Supramolecular Structure and Function.

Supramolecular Structure and Function.

180 The scientific material of the 28 posters cover, for various bio-heterocycles, many aspects like synthesis, structure-activity relationships, str...

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180

The scientific material of the 28 posters cover, for various bio-heterocycles, many aspects like synthesis, structure-activity relationships, structural elucidation, stereoselective allosteric interactions and in vitro availability. The book will be useful to those who work in bio-heterocyclic chemistry and try to understand its mechanism of action in bio-processes.

M. CIGNITTI Rome

Supramolecular Structure and Function. G. Pifat-Mrzljak (Editor). Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1986, ISBN 3-540-16102-3, viii + 191 pp., DM118.00.

This book is a collection of ten lectures delivered during an International School on Biophysics held in Dubrovnik in September 1984. It covers a wide range of topics including receptor structure and ligand-receptor recognition, intramolecular interactions determining self-organization of biomembranes, molecular mobility in membranes studied by electron spin resonance spectroscopy, nucleic acid structure as revealed by synchrotron radiation. NMR application for in vivo metabolic studies, image encoding in visual cortex, and Raman and fluorescence studies on aging and cataract formation in the lens. The two final chapters deal with the current ideas about the evolution of life and about the laws at the interface between chemistry and biology which determine regularities in the early stages of evolution. Although the lectures are very heterogeneous in terms of relative emphasis given to the biological problems or to the instrumental techniques, the message emerging clearly from them all is that the biophysical approach is playing a more and more prominent role in the elucidation of structure-function relationships in living matter. Developing a balanced sensibility towards the physical and the biological aspects of the various problems is the only prerequisite to insure full success to the scientific program of Biophysics and, even if some of the contributions reveal that such an achievement is not at all easy, some others, particularly those devoted to biomembranes or to the evolutionary implications of molecular interactions, must be mentioned as exemplary in this respect. The book will be of great interest especially for younger scientists in biophysics, biology and biochemistry at the doctoral or postdoctoral level, as well as for everybody interested in a broad overview of the biophysical approach to the study of some basic biological phenomena.

A. COLOSIMO Chieti