Synthesis and DNA-interacting properties of binuclear ruthenium(II) complexes

METAL COMPLEXES & DNA

30?.4

443

SYNTHESIS AND DNA-INTERACTING PROPERTIES OF BINUCLEAR RUTHENIUM(II) COMPLEXES

M. IMBERDIS, I. SASAKI, C. VERCHERE-BEAUR and A. GAUDEMER UnJversit6 Paris-XI - Cen~e d'Orsay- ICMO - Laboratoire de Chimie Bioorganique et Bioinorganique- Bat. 420 - 91405 Orsay (France)

Ru (II) complexeswith various bidentate aromatic amines (e.g. ophenanthroline) have been shownto interact strongly with DNA [I]. Various ligandsderived from 2,2'-bipyridine were synthetized in order to obtain binuclear complexes.

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The synthesis of these ligands and of the corresponding ruthenium (II) complexes are described. The complexeswere purified by Sephadex LH20 column chromatography and were characterized by PDMS, NMR spec~'oscopy and UV-visible speclroscopy. Studies on interactions with DN by elec~ophoresis experiments using plasmtd pBR 322 DNA and other methods will be reported. [I] A.M. Pyle,J.P. Rehmann,R. Meshoyrer, C.V. Kumar, N.J. Turro and J.K. Barton. J. Am. Chem. Soc., 1989, 111, 3051-3058