- Email: [email protected]
T502 INADEQUATE PAIN RELIEF IN KNEE OSTEOARTHRITIS: AN EARLY LOOK AT THE SURVEY OF OSTEOARTHRITIS REAL WORLD THERAPIES (SORT)
74
POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
difference was found. There is a trend towards younger patients being subjected to more pain. Conclusions: Almost half of the patients report chronic pain related to surgery. Allodynia from touch and pressure seems to be what causes most discomfort. Disclosure: None declared
T502 INADEQUATE PAIN RELIEF IN KNEE OSTEOARTHRITIS: AN EARLY LOOK AT THE SURVEY OF OSTEOARTHRITIS REAL WORLD THERAPIES (SORT) G.D.R. Martin1 , R. Balshaw2 , P.G. Conaghan3 , S.V. Everett4 , D.L. Watson5 , S.D. Taylor6 *. 1 Greenwood and Sneinton Family Medical Centre, Nottingham, UK; 2 Syreon, Vancouver, BC, Canada; 3 NIHR Leeds Muscloskeletal Biomedical Research Unit, University of Leeds, Leeds, UK; 4 Access Innovations & Operations, Merck & Co., Inc., Whitehouse Station, NJ, 5 Global Epidemiology, Merck & Co., Inc., Upper Gwynedd, PA, 6 Global Outcomes Research, Merck & Co., Inc., Whitehouse Station, NJ, USA Background and Aims: Osteoarthritis (OA) has an extremely high disease and economic burden. Despite treatments for OA pain management, data are limited on the adequacy of pain relief in OA patients. SORT will determine the adequacy of pain relief in patients with knee OA and compare patterns of clinical care and outcomes. Methods: SORT, a 12-month prospective, observational six-country study will enroll 1400 participants using oral or topical analgesics for knee OA symptoms. Participants visiting a PCP must be ≥50 years old with knee OA. Clinical history, medications, quality of life, resource use are collected at baseline and months 1, 3, 6, 9, & 12. Inadequate pain relief (IPR) was defined as Brief Pain Inventory “moderate or greater pain” score ≥4. Results: To date, 171 participants have provided baseline data: 69% women, median (range) age 68 years (50–90), 5.8 years post OA diagnosis, 61% taking pain medication-oral only. IPR was reported by 60%. IPR and non-IPR participants were similar in clinical characteristics: BMI 30 kg/m2 (20–55), co-exisitng OA of the hip (23%) & spine (35%). Hypertension (54%) was the most common co-morbidity. IPR participants scored worse across domains other than pain: WOMAC Stiffness (135 vs. 75, p < 0.01), Physical Function (986 vs. 527, p < 0.01); SF-12 General Health (fair/poor 44% vs. 28%, p = 0.05) & satisfaction with treatment side effects (very satisfied 17% vs. 40%, p < 0.01). Conclusions: With 60% of participants reporting IPR, the SORT study will provide valuable insight regarding the impact of IPR on individuals with knee OA. Disclosure: SV Everett, DL Watson and SD Taylor are employees for Merck & Co., Inc. the study sponsor.
