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TCT-591 Optical coherence tomography-guided PCI does not lead to an increase in contrast use compared to intravascular ultrasound-guided PCI
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 68, NO. 18, SUPPL B, 2016
clopidogrel or prasugrel according to the date of enrolment under monitoring of residual platelet reactivity. OCT evaluation was performed immediately after percutaneous coronary intervention (post PCI) and 10 days after index PCI (acute phase follow-up) for semiquantitative measuring of IST to calculate averaged IST score. The primary end point was delta averaged IST score.
who underwent OCT-guided PCI did not receive more contrast compared to those who underwent IVUS-guided PCI (260.5 92.8 mL vs. 266.9 98.6 mL, p ¼ 0.66, respectively). Furthermore, there was no significant difference in the radiation dose, fluoroscopy time, and procedure time between the two cohorts.
RESULTS 32 patients in prasugrel group and 64 patients in clopidogrel group were analysed. Averaged IST score post PCI were similar between two groups (0.68 0.41 vs. 0.68 0.40, p ¼ 0.99), however delta averaged IST score was significantly greater in prasugrel group compared with clopidogrel group (-0.411 0.288 vs. -0.299 0.271, p¼0.045). Decrease of averaged IST score was observed in all cases of prasgurel group and 87.5% in clopidogrel group (p¼0.03). The frequency of high residual platelet reactivity was significantly low in prasugrel group (10.0% vs 32.4%, p¼0.028). There was no complication of major bleeding in either group.
CONCLUSION OCT-guided PCI does not lead to significant differences in contrast volume, radiation dose, fluoroscopy time, and procedure time compared to IVUS-guided PCI. CATEGORIES IMAGING: Intravascular TCT-592 Difference of Tissue Characteristics between Early and Late Restenosis after Implanting Second-Generation Drug-Eluting Stents Assessed by Optical Coherence Tomography hiroyuki jinnouchi,1 Shoichi Kuramitsu,2 Takenori Domei,3 Kenji Ando4 1 Kokura Memorial Hospital, Kitakyusyu, Japan; 2kokura memorial hospital, Kitakyushu, Japan; 3Kokura memorial hospital, Kitakyusyu city, Japan; 4Kokura Memorial Hosiptal
CONCLUSION Prasugrel achieved greater acute phase reduction of IST over clopidogrel in ACS patients. CATEGORIES IMAGING: Intravascular
TCT-591 Optical coherence tomography-guided PCI does not lead to an increase in contrast use compared to intravascular ultrasoundguided PCI David Lee,1 Matteo Bianco,2 Paul Johnson,3 Prashant Kaul4 1 University of North Carolina, Chapel Hill, North Carolina, United States; 2Azienda Ospedaliero Universitaria San Luigi Gonzaga di Orbassano; 3Athens Regional Medical Center, Athens, Georgia, United States; 4UPMC BACKGROUND Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are catheter-based coronary imaging modalities that can be used to guide percutaneous coronary intervention (PCI). OCT provides images with higher resolution and greater speed, but requires additional contrast volume to displace blood for image acquisition. In comparison, IVUS provides lower resolution but greater tissue penetration without the need to displace blood. We aimed to compare the following procedural variables between OCTguided PCI and IVUS-guided PCI: contrast volume, radiation dose, fluoroscopy time, and procedure time. METHODS A single-center retrospective chart review was performed. We identified consecutive patients who underwent OCT-guided PCI and IVUS-guided PCI between August 2014 and February 2016. Baseline clinical characteristics and procedural variables were compared between the two cohorts. Statistical analysis was performed with SPSS software. RESULTS The final analysis included a total of 282 patients (55 underwent OCT-guided PCI, and 227 underwent IVUS-guided PCI). Despite requiring additional contrast for image acquisition, patients
BACKGROUND Previous optical coherence tomography (OCT) studies have reported about mechanism and time course between in-stent restenosis (ISR) of bare metal stent and first-generation drug eluting stent (DES) was different. However, mechanism and time course of second-generation DES-ISR is still unclear. We evaluated difference of tissue characteristics between different phases of second-generation DES-ISR using OCT. METHODS We compared tissue characteristics of early ISR (within 1 year: E-ISR, n¼35) and late ISR (beyond 1 year: L-ISR, n¼25). Qualitative restenotic tissue analysis included assessment of tissue structure (homogeneous and heterogeneous), presence of thin-cap fibroatheroma (TCFA), lipid laden, macrophage, neovascularization, thrombus, intimal disruption and peri-low intensity area (PLIA) was performed at every 1 mm slice of the entire stent length.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 68, NO. 18, SUPPL B, 2016
clopidogrel or prasugrel according to the date of enrolment under monitoring of residual platelet reactivity. OCT evaluation was performed immediately after percutaneous coronary intervention (post PCI) and 10 days after index PCI (acute phase follow-up) for semiquantitative measuring of IST to calculate averaged IST score. The primary end point was delta averaged IST score.
