032 XBD=2094 XBD=2443 XHG=1464 XHG=1536 XHG=1713 XHG=1809 XHG=1898 XHG=2054 XHG=2113 XHG=2466 YBD=1617YHG=1576>of YBD=1608 YBD=1609 YHG=1576>IN YHG=1586>a YHG=1576>1 YHG=1577>the YHG=1577>spread YHG=1577>of YHG=1577>foot-and-mouth YHG=1578>disease of study XBD=347 XHG=697 XBD=512 XBD=565 XBD=667 XBD=935 XBD=1087 XBD=1353 XHG=151 XHG=375 XHG=541 XHG=593 XHG=963YBD=1652 XHG=1116 YBD=1661 YBD=1653 YBD=1653 YHG=1621>produced YHG=1621>during YHG=1630>a YHG=1620>few YHG=1621>which YHG=1620>maintained " XBD=2610 XBD=1474 XBD=1541 XBD=1757 XBD=1910 XBD=2003 XBD=2115 XBD=2206 XBD=2337 XBD=2546 XHG=1414 XHG=1503 XHG=1569 XHG=1782 XHG=1936 XHG=2028 XHG=2140 XHG=2231 XHG=2364 XHG=2571 YBD=1652YHG=1621>subcultures YBD=1653 YBD=1663 YBD=1662 YBD=1654 YHG=1621>W. YHG=1621>S. YHG=1621>Bullough YHG=1622>points YHG=1623>out YHG=1621>that YHG=1622>the YHG=1624>great YHG=1622>majority YHG=1622>of " XBD=2628 XBD=252 XHG=848 XBD=472 XBD=581 XBD=817 XBD=984 XBD=1117 XBD=1245 XBD=1352 XBD=1622 XBD=1705 XBD=1841 XBD=2069 XBD=2139 XBD=2224 XBD=2411 XBD=2470 XHG=151 XHG=281 XHG=503 XHG=611 XHG=1014YBD=1707 XHG=1148 XHG=1275 XHG=1415 XHG=1642 XHG=1726 XHG=1862 XHG=2090 XHG=2158 XHG=2244 XHG=2431 XHG=2490 YBD=1697 YBD=1698 YBD=1697YHG=1666>during YBD=1707 YBD=1698 YBD=1699 YHG=1666>their YHG=1666>virulence YHG=1665>and YHG=1665>resistance YHG=1675>more YHG=1666>than YHG=1667>two YHG=1666>outbreaks YHG=1676>are YHG=1667>easily YHG=1666>explicable YHG=1676>on YHG=1666>the YHG=1667>grounds YHG=1667>of YHG=1663>direct " XBD=2606 XBD=1569 XBD=1759 XBD=1906 XBD=1969 XBD=2028 XBD=2112 XBD=2312 XBD=2371 XHG=1414 XHG=1589 XHG=1779 XHG=1928 XHG=1989 XHG=2046 XHG=2130 XHG=2332 XHG=2389 YBD=1749 YBD=1743 YBD=1742 YBD=1744 YHG=1712>contact YHG=1711>between YHG=1712>cattle, YHG=1722>or YHG=1712>of YHG=1712>the YHG=1712>infection YHG=1711>of YHG=1711>food-stuffs XBD=326 XHG=949 XBD=589 XBD=651 XBD=742 XBD=926 XBD=988 XBD=1077 XBD=1224 XBD=1353 XHG=150 XHG=350 XHG=611 XHG=674 XHG=764 XHG=1010YBD=1742 XHG=1101 XHG=1273 YBD=1752YHG=1711>of YHG=1710>hundred YHG=1710>subcultures YHG=1710>in YHG=1710>the YHG=1711>absence YHG=1711>the YHG=1710>drug.l YHG=1710>The " XBD=2605 XBD=1456 XBD=1657 XBD=1722 XBD=1783 XBD=1871 XBD=2129 XBD=2192 XBD=2346 XBD=2412 XHG=1414 XHG=1477 XHG=1681 XHG=1745 XHG=1805 XHG=1893 XHG=2153 XHG=2212 XHG=2369 XHG=2433 YBD=1787YHG=1765>a YBD=1797 YBD=1788 YBD=1789 YHG=1765>or YHG=1756>bedding, YHG=1757>the YHG=1758>movements YHG=1757>of YHG=1756>people YHG=1766>or YHG=1756>vehicles. XBD=293 XHG=853 XBD=416 XBD=508 XBD=763 XBD=829 XBD=876 XBD=1080 XBD=1296 XBD=1353 XHG=150 XHG=317 XHG=441 XHG=532 XHG=789 XHG=901YBD=1786 XHG=1106 XHG=1321 YBD=1796 YBD=1787 YHG=1756>danger YHG=1755>from YHG=1755>the YHG=1755>production YHG=1755>of YHG=1756>resistant YHG=1756>organism YHG=1755>is XBD=440 XHG=808 XBD=529 XBD=726 XBD=788 XBD=874 XBD=1043 XBD=1103 XBD=1249 XBD=1300 XBD=1352 XHG=149 XHG=461 XHG=551 XHG=745 XHG=893YBD=1831 XHG=1063 XHG=1122 XHG=1268 XHG=1320 YBD=1841 YBD=1841 YBD=1831YHG=1800>the YHG=1799>unfortunately YHG=1801>not YHG=1800>confined YHG=1801>to YHG=1800>patient YHG=1801>in YHG=1801>whom YHG=1800>it YHG=1800>is " XBD=2603 XBD=1492 XBD=1625 XBD=1794 XBD=1973 XBD=2215 XBD=2484 XHG=1414 XHG=1517 XHG=1649 XHG=1816 XHG=1989 XHG=2241 XHG=2509 YBD=1832 YBD=1842 YBD=1838 YBD=1833 YHG=1801>But YHG=1802>there YHG=1802>remain YHG=1802>those YHG=1802>mysterious YHG=1801>outbreaks,&dquo; YHG=1801>from &dquo; XBD=355 XHG=763 XBD=438 XBD=526 XBD=742 XBD=841 XBD=1119 XBD=1182 XBD=1352 XHG=148 XHG=377 XHG=460 XHG=549 XHG=862YBD=1876 XHG=1143 XHG=1203 YBD=1885 YBD=1875 YBD=1877 YBD=1876YHG=1845>and YHG=1845>produced, YHG=1845>for YHG=1844>the YHG=1844>virulence YHG=1845>invasiveness YHG=1846>of YHG=1845>further " XBD=2601 XBD=1536 XBD=1621 XBD=1768 XBD=1851 XBD=2035 XBD=2263 XBD=2330 XBD=2449 XHG=1411 XHG=1556 XHG=1642 XHG=1788 XHG=1871 XHG=2057 XHG=2282 XHG=2350 XHG=2471 YBD=1877 YBD=1884 YBD=1887 YBD=1878 YHG=1845>which YHG=1846>the YHG=1846>others YHG=1856>are YHG=1846>derived, YHG=1847>occurring, YHG=1846>he YHG=1856>says, YHG=1846>almost XBD=387 XHG=877 XBD=501 XBD=611 XBD=746 XBD=801 XBD=863 XBD=919 XBD=1038 XBD=1095 XBD=1218 XBD=1272 XBD=1352 XHG=147 XHG=401 XHG=515 XHG=623 XHG=759 XHG=816 XHG=932YBD=1921 XHG=1054 XHG=1108 XHG=1232 XHG=1285 YBD=1931 YBD=1920 YBD=1930 YBD=1921YHG=1899>as YBD=1920 YHG=1889>generations YHG=1889>have YHG=1890>been YHG=1889>found YHG=1891>to YHG=1889>be YHG=1892>great YHG=1899>as YHG=1890>those YHG=1889>of YHG=1889>the " XBD=2603 XBD=1614 XBD=1714 XBD=1777 XBD=1876 XBD=1990 XBD=2052 XBD=2139 XBD=2264 XBD=2489 XHG=1413 XHG=1638 XHG=1736 XHG=1800 XHG=1898 XHG=2014 XHG=2073 XHG=2161 XHG=2287 XHG=2509 YBD=1930 YBD=1923 YBD=1932 YBD=1931 YBD=1922 YHG=1891>anywhere YHG=1891>and YHG=1892>at YHG=1900>any YHG=1892>time YHG=1891>of YHG=1891>the YHG=1901>year, YHG=1891>separated YHG=1891>from XBD=285 XHG=663 XBD=459 XBD=526 XBD=639 XBD=843 XBD=1076 XBD=1171 XBD=1242 XBD=1348 XHG=147 XHG=310 XHG=486 XHG=551 XHG=868YBD=1965 XHG=1100 XHG=1194 XHG=1264 YBD=1975 YBD=1970 YBD=1975 YBD=1965YHG=1934>resistant YBD=1974 YHG=1935>parent YHG=1934>strains, YHG=1943>so YHG=1934>that YHG=1934>organisms YHG=1944>can YHG=1934>be YHG=1943>pro" XBD=2604 XBD=1478 XBD=1659 XBD=1853 XBD=2010 XBD=2093 XBD=2315 XBD=2539 XHG=1412 XHG=1508 XHG=1688 XHG=1883 XHG=2040 XHG=2122 XHG=2345 XHG=2567 YBD=1966 YBD=1968 YBD=1976 YBD=1967 YHG=1934>the YHG=1937>nearest YHG=1935>infected YHG=1938>centre YHG=1936>by YHG=1936>(perhaps) YHG=1936>hundreds YHG=1936>of XBD=315 XHG=759 XBD=382 XBD=461 XBD=556 XBD=733 XBD=876 XBD=1051 XBD=1282 XBD=1351 XHG=147 XHG=343 XHG=411 XHG=489 XHG=584 XHG=928YBD=2019 XHG=1079 XHG=1312 YBD=2010 YBD=2009 YBD=2010 YBD=2018YHG=1988>ways. YBD=2009 YHG=1978>pagated YHG=1979>in YHG=1978>all YHG=1979>the YHG=1979>normal YHG=1978>Minor YHG=1979>epidemics YHG=1978>of " XBD=2490 XBD=1518 XBD=1583 XBD=1701 XBD=1789 XBD=1882 XBD=2091 XBD=2164 XBD=2302 XHG=1412 XHG=1541 XHG=1602 XHG=1722 XHG=1808 XHG=1905 XHG=2110 XHG=2186 XHG=2323 YBD=2011 YBD=2012 YBD=2020 YBD=2021 YBD=2013 YHG=1979>miles YHG=1990>or YHG=1980>from YHG=1980>the YHG=1980>last YHG=1981>outbreak YHG=1980>by YHG=1990>many YHG=1980>months. and XBD=242 XBD=469 XBD=586 XBD=813 XHG=147 XHG=261 XHG=487 XHG=606 YBD=2055 YBD=2064 YBD=2060 YHG=2023>such YHG=2023>organisms YHG=2023>have YHG=2024>occurred " XBD=1348 XBD=989 XBD=1080 XBD=1137 XBD=1221 XHG=1008 XHG=1099 XHG=1156 XHG=1240 YBD=2054 YBD=2064 YHG=2033>one YHG=2023>of YHG=2024>the YHG=2033>arguXBD=1514XHG=927 XBD=1687 XBD=1811 XBD=1951 XBD=2043 XBD=2249 XBD=2392 XBD=2462 XBD=2505 XBD=2604 XHG=1460YBD=2054 XHG=1534 XHG=1704 XHG=1827 XHG=1966 XHG=2060 XHG=2267 XHG=2411 XHG=2482 XHG=2523 YBD=2055YHG=2032>are YBD=2065 YBD=2056 YBD=2066 YBD=2057 YHG=2024>To YHG=2025>explain YHG=2025>these YHG=2025>initial YHG=2026>foci YHG=2025>Bullough YHG=2026>builds YHG=2035>up YHG=2036>a YHG=2034>case XBD=272 XHG=632 XBD=348 XBD=384 XBD=504 XBD=616 XBD=802 XBD=1031 XBD=1348 XHG=147 XHG=286 XHG=362 XHG=401 XHG=518 XHG=816YBD=2108 XHG=1083 YBD=2099 YBD=2107 YBD=2108YHG=2067>dressing YHG=2069>ments YHG=2068>for YHG=2078>a YHG=2077>more YHG=2067>rigid YHG=2068>technique. YHG=2067>Fortunately, " XBD=2605 XBD=1469 XBD=1556 XBD=1816 XBD=1984 XBD=2071 XBD=2249 XBD=2310 XBD=2353 XHG=1408 XHG=1487 XHG=1575 XHG=1836 XHG=2005 XHG=2092 XHG=2269 XHG=2331 XHG=2374 YBD=2100 YBD=2110 YBD=2111 YBD=2101 YBD=2102 YHG=2069>for YHG=2069>the YHG=2070>prosecution YHG=2070>against YHG=2070>the YHG=2070>starling YHG=2080>as YHG=2080>a YHG=2069>mechanical XBD=351 XHG=760 XBD=419 XBD=517 XBD=664 XBD=734 XBD=874 XBD=1024 XBD=1254 XBD=1348 XHG=145 XHG=377 XHG=447 XHG=544 XHG=694 XHG=901YBD=2153 XHG=1050 XHG=1282 YBD=2144 YBD=2143 YBD=2153 YBD=2144YHG=2113>drugs YBD=2143 YHG=2112>resistance YHG=2114>to YHG=2122>one YHG=2121>group YHG=2112>of YHG=2112>rarely YHG=2112>influences YHG=2112>the " XBD=2604 XBD=1547 XBD=1622 XBD=1761 XBD=1895 XBD=1961 XBD=2112 XBD=2233 XBD=2341 XBD=2406 XHG=1409 XHG=1562 XHG=1637 XHG=1778 XHG=1911 XHG=1976 XHG=2128 XHG=2251 XHG=2358 XHG=2421 YBD=2145 YBD=2147 YBD=2155 YBD=2146 YBD=2156 YHG=2113>carrier YHG=2114>for YHG=2114>which YHG=2124>many YHG=2124>an YHG=2115>honest YHG=2115>juror YHG=2125>may YHG=2115>be YHG=2113>prepared " XBD=1347 XBD=426 XBD=482 XBD=708 XBD=765 XBD=806 XBD=1005 XBD=1197 XHG=146 XHG=443 XHG=499 XHG=724 XHG=822 XHG=1022 XHG=1213 YBD=2198 YBD=2197 YBD=2188 YBD=2197 YHG=2157>susceptibility YHG=2157>of YHG=2157>organisms YHG=2159>to YHG=2156>radically YHG=2157>different YHG=2166>group, XBD=1450XHG=783 XBD=1634 XBD=1740 XBD=1870 XBD=1980 XBD=2030 XBD=2078 XBD=2162 XBD=2252 XBD=2446 XBD=2602 XHG=1408YBD=2188 XHG=1469 XHG=1686 XHG=1758 XHG=1887 XHG=1997 XHG=2047 XHG=2096 XHG=2181 XHG=2269 XHG=2464 YBD=2200YHG=2167>a YBD=2190 YBD=2191 YBD=2201 YHG=2160>to YHG=2159>convict. YHG=2159>To YHG=2159>begin YHG=2159>with YHG=2160>it YHG=2160>is YHG=2159>the YHG=2169>one YHG=2169>common YHG=2160>species XBD=294 XHG=765 XBD=437 XBD=537 XBD=729 XBD=997 XBD=1348 XHG=147 