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Temporal control of movements after unilateral premotor and supplementar motor lesions in man
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TEMPORAL CONTROL OF MOVEMENTSAFTER UNILATERAL PREMOTOR AND
SUPPLEMENTARYMOTOR LESIONS IN MAN.
ULRIKE HALSBAND’.
HANS-JOACHIM FREUND’. AND JUN TANJI’. Departments of ‘Physiology, Tohoku Uni‘Neurology, Medizinische Einrichtungen der versity. School of Medicine, Sendai 980, Japan, and lleinrich-Heine-Universi tact Duesseldorf. D-4000 Duesseldorf 1. F. R. G. In the present study temporal control of movements was systematically analyzed in 14 patients with unilateral lesions of the lateral or medial premotor cortex (PMC) or supplementary motor The ability to learn new temporal adjustments was area (SMA) and 30 age-matched controls. in the presence of a sound assessed by examining rhythm reproduction ( unimanual vs bimanual ) signal and from memory. Handwriting of different amplitudes was taken as a task employing the recall of stored kinetic memories. The results reveal a severe disturbance in rhythm reproduction from memory in the absence of difficulties to produce the rhythms under auditory guidance after unilateral medial The deficit was most pronouncedafter left PMC or SMA lesions.
sided lesions using both hands in an alternatingmanner. After left lateral PMC lesions a severe breakdownof the isochronyof handwritingoccured. indicatinga disturbance in the automatic adjustment preponderance internally
left hemisphere between velocity and amplitude. The present findings point to a PMC and SMA in the production of in time control and suggest a critical role of determined motor sequences that fit into a precise timing plan.
CUTANEOUS AFFERENT ACTIVITY AND FINGER MOVEMENT DURING TEXTURE DISCRIMINATION BY ACTIVE TOUCH IN MAN. SINOBU TOMA AND YOSHIO NAKAJIMA, Department of Physiology, School of Medicine, Chiba University, 1-8-1, Inohana, Chiba 280, Japan Healthy subjects were blindfolded and asked to discriminate five different kinds of texture by active touch. Single afferent activity identified as rapid adapting (WI) or slowly adapting (SAI) type was recorded from the finger tip touching th& texture surface using a tungsten microelectrode inserted percutaneously into the median nerve. The finger scanning movement, flexion, friction and pressure were measured by an ultrasonic position transducer, goniometer, accelerometer and load-cell, respectively. RAI fired synchronously with undulating-acceleration, whose amplitude was proportional to the roughness of texture. SAI fired in coincidence with finger pressure change, particularly during the velocity-constant phase of the sinusoidal finger movement. It was supposed from these results that active finger movement is controlled to augment the characteristic sensitivity of RAI receptor, that the discharge pattern of RAI precisely conveys information of texture difference to higher center, and that finger pressure is controlled by SAI, which functions as to reduce a friction during active finger scanning movement.
THE RADIOLIGAND BINDING STUDY FOR 5-HT3 SEROTONIN RECEPTORS IN REGIONS CONCERNING MOTOR CONTROL OF RAT BRAIN. TAKANOBU YAMAMOTOI-* HIROYUKI FUKUIZ. ATSUSHI YAMATODANIZ. AND HIROSHI WADAZ,lFacultv of ~Arts.DeTezukavamaar631.mzDeDartmen~ of Pharmacoloey II. Facultv of Medicine. Osaka Universitv. Yamadaoka 2-2. Suita. Osaka. Jauan. We have reported that the rat whose striatum was lesioned bilaterally by the treatment of 5,7dihydroxytryptamine, or were administered i.p. with ICS 205-930 or SN-307 (ondansetron), specific 5HT3 serotonin receptor antagonists, showed an abnormal rolling movement during swimming exercise (1). However, methysergide, a 5-HTIA, 5-HTIB, 5-HTIC and 5-HT2 antagonist, had no effect. In the present report, we performed the radioligand binding study for 5-HT? serotonin receptors using [3H] GR65630 in regions concerning motor control of rat brain. The specific bindings of [SH] GR65630 to membranes from rat cerebral cortex were saturated with the Kd value of 0.38 * 0.02 nM and the Bmax value of 2.91 f 0.03 fmol/mg protein (n=4). These levels were lower than reported by Kilpatric et al., (2). Low levels of the radioligand bindings were detected in membranes from striatum and cerebellum (ranging from 0.6 to 1.0 fmol/mg protein). The. data that higher amount of 5-HT3 serotoninreceptorslocatedin the cerebral cortex may help in explaining the abnormal rolling movement during swimming exercise via 5-HTx receptors. (1) T.Yamamoto et al., Jpn. J. Pharmacol., 55 suppl. I,213~ (1991)
(2)G.J.Kilpatric et al., Nature, 330 24/31,746-748(1987)
TEMPORAL CONTROL OF MOVEMENTSAFTER UNILATERAL PREMOTOR AND
SUPPLEMENTARYMOTOR LESIONS IN MAN.
