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Supervoltage roentgen therapy in cancer of the mouth and throat
with adtlf~l ker:tt,oxs, hyperlteratosis, 2. Nonfissured, flat, or ichthyotic* leu~~oplskia: prolifrrntion parakeratosis, acanthosis, and ihr ;,rr~:clnr*r of c~lritlinic cc,llr : thy epithelixl is accentuated, sometimes with ad~letl layers 01’ the Rl:~lpighi:rt~ r~~itheliurn hut with r~l~%r cut basal limits without disorderetl or atypical c~t~lls. an(l, xuhsecluerltl~-, wlerotic 3. T,eueoplakia, aggravated and c~ornplic~atc~ll by fissurrs dermopapillar changes, vascuolization of the Malpighian cells, and tlekeratinization; the tendency to deep proliferation of the rl~itl~eliurn is still more ac~~~c~ntunfetl, with num~~~n~ aud nta,v result in pearl format iou. irregular ramifications, The authors characteristics.
describe
several
rases of leu(~oplakia
with
gradmtlly
increasing
malignant T. J. C.
Supervoltage Radiology
Roentgen Therapy in Cancer of the Mouth and Throat.
Milford
D. Schulz.
55: 52, 1950.
With the increase in the number of supervoltage generators being operated between 1,000 and 3,000 kv., an attempt should be made to establish the place and value of this form of therapy in the treatment of malignant disease. The author has chosen to compare this therapy with so-called conventional therapy (200 to 250 kv.) in the treatment of cancer of the mouth and throat. In evaluating any new tool for the treatment of malignant disease, one should (I) effectiveness in ridding the patient of his examine it from two major standpoints: disease and (2) the degree of harm to normal tissues. In this report carcinoma of the tongue and tonsil are chosen for comparison. One hundred forty cases of carcinoma of the tongue seen at the Massachusetts General Hospital, Boston, are included. In all of these cases the tumors were considered inoperable. Those treated with supervoltage therapy as well as those treated with conventional forms of therapy were given tumor doses of 5,000 roentgens. Eighty per cent of patients receiving supervoltage therapy died within five years, while 82 per cent of those treated with conventional therapy were dead within five years. Similar results are reported by other authors. Of patients with carcinoma of the tongue, who were treated with supervoltage therapy, 32 per cent survived three years;, only 18 per cent of those treated with conventional therapy survived three years. The five-year survival rate of those treated therapy, only with supervoltage was 24 per cent, and of those treated by conventional 6 per cent. The author .eoncluded that this difference may be related to the smaller tumor dose in the earlier years, whic,h was only 3,000 roentgens or less, using 200 kv. therapy. All patients treated with supervoltage were given .i,OOO roentgens or more. In recent years the survival rate seems about, the same with similar doses. Skin reactions are less with supervoltage therapy, and one must therefore think in terms of tissue dose rather than judge the amount of radiation given by its reaction on In treating small tumors, careful localization with small fields can be carried the skin. out, as the edges of the beam still retain t,he same close as the central portions. The relatively negligible differential tissue absorption of the supervoltage range rna,v prove to he an advantage. ‘I’. .T. (‘.
The Anemia of Cancer Patients and Its Relation to Metastases to the Bone Marrow. Shen and F. Hornburger. J. Lab. & Clin. Med. 37: 182, February, 1951.
S. C.
Morphologic studies of the peripheral blood and hone marrow were made in 193 patients with advanced cancer. One hundred sixteen (60.7 per coentj were considered to be anemic because the hemoglobin level was 80 per cent or below. Of these 116 anemic patients, the hemoglobin was between 70 and 80 per cent in fifty-two, between 55 and 69 per cent in forty-two, and between 38 and 54 per cent in twenty-two.
describe
several
rases of leu(~oplakia
with
gradmtlly
increasing
malignant T. J. C.
Supervoltage Radiology
Roentgen Therapy in Cancer of the Mouth and Throat.
Milford
D. Schulz.
55: 52, 1950.
With the increase in the number of supervoltage generators being operated between 1,000 and 3,000 kv., an attempt should be made to establish the place and value of this form of therapy in the treatment of malignant disease. The author has chosen to compare this therapy with so-called conventional therapy (200 to 250 kv.) in the treatment of cancer of the mouth and throat. In evaluating any new tool for the treatment of malignant disease, one should (I) effectiveness in ridding the patient of his examine it from two major standpoints: disease and (2) the degree of harm to normal tissues. In this report carcinoma of the tongue and tonsil are chosen for comparison. One hundred forty cases of carcinoma of the tongue seen at the Massachusetts General Hospital, Boston, are included. In all of these cases the tumors were considered inoperable. Those treated with supervoltage therapy as well as those treated with conventional forms of therapy were given tumor doses of 5,000 roentgens. Eighty per cent of patients receiving supervoltage therapy died within five years, while 82 per cent of those treated with conventional therapy were dead within five years. Similar results are reported by other authors. Of patients with carcinoma of the tongue, who were treated with supervoltage therapy, 32 per cent survived three years;, only 18 per cent of those treated with conventional therapy survived three years. The five-year survival rate of those treated therapy, only with supervoltage was 24 per cent, and of those treated by conventional 6 per cent. The author .eoncluded that this difference may be related to the smaller tumor dose in the earlier years, whic,h was only 3,000 roentgens or less, using 200 kv. therapy. All patients treated with supervoltage were given .i,OOO roentgens or more. In recent years the survival rate seems about, the same with similar doses. Skin reactions are less with supervoltage therapy, and one must therefore think in terms of tissue dose rather than judge the amount of radiation given by its reaction on In treating small tumors, careful localization with small fields can be carried the skin. out, as the edges of the beam still retain t,he same close as the central portions. The relatively negligible differential tissue absorption of the supervoltage range rna,v prove to he an advantage. ‘I’. .T. (‘.
The Anemia of Cancer Patients and Its Relation to Metastases to the Bone Marrow. Shen and F. Hornburger. J. Lab. & Clin. Med. 37: 182, February, 1951.
S. C.
Morphologic studies of the peripheral blood and hone marrow were made in 193 patients with advanced cancer. One hundred sixteen (60.7 per coentj were considered to be anemic because the hemoglobin level was 80 per cent or below. Of these 116 anemic patients, the hemoglobin was between 70 and 80 per cent in fifty-two, between 55 and 69 per cent in forty-two, and between 38 and 54 per cent in twenty-two.