XHG=331 XHG=473 XHG=573 XHG=1051YBD=2243 YBD=2234 YBD=2242YHG=2203>exceptions. YHG=2202>though YHG=2202>there YHG=2211>are YHG=2202>notable YHG=2201>Sulphonamide " XBD=2602 XBD=1449 XBD=1635 XBD=1775 XBD=2024 XBD=2269 XBD=2341 XBD=2469 XHG=1409 XHG=1490 XHG=1671 XHG=1807 XHG=2058 XHG=2301 XHG=2375 XHG=2503 YBD=2235 YBD=2236 YBD=2245 YHG=2203>of YHG=2203>British YHG=2204>birds YHG=2204>intimately YHG=2205>associated YHG=2205>in YHG=2214>very YHG=2206>large XBD=361 XHG=924 XBD=581 XBD=631 XBD=736 XBD=907 XBD=977 XBD=1061 XBD=1347 XHG=145 XHG=380 XHG=600 XHG=649 XHG=753 XHG=994YBD=2287 XHG=1080 YBD=2284 YBD=2285 YBD=2279 YBD=2278 YBD=2287YHG=2247>by YHG=2246>resistance, YHG=2247>therefore, YHG=2247>is YHG=2247>best YHG=2247>tackled YHG=2247>the YHG=2246>development " XBD=2601 XBD=1589 XBD=1724 XBD=1920 XBD=2063 XBD=2223 XBD=2342 XBD=2513 XHG=1405 XHG=1629 XHG=1765 XHG=1960 XHG=2106 XHG=2266 XHG=2384 XHG=2564 YBD=2290 YBD=2286 YBD=2281 YBD=2280 YHG=2249>numbers YHG=2249>with YHG=2251>pasture YHG=2249>land, YHG=2249>farms YHG=2250>and YHG=2249>cattle. YHG=2250>It " XBD=1346 XBD=187 XBD=232 XBD=393 XBD=491 XBD=554 XBD=733 XBD=795 XBD=900 XBD=1190 XHG=146 XHG=210 XHG=256 XHG=415 XHG=514 XHG=577 XHG=754 XHG=924 XHG=1213 YBD=2322 YBD=2323 YBD=2323 YBD=2332 YHG=2292>of YHG=2301>a YHG=2292>second YHG=2292>line YHG=2293>of YHG=2292>defence YHG=2292>in YHG=2291>antibacterial YHG=2292>agents XBD=1626XHG=818 XBD=1753 XBD=1904 XBD=2054 XBD=2118 XBD=2206 XBD=2338 XBD=2439 XBD=2539 XBD=2600 XHG=1406YBD=2324 XHG=1649 XHG=1770 XHG=1927 XHG=2079 XHG=2140 XHG=2229 XHG=2362 XHG=2461 XHG=2563 YBD=2334YHG=2301>new YBD=2326 YBD=2325 YHG=2294>frequently YHG=2294>feeds YHG=2294>within YHG=2294>inches YHG=2294>the YHG=2303>noses YHG=2294>and YHG=2294>feet YHG=2294>of " XBD=1346 XBD=216 XBD=369 XBD=455 XBD=1134 XBD=1266 XHG=146 XHG=252 XHG=406 XHG=488 XHG=1174 XHG=1304 YBD=2367 YBD=2368 YBD=2378 YBD=2368 YHG=2337>not YHG=2336>based YHG=2347>on YHG=2336>p-aminobenzenesulphonamide, YHG=2336>such XBD=1475 XHG=2504 XBD=1643 XBD=1817 XBD=1909 XBD=2053 XBD=2110 XBD=2184 XBD=2240 XBD=2427 XBD=2491 XBD=2601 XHG=1408 YBD=2370 XHG=1481 XHG=1658 XHG=1832 XHG=1918 XHG=2070 XHG=2124 XHG=2192 XHG=2254 XHG=2441 YBD=2385 YHG=2345>as YBD=2369 YHG=2338>theperch YHG=2339>grazing YHG=2339>animals YHG=2339>and YHG=2339>will YHG=2347>so YHG=2338>far YHG=2348>as YHG=2338>to YHG=2348>on YHG=2338>their go XBD=1538 XBD=1638 XBD=1722 XBD=1873 XBD=1921 XBD=2019 XBD=2157 XBD=2279 XBD=2379 XBD=2465 XHG=1408 XHG=1591 XHG=1655 XHG=1738 XHG=1889 XHG=1938 XHG=2030 XHG=2174 XHG=2297 XHG=2398 XHG=2483 YBD=2416 YBD=2414 YBD=2415 YHG=2383>backs. YHG=2379>In YHG=2384>the YHG=2384>winter YHG=2384>it YHG=2379>will YHG=2383>follow YHG=2383>them YHG=2383>into YHG=2383>the YHG=2383>cattle " XBD=2598 XBD=336 XHG=528 XBD=434 XBD=506 XBD=735 XBD=1040 XBD=1220 XBD=1347 XHG=143 XHG=358 XHG=455 XHG=773YBD=2414 XHG=1060 XHG=1242 YBD=2421 YBD=2413 YBD=2414 YBD=2413YHG=2381>relations YHG=2380>penicillin YHG=2382>and YHG=2382>its YHG=2381>antibacterial YHG=2381>warfare : YHG=2382>must XBD=241 XHG=455 XBD=283 XBD=439 XBD=574 XHG=145 XHG=260 XHG=301 YBD=2466 YBD=2457 YHG=2425>keep YHG=2434>a YHG=2426>mobile " XBD=2599 XBD=1520 XBD=1621 XBD=1788 XBD=1849 XBD=1984 XBD=2225 XBD=2325 XBD=2457 XHG=1407YBD=2458 XHG=1544 XHG=1643 XHG=1810 XHG=1872 XHG=2005 XHG=2278 XHG=2347 XHG=2479 YBD=2469YHG=2426>front. YBD=2459 YBD=2460 YHG=2429>sheds YHG=2429>and YHG=2429>remain YHG=2429>in YHG=2428>equal YHG=2428>proximity. YHG=2428>In YHG=2428>other YHG=2427>words " XBD=2598 XBD=1474 XHG=2506 XBD=1665 XBD=1771 XBD=2038 XBD=2093 XBD=2219 XBD=2478 XHG=1406 YBD=2504 XHG=1503 XHG=1693 XHG=1800 XHG=2053 XHG=2121 XHG=2250 YBD=2505 YHG=2471>with YBD=2512 YBD=2503 YHG=2474>the YHG=2474>accused YHG=2483>was YHG=2472>certainly YHG=2472>in YHG=2473>close YHG=2473>association &dquo; ACTIVITY OF LIVER EXTRACTS &dquo; " XBD=2598 XBD=1472 XHG=2490 XBD=1719 XBD=1827 XBD=1904 XBD=2170 XBD=2236 XBD=2357 XBD=2461 XHG=1404 XHG=1500 XHG=1751 XHG=1853 XHG=1933 XHG=2196 XHG=2263 XHG=2384 YBD=2550 YBD=2549 YBD=2548 YBD=2557 YHG=2518>the YHG=2518>deceased YHG=2518>and YHG=2518>its YHG=2519>movements YHG=2517>in YHG=2517>time YHG=2517>and YHG=2525>space " XBD=2599 XBD=1509 XBD=1582 XBD=1780 XBD=1897 XBD=2049 XBD=2224 XBD=2365 XBD=2431 XBD=2512 XHG=1405 XHG=1534 XHG=1605 XHG=1803 XHG=1951 XHG=2072 XHG=2249 XHG=2389 XHG=2452 XHG=2535 YBD=2594 YBD=2602 YBD=2593 YBD=2592 YHG=2564>must YHG=2563>be YHG=2562>inquired YHG=2563>into. YHG=2561>Such YHG=2561>inquiry YHG=2562>bodes YHG=2561>ill YHG=2561>for YHG=2561>the XBD=279 XHG=664 XBD=391 XBD=464 XBD=502 XBD=593 XBD=648 XBD=731 XBD=1001 XBD=1181 XBD=1236 XBD=1344 XHG=194 XHG=295 XHG=405 XHG=479 XHG=516 XHG=609 XHG=746YBD=2593 XHG=1015 XHG=1197 XHG=1248 YBD=2592 YBD=2594 YBD=2603YHG=2561>the YHG=2561>THE YHG=2561>need YHG=2562>for YHG=2571>a YHG=2563>test YHG=2562>of YHG=2562>anti-ansemic YHG=2564>potency YHG=2563>of YHG=2563>liver XBD=312 XHG=880 XBD=417 XBD=547 XBD=613 XBD=776 XBD=861 XBD=929 XBD=1106 XBD=1167 XBD=1224 XBD=1342 XHG=142 XHG=330 XHG=435 XHG=566 XHG=631 XHG=794 XHG=948YBD=2638 XHG=1125 XHG=1183 XHG=1241 YBD=2637 YBD=2638 YBD=2639 YHG=2607>extracts YHG=2605>that YHG=2606>could YHG=2606>be YHG=2607>carried YHG=2608>out YHG=2616>on YHG=2606>animals YHG=2616>or YHG=2607>in YHG=2607>vitro " XBD=2597 XBD=1576 XBD=1831 XBD=1952 XBD=2140 XBD=2213 XBD=2344 XBD=2400 XBD=2465 XBD=2534 XHG=1404 XHG=1627 XHG=1853 XHG=1975 XHG=2163 XHG=2235 XHG=2367 XHG=2423 XHG=2487 XHG=2558 YBD=2646 YBD=2638 YBD=2637 YBD=2647 YBD=2636 YHG=2607>starling. YHG=2607>Migrating YHG=2606>from YHG=2606>Norway YHG=2606>its YHG=2606>habit YHG=2606>is YHG=2604>to YHG=2615>go YHG=2607>to " XBD=2597 XBD=1612 XBD=1749 XBD=1882 XBD=2011 XBD=2072 XBD=2161 XBD=2381 XBD=2435 XHG=1405 XHG=1650 XHG=1773 XHG=1903 XHG=2034 XHG=2094 XHG=2183 XHG=2403 XHG=2456 YBD=2689 YBD=2690 YBD=2682 YBD=2681 YBD=2691 YHG=2651>Scotland YHG=2652>from YHG=2651>other YHG=2652>parts YHG=2651>of YHG=2650>the YHG=2651>continent YHG=2650>it YHG=2650>prefers ; XBD=212 XHG=837 XBD=328 XBD=449 XBD=706 XBD=811 XBD=903 XBD=1090 XBD=1158 XBD=1205 XBD=1340 XHG=141 XHG=238 XHG=353 XHG=475 XHG=735 XHG=931YBD=2682 XHG=1116 XHG=1183 XHG=1232 YBD=2691 YBD=2692 YBD=2683 YBD=2683YHG=2651>the YHG=2651>has YHG=2651>long YHG=2650>been YHG=2651>recognised, YHG=2651>and YHG=2651>absence YHG=2652>of YHG=2661>a YHG=2651>satis" XBD=2595 XBD=291 XHG=833 XBD=389 XBD=480 XBD=631 XBD=741 XBD=812 XBD=985 XBD=1083 XBD=1384 XBD=1580 XBD=1672 XBD=1823 XBD=1954 XBD=2111 XBD=2157 XBD=2255 XBD=2309 XBD=2506 XHG=140 XHG=313 XHG=410 XHG=501 XHG=653 XHG=762 XHG=1006YBD=2729 XHG=1105 XHG=1402 XHG=1595 XHG=1686 XHG=1874 XHG=1969 XHG=2125 XHG=2172 XHG=2268 XHG=2326 XHG=2522 YBD=2736 YBD=2726 YBD=2727 YBD=2736YHG=2695>reliable YBD=2731 YBD=2727 YBD=2726 YHG=2696>factory YHG=2697>test YHG=2695>has YHG=2697>meant YHG=2695>that YHG=2705>no YHG=2695>enforceable YHG=2685>England YHG=2696>and YHG=2695>Wales. YHG=2695>The YHG=2695>disease YHG=2695>is YHG=2704>rare YHG=2696>in YHG=2695>Scotland YHG=2694>and " XBD=338 XBD=449 XBD=509 XBD=582 XBD=700 XBD=775 XBD=942 XBD=991 XBD=1208 XHG=140 XHG=356 XHG=468 XHG=525 XHG=599 XHG=716 XHG=792 XHG=960 XHG=1009 XHG=1259 YBD=2777 YBD=2771 YBD=2778 YBD=2772 YBD=2772 YBD=2771 YHG=2740>standard, YHG=2740>such YHG=2749>as YHG=2750>we YHG=2739>have YHG=2740>for YHG=2740>insulin, YHG=2740>is YHG=2740>available. YHG=2740>The |>"XBD=1340 XBD=1540 XBD=1916 XBD=2145 XBD=2229 XBD=2298 XBD=2513 XBD=2596 XBD=1837 XHG=1401 XHG=1875 XHG=1956 XHG=2198 XHG=2267 XHG=2337 XHG=2559 XHG=1579 YBD=2780 YBD=2770 YBD=2771 YHG=2741>almost YHG=2740>in YHG=2740>Norway YHG=2740>it YHG=2741>is YHG=2749>common YHG=2739>in YHG=2740>non-existent ; XBD=234 XHG=904 XBD=320 XBD=357 XBD=517 XBD=573 XBD=692 XBD=825 XBD=889 XBD=970 XBD=1121 XBD=1178 XBD=1340 XHG=140 XHG=250 XHG=336 XHG=373 XHG=533 XHG=587 XHG=707 XHG=839 XHG=985YBD=2817 XHG=1137 XHG=1191 YBD=2825 YBD=2816 YBD=2817 YHG=2785>USP YHG=2785>has YHG=2794>a YHG=2774>system YHG=2785>of YHG=2785>units YHG=2785>based YHG=2794>on YHG=2785>results YHG=2785>of YHG=2783>clinical " XBD=2594 XBD=1579 XBD=1693 XBD=1854 XBD=1968 XBD=2099 XBD=2312 XBD=2389 XHG=1401 XHG=1615 XHG=1729 XHG=1892 XHG=2006 XHG=2136 XHG=2348 XHG=2428 YBD=2826YHG=2785>the YBD=2817 YBD=2824 YBD=2816 YBD=2819 YHG=2785>England YHG=2785>and YHG=2784>Wales YHG=2784>and YHG=2794>very YHG=2794>common YHG=2785>in YHG=2784>Sweden, " XBD=2595 XBD=1605 XBD=1818 XBD=1914 XBD=2110 XBD=2236 XBD=2426 XBD=2484 XHG=1398 XHG=1627 XHG=1837 XHG=1934 XHG=2162 XHG=2254 XHG=2443 XHG=2506 YBD=2866 YBD=2870 YBD=2861 YHG=2829>Denmark, YHG=2829>Germany YHG=2830>and YHG=2829>Holland. YHG=2829>For YHG=2830>instance YHG=2829>in YHG=2829>1925 XBD=281 XHG=651 XBD=347 XBD=528 XBD=638 XBD=864 XBD=1052 XBD=1139 XBD=1222 XBD=1338 XHG=138 XHG=297 XHG=359 XHG=543 XHG=880YBD=2870 XHG=1068 XHG=1155 XHG=1236 YBD=2861 YBD=2866 YBD=2860YHG=2830>pernicious YHG=2830>testing YHG=2839>on YHG=2829>patients YHG=2829>with YHG=2830>anaemia, YHG=2829>but