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T05-P-002 Carvedilol decreases neutrophils superoxide anion generation in patients with stable angina
Other Topics T5 Inflammation
164
Conclusions: Patients with the combination of smoking and obstructive sleep apnea syndrome have higher prevalence of dyslipidemia than non-smokers. ]
TO4-P-048 ] LIPROTEIN (a), ITS RELATION TO PLASMA LIPIDS AND O T H E R RISK FACTORS F O R ATHEROSCLEROSIS
L. Zlatohlavek, K. Zidkova, M. Vrablik, R. Prochazkova, M. Kvasilova, R. Ceska. 3rd Dept. of Internal Med., lst Faculty of Med., Charles
University, Prague, Czech Republic
Objective: Lp (a) is a considered as a independent risk factor for CHD. The objectives of this study were to determine relation Lp (a) to blood lipids and other risk factors for CHD. Methods: Group of 3916 patients with dyslipideamia, 1880 men, 2036 women, mean age 48 ± 21.5 yeats. Lp (a) was measured by LEIA, lipids and apoproteins were assayed using automatic machines. Clinical data were available in 600 patients. Results: Lp (a) levels did not correlate with total, LDL-, HDL- cholesterol, TG and apt B in the plasma (r = 0.6036, 0.13002, 0.071, -0.08923, 0.1277). Patients with diabetes mellitus, obesity, hypertension and smokers did not have statistically different Lp (a) levels than patients without this diseases. CHD (p< 0.024) is more frequent in patients with higher Lp (a). Conclusions: Higher levels of Lp (a) are associated with manifestation of CHD in our group. There is no correlation between Lp (a) and correlated serum lipids in our group. Supported by grants." GACR 301/02/D065 and IGA MHCR NB 7392-3.
T5
INFLAMMATION
T05-P-001 ] C-REACTIVE PROTEIN IN STABLE CORONARY H E A R T DISEASE PATIENTS M. Ezhov, A. Sumarokov, A. Kambegova, I. Raimbekova, V. Masenko, V. Naumov. Atherosclerosis, Cardiology Res. Complex, Moscow, Russia
Objective: To evaluate the association of C-reactive protein concentration with coronary heart disease presence and severity. Methods: We have examined 510 patients (424 men, 86 women, mean age 56±10 years) subjected coronary angiography for suspected or diagnosed coronary heart disease (CHD). Before angiography we performed physical examination, blood chemistry. High-sensitivity C-reactive protein (CRP) was analysed by Dade/Behring method. Remits: Median CRP level was 2.4 mg/L, mean total cholesterol concentration - 6.0±1.4 mmol/L. Among all patients CRP was distributed as follows: <1 m g / L - 142 (28%), 1-3 mg/L - 151 (30%), >3 m g / L - 217 (42%). Seventy patients (14%) had normal coronary arteries, 114 ( 2 2 % ) 1 diseased coronary vessel, 127 (25%) - 2 vessels, 199 (39%) - 3 vessels. There was no difference between the groups in CRP concentration. Patients with coronary lesions had stable angina II-IV class and/or myocardial infarction. More than 70% CHD patients had CRP> 1 mg/L, and 43% patients had C R P > 3 mg/L. Of examined patients, 360 (70%) had arterial hypertension, 167 (33%) - f a m i l y history of CHD, 157 (31%) were smokers and 71 (14%) - diabetics. There was no difference in CRP level in the presence or absence of hypertension, or smoking, or family history of CHD. We have revealed that CRP level was significantly higher in diabetics than in non-diabetics (median, 95% CI): 3.3, 2.4-4.9, versus 2.4, 2.0-2.9 mg/L, p=0.03, respectively. Conclusion: C-reactive protein concentration is increased in majority of stable coronary heart disease patients, especially in those with diabetes mellitus, but not associated with coronary atherosclerosis severity. TO5-P-O02 ] CARVEDILOL DECREASES N E U T R O P H I L S SUPEROX IDE ANION GENERATION IN PATIENTS W I T H STABLE ANGINA J. Kowalski, L. Pawlicki, J. Blaszczyk, R. Irzmanski, T. Ceglinski, A. Lewinski, J. Kedziora. Dep. of lnternal Medicine and Cardiological
Rehabilitation, Medical University of Lodz, Lod~ Poland
Objective: The oxidative stress plays an important role in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Increased generation of superoxide anion by PMNs leads initially to endothelial dysfunction and
then resuls in further progression of atherosclerosis. Thus, drugs that have antioxidative properties might be useful the treatment of patients with CHD. Methods: Effect of carvedflol on 02 generation by neutrophils was investigated in patients with stable angina. The study comprised 30 patients (20 men and l0 women), aged 37- 52 years (mean 47.9 years) with stable angina. The patients were administered carvedilol in increasing every four weeks doses: 12.5 mg/day, 25 mg/day, 50 mg/day. The control group consisted of 12 healthy subjects aged 39-49 years (mean 45.7 years). Blood samples were collected before, 4, 8 and 12 weeks after therapy in patients, and once in control group. Our study has been approved by the Local Ethics Committee. Superoxide anion generation by nonstimulated and OZ stimulated neutrophils was measured with Bellavite etal. method. Results: O2 generation by nonstimulated and OZ stimulated neutrophils in patients with stable angina was significantly (p < 0.05) higher than in control group. Neutrophil O2 generation did not differ 8 and 12 weeks after the therapy from that observed in healthy. Conclusions: The results of our study indicate that carvedilol inhibits neutrophil O2 generation equally effectively in both doses (25 mg/day and 50 mg/day) in patients with stable angina.
