SUN-P220: Paediatric Nutrition Week Survey: 6 Years of Malnutrition Assessment Campaigns

Paediatrics 1 never before was reported to express clock genes. Treatment with oleic acid regulates the expression of clock genes in the stomach morbidly obese patient, and re-established the correct circadian rhythm in the stomach of patients cited. Conclusion: We have identify clock genes presence on stomach. The clock genes on the stomach tissue are regulated by oleic acid and by bariatric surgery. The concept that the stomach is home to one of the food-entrainable oscillators that predicts the availability of food, especially when food becomes restricted, is the first time that is reported to be a peripheral clock. References Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 2005. Froy O. Metabolism and circadian rhythms-implications for obesity. Endocr Rev 2010. Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW. Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring) 2009. Disclosure of Interest: None declared

SUN-P218 EFFECTS OF MEAL FREQUENCY ON BODY COMPOSITION G. Okburan1, K. Uysal 1, S. Öğmen1. 1Eastern Mediterranean University, Mağusa, Turkey Rationale: It has been hypothesized that eating small, frequent meals enhances fat loss and helps to achieve better weight maintenance [1]. Also, there is uncertainty regarding whether breakfast consumption protects against overweight or obesity [2]. Methods: In total, 54 participants (27 women and 27 men) were included in this study. Anthropmetric measurements of participants were done with Tanita MC 980. Height were measured with stadiometer. Meal frequency and food frequency questionnaire were filled to all participants by the investigator. ANOVA were used to compare the data variables. Results: According to the results, there were a relationship between breakfast, lunch consumption and BMI. Participants who are having habit to eat breakfast tend to have lower BMI compared to non-breakfast eaters. Also, participants who are having habit to eat lunch have lower BMI compared to participants who are skipping lunch. However there were no relationship found between dinner consumption and BMI. An inverse relationship found between snack consumption and BMI. Participants who were eating snack regularly had lower BMI compared to participants who were not eating snack. Conclusion: There is a potential benefit of having a habit of eating breakfast and lunch as well as having snacks for enhancing body composition. References [1] Schoenfeld Brad Jon, Aragon Alan Albert, Krieger James W. Effects of meal frequency on weight loss and body composition: a meta-analysis. Nutrition Reviews, 73(2):69–82. [2] Szajewska Hania, Ruszczynski Marek. Systematic Review Demonstrating that Breakfast Consumption Influences Body Weight Outcomes in Children and Adolescents in Europe. Critical Reviews in Food Science and Nutrition, 50:113–119 (2010). Disclosure of Interest: None declared

S125 SUN-P219 RELATIONSHIP OF OBESITY AND OBESITY INDICES WITH VITAMIN D STATUS IN TYPE 2 DIABETICS H. Ozcaliskan1, G. Samur2. 1Nutrition and Dietetics, Erciyes University/Faculty of Health Sciences, Kayseri, 2Nutrition and Dietetics, Hacettepe University/Faculty of Health Sciences, Ankara, Turkey Rationale: While previous studies have linked vitamin D deficiency with obesity mostly due to adipose sequestration of vitamin D, type 2 diabetics have often hypovitaminosis D. This study aimed to determine the possible interaction of serum 25-hydroxyvitamin D (25-OHD) and obesity and its indices in regard to type 2 diabetes. Methods: The study consisted of 119 type 2 diabetics (93 female, mean age 54.7 ± 8.4 years) who were admitted to a university endocrinology department from January 2014 until May 2014 in Turkey. Serum 25-OHD level was measured by highperformance liquid chromatography (available for 112 patients). All subjects underwent anthropometrical, biochemical and nutritional assesment. Body composition was estimated by bioelectrical impedance analysis method. The data were analysed by using Fisher’s exact test and univariate general linear model. Results: Vitamin D status were significantly and inversely associated with the degree of obesity by body mass index (BMI) ( p = 0.026). For instance, 46.9% of type 2 diabetics with grade 1 obesity (BMI 30–34.9 kg/m2) and 75.0% of type 2 diabetics with grade 3 obesity (BMI > 40 kg/m2) had vitamin D deficiency (serum 25-OHD level <20 ng/mL). Waist circumference (WC) and body fat mass (BFM) values were significantly lower in the patient group whose mean 25-OHD level was ≥15 ng/mL as compared to the patient group whose mean 25-OHD level was <15 ng/mL (respectively 105.8 ± 11.3 cm vs 107.9 ± 9.6 cm; p = 0.046, 33.9 ± 10.9 kg vs 36.2 ± 8.8 kg; p = 0.015) after adjusting for a large range of dietary and nondietary confounders. Conclusion: Low 25-OHD levels were correlated with high body mass index, body fat mass and waist circumference values in type 2 diabetics. Additional randomized controlled trials are needed to understand the cause-effect relationships between low vitamin D status and obesity and its possible predictors such as BMI, WC and BFM in relation to type 2 diabetes. Disclosure of Interest: None declared