YHG=2829>the YHG=2828>basis "|>"XBD=2622 XBD=1465 XBD=1669 XBD=1726 XBD=1955 XBD=2147 XBD=2261 XBD=2375 XBD=2533 XHG=1398 XHG=1487 XHG=1686 XHG=1749 XHG=1970 XHG=2163 XHG=2285 XHG=2400 XHG=2556 YBD=2906 YBD=2915 YBD=2905 YBD=2911 YBD=2914 YHG=2874>the YHG=2874>numbers YHG=2874>of YHG=2874>outbreaks YHG=2874>reported YHG=2884>were YHG=2883>over YHG=2875>50,000 YHG=2873>in XBD=179 XBD=257 XBD=412 XBD=454 XBD=535 XBD=642 XBD=796 XBD=954 XBD=1060 XBD=1338 XHG=138 XHG=190 XHG=268 XHG=423 XHG=467 XHG=548 XHG=653 XHG=807 XHG=967 XHG=1072 YBD=2906 YBD=2905 YBD=2914 YBD=2915 YBD=2914 YBD=2913 YHG=2874>of YHG=2874>the YHG=2876>system YHG=2874>is YHG=2875>not YHG=2884>very YHG=2874>precise YHG=2874>though YHG=2874>they YHG=2873>undoubtedly "|>"XBD=2593 XBD=1606 XBD=1873 XBD=1931 XBD=2109 XBD=2207 XBD=2324 XBD=2382 XBD=1757 XHG=1397 XHG=1780 XHG=1891 XHG=1954 XHG=2130 XHG=2225 XHG=2341 XHG=2404 XHG=1625 YBD=2955 YBD=2950 YBD=2958 YBD=2959 YHG=2919>Denmark, YHG=2920>5000 YHG=2918>Sweden YHG=2918>and YHG=2928>none YHG=2919>in YHG=2919>Norway YHG=2918>nearly; XBD=223 XBD=264 XBD=403 XBD=532 XBD=592 XBD=678 XBD=846 XBD=1135 XBD=1265 XBD=1337 XHG=136 XHG=242 XHG=281 XHG=419 XHG=550 XHG=611 XHG=697 XHG=896 XHG=1154 XHG=1283 YBD=2958 YBD=2949 YBD=2959 YBD=2957 YBD=2957 YBD=2956 YHG=2919>give YHG=2928>a YHG=2918>rough YHG=2918>guide YHG=2920>to YHG=2918>the YHG=2919>dosage. YHG=2918>Laboratory YHG=2927>assay YHG=2917>by " XBD=2594 XBD=1504 XBD=1618 XBD=1704 XBD=1926 XBD=1981 XBD=2175 XBD=2267 XBD=2409 XBD=2503 XBD=2541 XHG=1396 XHG=1519 XHG=1634 XHG=1722 XHG=1942 XHG=1999 XHG=2191 XHG=2283 XHG=2425 XHG=2520 XHG=2556 YBD=3003 YBD=2994 YBD=2995 YBD=2993 YHG=2963>there YHG=2971>were YHG=2963>232 YHG=2963>outbreaks YHG=2962>in YHG=2963>England YHG=2963>Wales YHG=2963>and YHG=2965>0 YHG=2963>in XBD=334 XHG=920 XBD=423 XBD=695 XBD=896 XBD=961 XBD=1080 XBD=1272 XBD=1336 XHG=136 XHG=356 XHG=446 XHG=719 XHG=985YBD=2992 XHG=1104 XHG=1295 YBD=3003 YBD=2993 YBD=3005 YBD=3002 YBD=2992 YBD=2992YHG=2964>to YHG=2963>recording YHG=2962>the YHG=2962>reticulocyte YHG=2971>response YHG=2962>liver YHG=2963>extracts YHG=2961>in " XBD=2593 XBD=1593 XBD=1825 XBD=1955 XBD=2032 XBD=2224 XBD=2389 XBD=2479 XHG=1397 XHG=1645 XHG=1849 XHG=1980 XHG=2054 XHG=2249 XHG=2441 XHG=2505 YBD=3044 YBD=3039 YBD=3047 YHG=3007>Scotland. YHG=3007>Observe, YHG=3008>next, YHG=3008>its YHG=3007>roosting YHG=3007>habits. YHG=3007>It YHG=3015>may XBD=355 XHG=875 XBD=457 XBD=636 XBD=731 XBD=851 XBD=986 XBD=1083 XBD=1175 XBD=1335 XHG=134 XHG=380 XHG=481 XHG=661 XHG=755 XHG=1011YBD=3042 XHG=1107 XHG=1197 YBD=3047 YBD=3046 YBD=3037 YBD=3036YHG=3006>tried, YHG=3007>guineapigs YHG=3006>and YHG=3000>pigeons YHG=3007>has YHG=3007>been YHG=3005>but YHG=3005>the YHG=3005>results XBD=231 XHG=840 XBD=321 XBD=483 XBD=820 XBD=940 XBD=1109 XBD=1333 XHG=133 XHG=253 XHG=344 XHG=505 XHG=962YBD=3080 XHG=1129 YBD=3082 YBD=3081 YBD=3089 YBD=3090 YBD=3081 YBD=3080YHG=3050>from YHG=3060>were YHG=3052>not YHG=3049>clearly YHG=3050>distinguishable YHG=3048>normal YHG=3050>variation. " XBD=2592 XBD=1449 XBD=1591 XBD=1718 XBD=1763 XBD=1860 XBD=1978 XBD=2049 XBD=2220 XBD=2407 XBD=2469 XHG=1394 XHG=1470 XHG=1611 XHG=1739 XHG=1784 XHG=1879 XHG=1999 XHG=2069 XHG=2239 XHG=2427 XHG=2490 YBD=3091 YBD=3092 YBD=3083 YHG=3051>fly YHG=3052>40-50 YHG=3051>miles YHG=3061>a YHG=3052>day YHG=3052>from YHG=3052>its YHG=3051>feeding YHG=3052>grounds YHG=3053>to YHG=3052>roost XBD=356 XHG=743 XBD=421 XBD=720 XBD=923 XBD=1111 XBD=1256 XBD=1334 XHG=135 XHG=381 XHG=445 XHG=946YBD=3125 XHG=1136 XHG=1280 YBD=3133 YBD=3133 YBD=3124YHG=3094>anaemias YHG=3095>Treatment YHG=3094>of YHG=3094>experimental YHG=3093>brought YHG=3094>about YHG=3094>by " XBD=2589 XBD=1546 XBD=1739 XBD=1793 XBD=1986 XBD=2093 XBD=2211 XBD=2461 XHG=1394 XHG=1561 XHG=1752 XHG=1809 XHG=1999 XHG=2108 XHG=2232 XHG=2475 YBD=3136 YBD=3128 YBD=3127 YBD=3133 YBD=3132 YHG=3095>nightly YHG=3098>to YHG=3095>shoulder YHG=3096>with YHG=3104>some YHG=3097>50-100,000 YHG=3096>birds, XBD=352 XHG=775 XBD=518 XBD=626 XBD=737 XBD=871 XBD=1109 XBD=1181 XBD=1331 XHG=134 XHG=385 XHG=556 XHG=658 XHG=899YBD=3168 XHG=1139 XHG=1209 YBD=3178 YBD=3177 YBD=3168YHG=3138>been YBD=3178 YHG=3139>hsemolytic YHG=3139>agents YHG=3138>has YHG=3138>also YHG=3136>unhelpful, YHG=3147>as YHG=3138>might " XBD=2592 XBD=1445 XBD=1681 XBD=1959 XBD=2043 XBD=2133 XBD=2324 XBD=2389 XHG=1394 XHG=1471 XHG=1707 XHG=1983 XHG=2067 XHG=2159 XHG=2349 XHG=2413 YBD=3181 YBD=3171 YBD=3172 YBD=3173 YHG=3149>an YHG=3140>admirable YHG=3140>opportunity YHG=3140>for YHG=3140>the YHG=3140>transfer YHG=3141>of YHG=3140>infective XBD=233 XHG=739 XBD=359 XBD=576 XBD=709 XBD=839 XBD=1078 XBD=1140 XBD=1333 XHG=133 XHG=263 XHG=389 XHG=606 XHG=867YBD=3212 XHG=1108 XHG=1171 YBD=3221 YBD=3213 YBD=3221 YBD=3212YHG=3181>their YBD=3220 YHG=3183>have YHG=3183>been YHG=3181>expected YHG=3181>since YHG=3182>pathology YHG=3181>is YHG=3180>entirely " XBD=2591 XBD=1537 XBD=1632 XBD=1864 XBD=2107 XBD=2351 XBD=2400 XHG=1393 XHG=1555 XHG=1658 XHG=1881 XHG=2126 XHG=2377 XHG=2418 YBD=3215 YBD=3224 YBD=3216 YBD=3217 YHG=3185>matter YHG=3185>and YHG=3185>another YHG=3184>mysterious YHG=3184>outbreak YHG=3194>a YHG=3185>hundred &dquo; &dquo; "|>"XBD=1332 XBD=309 XBD=428 XBD=662 XBD=948 XBD=1037 XBD=856XHG=878 XHG=133 XHG=330 XHG=448 XHG=967 XHG=1058 XHG=684YBD=3256 YBD=3257 YBD=3265 YBD=3256 YBD=3261 YBD=3264 YHG=3226>different YHG=3226>from YHG=3224>pernicious YHG=3225>has YHG=3225>ansemia, YHG=3224>experimental XBD=1498 XBD=1643 XBD=1837 XBD=1889 XBD=2016 XBD=2158 XBD=2269 XBD=2386 XBD=2520 XBD=2591 XHG=1392 XHG=1520 XHG=1695 XHG=1850 XHG=1909 XHG=2036 XHG=2170 XHG=2289 XHG=2408 XHG=2540 YBD=3268YHG=3235>nor YBD=3259 YBD=3260 YBD=3269 YHG=3228>miles YHG=3237>away. YHG=3228>Counts YHG=3229>of YHG=3228>these YHG=3230>roosts YHG=3228>have YHG=3229>been YHG=3229>made YHG=3230>by XBD=463 XHG=509 XBD=669 XBD=1069 XBD=1329 XHG=131 XHG=715YBD=3299 XHG=1113 YBD=3309 YBD=3308 YBD=3300YHG=3268>difficult YHG=3271>gastrectomy―a YHG=3268>procedure-been YHG=3268>successful. " XBD=2590 XBD=1677 XBD=1765 XBD=1844 XBD=1903 XBD=1963 XBD=2088 XBD=2143 XBD=2226 XBD=2416 XBD=2473 XHG=1391 XHG=1688 XHG=1781 XHG=1861 XHG=1914 XHG=1972 XHG=2105 XHG=2160 XHG=2236 XHG=2433 XHG=2488 YBD=3312 YBD=3302 YBD=3303 YBD=3304 YHG=3272>ornithologists YHG=3273>and YHG=3273>act YHG=3281>as YHG=3281>an YHG=3272>index YHG=3272>the YHG=3273>numbers YHG=3273>of YHG=3273>birds Fisher XBD=230 XHG=611 XBD=334 XBD=584 XBD=838 XBD=1047 XBD=1173 XBD=1331 XHG=130 XHG=257 XHG=503 XHG=866 XHG=1074 XHG=1200 YBD=3343 YBD=3342 YBD=3346 YBD=3351 YBD=3343YHG=3311>Richmond, YHG=3313>Pace YHG=3312>and YHG=3311>3 YHG=3312>Virginia, YHG=3311>have YHG=3313>drawn of " XBD=2591 XBD=1597 XBD=1749 XBD=1823 XBD=1950 XBD=2119 XBD=2193 XBD=2291 XBD=2429 XHG=1391 XHG=1629 XHG=1782 XHG=1855 XHG=1983 XHG=2153 XHG=2225 XHG=2325 XHG=2480 YBD=3355 YBD=3346 YBD=3347 YBD=3356 YBD=3348 YHG=3316>travelling YHG=3316>about YHG=3316>in YHG=3315>each YHG=3316>month YHG=3316>of YHG=3317>the YHG=3326>year. YHG=3317>Their " XBD=1330 XBD=324 XBD=398 XBD=456 XBD=650 XBD=796 XBD=1013 XHG=130 XHG=356 XHG=433 XHG=492 XHG=829 XHG=1047 YBD=3387 YBD=3386 YBD=3386 YBD=3387 YHG=3356>attention YHG=3357>to YHG=3365>a YHG=3355>method YHG=3356>standard YHG=3356>tissue-culture XBD=1517XHG=684 XBD=1772 XBD=1850 XBD=1954 XBD=2103 XBD=2231 XBD=2401 XBD=2589 XHG=1391YBD=3395 XHG=1556 XHG=1811 XHG=1886 XHG=1991 XHG=2140 XHG=2269 XHG=2439 YBD=3396YHG=3355>using YBD=3390 YBD=3400 YBD=3392 YBD=3401 YBD=3399 YHG=3360>trend, YHG=3359>gentlemen YHG=3359>of YHG=3360>the YHG=3360>Jury, YHG=3370>runs YHG=3361>nearly YHG=3360>exactly " XBD=1329 XBD=345 XBD=578 XBD=807 XBD=891 XBD=989 XBD=1132 XHG=129 XHG=378 XHG=611 XHG=838 XHG=1023 XHG=1164 YBD=3438 YBD=3437 YBD=3431 YHG=3399>technique, YHG=3399>originally YHG=3399>described YHG=3399>by YHG=3399>Swiss YHG=3400>workers XBD=1547XHG=923 XBD=1677 XBD=1780 XBD=1994 XBD=2222 XBD=2299 XBD=2589 XHG=1388YBD=3429 XHG=1583 XHG=1714 XHG=1818 XHG=2029 XHG=2259 XHG=2336 YBD=3443YHG=3399>the YBD=3434 YBD=3436 YBD=3435 YBD=3444 YHG=3403>parallel YHG=3403>with YHG=3403>the YHG=3403>monthly YHG=3404>incidence YHG=3404>of YHG=3404>unexplained " XBD=2587 XBD=1609 XBD=1809 XBD=2026 XBD=2228 XBD=2342 XBD=2406 XHG=1390 XHG=1662 XHG=1836 XHG=2051 XHG=2253 XHG=2365 XHG=2433 YBD=3478 YBD=3487 YBD=3488 YBD=3480 YBD=3479 YHG=3446>outbreaks. YHG=3446>Lastly, YHG=3447>Bullough YHG=3448>observes YHG=3448>that YHG=3448>in YHG=3448>Sweden 1. Schmidt, L. H., Sesler, C. and Dettwiler, H. A. J. Pharmacol. 1942, 74, 175. " XBD=2588 XBD=1457 XBD=1659 XBD=1732 XBD=1911 XBD=1985 XBD=2184 XBD=2294 XBD=2476 XHG=1389 XHG=1499 XHG=1700 XHG=1775 XHG=1945 XHG=2021 XHG=2216 XHG=2328 XHG=2512 YBD=3531 YHG=3490>and YBD=3525 YBD=3522 YBD=3527 YBD=3521 YHG=3490>the YHG=3490>starling YHG=3490>is YHG=3490>absent YHG=3491>in YHG=3493>autumn YHG=3492>and YHG=3492>winter, 2. Francis, A. E. Lancet, 1942, i. 408. 3. Pace, N. and Fisher, R. S. J. Pharmacol. 1942, 74, 256.
