Synthesis of trifluoromethyl containing organic compounds from simple precursors

84

M-l I SYNTHESIS OF TRIFLUOROMETHYL FROM SIMPLE PRECURSORS

CONTAINING

ORGANIC COMPOUNDS

Claude Wakselman CNRSCERCOA,

Steroids junction tanedione

bearing

have been (for

The biological ethynyl

2 rue Henri Dunant, 94320 Thiais (France)

the

from

synthesis

of of

trifluoromethyl

from usual

are

of

group

2-trifluoromethyl the

starting

at

the

see

Poster

and 18,18,18-trifluoro

trifluoromethyl

ketones, (CF2X2,

34).

17 a-

reported.

halogenofluoroalkanes

C/D

1,3-cyclopen-

dione

18,18,18-trifluoroestradiol,

18,18,18-trifluoroestradiol

The preparation

studied.

prepared

properties

19-nortestosterone

sulfides

an angular

acids

and

CF3Br)

is