Paediatrics 1 SUN-P220 PAEDIATRIC NUTRITION WEEK SURVEY: 6 YEARS OF MALNUTRITION ASSESSMENT CAMPAIGNS A. De Luca1,2, M. Fischbach3, D. Guimber4, N. Peretti5, H. Piloquet6, R. Hankard1,2, on behalf of The Paediatric Nutritional Assessment Network (www.epinut.fr). 1Inserm UMR U1069, 2Unité Mobile de Nutrition, Chu Tours, Tours, 3 University Hospital, Strasbourg, 4University Hospital, Lille, 5 University Hospital, Lyon, 6University Hospital, Nantes, France Rationale: Assessment of protein-energy malnutrition (PEM) remains insufficient in paediatric wards. Since 2010, we conduct annual surveys with systematic nutritional assessment

S126 in hospitalised children. These surveys aim to improve awareness of PEM diagnosis. After 6 editions, we propose an overview of this initiative. Methods: These cross-sectional observational surveys included patients below 18 years. All hospitalised children admitted the same two weeks (in March) per year since 2010 were weighed and measured at admittance. Children below the 3rd centile of body mass index for age and sex had full diagnostic procedure, according to the guidelines of the French Paediatric Society. Since 2012, data were recorded using e-Pinut webbased tool (www.epinut.fr). Results are expressed as means and percentages. Results: Since 2010 to 2015, 10,057 patients were included in our surveys (mean: 1,676 patients/year, max: 2,845). The cumulative number of centres was 269 (mean: 45/year, max: 72). Nine countries joined our network: France, Algeria, Belgium, Canada, Colombia, Democratic republic of the Congo, Gabon, Ivory Coast, and Tunisia. The global frequency of PEM was 9% in 2010, 12% in 2011, 11% in 2012, 14% in 2013, 11% in 2014, and 11% in 2015. Post-surveys questionnaires showed an increased awareness in medical and paramedical staffs, from 82% to 95%. Systematic nutritional assessment was set up in 44% of centres after the surveys. Conclusion: Since the set-up of our survey 7 years ago, our main result is the large number of participating centres and countries, showing a lasting mobilisation in malnutrition concern. The introduction of our web-based tool allowed a dramatic increase of participating centres and enrolment of several countries. Our surveys improved awareness in nutritional assessment. The results of 2016 edition will be presented in late breaking news. Disclosure of Interest: A. De Luca Grant/Research Support from: Nutricia, Advanced Medical Nutrition – France, M. Fischbach: None declared, D. Guimber: None declared, N. Peretti: None declared, H. Piloquet: None declared, R. Hankard: None declared