1. Communicated to the
AGAINST THE
Royal Society, April 23,
&dquo;
1942.
" XBD=2622 XBD=1636 XHG=2464 XBD=1839 XBD=1909 XBD=2056 XBD=2155 XBD=2286 XBD=2445 XHG=1428 YBD=295 XHG=1661 XHG=1862 XHG=1930 XHG=2077 XHG=2176 XHG=2338 YBD=292 YBD=297 YBD=287 YHG=255>Overbeek, YHG=255>Gaillard, YHG=256>de YHG=256>Jongh YHG=257>and YHG=257>Yam. YHG=255>They YHG=255>planted Annotations " XBD=2621 XBD=1492 XHG=2599 XBD=1620 XBD=1844 XBD=1901 XBD=2192 XBD=2306 XBD=2388 XBD=2529 XBD=2583 XHG=1425 YBD=330 XHG=1510 XHG=1636 XHG=1862 XHG=1916 XHG=2207 XHG=2323 XHG=2405 XHG=2545 YBD=339 YHG=309>a YBD=331 YBD=329 YHG=301>out YHG=299>small YHG=300>fragments YHG=300>of YHG=300>bone-marrow YHG=301>from YHG=299>the YHG=300>femur YHG=299>of " XBD=2620 XBD=1627 XHG=2506 XBD=1737 XBD=1790 XBD=1985 XBD=2055 XBD=2285 XBD=2474 XHG=1423 XHG=1656 XHG=1769 XHG=1822 XHG=2017 XHG=2084 XHG=2313 YBD=374 YHG=342>saline YBD=375 YBD=384 YBD=383 YBD=373 YHG=343>guineapig YHG=343>into YHG=351>a YHG=344>mixture YHG=344>of YHG=344>guineapig YHG=343>plasma, RESISTANCE SULPHONAMIDE " XBD=2617 XBD=1501 XHG=2601 XBD=1697 XBD=1749 XBD=1857 XBD=2039 XBD=2212 XBD=2325 XBD=2360 XBD=2418 XBD=2529 XBD=2584 XHG=1425 YBD=417 XHG=1514 XHG=1710 XHG=1763 XHG=1872 XHG=2054 XHG=2226 XHG=2345 XHG=2379 XHG=2436 XHG=2545 YBD=428 YHG=388>1 YBD=418 YBD=416 YHG=386>and YHG=385>dilutions YHG=387>of YHG=387>liver YHG=389>extracts YHG=388>ranging YHG=388>from YHG=389>1 YHG=387>in YHG=388>5000 YHG=388>to " XBD=293 XBD=372 XBD=621 XBD=675 XBD=976 XBD=1151 XHG=211 XHG=306 XHG=385 XHG=634 XHG=987 XHG=1164 YBD=448 YBD=449 YBD=460 YBD=450 YBD=460 YBD=461 YHG=422>ALL YHG=422>the YHG=422>advantages YHG=422>of YHG=422>therapy YHG=422>disappear " XBD=1365 XBD=1464XHG=687 XBD=1647 XBD=1813 XBD=1933 XBD=2122 XBD=2358 XBD=2413 XBD=2514 XBD=2619 XHG=1423YBD=459 XHG=1481 XHG=1699 XHG=1827 XHG=1947 XHG=2137 XHG=2374 XHG=2427 XHG=2529 YBD=467YHG=422>sulphonamide YBD=471 YBD=472 YBD=461 YBD=462 YHG=431>in YHG=431>150,000. YHG=431>From YHG=430>these YHG=431>explants YHG=431>migrations YHG=431>of YHG=430>cells YHG=430>took XBD=274 XHG=821 XBD=336 XBD=554 XBD=783 XBD=853 XBD=1158 XBD=1275 XBD=1364 XHG=163 XHG=313 XHG=372 XHG=593 XHG=891YBD=494 XHG=1198 XHG=1314 YBD=493 YBD=503 YBD=501 YBD=495YHG=463>is YHG=461>when YHG=471>a YHG=462>resistant YHG=463>organism YHG=464>encountered, YHG=464>and YHG=474>an "" XBD=2617 XBD=1531 XBD=1619 XBD=1731 XBD=1791 XBD=2164 XBD=2242 XBD=2343 XBD=2393 XBD=2473 XHG=1423 XHG=1542 XHG=1633 XHG=1749 XHG=1805 XHG=2176 XHG=2257 XHG=2354 XHG=2407 XHG=2486 YBD=506 YBD=505 YBD=514 YHG=473>place YHG=474>and YHG=474>after YHG=476>15 YHG=475>hours’ YHG=475>the YHG=484>area YHG=474>of YHG=474>the YHG=474>migraincubation " XBD=1363 XBD=395 XBD=525 XBD=587 XBD=679 XBD=737 XBD=820 XBD=1145 XBD=1194 XHG=161 XHG=410 XHG=545 XHG=607 XHG=697 XHG=838 XHG=1163 XHG=1212 YBD=546 YBD=538 YBD=547 YBD=540 YBD=548 YHG=506>organism YHG=506>fast YHG=508>to YHG=516>one YHG=508>of YHG=507>the YHG=507>sulphonamides YHG=508>is YHG=508>usually &dquo; &dquo; XBD=1505XHG=752 XBD=1608 XBD=1698 XBD=1920 XBD=2010 XBD=2100 XBD=2232 XBD=2333 XBD=2440 XBD=2618 XHG=1423 XHG=1518 XHG=1619 XHG=1712 XHG=1972 XHG=2022 XHG=2112 XHG=2245 XHG=2345 XHG=2453 YBD=550 YBD=549 YHG=519>tion YHG=517>field YHG=525>was YHG=518>measured. YHG=519>It YHG=528>was YHG=518>found YHG=519>that YHG=517>liver YHG=519>extracts "" XBD=1361 XBD=239 XBD=310 XBD=392 XBD=489 XBD=739 XBD=862 XBD=1007 XBD=1078 XBD=1184 XHG=159 XHG=269 XHG=343 XHG=422 XHG=520 XHG=768 XHG=893 XHG=1038 XHG=1106 XHG=1213 YBD=580 YBD=581 YBD=591 YBD=583 YBD=592 YBD=583 YBD=592 YHG=550>fast YHG=551>to YHG=550>all YHG=551>the YHG=551>commonly YHG=552>used YHG=552>drugs YHG=552>of YHG=552>this YHG=561>group ; XBD=1648 XHG=2460 XBD=1861 XBD=1949 XBD=2046 XBD=2163 XBD=2250 XBD=2284 XBD=2449 XBD=2618 XHG=1424 YBD=601 XHG=1659 XHG=1873 XHG=1959 XHG=2056 XHG=2172 XHG=2262 XHG=2295 YBD=602 YHG=561>optimal YBD=594 YBD=592 YBD=593 YHG=561>stimulated YHG=562>migration YHG=562>and YHG=562>that YHG=562>there YHG=571>was YHG=570>a YHG=562>definite XBD=229 XHG=907 XBD=427 XBD=554 XBD=672 XBD=762 XBD=884 XBD=957 XBD=1362 XHG=161 XHG=253 XHG=449 XHG=577 XHG=694 XHG=784 XHG=986YBD=627 YBD=625 YBD=626 YBD=636 YHG=593>the YHG=594>clinician YHG=596>must YHG=595>then YHG=595>fall YHG=595>back YHG=595>pre-sulphonamide "" XBD=2615 XBD=1588 XBD=1640 XBD=1774 XBD=1849 XBD=1998 XBD=2212 XBD=2310 XBD=2397 XHG=1424 XHG=1599 XHG=1650 XHG=1784 XHG=1859 XHG=2010 XHG=2221 XHG=2320 XHG=2408 YBD=637YHG=605>on YBD=645 YBD=636 YBD=646 YHG=606>dilution YHG=607>at YHG=606>which YHG=606>the YHG=605>largest YHG=605>migration YHG=605>field YHG=614>was YHG=606>produced; " XBD=1360 XBD=294 XBD=409 XBD=471 XBD=713 XBD=810 XBD=973 XBD=1122 XHG=160 XHG=316 XHG=430 XHG=493 XHG=733 XHG=992 XHG=1174 YBD=679 YBD=669 YBD=670 YBD=671 YBD=680 YBD=671 YBD=680 YHG=639>agents YHG=638>such YHG=648>as YHG=639>acriflavine YHG=640>and YHG=639>crystal YHG=639>violet. YHG=639>DevelopXBD=1584XHG=831 XBD=1670 XBD=1833 XBD=2011 XBD=2081 XBD=2248 XBD=2305 XBD=2447 XBD=2506 XBD=2615 XHG=1421 XHG=1603 XHG=1687 XHG=1848 XHG=2032 XHG=2098 XHG=2265 XHG=2330 XHG=2467 XHG=2525 YBD=686 YBD=681 YHG=650>further, YHG=650>the YHG=649>more YHG=650>active YHG=658>an YHG=651>extract YHG=650>in YHG=651>terms YHG=649>of YHG=649>USP &dquo; &dquo; "" XBD=1361 XBD=265 XBD=323 XBD=629 XBD=850 XBD=1010 XBD=1093 XBD=1213 XHG=159 XHG=282 XHG=339 XHG=644 XHG=865 XHG=1026 XHG=1109 XHG=1230 YBD=714 YBD=724 YBD=716 YBD=719 YBD=715 YHG=683>ment YHG=682>of YHG=682>sulphonamide YHG=684>resistance YHG=684>follows YHG=683>the YHG=693>same YHG=693>course XBD=1526 XBD=1617 XBD=1793 XBD=1886 XBD=2078 XBD=2252 XBD=2317 XBD=2514 XBD=2615 XHG=1421 XHG=1551 XHG=1644 XHG=1820 XHG=1916 XHG=2107 XHG=2275 XHG=2346 XHG=2543 YBD=726 YBD=735 YBD=724 YBD=733 YBD=725 YHG=695>units YHG=694>the YHG=696>greater YHG=693>the YHG=693>dilution YHG=694>needed YHG=696>to YHG=694>produce YHG=693>this " XBD=201 XBD=418 XBD=472 XBD=598 XBD=877 XBD=1123 XBD=1214 XBD=1300 XHG=158 XHG=213 XHG=430 XHG=488 XHG=890 XHG=1176 XHG=1228 XHG=1312 YBD=759 YBD=759 YBD=759 YHG=736>as YHG=726>resistance YHG=729>to YHG=728>other YHG=728>substances. YHG=729>It YHG=737>can YHG=728>be " XBD=1361 XBD=1584XHG=611 XBD=1817 XBD=2001 XBD=2113 XBD=2209 XBD=2304 XBD=2526 XBD=2611 XHG=1422YBD=760 XHG=1602 XHG=1862 XHG=2020 XHG=2130 XHG=2227 XHG=2322 XHG=2548 YBD=774YHG=728>antibacterial YBD=778 YBD=769 YBD=777 YBD=771 YHG=738>optimal YHG=738>migration. YHG=738>Hence, YHG=737>they YHG=747>say, YHG=738>this YHG=738>technique YHG=747>can " XBD=1360 XBD=354 XBD=696 XBD=815 XBD=879 XBD=991 XBD=1094 XBD=1157 XBD=1282 XHG=158 XHG=377 XHG=718 XHG=838 XHG=902 XHG=1017 XHG=1116 XHG=1181 XHG=1306 YBD=812 YBD=813 YBD=803 YBD=811 YBD=802 YBD=803 YBD=813 YHG=772>produced YHG=772>experimentally YHG=773>both YHG=773>in YHG=772>vivo YHG=772>and YHG=772>in YHG=772>vitro XBD=1469 XHG=2459 XBD=1574 XBD=1624 XBD=1843 XBD=1916 XBD=2086 XBD=2130 XBD=2452 XBD=2615 XHG=1411 YBD=812 XHG=1478 XHG=1584 XHG=1636 XHG=1850 XHG=1923 XHG=2093 XHG=2141 YBD=821 YHG=772>by YHG=779>be YHG=782>used YHG=781>to YHG=782>determine YHG=782>the YHG=781>activity YHG=782>of YHG=782>anti-pernicious YHG=782>anaemia, " XBD=1357 XBD=378 XBD=596 XBD=652 XBD=931 XBD=968 XBD=1210 XHG=157 XHG=391 XHG=610 XHG=667 XHG=946 XHG=983 XHG=1226 YBD=848 YBD=857 YBD=847 YBD=856 YBD=857 YHG=816>repeatedly YHG=816>passaging YHG=826>or YHG=816>subculturing YHG=826>a YHG=815>susceptible XBD=1514 XHG=2472 XBD=1702 XBD=1761 XBD=1888 XBD=1983 XBD=2093 XBD=2224 XBD=2328 XBD=2374 XBD=2456 XBD=2615 XHG=1419 YBD=866 XHG=1533 XHG=1721 XHG=1775 XHG=1907 XHG=1999 XHG=2103 XHG=2240 XHG=2344 XHG=2389 YBD=858 YHG=826>organYBD=862 YHG=826>liver YHG=827>extracts YHG=826>in YHG=826>vitro, YHG=825>and YHG=825>they YHG=825>found YHG=826>that YHG=826>if YHG=826>the YHG=825>clinical XBD=230 XHG=695 XBD=298 XBD=392 XBD=598 XBD=668 XBD=905 XBD=1238 XBD=1308 XBD=1359 XHG=157 XHG=257 XHG=326 XHG=420 XHG=628 XHG=934YBD=902 XHG=1268 XHG=1336 YBD=892 YBD=901 YBD=893 YBD=892 YBD=892YHG=861>increasing YBD=891 YHG=861>ism YHG=861>in YHG=861>the YHG=870>presence YHG=861>of YHG=860>concentrations YHG=861>of YHG=870>a " XBD=2615 XBD=1588 XBD=1644 XBD=1715 XBD=1880 XBD=1974 XBD=2313 XBD=2383 XBD=2543 XHG=1419 XHG=1604 XHG=1665 XHG=1731 XHG=1896 XHG=1993 XHG=2330 XHG=2400 XHG=2559 YBD=902 YBD=911 YBD=910 YBD=901 YHG=872>potency YHG=871>of YHG=880>an YHG=872>extract YHG=879>was YHG=870>destroyed-say YHG=870>by YHG=870>boiling YHG=870>for " XBD=1358 XBD=460 XBD=736 XBD=945 XBD=1168 XBD=1268 XHG=145 XHG=514 XHG=968 XHG=1191 XHG=1292 YBD=946 YBD=938 YBD=946 YBD=936 YHG=905>,sulphonamide. YHG=906>Resistance YHG=905>gradually YHG=905>and YHG=905>the XBD=1469XHG=759 XBD=1590 XBD=1707 XBD=1800 XBD=2017 XBD=2240 XBD=2612 XHG=1420YBD=937 XHG=1491 XHG=1611 XHG=1731 XHG=1825 XHG=2040 XHG=2264 YBD=947YHG=905>increases