T503 PTSD PREVALENCE IN A MULTIDISCIPLINARY PAIN CLINIC. A STUDY FROM PAIN CLINICS IN ODENSE, DENMARK AND OULU, FINLAND P.G. Andersen1 *, M.A. Wakkala2 , D. Ditlevsen1 , L. Kantojarvi ¨ 2, L.-A.C. Andersen3 . 1 Odense University Hospital, Odense, Denmark; 2 Oulu University Hospital, Oulu, Finland; 3 University of Southern Denmark, Odense, Denmark Background and Aims: Chronic non-malignant-pain-associated disorder (CNMPAD) represents a major medical and psychosocial problem. The typical symptomatology presented in CNMPAD is to some extend similar to symptoms of posttraumatic stress disorder (PTSD) and commonly co-occur. Previous findings suggest that the prevalence of PTSD is approximately 3–4% in the general population. Methods: The study has been completed simultaneously in two university hospital multidiciplinary non-malignant pain clinics,
Patients recieved a questionaire prior to their first visit. Critical components of the diagnostic criteria of PTSD were examined. Of 220 patients completing the questionaire in Odense, 185 could be tested, and of 84 in Oulu, 65 could be tested with the Harvard Trauma Questionaire (HTQ), to obtain PTSD score. Results: The prevalence of PTSD among CNMPAD patients was 23.6% (n = 52) in the Danish study, and 21.4% (n = 18) in the Finnish study. Effect size measures (Cohen’s d, 0.2 = small; 0.5 = medium; 0.8 = large) showed no difference in the prevalence of PTSD between Denmark and Finland (d 0.1223). There was no gender difference in the prevalence of PTSD in the Danish study (d 0.0439), or in the Finnish study (d 0.1643), and no overall gender difference was found either (d 0.0378). Conclusions: In Odense and Oulu we found the same significant higher prevalence of PTSD among CNMPAD patients than in the general population. This study highlights the importance of considering co-morbid PTSD in assessing patients with chronic non-malignant-painassociated disorder. Disclosure: None declared
T504 OBESITY IN ADULTS IS ASSOCIATED WITH INCREASED PAIN PREVALENCE AND PAIN-RELATED INTERFERENCE: A POPULATION-BASED STUDY K.A.S.L. Ferreira1,2,3 *, T.R.D. Dias4 , M.J. Teixeira1 , M.D.R.D.O. Latorre5 , A.M. Silva5 , J.C. Appolinario4 . 1 Multidisciplinary Pain Center, Department of Neurosurgery, Hospital das Clinicas, School of Medicine, University of S˜ ao Paulo, 2 School of Nursing, University of Guarulhos (UnG), 3 Instituto do Cancer do Estado de S˜ ao Paulo (ICESP), 4 Medical Scientific Department, Janssen Brazil; 5 Department of Epidemiology, School of Public Health, University of S˜ ao Paulo, S˜ ao Paulo, Brazil Aims: To examine the relationship between pain and obesity in a general population. Methods: A cross-sectional study was conducted in a populationbased sample in S˜ao Paulo, Brazil. The body mass index (BMI = weight(kg)/(height)2 ) was calculated considering the recalled body weight: underweight (UW) (BMI < 18.5 kg/m2 ), normal weight (NW) (18.5 to 24.9), overweight (OW) (25 to 29.9), obese class I (OI) (30 to 34.9), obese class II (OII) (35 to 39.9) and obese class III (OIII) (BMI ≥ 40). Chi-squared test and ANOVA were used for comparisons between BMI categories. Results: A number of 2,446 adults living at households were interviewed. The mean BMI was 25.31 (SD = 4.55). BMI classification: 2.3% UW, 47.6% NW, 31.4% OW, 9.4% OI, 2.3% OII and 7.0% OIII. 29.2% reported pain during the last 3 months. According to the BMI category, the frequency of pain was: 21.8% of UW, 26.5% of NW, 30.7% of OW, 36.3% of OI, and 28.7% of OIII. Obese class II reported the highest pain prevalence (49.1%) (p = 0.004). Respondents with NW were more likely (48.9%) to report head and neck pain (p = 0.003) and headache (54.1%) than other BMI categories. OII were more likely to report pain on multiple places, and OI (30.5%) and OIII (28.6%) pain on legs and feet. Pain interference: no statistically significant difference was observed on the mean pain interference with mood, sleep, relationship with others and normal work when comparing groups. It was observed that respondents with OIII reported higher pain interference with walking ability than NW (p = 0.010). Conclusions: Obesity was associated with chronic pain. Obese class II were more likely to report pain. Acknowledgements: This study was funded by Janssen Brazil. Disclosure: The authors Karine A. S. L. Ferreira, Manoel J. Teixeira, and Maria Rosario D. O. Latorre performed work as consultant/advisor for Janssen Brazil. The authors Telma R. Dias and Jose C. Appolinario are Janssen Brazil employees.
POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
difference was found. There is a trend towards younger patients being subjected to more pain. Conclusions: Almost half of the patients report chronic pain related to surgery. Allodynia from touch and pressure seems to be what causes most discomfort. Disclosure: None declared
T502 INADEQUATE PAIN RELIEF IN KNEE OSTEOARTHRITIS: AN EARLY LOOK AT THE SURVEY OF OSTEOARTHRITIS REAL WORLD THERAPIES (SORT) G.D.R. Martin1 , R. Balshaw2 , P.G. Conaghan3 , S.V. Everett4 , D.L. Watson5 , S.D. Taylor6 *. 1 Greenwood and Sneinton Family Medical Centre, Nottingham, UK; 2 Syreon, Vancouver, BC, Canada; 3 NIHR Leeds Muscloskeletal Biomedical Research Unit, University of Leeds, Leeds, UK; 4 Access Innovations & Operations, Merck & Co., Inc., Whitehouse Station, NJ, 5 Global Epidemiology, Merck & Co., Inc., Upper Gwynedd, PA, 6 Global Outcomes Research, Merck & Co., Inc., Whitehouse Station, NJ, USA Background and Aims: Osteoarthritis (OA) has an extremely high disease and economic burden. Despite treatments for OA pain management, data are limited on the adequacy of pain relief in OA patients. SORT will determine the adequacy of pain relief in patients with knee OA and compare patterns of clinical care and outcomes. Methods: SORT, a 12-month prospective, observational six-country study will enroll 1400 participants using oral or topical analgesics for knee OA symptoms. Participants visiting a PCP must be ≥50 years old with knee OA. Clinical history, medications, quality of life, resource use are collected at baseline and months 1, 3, 6, 9, & 12. Inadequate pain relief (IPR) was defined as Brief Pain Inventory “moderate or greater pain” score ≥4. Results: To date, 171 participants have provided baseline data: 69% women, median (range) age 68 years (50–90), 5.8 years post OA diagnosis, 61% taking pain medication-oral only. IPR was reported by 60%. IPR and non-IPR participants were similar in clinical characteristics: BMI 30 kg/m2 (20–55), co-exisitng OA of the hip (23%) & spine (35%). Hypertension (54%) was the most common co-morbidity. IPR participants scored worse across domains other than pain: WOMAC Stiffness (135 vs. 75, p < 0.01), Physical Function (986 vs. 527, p < 0.01); SF-12 General Health (fair/poor 44% vs. 28%, p = 0.05) & satisfaction with treatment side effects (very satisfied 17% vs. 40%, p < 0.01). Conclusions: With 60% of participants reporting IPR, the SORT study will provide valuable insight regarding the impact of IPR on individuals with knee OA. Disclosure: SV Everett, DL Watson and SD Taylor are employees for Merck & Co., Inc. the study sponsor.
