Table of Contents and barcode update

Volume 5, Number 6, November–December 2003

CONTENTS Invited Commentary 347

Critical Factors in the Design of Central Nervous System Receptor Imaging Probes for Use in Drug Discovery and Development Rikki N. Waterhouse, PhD, Timothy J. McCarthy, PhD, T. Lee Collier, PhD, H. Donald Burns, PhD Articles

350

Predicting the Success of a Radiopharmaceutical for In Vivo Imaging of Central Nervous System Neuroreceptor Systems Dean F. Wong, MD, PhD, Martin G. Pomper, MD, PhD

363

Relationships between Radiotracer Properties and Image Quality in Molecular Imaging of the Brain with Positron Emission Tomography Marc Laruelle, MD, Mark Slifstein, PhD, Yiyun Huang, PhD

376

Determination of Lipophilicity and Its Use as a Predictor of Blood–Brain Barrier Penetration of Molecular Imaging Agents Rikki N. Waterhouse, PhD

390

Autoradiography with Positron Emitting Isotopes in Positron Emission Tomography Tracer Discovery Mats Bergström, PhD, Raymond Awad, PhD, Sergio Estrada, PhD, Johan Mälman, Li Lu, PhD, Gabor Lendvai, Elisabeth Bergström-Pettermann, Bengt Långström, PhD

397

Application of LC-MS to the Analysis of New Radiopharmaceuticals Ying Ma, PhD, Dale Kiesewetter, PhD, Lixin Lang, PhD, William C. Eckelman, PhD

404

2-Dialkylamino-6-Acylmalononitrile Substituted Naphthalenes (DDNP Analogs): Novel Diagnostic and Therapeutic Tools in Alzheimer’s Disease Eric D. Agdeppa, PhD, Vladimir Kepe, PhD, Jie Liu, PhD, Gary W. Small, MD, Sung-Cheng Huang, DSc, Andrej Petricˇ, PhD, Nagichettiar Satyamurthy, PhD, Jorge R. Barrio, PhD Iodinated Tracers for Imaging Amyloid Plaques in the Brain Hang F. Kung, PhD, Mei-Ping Kung, PhD, Zhi Ping Zhuang, PhD, Catherine Hou, PhD, Chi-Wan Lee, PhD, Karl Plössl, PhD, Bing Zhuang, PhD, Daniel M. Skovronsky, PhD, Virgina M.-Y. Lee, PhD, John Q. Trojanowski, MD, PhD

418