YBD=948 YBD=955 YBD=946 YBD=956 YHG=925>an YHG=916>hour YHG=915>with YHG=915>2% YHG=914>sulphuric YHG=914>acid-the YHG=915>migration-stimu" XBD=1356 XBD=250 XBD=396 XBD=474 XBD=562 XBD=771 XBD=1099 XBD=1169 XHG=157 XHG=276 XHG=423 XHG=501 XHG=586 XHG=798 XHG=1126 XHG=1194 YBD=982 YBD=985 YBD=981 YBD=988 YBD=991 YBD=981 YBD=990 YHG=950>final YHG=950>strain YHG=950>of, YHG=950>for YHG=950>instance, YHG=959>pneumococcus YHG=959>or XBD=1541 XHG=2541 XBD=1777 XBD=1901 XBD=2006 XBD=2250 XBD=2421 XBD=2512 XBD=2614 XHG=1418 YBD=991 XHG=1567 XHG=1803 XHG=1928 XHG=2036 XHG=2301 XHG=2448 YBD=1001YHG=951>streptoYBD=992 YBD=1000 YHG=969>were YHG=959>also YHG=959>There YHG=968>are YHG=959>still YHG=960>lating YHG=960>properties YHG=959>destroyed. " XBD=2613 XBD=290 XHG=738 XBD=404 XBD=474 XBD=717 XBD=780 XBD=1001 XBD=1207 XBD=1270 XBD=1358 XHG=156 XHG=313 XHG=425 XHG=494 XHG=803YBD=1027 XHG=1023 XHG=1231 XHG=1291 YBD=1028 YBD=1035 YBD=1026 YBD=1027 YBD=1026YHG=996>to YHG=1004>coccus YHG=1005>may YHG=995>be YHG=995>insensitive YHG=995>saturated YHG=994>solutions YHG=995>of YHG=995>the XBD=1537 XBD=1689 XBD=1754 XBD=1826 XBD=2060 XBD=2187 XBD=2392 XBD=2517 XHG=1420 XHG=1560 XHG=1713 XHG=1778 XHG=1848 XHG=2112 XHG=2208 XHG=2417 XHG=2541 YBD=1045 YBD=1041 YBD=1035 YBD=1036 YHG=1014>many YHG=1005>points YHG=1006>to YHG=1005>be YHG=1003>explained. YHG=1005>For YHG=1005>instance, YHG=1004>Pace YHG=1004>and " XBD=1355 XBD=283 XBD=547 XBD=661 XBD=884 XBD=944 XBD=1082 XBD=1211 XHG=157 XHG=337 XHG=566 XHG=679 XHG=965 XHG=1101 XHG=1230 YBD=1081 YBD=1080 YBD=1072 YBD=1071 YBD=1080 YBD=1070 YBD=1080 YHG=1040>drugs. YHG=1040>Compared YHG=1040>with YHG=1040>resistance YHG=1049>many YHG=1039>other YHG=1039>drugs, XBD=1551XHG=903 XBD=1620 XBD=1709 XBD=1900 XBD=1986 XBD=2141 XBD=2200 XBD=2286 XBD=2510 XBD=2613 XHG=1419YBD=1070 XHG=1572 XHG=1640 XHG=1731 XHG=1919 XHG=2005 XHG=2162 XHG=2218 XHG=2306 XHG=2530 YBD=1081YHG=1041>to YBD=1089 YHG=1049>Fisher YHG=1049>do YHG=1050>not YHG=1049>mention YHG=1050>nature YHG=1049>of YHG=1049>the YHG=1049>migrating YHG=1049>cells " XBD=1357 XBD=446 XBD=671 XBD=723 XBD=833 XBD=893 XBD=1131 XBD=1183 XHG=156 XHG=465 XHG=690 XHG=742 XHG=852 XHG=913 XHG=1150 XHG=1203 YBD=1125 YBD=1116 YBD=1116 YBD=1116 YHG=1084>sulphonamide YHG=1084>resistance YHG=1084>is YHG=1094>easy YHG=1086>to YHG=1083>induce-it YHG=1084>is XBD=1612 XHG=2504 XBD=1742 XBD=1834 XBD=1989 XBD=2100 XBD=2217 XBD=2306 XBD=2480 XBD=2611 XHG=1420 YBD=1125 XHG=1636 XHG=1764 XHG=1858 XHG=2014 XHG=2124 XHG=2242 XHG=2330 YBD=1126 YHG=1084>evident YBD=1134 YBD=1133 YHG=1094>(previous YHG=1094>work YHG=1093>has YHG=1094>shown YHG=1094>that YHG=1093>they YHG=1103>are YHG=1093>usually YHG=1093>fibroXBD=197 XHG=898 XBD=307 XBD=415 XBD=515 XBD=591 XBD=803 XBD=869 XBD=967 XBD=1247 XBD=1356 XHG=155 XHG=225 XHG=338 XHG=443 XHG=542 XHG=619 XHG=830 XHG=998YBD=1166 XHG=1300 YBD=1161 YBD=1160 YBD=1160 YBD=1159 YHG=1130>in YHG=1139>one, YHG=1129>and YHG=1138>can YHG=1129>be YHG=1129>maximal YHG=1129>in YHG=1129>six, YHG=1129>subcultures. YHG=1129>Its "" XBD=2612 XBD=1539 XBD=1647 XBD=2082 XBD=2366 XBD=2482 XHG=1419 XHG=1571 XHG=1676 XHG=2109 XHG=2412 XHG=2510 YBD=1179 YBD=1169 YBD=1170 YHG=1138>blasts YHG=1139>and YHG=1138>polymorphonuclear YHG=1138>leucocytes) YHG=1147>nor YHG=1138>what ; "" XBD=1355 XBD=379 XBD=551 XBD=874 XBD=1070 XBD=1133 XHG=154 XHG=414 XHG=906 XHG=1101 XHG=1166 YBD=1206 YBD=1214 YBD=1205 YHG=1183>occurrence YHG=1173>during YHG=1173>therapy YHG=1173>is YHG=1173>therefore XBD=1582XHG=584 XBD=1700 XBD=1925 XBD=2041 XBD=2101 XBD=2191 XBD=2473 XBD=2609 XHG=1419YBD=1214 XHG=1600 XHG=1715 XHG=1942 XHG=2060 XHG=2122 XHG=2207 XHG=2492 YBD=1215YHG=1173>sulphonamide YBD=1214 YBD=1224 YBD=1223 YHG=1183>relation YHG=1183>their YHG=1184>properties YHG=1183>have YHG=1184>to YHG=1183>the YHG=1181>pathology-of YHG=1184>perni" XBD=1355 XBD=275 XBD=557 XBD=725 XBD=829 XBD=1004 XBD=1265 XHG=156 XHG=311 XHG=608 XHG=865 XHG=1039 XHG=1303 YBD=1259 YBD=1250 YBD=1250 YBD=1259 YBD=1257 YHG=1218>easily YHG=1218>understood. YHG=1218>From YHG=1218>known YHG=1219>procedures YHG=1217>by XBD=1522XHG=761 XBD=1722 XBD=1847 XBD=2006 XBD=2361 XBD=2473 XBD=2608 XHG=1419YBD=1249 XHG=1536 XHG=1748 XHG=1859 XHG=2019 XHG=2373 XHG=2486 YBD=1266YHG=1218>the YBD=1268 YBD=1260 YHG=1227>cious ; also YHG=1228>anaemia YHG=1227>their YHG=1228>control YHG=1228>experiments YHG=1231>seem YHG=1228>inadeXBD=278 XHG=644 XBD=333 XBD=387 XBD=621 XBD=958 XBD=1054 XBD=1188 XBD=1355 XHG=153 XHG=301 XHG=355 XHG=412 XHG=982YBD=1304 XHG=1076 XHG=1211 YBD=1296 YBD=1295 YBD=1294 YBD=1294YHG=1263>experimentally YHG=1263>which YHG=1263>it YHG=1264>is YHG=1262>developed YHG=1273>one YHG=1263>could YHG=1262>deduce " XBD=2606 XBD=1547 XBD=1678 XBD=1769 XBD=1951 XBD=2048 XBD=2256 XBD=2379 XHG=1418 XHG=1599 XHG=1702 XHG=1793 XHG=1972 XHG=2072 XHG=2278 XHG=2402 YBD=1312 YBD=1304 YBD=1305 YBD=1313 YHG=1274>quate. YHG=1273>But YHG=1273>the YHG=1272>method YHG=1272>will YHG=1272>certainly YHG=1272>have YHG=1272>important "" XBD=1354 XBD=244 XBD=476 XBD=632 XBD=710 XBD=840 XBD=984 XBD=1055 XBD=1132 XHG=153 XHG=270 XHG=504 XHG=661 XHG=740 XHG=1013 XHG=1085 XHG=1161 YBD=1340 YBD=1339 YBD=1339 YBD=1348 YHG=1309>that YHG=1308>resistance YHG=1307>would YHG=1308>be YHG=1309>most YHG=1309>to YHG=1307>be YHG=1307>produced XBD=1670XHG=868 XBD=1723 XBD=1894 XBD=2022 XBD=2168 XBD=2222 XBD=2288 XBD=2361 XBD=2607 XHG=1417YBD=1348 XHG=1693 XHG=1746 XHG=1916 XHG=2046 XHG=2191 XHG=2247 XHG=2313 XHG=2386 YBD=1358YHG=1307>likely YBD=1348 YBD=1349 YBD=1359 YHG=1312>applications YHG=1317>if YHG=1317>further YHG=1317>work YHG=1316>shows YHG=1317>it YHG=1318>to YHG=1317>be YHG=1318>sufficiently " XBD=1353 XBD=263 XBD=307 XBD=482 XBD=578 XBD=682 XBD=816 XBD=947 XBD=1075 XBD=1137 XBD=1224 XHG=152 XHG=284 XHG=328 XHG=499 XHG=597 XHG=702 XHG=837 XHG=968 XHG=1098 XHG=1157 XHG=1246 YBD=1385 YBD=1394 YBD=1388 YBD=1393 YBD=1384 YBD=1384 YBD=1384 YBD=1393 YHG=1353>when YHG=1362>a YHG=1353>patient YHG=1361>was YHG=1353>first YHG=1352>given YHG=1352>small YHG=1352>doses YHG=1353>of YHG=1353>the XBD=1596 XHG=2525 XBD=1702 XBD=1945 XBD=2045 XBD=2195 XBD=2260 XBD=2433 XBD=2502 XBD=2608 XHG=1416 YBD=1394 XHG=1634 XHG=1725 XHG=1968 XHG=2070 XHG=2218 XHG=2284 XHG=2456 YBD=1401 YHG=1352>drug, YBD=1397 YBD=1395 YHG=1361>reliable; YHG=1362>the YHG=1361>Weil-Felix YHG=1362>test YHG=1370>serves YHG=1363>to YHG=1362>remind YHG=1372>us YHG=1362>that XBD=329 XHG=879 XBD=409 XBD=459 XBD=645 XBD=850 XBD=956 XBD=1076 XBD=1134 XBD=1228 XBD=1352 XHG=152 XHG=355 XHG=436 XHG=485 XHG=671 XHG=984YBD=1429 XHG=1103 XHG=1162 XHG=1255 YBD=1430 YBD=1439 YBD=1438 YBD=1434 YBD=1429 YBD=1429YHG=1397>and YBD=1428 YHG=1397>followed YHG=1397>by YHG=1407>a YHG=1397>gradual YHG=1397>increase, YHG=1397>such YHG=1397>is YHG=1397>the YHG=1406>case. " XBD=2608 XBD=1540 XBD=1649 XBD=1754 XBD=1811 XBD=1945 XBD=1998 XBD=2111 XBD=2293 XHG=1415 XHG=1553 XHG=1664 XHG=1764 XHG=1824 XHG=1957 XHG=2012 XHG=2123 XHG=2306 YBD=1439 YBD=1447 YBD=1438 YBD=1437 YBD=1448 YBD=1440 YHG=1407>useful YHG=1408>tests YHG=1416>may YHG=1406>be YHG=1406>found YHG=1407>in YHG=1408>most YHG=1406>unlikely YHG=1407>circumstances. " XBD=1353 XBD=285 XHG=848 XBD=374 XBD=566 XBD=825 XBD=887 XBD=1072 XBD=1233 XHG=156 XHG=306 XHG=396 XHG=586 XHG=909YBD=1473 XHG=1095 XHG=1254 YBD=1474 YBD=1482 YBD=1474 YBD=1483YHG=1442>of YBD=1473 YHG=1442>Hence YHG=1443>the YHG=1443>extreme YHG=1442>importance YHG=1442>massive YHG=1442>dosage YHG=1442>from CIRCUMSTANTIAL EVIDENCE " XBD=1351 XBD=111 XHG=477 XBD=222 XBD=378 XBD=447 XBD=788 XBD=1000 XBD=1147 XHG=108 XHG=153 XHG=250 XHG=407 XHG=840YBD=1527 XHG=1030 XHG=1175 YBD=1525 YBD=1523 YBD=1519 YBD=1528 YBD=1528YHG=1487>chemotherapy. YBD=1523 YHG=1521>, YHG=1488>the YHG=1488>outset YHG=1488>in YHG=1487>Though YHG=1487>easily YHG=1486>induced, STARLING " XBD=1352 XBD=357 XHG=915 XBD=431 XBD=776 XBD=881 XBD=963 XBD=1089 XHG=151 XHG=390 XHG=466 XHG=810 XHG=995YBD=1563 XHG=1120 YBD=1564 YBD=1572 YBD=1572 YBD=1572YHG=1532>be YHG=1532>resistance YHG=1534>to YHG=1532>sulphonamides YHG=1541>can YHG=1542>very YHG=1533>persistent; XBD=177 XHG=601 XBD=341 XBD=531 XBD=581 XBD=641 XBD=1066 XBD=1354 XHG=152 XHG=195 XHG=358 XHG=549 XHG=660YBD=1607 XHG=1084 YBD=1617 YBD=1608 YBD=1617 YHG=1587>a YHG=1576>typical YHG=1576>instance YHG=1576>is YHG=1576>sulphapyridine-fast YHG=1576>pneumococci " XBD=2609 XBD=1511 XBD=1560 XBD=1788 XBD=1876 XBD=2032 XBD=2094 XBD=2443 XHG=1464 XHG=1536 XHG=1713 XHG=1809 XHG=1898 XHG=2054 XHG=2113 XHG=2466 YBD=1617YHG=1576>of YBD=1608 YBD=1609 YHG=1576>IN YHG=1586>a YHG=1576>1 YHG=1577>the YHG=1577>spread YHG=1577>of YHG=1577>foot-and-mouth YHG=1578>disease of study XBD=347 XHG=697 XBD=512 XBD=565 XBD=667 XBD=935 XBD=1087 XBD=1353 XHG=151 XHG=375 XHG=541 XHG=593 XHG=963YBD=1652 XHG=1116 YBD=1661 YBD=1653 YBD=1653 YHG=1621>produced YHG=1621>during YHG=1630>a YHG=1620>few