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Tap water sodium in the low sodium diet
SELECTED
319
ABSTRACTS
Leaman, W. G., Wikingaaon, M. B., Webster, M. B., and Penicillin in Subaeute aaCteria1 Endocarditis Ann. Int. Med. 30~646 (March), 1949.
and Shaw, C. C.: Due to Streptoeoeeus
Carmw+ide Faeadie.
A 25year-old Negro woman, with mitral stenosis, developed subacute bacterial endocarditis approximately seven days following delivery. The nidus of infection was apparently an endometritis. The offending organism was a resistant type of Streptococcus faecalis which was isolated upon culture of the lochia and from the patient’s blood stream. The organism was resistant to 1 million units of penicillin daily, but responded promptly to 4.0 Gm. of streptomycin per day. One week following withdrawal of streptomycin, there was a recrudescenae of infection as shown by The organism was then found to have developed increased repeatedly positive blood cultures. penicillin resistance. This was overcome by the co-administration of oral Caronamide (24 Gm.) and intramuscular aqueous penicillin (4 million units per day). Blood samples were obtained at appropriate intervals during this therapeutic regimen to demonstrate the action of Caronamide in enhancing the concentration of penicillin in the plasma when compared with plasma levels of antibiotic when equal doses of penicillin alone were administered. Caronamide plasma concentrations were also determined. The patient reported herein, tolerated a daily dose of 24 Gm. of Caronamide for sixty-six consecutive days without tubular epithelial damage or renal impairment. Adequate peniciliin plasma levels during this period resulted in sterilization of the patient’s blood stream and an apparent clinical arrest of her disease. WENDROS. Sampson, M. C., Eissler, K. R., and Nay, R. M. t Unusual Case. Ann. Int. Med. 30:668 (March),
Polyarteritis 1949.
Nodosa:
A Report
of an
A 26-year-old man was first admitted to the hospital because of the sudden onset of a rightsided hemiparesis associated with a slurred speech and numbness of the right arm, right leg, and right side of the face. Since the age of 16 he had suffered from repeated bouts of polyarthritis, fever, and transient subcutaneous nodules. At the age of 21, evidences of nephritis were disdiscovered. Physical examination at the time of admission revealed signs indicative of widespread patchy involvement of the central nervous system. No significant eosinophilia was observed in the peripheral blood. Urinalysis revealed evidences of renal disease and renal impairment. During a two-month period of hospitalization, the neurological findings gradually disappeared and several crops of cystic subcutaneous nodules made their appearance. Biopsy of one of these nodules revealed changes in the blood vessels traversing the areolar tissue which were compatible with a diagnosis of polyarteritis nodosa. WENDKOS. Cole,
S. L. :
Tap
Water
Sodium
in
the Low
Sodium
Diet.
J. A. M. A. 140:19
(May),
1949.
This paper points out that the sodium content of drinking water is a factor to be considered when a salt-poor regimen is instituted in the treatment of heart failure, hypertension, or renal disease. Tap water high in sodium may nullify the effects of a stringent low salt diet. In a number of cities (Los Angeles, Houston, Phoenix, etc.) the sodium level of tap water is in excess of 10 mg. per hundred cubic centimeters. The concentration of sodium may be increased by the softening processes in the various institutions in which the water is used. It is suggested that distilled, deionized, or spring water be used in conjunction with a low sodium diet in areas where the tap water shows a high sodium concentration. HANNO.
319
ABSTRACTS
Leaman, W. G., Wikingaaon, M. B., Webster, M. B., and Penicillin in Subaeute aaCteria1 Endocarditis Ann. Int. Med. 30~646 (March), 1949.
and Shaw, C. C.: Due to Streptoeoeeus
Carmw+ide Faeadie.
A 25year-old Negro woman, with mitral stenosis, developed subacute bacterial endocarditis approximately seven days following delivery. The nidus of infection was apparently an endometritis. The offending organism was a resistant type of Streptococcus faecalis which was isolated upon culture of the lochia and from the patient’s blood stream. The organism was resistant to 1 million units of penicillin daily, but responded promptly to 4.0 Gm. of streptomycin per day. One week following withdrawal of streptomycin, there was a recrudescenae of infection as shown by The organism was then found to have developed increased repeatedly positive blood cultures. penicillin resistance. This was overcome by the co-administration of oral Caronamide (24 Gm.) and intramuscular aqueous penicillin (4 million units per day). Blood samples were obtained at appropriate intervals during this therapeutic regimen to demonstrate the action of Caronamide in enhancing the concentration of penicillin in the plasma when compared with plasma levels of antibiotic when equal doses of penicillin alone were administered. Caronamide plasma concentrations were also determined. The patient reported herein, tolerated a daily dose of 24 Gm. of Caronamide for sixty-six consecutive days without tubular epithelial damage or renal impairment. Adequate peniciliin plasma levels during this period resulted in sterilization of the patient’s blood stream and an apparent clinical arrest of her disease. WENDROS. Sampson, M. C., Eissler, K. R., and Nay, R. M. t Unusual Case. Ann. Int. Med. 30:668 (March),
Polyarteritis 1949.
Nodosa:
A Report
of an
A 26-year-old man was first admitted to the hospital because of the sudden onset of a rightsided hemiparesis associated with a slurred speech and numbness of the right arm, right leg, and right side of the face. Since the age of 16 he had suffered from repeated bouts of polyarthritis, fever, and transient subcutaneous nodules. At the age of 21, evidences of nephritis were disdiscovered. Physical examination at the time of admission revealed signs indicative of widespread patchy involvement of the central nervous system. No significant eosinophilia was observed in the peripheral blood. Urinalysis revealed evidences of renal disease and renal impairment. During a two-month period of hospitalization, the neurological findings gradually disappeared and several crops of cystic subcutaneous nodules made their appearance. Biopsy of one of these nodules revealed changes in the blood vessels traversing the areolar tissue which were compatible with a diagnosis of polyarteritis nodosa. WENDKOS. Cole,
S. L. :
Tap
Water
Sodium
in
the Low
Sodium
Diet.
J. A. M. A. 140:19
(May),
1949.
This paper points out that the sodium content of drinking water is a factor to be considered when a salt-poor regimen is instituted in the treatment of heart failure, hypertension, or renal disease. Tap water high in sodium may nullify the effects of a stringent low salt diet. In a number of cities (Los Angeles, Houston, Phoenix, etc.) the sodium level of tap water is in excess of 10 mg. per hundred cubic centimeters. The concentration of sodium may be increased by the softening processes in the various institutions in which the water is used. It is suggested that distilled, deionized, or spring water be used in conjunction with a low sodium diet in areas where the tap water shows a high sodium concentration. HANNO.