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TELOMERE LENGTH IS AN INDEPENDENT PREDICTOR OF DISEASE SEVERITY IN OLDER PATIENTS PRESENTING WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME
A92 JACC March 17, 2015 Volume 65, Issue 10S
Acute Coronary Syndromes Telomere Length Is an Independent Predictor of Disease Severity in Older Patients Presenting with Non-ST Elevation Acute Coronary Syndrome Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Insights from Subgroups: Age, Gender and Diabetes Abstract Category: 2. Acute Coronary Syndromes: Clinical Presentation Number: 1138-071 Authors: Jonathan Adam Batty, Meedya Sharifpour, Murugapathy Veerasamy, Hannah Sinclair, Dermot Neely, Carmen Martin-Ruiz, Gabriele Saretzki, Vijayalakshmi Kunadian, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, Freeman Hospital, Newcastle upon Tyne, United Kingdom
Background: Although telomere length (TL) is a proposed biomarker for coronary artery disease (CAD) and a determinant of interindividual differences in cardiovascular ageing, few data exist regarding the clinical significance of telomere attrition in older patients presenting with non-ST-elevation acute coronary syndrome (NSTEACS). This study evaluated the association of TL with CAD severity in such individuals.
Methods: DNA was extracted from peripheral blood mononuclear cells, obtained from patients ≥ 75 year-old, admitted for invasive management of NSTEACS. Analysis of mean TL was performed using a quantitative polymerase chain reaction-based assay. Angiographic CAD severity was evaluated using the SYNTAX Score.
Results: 54 patients (mean age 81.1; 56% male) had a median ± interquartile range TL of 2386 ± 1042 base pairs. TL was not significantly associated with conventional cardiovascular risk factors (age, gender, smoking status, hypertension, diabetes; p > 0.05) or frailty (p = 0.39). However, natural log-transformed TL was associated with SYNTAX Score in unadjusted analysis (Figure 1), and following multivariate adjustment for conventional risk factors (age, diabetes, hypertension) and frailty (p = 0.007).
Conclusion: Telomere attrition is a significant, independent predictor of CAD severity among older patients. Further, longitudinal studies are required to evaluate long-term prognostic implications, and elucidate the key biological processes underlying these effects.
Acute Coronary Syndromes Telomere Length Is an Independent Predictor of Disease Severity in Older Patients Presenting with Non-ST Elevation Acute Coronary Syndrome Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Insights from Subgroups: Age, Gender and Diabetes Abstract Category: 2. Acute Coronary Syndromes: Clinical Presentation Number: 1138-071 Authors: Jonathan Adam Batty, Meedya Sharifpour, Murugapathy Veerasamy, Hannah Sinclair, Dermot Neely, Carmen Martin-Ruiz, Gabriele Saretzki, Vijayalakshmi Kunadian, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, Freeman Hospital, Newcastle upon Tyne, United Kingdom
Background: Although telomere length (TL) is a proposed biomarker for coronary artery disease (CAD) and a determinant of interindividual differences in cardiovascular ageing, few data exist regarding the clinical significance of telomere attrition in older patients presenting with non-ST-elevation acute coronary syndrome (NSTEACS). This study evaluated the association of TL with CAD severity in such individuals.
Methods: DNA was extracted from peripheral blood mononuclear cells, obtained from patients ≥ 75 year-old, admitted for invasive management of NSTEACS. Analysis of mean TL was performed using a quantitative polymerase chain reaction-based assay. Angiographic CAD severity was evaluated using the SYNTAX Score.
Results: 54 patients (mean age 81.1; 56% male) had a median ± interquartile range TL of 2386 ± 1042 base pairs. TL was not significantly associated with conventional cardiovascular risk factors (age, gender, smoking status, hypertension, diabetes; p > 0.05) or frailty (p = 0.39). However, natural log-transformed TL was associated with SYNTAX Score in unadjusted analysis (Figure 1), and following multivariate adjustment for conventional risk factors (age, diabetes, hypertension) and frailty (p = 0.007).
Conclusion: Telomere attrition is a significant, independent predictor of CAD severity among older patients. Further, longitudinal studies are required to evaluate long-term prognostic implications, and elucidate the key biological processes underlying these effects.