YHG=1621>which YHG=1620>maintained " XBD=2610 XBD=1474 XBD=1541 XBD=1757 XBD=1910 XBD=2003 XBD=2115 XBD=2206 XBD=2337 XBD=2546 XHG=1414 XHG=1503 XHG=1569 XHG=1782 XHG=1936 XHG=2028 XHG=2140 XHG=2231 XHG=2364 XHG=2571 YBD=1652YHG=1621>subcultures YBD=1653 YBD=1663 YBD=1662 YBD=1654 YHG=1621>W. YHG=1621>S. YHG=1621>Bullough YHG=1622>points YHG=1623>out YHG=1621>that YHG=1622>the YHG=1624>great YHG=1622>majority YHG=1622>of " XBD=2628 XBD=252 XHG=848 XBD=472 XBD=581 XBD=817 XBD=984 XBD=1117 XBD=1245 XBD=1352 XBD=1622 XBD=1705 XBD=1841 XBD=2069 XBD=2139 XBD=2224 XBD=2411 XBD=2470 XHG=151 XHG=281 XHG=503 XHG=611 XHG=1014YBD=1707 XHG=1148 XHG=1275 XHG=1415 XHG=1642 XHG=1726 XHG=1862 XHG=2090 XHG=2158 XHG=2244 XHG=2431 XHG=2490 YBD=1697 YBD=1698 YBD=1697YHG=1666>during YBD=1707 YBD=1698 YBD=1699 YHG=1666>their YHG=1666>virulence YHG=1665>and YHG=1665>resistance YHG=1675>more YHG=1666>than YHG=1667>two YHG=1666>outbreaks YHG=1676>are YHG=1667>easily YHG=1666>explicable YHG=1676>on YHG=1666>the YHG=1667>grounds YHG=1667>of YHG=1663>direct " XBD=2606 XBD=1569 XBD=1759 XBD=1906 XBD=1969 XBD=2028 XBD=2112 XBD=2312 XBD=2371 XHG=1414 XHG=1589 XHG=1779 XHG=1928 XHG=1989 XHG=2046 XHG=2130 XHG=2332 XHG=2389 YBD=1749 YBD=1743 YBD=1742 YBD=1744 YHG=1712>contact YHG=1711>between YHG=1712>cattle, YHG=1722>or YHG=1712>of YHG=1712>the YHG=1712>infection YHG=1711>of YHG=1711>food-stuffs XBD=326 XHG=949 XBD=589 XBD=651 XBD=742 XBD=926 XBD=988 XBD=1077 XBD=1224 XBD=1353 XHG=150 XHG=350 XHG=611 XHG=674 XHG=764 XHG=1010YBD=1742 XHG=1101 XHG=1273 YBD=1752YHG=1711>of YHG=1710>hundred YHG=1710>subcultures YHG=1710>in YHG=1710>the YHG=1711>absence YHG=1711>the YHG=1710>drug.l YHG=1710>The " XBD=2605 XBD=1456 XBD=1657 XBD=1722 XBD=1783 XBD=1871 XBD=2129 XBD=2192 XBD=2346 XBD=2412 XHG=1414 XHG=1477 XHG=1681 XHG=1745 XHG=1805 XHG=1893 XHG=2153 XHG=2212 XHG=2369 XHG=2433 YBD=1787YHG=1765>a YBD=1797 YBD=1788 YBD=1789 YHG=1765>or YHG=1756>bedding, YHG=1757>the YHG=1758>movements YHG=1757>of YHG=1756>people YHG=1766>or YHG=1756>vehicles. XBD=293 XHG=853 XBD=416 XBD=508 XBD=763 XBD=829 XBD=876 XBD=1080 XBD=1296 XBD=1353 XHG=150 XHG=317 XHG=441 XHG=532 XHG=789 XHG=901YBD=1786 XHG=1106 XHG=1321 YBD=1796 YBD=1787 YHG=1756>danger YHG=1755>from YHG=1755>the YHG=1755>production YHG=1755>of YHG=1756>resistant YHG=1756>organism YHG=1755>is XBD=440 XHG=808 XBD=529 XBD=726 XBD=788 XBD=874 XBD=1043 XBD=1103 XBD=1249 XBD=1300 XBD=1352 XHG=149 XHG=461 XHG=551 XHG=745 XHG=893YBD=1831 XHG=1063 XHG=1122 XHG=1268 XHG=1320 YBD=1841 YBD=1841 YBD=1831YHG=1800>the YHG=1799>unfortunately YHG=1801>not YHG=1800>confined YHG=1801>to YHG=1800>patient YHG=1801>in YHG=1801>whom YHG=1800>it YHG=1800>is " XBD=2603 XBD=1492 XBD=1625 XBD=1794 XBD=1973 XBD=2215 XBD=2484 XHG=1414 XHG=1517 XHG=1649 XHG=1816 XHG=1989 XHG=2241 XHG=2509 YBD=1832 YBD=1842 YBD=1838 YBD=1833 YHG=1801>But YHG=1802>there YHG=1802>remain YHG=1802>those YHG=1802>mysterious YHG=1801>outbreaks,&dquo; YHG=1801>from &dquo; XBD=355 XHG=763 XBD=438 XBD=526 XBD=742 XBD=841 XBD=1119 XBD=1182 XBD=1352 XHG=148 XHG=377 XHG=460 XHG=549 XHG=862YBD=1876 XHG=1143 XHG=1203 YBD=1885 YBD=1875 YBD=1877 YBD=1876YHG=1845>and YHG=1845>produced, YHG=1845>for YHG=1844>the YHG=1844>virulence YHG=1845>invasiveness YHG=1846>of YHG=1845>further " XBD=2601 XBD=1536 XBD=1621 XBD=1768 XBD=1851 XBD=2035 XBD=2263 XBD=2330 XBD=2449 XHG=1411 XHG=1556 XHG=1642 XHG=1788 XHG=1871 XHG=2057 XHG=2282 XHG=2350 XHG=2471 YBD=1877 YBD=1884 YBD=1887 YBD=1878 YHG=1845>which YHG=1846>the YHG=1846>others YHG=1856>are YHG=1846>derived, YHG=1847>occurring, YHG=1846>he YHG=1856>says, YHG=1846>almost XBD=387 XHG=877 XBD=501 XBD=611 XBD=746 XBD=801 XBD=863 XBD=919 XBD=1038 XBD=1095 XBD=1218 XBD=1272 XBD=1352 XHG=147 XHG=401 XHG=515 XHG=623 XHG=759 XHG=816 XHG=932YBD=1921 XHG=1054 XHG=1108 XHG=1232 XHG=1285 YBD=1931 YBD=1920 YBD=1930 YBD=1921YHG=1899>as YBD=1920 YHG=1889>generations YHG=1889>have YHG=1890>been YHG=1889>found YHG=1891>to YHG=1889>be YHG=1892>great YHG=1899>as YHG=1890>those YHG=1889>of YHG=1889>the " XBD=2603 XBD=1614 XBD=1714 XBD=1777 XBD=1876 XBD=1990 XBD=2052 XBD=2139 XBD=2264 XBD=2489 XHG=1413 XHG=1638 XHG=1736 XHG=1800 XHG=1898 XHG=2014 XHG=2073 XHG=2161 XHG=2287 XHG=2509 YBD=1930 YBD=1923 YBD=1932 YBD=1931 YBD=1922 YHG=1891>anywhere YHG=1891>and YHG=1892>at YHG=1900>any YHG=1892>time YHG=1891>of YHG=1891>the YHG=1901>year, YHG=1891>separated YHG=1891>from XBD=285 XHG=663 XBD=459 XBD=526 XBD=639 XBD=843 XBD=1076 XBD=1171 XBD=1242 XBD=1348 XHG=147 XHG=310 XHG=486 XHG=551 XHG=868YBD=1965 XHG=1100 XHG=1194 XHG=1264 YBD=1975 YBD=1970 YBD=1975 YBD=1965YHG=1934>resistant YBD=1974 YHG=1935>parent YHG=1934>strains, YHG=1943>so YHG=1934>that YHG=1934>organisms YHG=1944>can YHG=1934>be YHG=1943>pro" XBD=2604 XBD=1478 XBD=1659 XBD=1853 XBD=2010 XBD=2093 XBD=2315 XBD=2539 XHG=1412 XHG=1508 XHG=1688 XHG=1883 XHG=2040 XHG=2122 XHG=2345 XHG=2567 YBD=1966 YBD=1968 YBD=1976 YBD=1967 YHG=1934>the YHG=1937>nearest YHG=1935>infected YHG=1938>centre YHG=1936>by YHG=1936>(perhaps) YHG=1936>hundreds YHG=1936>of XBD=315 XHG=759 XBD=382 XBD=461 XBD=556 XBD=733 XBD=876 XBD=1051 XBD=1282 XBD=1351 XHG=147 XHG=343 XHG=411 XHG=489 XHG=584 XHG=928YBD=2019 XHG=1079 XHG=1312 YBD=2010 YBD=2009 YBD=2010 YBD=2018YHG=1988>ways. YBD=2009 YHG=1978>pagated YHG=1979>in YHG=1978>all YHG=1979>the YHG=1979>normal YHG=1978>Minor YHG=1979>epidemics YHG=1978>of " XBD=2490 XBD=1518 XBD=1583 XBD=1701 XBD=1789 XBD=1882 XBD=2091 XBD=2164 XBD=2302 XHG=1412 XHG=1541 XHG=1602 XHG=1722 XHG=1808 XHG=1905 XHG=2110 XHG=2186 XHG=2323 YBD=2011 YBD=2012 YBD=2020 YBD=2021 YBD=2013 YHG=1979>miles YHG=1990>or YHG=1980>from YHG=1980>the YHG=1980>last YHG=1981>outbreak YHG=1980>by YHG=1990>many YHG=1980>months. and XBD=242 XBD=469 XBD=586 XBD=813 XHG=147 XHG=261 XHG=487 XHG=606 YBD=2055 YBD=2064 YBD=2060 YHG=2023>such YHG=2023>organisms YHG=2023>have YHG=2024>occurred " XBD=1348 XBD=989 XBD=1080 XBD=1137 XBD=1221 XHG=1008 XHG=1099 XHG=1156 XHG=1240 YBD=2054 YBD=2064 YHG=2033>one YHG=2023>of YHG=2024>the YHG=2033>arguXBD=1514XHG=927 XBD=1687 XBD=1811 XBD=1951 XBD=2043 XBD=2249 XBD=2392 XBD=2462 XBD=2505 XBD=2604 XHG=1460YBD=2054 XHG=1534 XHG=1704 XHG=1827 XHG=1966 XHG=2060 XHG=2267 XHG=2411 XHG=2482 XHG=2523 YBD=2055YHG=2032>are YBD=2065 YBD=2056 YBD=2066 YBD=2057 YHG=2024>To YHG=2025>explain YHG=2025>these YHG=2025>initial YHG=2026>foci YHG=2025>Bullough YHG=2026>builds YHG=2035>up YHG=2036>a YHG=2034>case XBD=272 XHG=632 XBD=348 XBD=384 XBD=504 XBD=616 XBD=802 XBD=1031 XBD=1348 XHG=147 XHG=286 XHG=362 XHG=401 XHG=518 XHG=816YBD=2108 XHG=1083 YBD=2099 YBD=2107 YBD=2108YHG=2067>dressing YHG=2069>ments YHG=2068>for YHG=2078>a YHG=2077>more YHG=2067>rigid YHG=2068>technique. YHG=2067>Fortunately, " XBD=2605 XBD=1469 XBD=1556 XBD=1816 XBD=1984 XBD=2071 XBD=2249 XBD=2310 XBD=2353 XHG=1408 XHG=1487 XHG=1575 XHG=1836 XHG=2005 XHG=2092 XHG=2269 XHG=2331 XHG=2374 YBD=2100 YBD=2110 YBD=2111 YBD=2101 YBD=2102 YHG=2069>for YHG=2069>the YHG=2070>prosecution YHG=2070>against YHG=2070>the YHG=2070>starling YHG=2080>as YHG=2080>a YHG=2069>mechanical XBD=351 XHG=760 XBD=419 XBD=517 XBD=664 XBD=734 XBD=874 XBD=1024 XBD=1254 XBD=1348 XHG=145 XHG=377 XHG=447 XHG=544 XHG=694 XHG=901YBD=2153 XHG=1050 XHG=1282 YBD=2144 YBD=2143 YBD=2153 YBD=2144YHG=2113>drugs YBD=2143 YHG=2112>resistance YHG=2114>to YHG=2122>one YHG=2121>group YHG=2112>of YHG=2112>rarely YHG=2112>influences YHG=2112>the " XBD=2604 XBD=1547 XBD=1622 XBD=1761 XBD=1895 XBD=1961 XBD=2112 XBD=2233 XBD=2341 XBD=2406 XHG=1409 XHG=1562 XHG=1637 XHG=1778 XHG=1911 XHG=1976 XHG=2128 XHG=2251 XHG=2358 XHG=2421 YBD=2145 YBD=2147 YBD=2155 YBD=2146 YBD=2156 YHG=2113>carrier YHG=2114>for YHG=2114>which YHG=2124>many YHG=2124>an YHG=2115>honest YHG=2115>juror YHG=2125>may YHG=2115>be YHG=2113>prepared " XBD=1347 XBD=426 XBD=482 XBD=708 XBD=765 XBD=806 XBD=1005 XBD=1197 XHG=146 XHG=443 XHG=499 XHG=724 XHG=822 XHG=1022 XHG=1213 YBD=2198 YBD=2197 YBD=2188 YBD=2197 YHG=2157>susceptibility YHG=2157>of YHG=2157>organisms YHG=2159>to YHG=2156>radically YHG=2157>different YHG=2166>group, XBD=1450XHG=783 XBD=1634 XBD=1740 XBD=1870 XBD=1980 XBD=2030 XBD=2078 XBD=2162 XBD=2252 XBD=2446 XBD=2602 XHG=1408YBD=2188 XHG=1469 XHG=1686 XHG=1758 XHG=1887 XHG=1997 XHG=2047 XHG=2096 XHG=2181 XHG=2269 XHG=2464 YBD=2200YHG=2167>a YBD=2190 YBD=2191 YBD=2201 YHG=2160>to YHG=2159>convict. YHG=2159>To YHG=2159>begin YHG=2159>with YHG=2160>it YHG=2160>is YHG=2159>the YHG=2169>one YHG=2169>common YHG=2160>species XBD=294 XHG=765 XBD=437 XBD=537 XBD=729 XBD=997 XBD=1348 XHG=147 XHG=331 XHG=473 XHG=573 XHG=1051YBD=2243 YBD=2234 YBD=2242YHG=2203>exceptions. YHG=2202>though YHG=2202>there YHG=2211>are YHG=2202>notable YHG=2201>Sulphonamide " XBD=2602 XBD=1449 XBD=1635 XBD=1775 XBD=2024 XBD=2269 XBD=2341 XBD=2469 XHG=1409 XHG=1490 XHG=1671 XHG=1807 XHG=2058 XHG=2301 XHG=2375 XHG=2503 YBD=2235 YBD=2236 YBD=2245 