I T05-P-003 1 THE ASSOCIATION B E T W E E N PREHYPERTENSION STATUS AND INFLAMMATORY M A R K E R S RELATED TO A T H E R O S C L E R O T I C DISEASE; THE ATTICA STUDY D. Panagiotakos, C. Pitsavos, I. Skoumas, C. Stefanadis. First Cardiology
Clinic, Athens Medical School, Athens, Greece Background: The aim of this work was to evaluate the association between pre-hypertension status and inflammatory markers (C-reactive protein, white blood cells, interleukin-6, tumor necrosis factor-a, amyloid-a, homocysteine and fibrinogen), in a random sample of cardiovascular disease free adults, in Greece. Methods: The ATTICA study is a cross sectional population-based survey that conducted in Athens greater area during 2001-2002. Based on a multistage random sampling, 1514 men and 1528 women (18 - 89 years old) were enrolled. The survey included a detailed interview; blood samples collected after 12 hours of fasting and, among other clinical measurements, status of blood pressure levels was evaluated. Results: 653 men (43%) and 535 women (35%) were defined as prehypertensives. Compared to normotensives, and after controlling for several potential confounders, pre-hypertensive individuals showed a 31% relative increase in C-reactive protein, a 32% relative increase in tumor necrosis factor - a levels, a 9% increase in amyloid - A, a 6% increase in homocysteine levels and a 10% increase in white blood cell counts compared to normotensive subjects (all p < 0.05). Conclusions: We revealed a positive association between prehypertension and inflammatory markers related with the atherosclerotic process in cardiovascular disease free individuals from the general population. These associations were independent from other coexisting risk factors or unhealthy life-style behaviors, and may indicate a direct association of prehypertension with atherosclerotic disease.
I T0$-P-004 I ASSOCIATION B E T W E E N C-REACTIVE PROTEIN AND METABO LIC/HAEMODYNAMIC PARAMETERS J. Saban-Ruiz, E. Bemal, O. Sanchez, E. Sanchez-Largo, A. Ugalde, E. Femadez, D. Coca, R. Fabregate, L.M. Villar, J. Marquez. Endothelial
Pathology Unig Ramon y Cajal Hospital, Madrid, Spain Introduction: The increase of normal pulse pressure (PP) is associated with arteriosclerosis, a phenomenon considered degenerative and inactive, in contrast to atherosclerosis. Although C-reactive protein (CRP) has behaved as a marker of the insulin resistance (IR) syndrome, a marker of ED and a good predictor of acute events, all related with "atherosclerosis", it is not known if it could also he an indicator of "arteriosclerosis". Objectives: 1.To evaluate the biochemical and clinical parameters related with the CRP. 2.To determine if the ambulatory PP is independently related with the CRP. Material and Methods: N= 183, aged 57 + 12 yr, 55% f, 65% hypertensive, 35% DM2, 32% dyslipemic, and 15% active smokers. Methods: Waist; BMI, Biochemical:glucose total cholesterol, creatinine, HDL, and triglycerides, by HITACHI auto-analyzer,CRP (mg/l): Latex-
75th EAS Congress, 23-26 April 2005, Prague, Czech Republic
164
Conclusions: Patients with the combination of smoking and obstructive sleep apnea syndrome have higher prevalence of dyslipidemia than non-smokers. ]
TO4-P-048 ] LIPROTEIN (a), ITS RELATION TO PLASMA LIPIDS AND O T H E R RISK FACTORS F O R ATHEROSCLEROSIS
L. Zlatohlavek, K. Zidkova, M. Vrablik, R. Prochazkova, M. Kvasilova, R. Ceska. 3rd Dept. of Internal Med., lst Faculty of Med., Charles
University, Prague, Czech Republic
Objective: Lp (a) is a considered as a independent risk factor for CHD. The objectives of this study were to determine relation Lp (a) to blood lipids and other risk factors for CHD. Methods: Group of 3916 patients with dyslipideamia, 1880 men, 2036 women, mean age 48 ± 21.5 yeats. Lp (a) was measured by LEIA, lipids and apoproteins were assayed using automatic machines. Clinical data were available in 600 patients. Results: Lp (a) levels did not correlate with total, LDL-, HDL- cholesterol, TG and apt B in the plasma (r = 0.6036, 0.13002, 0.071, -0.08923, 0.1277). Patients with diabetes mellitus, obesity, hypertension and smokers did not have statistically different Lp (a) levels than patients without this diseases. CHD (p< 0.024) is more frequent in patients with higher Lp (a). Conclusions: Higher levels of Lp (a) are associated with manifestation of CHD in our group. There is no correlation between Lp (a) and correlated serum lipids in our group. Supported by grants." GACR 301/02/D065 and IGA MHCR NB 7392-3.