ULRIKE HALSBAND’.
HANS-JOACHIM FREUND’. AND JUN TANJI’. Departments of ‘Physiology, Tohoku Uni‘Neurology, Medizinische Einrichtungen der versity. School of Medicine, Sendai 980, Japan, and lleinrich-Heine-Universi tact Duesseldorf. D-4000 Duesseldorf 1. F. R. G. In the present study temporal control of movements was systematically analyzed in 14 patients with unilateral lesions of the lateral or medial premotor cortex (PMC) or supplementary motor The ability to learn new temporal adjustments was area (SMA) and 30 age-matched controls. in the presence of a sound assessed by examining rhythm reproduction ( unimanual vs bimanual ) signal and from memory. Handwriting of different amplitudes was taken as a task employing the recall of stored kinetic memories. The results reveal a severe disturbance in rhythm reproduction from memory in the absence of difficulties to produce the rhythms under auditory guidance after unilateral medial The deficit was most pronouncedafter left PMC or SMA lesions.
sided lesions using both hands in an alternatingmanner. After left lateral PMC lesions a severe breakdownof the isochronyof handwritingoccured. indicatinga disturbance in the automatic adjustment preponderance internally
left hemisphere between velocity and amplitude. The present findings point to a PMC and SMA in the production of in time control and suggest a critical role of determined motor sequences that fit into a precise timing plan.
CUTANEOUS AFFERENT ACTIVITY AND FINGER MOVEMENT DURING TEXTURE DISCRIMINATION BY ACTIVE TOUCH IN MAN. SINOBU TOMA AND YOSHIO NAKAJIMA, Department of Physiology, School of Medicine, Chiba University, 1-8-1, Inohana, Chiba 280, Japan Healthy subjects were blindfolded and asked to discriminate five different kinds of texture by active touch. Single afferent activity identified as rapid adapting (WI) or slowly adapting (SAI) type was recorded from the finger tip touching th& texture surface using a tungsten microelectrode inserted percutaneously into the median nerve. The finger scanning movement, flexion, friction and pressure were measured by an ultrasonic position transducer, goniometer, accelerometer and load-cell, respectively. RAI fired synchronously with undulating-acceleration, whose amplitude was proportional to the roughness of texture. SAI fired in coincidence with finger pressure change, particularly during the velocity-constant phase of the sinusoidal finger movement. It was supposed from these results that active finger movement is controlled to augment the characteristic sensitivity of RAI receptor, that the discharge pattern of RAI precisely conveys information of texture difference to higher center, and that finger pressure is controlled by SAI, which functions as to reduce a friction during active finger scanning movement.
THE RADIOLIGAND BINDING STUDY FOR 5-HT3 SEROTONIN RECEPTORS IN REGIONS CONCERNING MOTOR CONTROL OF RAT BRAIN. TAKANOBU YAMAMOTOI-* HIROYUKI FUKUIZ. ATSUSHI YAMATODANIZ. AND HIROSHI WADAZ,lFacultv of ~Arts.DeTezukavamaar631.mzDeDartmen~ of Pharmacoloey II. Facultv of Medicine. Osaka Universitv. Yamadaoka 2-2. Suita. Osaka. Jauan. We have reported that the rat whose striatum was lesioned bilaterally by the treatment of 5,7dihydroxytryptamine, or were administered i.p. with ICS 205-930 or SN-307 (ondansetron), specific 5HT3 serotonin receptor antagonists, showed an abnormal rolling movement during swimming exercise (1). However, methysergide, a 5-HTIA, 5-HTIB, 5-HTIC and 5-HT2 antagonist, had no effect. In the present report, we performed the radioligand binding study for 5-HT? serotonin receptors using [3H] GR65630 in regions concerning motor control of rat brain. The specific bindings of [SH] GR65630 to membranes from rat cerebral cortex were saturated with the Kd value of 0.38 * 0.02 nM and the Bmax value of 2.91 f 0.03 fmol/mg protein (n=4). These levels were lower than reported by Kilpatric et al., (2). Low levels of the radioligand bindings were detected in membranes from striatum and cerebellum (ranging from 0.6 to 1.0 fmol/mg protein). The. data that higher amount of 5-HT3 serotoninreceptorslocatedin the cerebral cortex may help in explaining the abnormal rolling movement during swimming exercise via 5-HTx receptors. (1) T.Yamamoto et al., Jpn. J. Pharmacol., 55 suppl. I,213~ (1991)
(2)G.J.Kilpatric et al., Nature, 330 24/31,746-748(1987)