YHG=2203>of YHG=2203>British YHG=2204>birds YHG=2204>intimately YHG=2205>associated YHG=2205>in YHG=2214>very YHG=2206>large XBD=361 XHG=924 XBD=581 XBD=631 XBD=736 XBD=907 XBD=977 XBD=1061 XBD=1347 XHG=145 XHG=380 XHG=600 XHG=649 XHG=753 XHG=994YBD=2287 XHG=1080 YBD=2284 YBD=2285 YBD=2279 YBD=2278 YBD=2287YHG=2247>by YHG=2246>resistance, YHG=2247>therefore, YHG=2247>is YHG=2247>best YHG=2247>tackled YHG=2247>the YHG=2246>development " XBD=2601 XBD=1589 XBD=1724 XBD=1920 XBD=2063 XBD=2223 XBD=2342 XBD=2513 XHG=1405 XHG=1629 XHG=1765 XHG=1960 XHG=2106 XHG=2266 XHG=2384 XHG=2564 YBD=2290 YBD=2286 YBD=2281 YBD=2280 YHG=2249>numbers YHG=2249>with YHG=2251>pasture YHG=2249>land, YHG=2249>farms YHG=2250>and YHG=2249>cattle. YHG=2250>It " XBD=1346 XBD=187 XBD=232 XBD=393 XBD=491 XBD=554 XBD=733 XBD=795 XBD=900 XBD=1190 XHG=146 XHG=210 XHG=256 XHG=415 XHG=514 XHG=577 XHG=754 XHG=924 XHG=1213 YBD=2322 YBD=2323 YBD=2323 YBD=2332 YHG=2292>of YHG=2301>a YHG=2292>second YHG=2292>line YHG=2293>of YHG=2292>defence YHG=2292>in YHG=2291>antibacterial YHG=2292>agents XBD=1626XHG=818 XBD=1753 XBD=1904 XBD=2054 XBD=2118 XBD=2206 XBD=2338 XBD=2439 XBD=2539 XBD=2600 XHG=1406YBD=2324 XHG=1649 XHG=1770 XHG=1927 XHG=2079 XHG=2140 XHG=2229 XHG=2362 XHG=2461 XHG=2563 YBD=2334YHG=2301>new YBD=2326 YBD=2325 YHG=2294>frequently YHG=2294>feeds YHG=2294>within YHG=2294>inches YHG=2294>the YHG=2303>noses YHG=2294>and YHG=2294>feet YHG=2294>of " XBD=1346 XBD=216 XBD=369 XBD=455 XBD=1134 XBD=1266 XHG=146 XHG=252 XHG=406 XHG=488 XHG=1174 XHG=1304 YBD=2367 YBD=2368 YBD=2378 YBD=2368 YHG=2337>not YHG=2336>based YHG=2347>on YHG=2336>p-aminobenzenesulphonamide, YHG=2336>such XBD=1475 XHG=2504 XBD=1643 XBD=1817 XBD=1909 XBD=2053 XBD=2110 XBD=2184 XBD=2240 XBD=2427 XBD=2491 XBD=2601 XHG=1408 YBD=2370 XHG=1481 XHG=1658 XHG=1832 XHG=1918 XHG=2070 XHG=2124 XHG=2192 XHG=2254 XHG=2441 YBD=2385 YHG=2345>as YBD=2369 YHG=2338>theperch YHG=2339>grazing YHG=2339>animals YHG=2339>and YHG=2339>will YHG=2347>so YHG=2338>far YHG=2348>as YHG=2338>to YHG=2348>on YHG=2338>their go XBD=1538 XBD=1638 XBD=1722 XBD=1873 XBD=1921 XBD=2019 XBD=2157 XBD=2279 XBD=2379 XBD=2465 XHG=1408 XHG=1591 XHG=1655 XHG=1738 XHG=1889 XHG=1938 XHG=2030 XHG=2174 XHG=2297 XHG=2398 XHG=2483 YBD=2416 YBD=2414 YBD=2415 YHG=2383>backs. YHG=2379>In YHG=2384>the YHG=2384>winter YHG=2384>it YHG=2379>will YHG=2383>follow YHG=2383>them YHG=2383>into YHG=2383>the YHG=2383>cattle " XBD=2598 XBD=336 XHG=528 XBD=434 XBD=506 XBD=735 XBD=1040 XBD=1220 XBD=1347 XHG=143 XHG=358 XHG=455 XHG=773YBD=2414 XHG=1060 XHG=1242 YBD=2421 YBD=2413 YBD=2414 YBD=2413YHG=2381>relations YHG=2380>penicillin YHG=2382>and YHG=2382>its YHG=2381>antibacterial YHG=2381>warfare : YHG=2382>must XBD=241 XHG=455 XBD=283 XBD=439 XBD=574 XHG=145 XHG=260 XHG=301 YBD=2466 YBD=2457 YHG=2425>keep YHG=2434>a YHG=2426>mobile " XBD=2599 XBD=1520 XBD=1621 XBD=1788 XBD=1849 XBD=1984 XBD=2225 XBD=2325 XBD=2457 XHG=1407YBD=2458 XHG=1544 XHG=1643 XHG=1810 XHG=1872 XHG=2005 XHG=2278 XHG=2347 XHG=2479 YBD=2469YHG=2426>front. YBD=2459 YBD=2460 YHG=2429>sheds YHG=2429>and YHG=2429>remain YHG=2429>in YHG=2428>equal YHG=2428>proximity. YHG=2428>In YHG=2428>other YHG=2427>words " XBD=2598 XBD=1474 XHG=2506 XBD=1665 XBD=1771 XBD=2038 XBD=2093 XBD=2219 XBD=2478 XHG=1406 YBD=2504 XHG=1503 XHG=1693 XHG=1800 XHG=2053 XHG=2121 XHG=2250 YBD=2505 YHG=2471>with YBD=2512 YBD=2503 YHG=2474>the YHG=2474>accused YHG=2483>was YHG=2472>certainly YHG=2472>in YHG=2473>close YHG=2473>association &dquo; ACTIVITY OF LIVER EXTRACTS &dquo; " XBD=2598 XBD=1472 XHG=2490 XBD=1719 XBD=1827 XBD=1904 XBD=2170 XBD=2236 XBD=2357 XBD=2461 XHG=1404 XHG=1500 XHG=1751 XHG=1853 XHG=1933 XHG=2196 XHG=2263 XHG=2384 YBD=2550 YBD=2549 YBD=2548 YBD=2557 YHG=2518>the YHG=2518>deceased YHG=2518>and YHG=2518>its YHG=2519>movements YHG=2517>in YHG=2517>time YHG=2517>and YHG=2525>space " XBD=2599 XBD=1509 XBD=1582 XBD=1780 XBD=1897 XBD=2049 XBD=2224 XBD=2365 XBD=2431 XBD=2512 XHG=1405 XHG=1534 XHG=1605 XHG=1803 XHG=1951 XHG=2072 XHG=2249 XHG=2389 XHG=2452 XHG=2535 YBD=2594 YBD=2602 YBD=2593 YBD=2592 YHG=2564>must YHG=2563>be YHG=2562>inquired YHG=2563>into. YHG=2561>Such YHG=2561>inquiry YHG=2562>bodes YHG=2561>ill YHG=2561>for YHG=2561>the XBD=279 XHG=664 XBD=391 XBD=464 XBD=502 XBD=593 XBD=648 XBD=731 XBD=1001 XBD=1181 XBD=1236 XBD=1344 XHG=194 XHG=295 XHG=405 XHG=479 XHG=516 XHG=609 XHG=746YBD=2593 XHG=1015 XHG=1197 XHG=1248 YBD=2592 YBD=2594 YBD=2603YHG=2561>the YHG=2561>THE YHG=2561>need YHG=2562>for YHG=2571>a YHG=2563>test YHG=2562>of YHG=2562>anti-ansemic YHG=2564>potency YHG=2563>of YHG=2563>liver XBD=312 XHG=880 XBD=417 XBD=547 XBD=613 XBD=776 XBD=861 XBD=929 XBD=1106 XBD=1167 XBD=1224 XBD=1342 XHG=142 XHG=330 XHG=435 XHG=566 XHG=631 XHG=794 XHG=948YBD=2638 XHG=1125 XHG=1183 XHG=1241 YBD=2637 YBD=2638 YBD=2639 YHG=2607>extracts YHG=2605>that YHG=2606>could YHG=2606>be YHG=2607>carried YHG=2608>out YHG=2616>on YHG=2606>animals YHG=2616>or YHG=2607>in YHG=2607>vitro " XBD=2597 XBD=1576 XBD=1831 XBD=1952 XBD=2140 XBD=2213 XBD=2344 XBD=2400 XBD=2465 XBD=2534 XHG=1404 XHG=1627 XHG=1853 XHG=1975 XHG=2163 XHG=2235 XHG=2367 XHG=2423 XHG=2487 XHG=2558 YBD=2646 YBD=2638 YBD=2637 YBD=2647 YBD=2636 YHG=2607>starling. YHG=2607>Migrating YHG=2606>from YHG=2606>Norway YHG=2606>its YHG=2606>habit YHG=2606>is YHG=2604>to YHG=2615>go YHG=2607>to " XBD=2597 XBD=1612 XBD=1749 XBD=1882 XBD=2011 XBD=2072 XBD=2161 XBD=2381 XBD=2435 XHG=1405 XHG=1650 XHG=1773 XHG=1903 XHG=2034 XHG=2094 XHG=2183 XHG=2403 XHG=2456 YBD=2689 YBD=2690 YBD=2682 YBD=2681 YBD=2691 YHG=2651>Scotland YHG=2652>from YHG=2651>other YHG=2652>parts YHG=2651>of YHG=2650>the YHG=2651>continent YHG=2650>it YHG=2650>prefers ; XBD=212 XHG=837 XBD=328 XBD=449 XBD=706 XBD=811 XBD=903 XBD=1090 XBD=1158 XBD=1205 XBD=1340 XHG=141 XHG=238 XHG=353 XHG=475 XHG=735 XHG=931YBD=2682 XHG=1116 XHG=1183 XHG=1232 YBD=2691 YBD=2692 YBD=2683 YBD=2683YHG=2651>the YHG=2651>has YHG=2651>long YHG=2650>been YHG=2651>recognised, YHG=2651>and YHG=2651>absence YHG=2652>of YHG=2661>a YHG=2651>satis" XBD=2595 XBD=291 XHG=833 XBD=389 XBD=480 XBD=631 XBD=741 XBD=812 XBD=985 XBD=1083 XBD=1384 XBD=1580 XBD=1672 XBD=1823 XBD=1954 XBD=2111 XBD=2157 XBD=2255 XBD=2309 XBD=2506 XHG=140 XHG=313 XHG=410 XHG=501 XHG=653 XHG=762 XHG=1006YBD=2729 XHG=1105 XHG=1402 XHG=1595 XHG=1686 XHG=1874 XHG=1969 XHG=2125 XHG=2172 XHG=2268 XHG=2326 XHG=2522 YBD=2736 YBD=2726 YBD=2727 YBD=2736YHG=2695>reliable YBD=2731 YBD=2727 YBD=2726 YHG=2696>factory YHG=2697>test YHG=2695>has YHG=2697>meant YHG=2695>that YHG=2705>no YHG=2695>enforceable YHG=2685>England YHG=2696>and YHG=2695>Wales. YHG=2695>The YHG=2695>disease YHG=2695>is YHG=2704>rare YHG=2696>in YHG=2695>Scotland YHG=2694>and " XBD=338 XBD=449 XBD=509 XBD=582 XBD=700 XBD=775 XBD=942 XBD=991 XBD=1208 XHG=140 XHG=356 XHG=468 XHG=525 XHG=599 XHG=716 XHG=792 XHG=960 XHG=1009 XHG=1259 YBD=2777 YBD=2771 YBD=2778 YBD=2772 YBD=2772 YBD=2771 YHG=2740>standard, YHG=2740>such YHG=2749>as YHG=2750>we YHG=2739>have YHG=2740>for YHG=2740>insulin, YHG=2740>is YHG=2740>available. YHG=2740>The |>"XBD=1340 XBD=1540 XBD=1916 XBD=2145 XBD=2229 XBD=2298 XBD=2513 XBD=2596 XBD=1837 XHG=1401 XHG=1875 XHG=1956 XHG=2198 XHG=2267 XHG=2337 XHG=2559 XHG=1579 YBD=2780 YBD=2770 YBD=2771 YHG=2741>almost YHG=2740>in YHG=2740>Norway YHG=2740>it YHG=2741>is YHG=2749>common YHG=2739>in YHG=2740>non-existent ; XBD=234 XHG=904 XBD=320 XBD=357 XBD=517 XBD=573 XBD=692 XBD=825 XBD=889 XBD=970 XBD=1121 XBD=1178 XBD=1340 XHG=140 XHG=250 XHG=336 XHG=373 XHG=533 XHG=587 XHG=707 XHG=839 XHG=985YBD=2817 XHG=1137 XHG=1191 YBD=2825 YBD=2816 YBD=2817 YHG=2785>USP YHG=2785>has YHG=2794>a YHG=2774>system YHG=2785>of YHG=2785>units YHG=2785>based YHG=2794>on YHG=2785>results YHG=2785>of YHG=2783>clinical " XBD=2594 XBD=1579 XBD=1693 XBD=1854 XBD=1968 XBD=2099 XBD=2312 XBD=2389 XHG=1401 XHG=1615 XHG=1729 XHG=1892 XHG=2006 XHG=2136 XHG=2348 XHG=2428 YBD=2826YHG=2785>the YBD=2817 YBD=2824 YBD=2816 YBD=2819 YHG=2785>England YHG=2785>and YHG=2784>Wales YHG=2784>and YHG=2794>very YHG=2794>common YHG=2785>in YHG=2784>Sweden, " XBD=2595 XBD=1605 XBD=1818 XBD=1914 XBD=2110 XBD=2236 XBD=2426 XBD=2484 XHG=1398 XHG=1627 XHG=1837 XHG=1934 XHG=2162 XHG=2254 XHG=2443 XHG=2506 YBD=2866 YBD=2870 YBD=2861 YHG=2829>Denmark, YHG=2829>Germany YHG=2830>and YHG=2829>Holland. YHG=2829>For YHG=2830>instance YHG=2829>in YHG=2829>1925 XBD=281 XHG=651 XBD=347 XBD=528 XBD=638 XBD=864 XBD=1052 XBD=1139 XBD=1222 XBD=1338 XHG=138 XHG=297 XHG=359 XHG=543 XHG=880YBD=2870 XHG=1068 XHG=1155 XHG=1236 YBD=2861 YBD=2866 YBD=2860YHG=2830>pernicious YHG=2830>testing YHG=2839>on YHG=2829>patients YHG=2829>with YHG=2830>anaemia, YHG=2829>but YHG=2829>the YHG=2828>basis "|>"XBD=2622 XBD=1465 XBD=1669 XBD=1726 XBD=1955 XBD=2147 XBD=2261 XBD=2375 XBD=2533 XHG=1398 XHG=1487 XHG=1686 XHG=1749 XHG=1970 XHG=2163 XHG=2285 XHG=2400 XHG=2556 