CLINICAL ASSESSMFVIOF A THIAZIDE DRUGINFORMATIONLEAFLET Louis A. Morris, HFD-107, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; David E. Kanouse; Brian Zax; Michael Cohn and Paul Gibbs A controlled trial was designed to assess the effects of an informational leaflet describing the uses, cautions and side effects of thiazide drugs. Subjects were 249 newly diagnosed clinic patients with mild essential hyOne group of subjects received the leaflet and completed inpertension. terviews at the initial and second visits (about 30 days later); a second group received the leaflet but was not interviewed until the second visit; a third group did not receive the leaflet but was interviewed at both visits. -The-results indicate that the leaflet (1) improved knowledge about the drug but not the disease; (2) did not increase the reported frequency of subsequent health problems (i.e., side effects), but did increase the probability that patients would label these reactions as drug induced; (3) had a positive effect on appointment keeping and (4) was favorably evaluated by recipients.
A-162 SURVEY OF ADHERENCE TO ANTIHYPERTENSIVE TREATMENT Timothy Toye Moses, San Francisco Hypertension Coordinating Heart Association, 421 Powell St., San Francisco, California Newman.
Council, 94102;
San Francisco Jeffrey M.
Two hundred participants at hypertension clinics, classes, and health fairs were Ages ranged from 50-69, 65% were interviewed to assess adherence to treatment. male, 35% were female, 55% were Black, 35% were White, and 10% were Mexican or Asian-American. In this non-random sample, 60% stated that they had stopped their medicines on their own. Only 5(2.5%) stated that their medications had been stopped by their physician. This high rate of self-admitted non-adherence supports other studies identifying this as the major obstacle to effective hypertensive treatment. It is imperative that more efforts be focused on patients to improve adherence to medication. Such improvements will be: more patient education, verbal reinforcement and encouragement to follow their regimens at the time prescription refills are made. At San Francisco's Hypertension Coordinating Council, patient education to minimize non-adherence is our highest priority.