who underwent OCT-guided PCI did not receive more contrast compared to those who underwent IVUS-guided PCI (260.5 92.8 mL vs. 266.9 98.6 mL, p ¼ 0.66, respectively). Furthermore, there was no significant difference in the radiation dose, fluoroscopy time, and procedure time between the two cohorts.
RESULTS 32 patients in prasugrel group and 64 patients in clopidogrel group were analysed. Averaged IST score post PCI were similar between two groups (0.68 0.41 vs. 0.68 0.40, p ¼ 0.99), however delta averaged IST score was significantly greater in prasugrel group compared with clopidogrel group (-0.411 0.288 vs. -0.299 0.271, p¼0.045). Decrease of averaged IST score was observed in all cases of prasgurel group and 87.5% in clopidogrel group (p¼0.03). The frequency of high residual platelet reactivity was significantly low in prasugrel group (10.0% vs 32.4%, p¼0.028). There was no complication of major bleeding in either group.
CONCLUSION OCT-guided PCI does not lead to significant differences in contrast volume, radiation dose, fluoroscopy time, and procedure time compared to IVUS-guided PCI. CATEGORIES IMAGING: Intravascular TCT-592 Difference of Tissue Characteristics between Early and Late Restenosis after Implanting Second-Generation Drug-Eluting Stents Assessed by Optical Coherence Tomography hiroyuki jinnouchi,1 Shoichi Kuramitsu,2 Takenori Domei,3 Kenji Ando4 1 Kokura Memorial Hospital, Kitakyusyu, Japan; 2kokura memorial hospital, Kitakyushu, Japan; 3Kokura memorial hospital, Kitakyusyu city, Japan; 4Kokura Memorial Hosiptal
CONCLUSION Prasugrel achieved greater acute phase reduction of IST over clopidogrel in ACS patients. CATEGORIES IMAGING: Intravascular
TCT-591 Optical coherence tomography-guided PCI does not lead to an increase in contrast use compared to intravascular ultrasoundguided PCI David Lee,1 Matteo Bianco,2 Paul Johnson,3 Prashant Kaul4 1 University of North Carolina, Chapel Hill, North Carolina, United States; 2Azienda Ospedaliero Universitaria San Luigi Gonzaga di Orbassano; 3Athens Regional Medical Center, Athens, Georgia, United States; 4UPMC BACKGROUND Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are catheter-based coronary imaging modalities that can be used to guide percutaneous coronary intervention (PCI). OCT provides images with higher resolution and greater speed, but requires additional contrast volume to displace blood for image acquisition. In comparison, IVUS provides lower resolution but greater tissue penetration without the need to displace blood. We aimed to compare the following procedural variables between OCTguided PCI and IVUS-guided PCI: contrast volume, radiation dose, fluoroscopy time, and procedure time. METHODS A single-center retrospective chart review was performed. We identified consecutive patients who underwent OCT-guided PCI and IVUS-guided PCI between August 2014 and February 2016. Baseline clinical characteristics and procedural variables were compared between the two cohorts. Statistical analysis was performed with SPSS software. RESULTS The final analysis included a total of 282 patients (55 underwent OCT-guided PCI, and 227 underwent IVUS-guided PCI). Despite requiring additional contrast for image acquisition, patients
BACKGROUND Previous optical coherence tomography (OCT) studies have reported about mechanism and time course between in-stent restenosis (ISR) of bare metal stent and first-generation drug eluting stent (DES) was different. However, mechanism and time course of second-generation DES-ISR is still unclear. We evaluated difference of tissue characteristics between different phases of second-generation DES-ISR using OCT. METHODS We compared tissue characteristics of early ISR (within 1 year: E-ISR, n¼35) and late ISR (beyond 1 year: L-ISR, n¼25). Qualitative restenotic tissue analysis included assessment of tissue structure (homogeneous and heterogeneous), presence of thin-cap fibroatheroma (TCFA), lipid laden, macrophage, neovascularization, thrombus, intimal disruption and peri-low intensity area (PLIA) was performed at every 1 mm slice of the entire stent length.