YBD=2906 YBD=2915 YBD=2905 YBD=2911 YBD=2914 YHG=2874>the YHG=2874>numbers YHG=2874>of YHG=2874>outbreaks YHG=2874>reported YHG=2884>were YHG=2883>over YHG=2875>50,000 YHG=2873>in XBD=179 XBD=257 XBD=412 XBD=454 XBD=535 XBD=642 XBD=796 XBD=954 XBD=1060 XBD=1338 XHG=138 XHG=190 XHG=268 XHG=423 XHG=467 XHG=548 XHG=653 XHG=807 XHG=967 XHG=1072 YBD=2906 YBD=2905 YBD=2914 YBD=2915 YBD=2914 YBD=2913 YHG=2874>of YHG=2874>the YHG=2876>system YHG=2874>is YHG=2875>not YHG=2884>very YHG=2874>precise YHG=2874>though YHG=2874>they YHG=2873>undoubtedly "|>"XBD=2593 XBD=1606 XBD=1873 XBD=1931 XBD=2109 XBD=2207 XBD=2324 XBD=2382 XBD=1757 XHG=1397 XHG=1780 XHG=1891 XHG=1954 XHG=2130 XHG=2225 XHG=2341 XHG=2404 XHG=1625 YBD=2955 YBD=2950 YBD=2958 YBD=2959 YHG=2919>Denmark, YHG=2920>5000 YHG=2918>Sweden YHG=2918>and YHG=2928>none YHG=2919>in YHG=2919>Norway YHG=2918>nearly; XBD=223 XBD=264 XBD=403 XBD=532 XBD=592 XBD=678 XBD=846 XBD=1135 XBD=1265 XBD=1337 XHG=136 XHG=242 XHG=281 XHG=419 XHG=550 XHG=611 XHG=697 XHG=896 XHG=1154 XHG=1283 YBD=2958 YBD=2949 YBD=2959 YBD=2957 YBD=2957 YBD=2956 YHG=2919>give YHG=2928>a YHG=2918>rough YHG=2918>guide YHG=2920>to YHG=2918>the YHG=2919>dosage. YHG=2918>Laboratory YHG=2927>assay YHG=2917>by " XBD=2594 XBD=1504 XBD=1618 XBD=1704 XBD=1926 XBD=1981 XBD=2175 XBD=2267 XBD=2409 XBD=2503 XBD=2541 XHG=1396 XHG=1519 XHG=1634 XHG=1722 XHG=1942 XHG=1999 XHG=2191 XHG=2283 XHG=2425 XHG=2520 XHG=2556 YBD=3003 YBD=2994 YBD=2995 YBD=2993 YHG=2963>there YHG=2971>were YHG=2963>232 YHG=2963>outbreaks YHG=2962>in YHG=2963>England YHG=2963>Wales YHG=2963>and YHG=2965>0 YHG=2963>in XBD=334 XHG=920 XBD=423 XBD=695 XBD=896 XBD=961 XBD=1080 XBD=1272 XBD=1336 XHG=136 XHG=356 XHG=446 XHG=719 XHG=985YBD=2992 XHG=1104 XHG=1295 YBD=3003 YBD=2993 YBD=3005 YBD=3002 YBD=2992 YBD=2992YHG=2964>to YHG=2963>recording YHG=2962>the YHG=2962>reticulocyte YHG=2971>response YHG=2962>liver YHG=2963>extracts YHG=2961>in " XBD=2593 XBD=1593 XBD=1825 XBD=1955 XBD=2032 XBD=2224 XBD=2389 XBD=2479 XHG=1397 XHG=1645 XHG=1849 XHG=1980 XHG=2054 XHG=2249 XHG=2441 XHG=2505 YBD=3044 YBD=3039 YBD=3047 YHG=3007>Scotland. YHG=3007>Observe, YHG=3008>next, YHG=3008>its YHG=3007>roosting YHG=3007>habits. YHG=3007>It YHG=3015>may XBD=355 XHG=875 XBD=457 XBD=636 XBD=731 XBD=851 XBD=986 XBD=1083 XBD=1175 XBD=1335 XHG=134 XHG=380 XHG=481 XHG=661 XHG=755 XHG=1011YBD=3042 XHG=1107 XHG=1197 YBD=3047 YBD=3046 YBD=3037 YBD=3036YHG=3006>tried, YHG=3007>guineapigs YHG=3006>and YHG=3000>pigeons YHG=3007>has YHG=3007>been YHG=3005>but YHG=3005>the YHG=3005>results XBD=231 XHG=840 XBD=321 XBD=483 XBD=820 XBD=940 XBD=1109 XBD=1333 XHG=133 XHG=253 XHG=344 XHG=505 XHG=962YBD=3080 XHG=1129 YBD=3082 YBD=3081 YBD=3089 YBD=3090 YBD=3081 YBD=3080YHG=3050>from YHG=3060>were YHG=3052>not YHG=3049>clearly YHG=3050>distinguishable YHG=3048>normal YHG=3050>variation. " XBD=2592 XBD=1449 XBD=1591 XBD=1718 XBD=1763 XBD=1860 XBD=1978 XBD=2049 XBD=2220 XBD=2407 XBD=2469 XHG=1394 XHG=1470 XHG=1611 XHG=1739 XHG=1784 XHG=1879 XHG=1999 XHG=2069 XHG=2239 XHG=2427 XHG=2490 YBD=3091 YBD=3092 YBD=3083 YHG=3051>fly YHG=3052>40-50 YHG=3051>miles YHG=3061>a YHG=3052>day YHG=3052>from YHG=3052>its YHG=3051>feeding YHG=3052>grounds YHG=3053>to YHG=3052>roost XBD=356 XHG=743 XBD=421 XBD=720 XBD=923 XBD=1111 XBD=1256 XBD=1334 XHG=135 XHG=381 XHG=445 XHG=946YBD=3125 XHG=1136 XHG=1280 YBD=3133 YBD=3133 YBD=3124YHG=3094>anaemias YHG=3095>Treatment YHG=3094>of YHG=3094>experimental YHG=3093>brought YHG=3094>about YHG=3094>by " XBD=2589 XBD=1546 XBD=1739 XBD=1793 XBD=1986 XBD=2093 XBD=2211 XBD=2461 XHG=1394 XHG=1561 XHG=1752 XHG=1809 XHG=1999 XHG=2108 XHG=2232 XHG=2475 YBD=3136 YBD=3128 YBD=3127 YBD=3133 YBD=3132 YHG=3095>nightly YHG=3098>to YHG=3095>shoulder YHG=3096>with YHG=3104>some YHG=3097>50-100,000 YHG=3096>birds, XBD=352 XHG=775 XBD=518 XBD=626 XBD=737 XBD=871 XBD=1109 XBD=1181 XBD=1331 XHG=134 XHG=385 XHG=556 XHG=658 XHG=899YBD=3168 XHG=1139 XHG=1209 YBD=3178 YBD=3177 YBD=3168YHG=3138>been YBD=3178 YHG=3139>hsemolytic YHG=3139>agents YHG=3138>has YHG=3138>also YHG=3136>unhelpful, YHG=3147>as YHG=3138>might " XBD=2592 XBD=1445 XBD=1681 XBD=1959 XBD=2043 XBD=2133 XBD=2324 XBD=2389 XHG=1394 XHG=1471 XHG=1707 XHG=1983 XHG=2067 XHG=2159 XHG=2349 XHG=2413 YBD=3181 YBD=3171 YBD=3172 YBD=3173 YHG=3149>an YHG=3140>admirable YHG=3140>opportunity YHG=3140>for YHG=3140>the YHG=3140>transfer YHG=3141>of YHG=3140>infective XBD=233 XHG=739 XBD=359 XBD=576 XBD=709 XBD=839 XBD=1078 XBD=1140 XBD=1333 XHG=133 XHG=263 XHG=389 XHG=606 XHG=867YBD=3212 XHG=1108 XHG=1171 YBD=3221 YBD=3213 YBD=3221 YBD=3212YHG=3181>their YBD=3220 YHG=3183>have YHG=3183>been YHG=3181>expected YHG=3181>since YHG=3182>pathology YHG=3181>is YHG=3180>entirely " XBD=2591 XBD=1537 XBD=1632 XBD=1864 XBD=2107 XBD=2351 XBD=2400 XHG=1393 XHG=1555 XHG=1658 XHG=1881 XHG=2126 XHG=2377 XHG=2418 YBD=3215 YBD=3224 YBD=3216 YBD=3217 YHG=3185>matter YHG=3185>and YHG=3185>another YHG=3184>mysterious YHG=3184>outbreak YHG=3194>a YHG=3185>hundred &dquo; &dquo; "|>"XBD=1332 XBD=309 XBD=428 XBD=662 XBD=948 XBD=1037 XBD=856XHG=878 XHG=133 XHG=330 XHG=448 XHG=967 XHG=1058 XHG=684YBD=3256 YBD=3257 YBD=3265 YBD=3256 YBD=3261 YBD=3264 YHG=3226>different YHG=3226>from YHG=3224>pernicious YHG=3225>has YHG=3225>ansemia, YHG=3224>experimental XBD=1498 XBD=1643 XBD=1837 XBD=1889 XBD=2016 XBD=2158 XBD=2269 XBD=2386 XBD=2520 XBD=2591 XHG=1392 XHG=1520 XHG=1695 XHG=1850 XHG=1909 XHG=2036 XHG=2170 XHG=2289 XHG=2408 XHG=2540 YBD=3268YHG=3235>nor YBD=3259 YBD=3260 YBD=3269 YHG=3228>miles YHG=3237>away. YHG=3228>Counts YHG=3229>of YHG=3228>these YHG=3230>roosts YHG=3228>have YHG=3229>been YHG=3229>made YHG=3230>by XBD=463 XHG=509 XBD=669 XBD=1069 XBD=1329 XHG=131 XHG=715YBD=3299 XHG=1113 YBD=3309 YBD=3308 YBD=3300YHG=3268>difficult YHG=3271>gastrectomy―a YHG=3268>procedure-been YHG=3268>successful. " XBD=2590 XBD=1677 XBD=1765 XBD=1844 XBD=1903 XBD=1963 XBD=2088 XBD=2143 XBD=2226 XBD=2416 XBD=2473 XHG=1391 XHG=1688 XHG=1781 XHG=1861 XHG=1914 XHG=1972 XHG=2105 XHG=2160 XHG=2236 XHG=2433 XHG=2488 YBD=3312 YBD=3302 YBD=3303 YBD=3304 YHG=3272>ornithologists YHG=3273>and YHG=3273>act YHG=3281>as YHG=3281>an YHG=3272>index YHG=3272>the YHG=3273>numbers YHG=3273>of YHG=3273>birds Fisher XBD=230 XHG=611 XBD=334 XBD=584 XBD=838 XBD=1047 XBD=1173 XBD=1331 XHG=130 XHG=257 XHG=503 XHG=866 XHG=1074 XHG=1200 YBD=3343 YBD=3342 YBD=3346 YBD=3351 YBD=3343YHG=3311>Richmond, YHG=3313>Pace YHG=3312>and YHG=3311>3 YHG=3312>Virginia, YHG=3311>have YHG=3313>drawn of " XBD=2591 XBD=1597 XBD=1749 XBD=1823 XBD=1950 XBD=2119 XBD=2193 XBD=2291 XBD=2429 XHG=1391 XHG=1629 XHG=1782 XHG=1855 XHG=1983 XHG=2153 XHG=2225 XHG=2325 XHG=2480 YBD=3355 YBD=3346 YBD=3347 YBD=3356 YBD=3348 YHG=3316>travelling YHG=3316>about YHG=3316>in YHG=3315>each YHG=3316>month YHG=3316>of YHG=3317>the YHG=3326>year. YHG=3317>Their " XBD=1330 XBD=324 XBD=398 XBD=456 XBD=650 XBD=796 XBD=1013 XHG=130 XHG=356 XHG=433 XHG=492 XHG=829 XHG=1047 YBD=3387 YBD=3386 YBD=3386 YBD=3387 YHG=3356>attention YHG=3357>to YHG=3365>a YHG=3355>method YHG=3356>standard YHG=3356>tissue-culture XBD=1517XHG=684 XBD=1772 XBD=1850 XBD=1954 XBD=2103 XBD=2231 XBD=2401 XBD=2589 XHG=1391YBD=3395 XHG=1556 XHG=1811 XHG=1886 XHG=1991 XHG=2140 XHG=2269 XHG=2439 YBD=3396YHG=3355>using YBD=3390 YBD=3400 YBD=3392 YBD=3401 YBD=3399 YHG=3360>trend, YHG=3359>gentlemen YHG=3359>of YHG=3360>the YHG=3360>Jury, YHG=3370>runs YHG=3361>nearly YHG=3360>exactly " XBD=1329 XBD=345 XBD=578 XBD=807 XBD=891 XBD=989 XBD=1132 XHG=129 XHG=378 XHG=611 XHG=838 XHG=1023 XHG=1164 YBD=3438 YBD=3437 YBD=3431 YHG=3399>technique, YHG=3399>originally YHG=3399>described YHG=3399>by YHG=3399>Swiss YHG=3400>workers XBD=1547XHG=923 XBD=1677 XBD=1780 XBD=1994 XBD=2222 XBD=2299 XBD=2589 XHG=1388YBD=3429 XHG=1583 XHG=1714 XHG=1818 XHG=2029 XHG=2259 XHG=2336 YBD=3443YHG=3399>the YBD=3434 YBD=3436 YBD=3435 YBD=3444 YHG=3403>parallel YHG=3403>with YHG=3403>the YHG=3403>monthly YHG=3404>incidence YHG=3404>of YHG=3404>unexplained " XBD=2587 XBD=1609 XBD=1809 XBD=2026 XBD=2228 XBD=2342 XBD=2406 XHG=1390 XHG=1662 XHG=1836 XHG=2051 XHG=2253 XHG=2365 XHG=2433 YBD=3478 YBD=3487 YBD=3488 YBD=3480 YBD=3479 YHG=3446>outbreaks. YHG=3446>Lastly, YHG=3447>Bullough YHG=3448>observes YHG=3448>that YHG=3448>in YHG=3448>Sweden 1. Schmidt, L. H., Sesler, C. and Dettwiler, H. A. J. Pharmacol. 1942, 74, 175. " XBD=2588 XBD=1457 XBD=1659 XBD=1732 XBD=1911 XBD=1985 XBD=2184 XBD=2294 XBD=2476 XHG=1389 XHG=1499 XHG=1700 XHG=1775 XHG=1945 XHG=2021 XHG=2216 XHG=2328 XHG=2512 YBD=3531 YHG=3490>and YBD=3525 YBD=3522 YBD=3527 YBD=3521 YHG=3490>the YHG=3490>starling YHG=3490>is YHG=3490>absent YHG=3491>in YHG=3493>autumn YHG=3492>and YHG=3492>winter, 2. Francis, A. E. Lancet, 1942, i. 408. 3. Pace, N. and Fisher, R. S. J. Pharmacol. 1942, 74, 256.
1. Communicated to the
AGAINST THE
Royal Society, April 23,
&dquo;
1942.