T503 PTSD PREVALENCE IN A MULTIDISCIPLINARY PAIN CLINIC. A STUDY FROM PAIN CLINICS IN ODENSE, DENMARK AND OULU, FINLAND P.G. Andersen1 *, M.A. Wakkala2 , D. Ditlevsen1 , L. Kantojarvi ¨ 2, L.-A.C. Andersen3 . 1 Odense University Hospital, Odense, Denmark; 2 Oulu University Hospital, Oulu, Finland; 3 University of Southern Denmark, Odense, Denmark Background and Aims: Chronic non-malignant-pain-associated disorder (CNMPAD) represents a major medical and psychosocial problem. The typical symptomatology presented in CNMPAD is to some extend similar to symptoms of posttraumatic stress disorder (PTSD) and commonly co-occur. Previous findings suggest that the prevalence of PTSD is approximately 3–4% in the general population. Methods: The study has been completed simultaneously in two university hospital multidiciplinary non-malignant pain clinics,
Patients recieved a questionaire prior to their first visit. Critical components of the diagnostic criteria of PTSD were examined. Of 220 patients completing the questionaire in Odense, 185 could be tested, and of 84 in Oulu, 65 could be tested with the Harvard Trauma Questionaire (HTQ), to obtain PTSD score. Results: The prevalence of PTSD among CNMPAD patients was 23.6% (n = 52) in the Danish study, and 21.4% (n = 18) in the Finnish study. Effect size measures (Cohen’s d, 0.2 = small; 0.5 = medium; 0.8 = large) showed no difference in the prevalence of PTSD between Denmark and Finland (d 0.1223). There was no gender difference in the prevalence of PTSD in the Danish study (d 0.0439), or in the Finnish study (d 0.1643), and no overall gender difference was found either (d 0.0378). Conclusions: In Odense and Oulu we found the same significant higher prevalence of PTSD among CNMPAD patients than in the general population. This study highlights the importance of considering co-morbid PTSD in assessing patients with chronic non-malignant-painassociated disorder. Disclosure: None declared
T504 OBESITY IN ADULTS IS ASSOCIATED WITH INCREASED PAIN PREVALENCE AND PAIN-RELATED INTERFERENCE: A POPULATION-BASED STUDY K.A.S.L. Ferreira1,2,3 *, T.R.D. Dias4 , M.J. Teixeira1 , M.D.R.D.O. Latorre5 , A.M. Silva5 , J.C. Appolinario4 . 1 Multidisciplinary Pain Center, Department of Neurosurgery, Hospital das Clinicas, School of Medicine, University of S˜ ao Paulo, 2 School of Nursing, University of Guarulhos (UnG), 3 Instituto do Cancer do Estado de S˜ ao Paulo (ICESP), 4 Medical Scientific Department, Janssen Brazil; 5 Department of Epidemiology, School of Public Health, University of S˜ ao Paulo, S˜ ao Paulo, Brazil Aims: To examine the relationship between pain and obesity in a general population. Methods: A cross-sectional study was conducted in a populationbased sample in S˜ao Paulo, Brazil. The body mass index (BMI = weight(kg)/(height)2 ) was calculated considering the recalled body weight: underweight (UW) (BMI < 18.5 kg/m2 ), normal weight (NW) (18.5 to 24.9), overweight (OW) (25 to 29.9), obese class I (OI) (30 to 34.9), obese class II (OII) (35 to 39.9) and obese class III (OIII) (BMI ≥ 40). Chi-squared test and ANOVA were used for comparisons between BMI categories. Results: A number of 2,446 adults living at households were interviewed. The mean BMI was 25.31 (SD = 4.55). BMI classification: 2.3% UW, 47.6% NW, 31.4% OW, 9.4% OI, 2.3% OII and 7.0% OIII. 29.2% reported pain during the last 3 months. According to the BMI category, the frequency of pain was: 21.8% of UW, 26.5% of NW, 30.7% of OW, 36.3% of OI, and 28.7% of OIII. Obese class II reported the highest pain prevalence (49.1%) (p = 0.004). Respondents with NW were more likely (48.9%) to report head and neck pain (p = 0.003) and headache (54.1%) than other BMI categories. OII were more likely to report pain on multiple places, and OI (30.5%) and OIII (28.6%) pain on legs and feet. Pain interference: no statistically significant difference was observed on the mean pain interference with mood, sleep, relationship with others and normal work when comparing groups. It was observed that respondents with OIII reported higher pain interference with walking ability than NW (p = 0.010). Conclusions: Obesity was associated with chronic pain. Obese class II were more likely to report pain. Acknowledgements: This study was funded by Janssen Brazil. Disclosure: The authors Karine A. S. L. Ferreira, Manoel J. Teixeira, and Maria Rosario D. O. Latorre performed work as consultant/advisor for Janssen Brazil. The authors Telma R. Dias and Jose C. Appolinario are Janssen Brazil employees.