Surgical Stress and Removal of Primary Lesion Influence Breast Cancer Progression, but Survival is Determined by Overall Tumor Burden

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ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS

52.19. Profiling of Autoantibodies in Sera of Pancreatic Cancer Patients. Y. Nagayoshi,1 M. Nakamura,2 K. Matsuoka,3 T. Aso,1 N. Ideno,1 H. Kono,1 Y. Mori,1 T. Ohtsuka,1 S. Takahata,1 T. Sawasaki,4 M. Tanaka1; 1Department of Surgery and Oncology, Kyushu University, Fukuoka, Fukuoka; 2Department of Digestive Surgery, Kawasaki Medical School, Kurashiki, Okayama; 3Nagoya Medical Center, Nagoya, Aichi; 4Cell-Free Science and Technology Center, Ehime University, Matsuyama, Ehime 52.20. RAGE Expression is Permissive for Early Pancreatic Neoplasia. R. Kang; Departments of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA

ONCOLOGY 5: BREAST CANCER 53.1. Pterostilbene Induces Mitochondrially-Derived Apoptosis in Breast Cancer in Vitro Via Bax Activation and Cytosolic Calcium Overload. D. Moon, S. Lomas, D. McDonald, D. McFadden; University of Vermont College of Medicine/Fletcher Allen Health Care, Burlington, VT 53.2. A New Mechanism of Action for Withaferin a in Breast Cancer: Induction of Proteasomal-degradation of Notch1 and Notch3 Proteins. X. Zhang,1 S. Stecklein,2 F. Behbod,2 M. S. Cohen1; 1Deparment of Surgery, Kansas City, KS; 2Department of Pathology and Laboratory Medicine, Kansas City, KS 53.3. Building a Better Model of Basal-like Breast Cancer. C. B. Matsen,1,2 I. J. Stijleman,1 P. S. Bernard,1,3,4 L. A. Neumayer,1,2 B. E. Welm1,2; 1Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT; 2The University of Utah Department of Surgery, School of Medicine, Salt Lake City, UT; 3University of Utah Department of Pathology, School of Medicine, Salt Lake City, UT; 4ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 53.4. Targeting Breast Cancer Metastasis Using FTY720. B. J. Adams,1 M. Nagahashi,2 S. Ramachandran,2 N. Hait,2 S. Milstien,2 S. Spiegel,2 K. Takabe1; 1Virginia Commonwealth University Department of Surgery, Richmond, VA; 2Virginia Commonwealth University Department of Biochemistry, Richmond, VA 53.5. Genome-wide Microarray Analysis Demonstrates Significantly Different Tumor Gene Expression Profiles Between Sites of 4T1 Cell Implantation. O. M. Rashid,1 M. Nagahashi,1,2 C. Dumur,3 S. Ramachandran,2 K. Takabe1,2; 1 Virginia Commonwealth University Department of Surgery, Richmond, VA; 2Virginia Commonwealth University Department of Biochemistry, Richmond, VA; 3Virginia Commonwealth University Department of Pathology, Richmond, VA 53.6. Surgical Stress and Removal of Primary Lesion Influence Breast Cancer Progression, but Survival is Determined by Overall Tumor Burden. O. M. Rashid,1 M. Nagahashi,1,2 S. Ramachandran,2 K. Takabe1,2; 1Virginia Commonwealth University Department of Surgery, Richmond, VA; 2Virginia Commonwealth University Department of Biochemistry, Richmond, VA

53.7. Combination of Oral Scutellaria Baicalensis Extract and Intraperitoneal Cisplastin Suppresses Tumor Growth and Inhibits MTOR in a Mouse Breast Cancer Model. M. N. Le, Y. Akmal, M. Senthil, J. Yan, Q. Xing, Y. Wang, D. Tully, J. H. Yim; City of Hope National Medical Center, Duarte, CA 53.8. Breast Cancer Survival Disparities; not So Black and White. C. J. Wray, E. Castro-Echeverry, E. K. Robinson, T. C. Ko, L. S. Kao; University of Texas Medical School at Houston, Houston, TX 53.9. Ki67 and P53 as Prognostic Factors for Luminal Type Breast Cancer. K. Kim; Department of Surgery, Seoul, NC 53.10. Oncotype DX in Patients Treated with Targeted Intraoperative Radiotherapy. J. L. Deneve, M. C. Lee, N. Khakpour, J. V. Kiluk, G. Acs, C. Laronga; Moffitt Cancer Center and Research Institute, Tampa, FL 53.11. Radiologic Evaluation of Palpable Nodules Following Autologous Fat Grafting in Breast Reconstruction. R. P. Parikh,1 P. D. Smith,1 B. Mooney,2 M. C. Lee,3 E. Doren,1 W. J. Fulp,4 C. Laronga3; 1University of South Florida, Department of Surgery, Tampa, FL; 2Moffitt Cancer Center and Research Institute, Department of Radiology, Tampa, FL; 3Moffitt Cancer Center and Research Institute, Comprehensive Breast Program, Tampa, FL; 4Moffitt Cancer Center and Research Institute, Department of Biostatistics, Tampa, FL 53.12. Patient Surveillance After Breast Cancer Treatment: What Motivates Clinicians?. H. D. Mogal,1 E. Allam,1 J. A. Margenthaler,2 L. Chen,2 K. S. Virgo,3 F. E. Johnson4; 1 Saint Louis University School of Medicine, St. Louis, MO; 2 Washington University School of Medicine, St. Louis, MO; 3 American Cancer Society, Atlanta, GA; 4Veterans Affairs Medical Center, St. Louis, MO 53.13. Ipsilateral Locoregional Recurrence After Axillary Lymph Node Dissection in Patients with Breast Cancer. N. J. Walsh,1 J. V. Kiluk,2 N. Khakpour,2 C. Laronga,2 M. Lee2; 1University of South Florida College of Medicine, Tampa, FL; 2Comprehensive Breast Program H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 53.14. The Impact of Ethnicity on the, Incidence, Tumor Characteristics and Treatment of Ductal Carcinoma in Situ? An 11 Year Clinical Experience at a High Volume Teaching Hospital. L. S. Sparber,1 V. Murthy,1 S. Patil,1 U. K. Ballehaninna,1,2 R. S. Chamberlain1,3,4; 1Saint Barnabas Medical Center, Livingston, NJ; 2Maimonides Medical Center, Brooklyn, NY; 3University of Medicine and Dentistry of NJ - NJ Medical School, Newark, NJ; 4Saint George’s University, Grenada, Grenada 53.15. Impact of Breast Cancer Stage on Complication Rates Following Mastectomy with Immediate Reconstruction: the Importance of the Mastectomy Skin Flap. A. K. Seth, E. M. Hirsch, N. A. Fine; Northwestern University Feinberg School of Medicine, Chicago, IL 53.16. Revisiting the Latissimus Dorsi Flap: A Potential FirstLine Option Breast Reconstruction. J. P. Bloom,1,2 B. R. DeGeorge,1 P. R. Bucciarelli,1 A. L. Rosenberg,1 S. E. Copit1; 1 Thomas Jefferson University, Philadelphia, PA; 2 Massachusetts General Hospital, Boston, MA