SUN-P221 EFFECTS OF MATERNAL EXERCISE BEFORE AND DURING GESTATION OR DURING LACTATION ON OFFSPRING METABOLIC HEALTH: BODY COMPOSITION PANCREATIC FUNCTION AND ENERGY SUBSTRATES MANAGEMENT C. Quiclet1, F. Siti2, H. Dubouchaud1, H. Sanchez3, G. Vial4, P. Berthon5, E. Fontaine1, C. Batandier1, K. Couturier1. 1 LBFA, Univ. Grenoble Alpes, Grenoble, France; 2Faculty of Universitas Indonesia, Jakarta, Indonesia; 3IRBA, Brétigny sur Orge, 4CarMEn, Faculté de Médecine Lyon-Sud, Lyon, 5 LIBM, Univ. Savoie Mont-Blanc, Chambéry, France Rationale: It is now well-known that perinatal environment (maternal nutrition, physical activity level, obesity…) has an impact on offspring future health. However, only few studies explored the effects of regular maternal training on offspring health. We investigate the impact of submaximal but yet intense maternal exercise during gestation or lactation on offspring metabolism. Methods: Female Wistar rats were trained (T) or remained sedentary (C) before and during gestation or during lactation. Male offspring fed with control diet were tested at weaning and at 7 months of age. Other babies were fed either a control (CD) or high-fat high-sucrose diet (HFD) for 10 weeks and were tested at 3 months of age. Offspring underwent Intraperitoneal Glucose Tolerance, Intraperitoneal Insulin Tolerance and

Poster insulin load tests to examine glucose regulation and insulin pathway. Pancreas were used to determine their insulin content and isolated islets for insulin secretion tests. Muscles were explored for mitochondrial metabolism. Results: Gestational training reduced offspring basal glycemia, pancreas weight and islets mean area at weaning. At 7 months of age, it reduced offspring glucose tolerance and tended to decrease islets secretory capacity. At 3 months of age, offspring from T dams gained less body weight and less fat under HFD. They also displayed a better muscle mitochondrial affinity to carbohydrates and lipids under CD. Submaximal exercise during lactation reduced offspring basal glycemia and increased pancreas weight at weaning and led to a higher body weight gain in 7 month-old offspring. Conclusion: Our work show that maternal submaximal exercise during gestation or lactation impacts offspring growth, organs development and energy substrate handling. These effects will change with age depending on the offspring nutrition. Disclosure of Interest: None declared

SUN-P222 ANALYSIS OF THE RELATIONSHIP BETWEEN COLLATION INTAKE AND INTELLIGENCE QUOTIENT IN SCHOOLCHILDREN OF ECUADOR C. Mayorga-Mazón1, J. Herrera-Moncayo1, I. Cando2, A. Díaz-Silva1, M. Guerendiain1. 1School of Medicine, 2School of Clinical Psychology, National University of Chimborazo, Riobamba, Ecuador Rationale: Nutrition in childhood is critical for optimal brain development, however, few studies have evaluated the impact of the dietary patterns on cognitive performance and the results are inconsistent. For this reason, we analysed the relationship between collations intake and intelligence quotient in children from a rural school in Chimborazo. Methods: The study included 30 healthy children (from 5 to 11 years old) of the EVANES project. The anthropometric assessment was carried out using the standard deviation score (SDS) of height and body mass index (BMI). To know the dietary patterns of children, a survey was applied to parents. Total intelligence quotient (IQ) was evaluated by the Wechsler Preschool and Primary Scale of Intelligence (WPPSI) and Wechsler Intelligence Scale for Children (WISC). Schoolchildren were divided into normal (n = 22) and low (n = 8) total IQ. This study was conducted according to the ethical rules of the Helsinki Declaration and was approved by the Ethic Committee of the San Francisco de Quito University. Results: The means of daily collations amount, SDS of height, SDS-BMI and total IQ were 1.54 ± 0.65, −1.40 ± 1.06, 0.40 ± 0.77, 86 ± 14.11, respectively. Children aged from 5 to 6 years old who consumed collation had higher total IQ than their counterparts ( p = 0.041). Those with normal total IQ ate greater number of collations in comparison with low total IQ group ( p = 0.030). A positive relationship between total IQ and daily collations amount was found ( p = 0.048). All models were adjusted for age, sex and hemoglobin concentration. In older schoolchildren, these results have not been confirmed. Conclusion: The collation intake is linked to a higher cognitive performance in preschool children, but not at a school age. This suggest that collations are more important at early stage of life. Disclosure of Interest: None declared