T5
INFLAMMATION
T05-P-001 ] C-REACTIVE PROTEIN IN STABLE CORONARY H E A R T DISEASE PATIENTS M. Ezhov, A. Sumarokov, A. Kambegova, I. Raimbekova, V. Masenko, V. Naumov. Atherosclerosis, Cardiology Res. Complex, Moscow, Russia
Objective: To evaluate the association of C-reactive protein concentration with coronary heart disease presence and severity. Methods: We have examined 510 patients (424 men, 86 women, mean age 56±10 years) subjected coronary angiography for suspected or diagnosed coronary heart disease (CHD). Before angiography we performed physical examination, blood chemistry. High-sensitivity C-reactive protein (CRP) was analysed by Dade/Behring method. Remits: Median CRP level was 2.4 mg/L, mean total cholesterol concentration - 6.0±1.4 mmol/L. Among all patients CRP was distributed as follows: <1 m g / L - 142 (28%), 1-3 mg/L - 151 (30%), >3 m g / L - 217 (42%). Seventy patients (14%) had normal coronary arteries, 114 ( 2 2 % ) 1 diseased coronary vessel, 127 (25%) - 2 vessels, 199 (39%) - 3 vessels. There was no difference between the groups in CRP concentration. Patients with coronary lesions had stable angina II-IV class and/or myocardial infarction. More than 70% CHD patients had CRP> 1 mg/L, and 43% patients had C R P > 3 mg/L. Of examined patients, 360 (70%) had arterial hypertension, 167 (33%) - f a m i l y history of CHD, 157 (31%) were smokers and 71 (14%) - diabetics. There was no difference in CRP level in the presence or absence of hypertension, or smoking, or family history of CHD. We have revealed that CRP level was significantly higher in diabetics than in non-diabetics (median, 95% CI): 3.3, 2.4-4.9, versus 2.4, 2.0-2.9 mg/L, p=0.03, respectively. Conclusion: C-reactive protein concentration is increased in majority of stable coronary heart disease patients, especially in those with diabetes mellitus, but not associated with coronary atherosclerosis severity. TO5-P-O02 ] CARVEDILOL DECREASES N E U T R O P H I L S SUPEROX IDE ANION GENERATION IN PATIENTS W I T H STABLE ANGINA J. Kowalski, L. Pawlicki, J. Blaszczyk, R. Irzmanski, T. Ceglinski, A. Lewinski, J. Kedziora. Dep. of lnternal Medicine and Cardiological
Rehabilitation, Medical University of Lodz, Lod~ Poland
Objective: The oxidative stress plays an important role in the pathogenesis of atherosclerosis and coronary heart disease (CHD). Increased generation of superoxide anion by PMNs leads initially to endothelial dysfunction and
then resuls in further progression of atherosclerosis. Thus, drugs that have antioxidative properties might be useful the treatment of patients with CHD. Methods: Effect of carvedflol on 02 generation by neutrophils was investigated in patients with stable angina. The study comprised 30 patients (20 men and l0 women), aged 37- 52 years (mean 47.9 years) with stable angina. The patients were administered carvedilol in increasing every four weeks doses: 12.5 mg/day, 25 mg/day, 50 mg/day. The control group consisted of 12 healthy subjects aged 39-49 years (mean 45.7 years). Blood samples were collected before, 4, 8 and 12 weeks after therapy in patients, and once in control group. Our study has been approved by the Local Ethics Committee. Superoxide anion generation by nonstimulated and OZ stimulated neutrophils was measured with Bellavite etal. method. Results: O2 generation by nonstimulated and OZ stimulated neutrophils in patients with stable angina was significantly (p < 0.05) higher than in control group. Neutrophil O2 generation did not differ 8 and 12 weeks after the therapy from that observed in healthy. Conclusions: The results of our study indicate that carvedilol inhibits neutrophil O2 generation equally effectively in both doses (25 mg/day and 50 mg/day) in patients with stable angina.
I T05-P-003 1 THE ASSOCIATION B E T W E E N PREHYPERTENSION STATUS AND INFLAMMATORY M A R K E R S RELATED TO A T H E R O S C L E R O T I C DISEASE; THE ATTICA STUDY D. Panagiotakos, C. Pitsavos, I. Skoumas, C. Stefanadis. First Cardiology
Clinic, Athens Medical School, Athens, Greece Background: The aim of this work was to evaluate the association between pre-hypertension status and inflammatory markers (C-reactive protein, white blood cells, interleukin-6, tumor necrosis factor-a, amyloid-a, homocysteine and fibrinogen), in a random sample of cardiovascular disease free adults, in Greece. Methods: The ATTICA study is a cross sectional population-based survey that conducted in Athens greater area during 2001-2002. Based on a multistage random sampling, 1514 men and 1528 women (18 - 89 years old) were enrolled. The survey included a detailed interview; blood samples collected after 12 hours of fasting and, among other clinical measurements, status of blood pressure levels was evaluated. Results: 653 men (43%) and 535 women (35%) were defined as prehypertensives. Compared to normotensives, and after controlling for several potential confounders, pre-hypertensive individuals showed a 31% relative increase in C-reactive protein, a 32% relative increase in tumor necrosis factor - a levels, a 9% increase in amyloid - A, a 6% increase in homocysteine levels and a 10% increase in white blood cell counts compared to normotensive subjects (all p < 0.05). Conclusions: We revealed a positive association between prehypertension and inflammatory markers related with the atherosclerotic process in cardiovascular disease free individuals from the general population. These associations were independent from other coexisting risk factors or unhealthy life-style behaviors, and may indicate a direct association of prehypertension with atherosclerotic disease.
I T0$-P-004 I ASSOCIATION B E T W E E N C-REACTIVE PROTEIN AND METABO LIC/HAEMODYNAMIC PARAMETERS J. Saban-Ruiz, E. Bemal, O. Sanchez, E. Sanchez-Largo, A. Ugalde, E. Femadez, D. Coca, R. Fabregate, L.M. Villar, J. Marquez. Endothelial
Pathology Unig Ramon y Cajal Hospital, Madrid, Spain Introduction: The increase of normal pulse pressure (PP) is associated with arteriosclerosis, a phenomenon considered degenerative and inactive, in contrast to atherosclerosis. Although C-reactive protein (CRP) has behaved as a marker of the insulin resistance (IR) syndrome, a marker of ED and a good predictor of acute events, all related with "atherosclerosis", it is not known if it could also he an indicator of "arteriosclerosis". Objectives: 1.To evaluate the biochemical and clinical parameters related with the CRP. 2.To determine if the ambulatory PP is independently related with the CRP. Material and Methods: N= 183, aged 57 + 12 yr, 55% f, 65% hypertensive, 35% DM2, 32% dyslipemic, and 15% active smokers. Methods: Waist; BMI, Biochemical:glucose total cholesterol, creatinine, HDL, and triglycerides, by HITACHI auto-analyzer,CRP (mg/l): Latex-
75th EAS Congress, 23-26 April 2005, Prague, Czech Republic