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Thalamic involvement in the genesis of migraine: Psychophysiological evidence
J. Gruzelier, ed. / Psychophysiology
Society abstracts
101
THALAMIC INVOLVEMENT IN THE GENESIS OF MIGRAINE: PSYCHOPHYSIOLOGICAL EVIDENCE
John GRUZELIER Department
of Psychiatry,
Charing Cross & Westminster
Medical School, London, U.K.
Although prominance was given in the last century to the possibility of primary neurogenic involvement in migraine (Gowers, lSSS>, until recently most research has sought an explanation in changes in the extra-cranial vasculature, notably dilatation of the cephalic artery found to coincide with the experience of throbbing pain. Reasons for the renewal of interest in the neural hypothesis will be outlined including the nature of cerebral bloodflow during the various stages of the migraine at-tack, consideration of prodromal and precipitating factors, but giving particular emphasis to psychophysiological studies of migraineurs during interictal phases. The neural mechanisms that underly abnormalities in the focal regulation of cortical activation revealed by the psychophysiological investigations (including research in our laboratory outlined in a companion poster) implicate the nonspecific thalamo-cortical system and its interconnections with the hypothalamus and reticular system. This hypothesis is compatible with the accessory sensory, motor and prodromal symptoms of the migraine syndrome, and finds support in recent neuropathological case studies.
References Gowers, W.R. (1888). Churchill.
A manual
of diseases of the nervous system
4.3. CNS DYSFUNCTION IN SCHIZOPHRENIA: PSYCHOPHYSIOLOGICAL APPROACHES
Symposium convened by John GRUZELIER
(Vol. 2, p. 789). London:
Society abstracts
101
THALAMIC INVOLVEMENT IN THE GENESIS OF MIGRAINE: PSYCHOPHYSIOLOGICAL EVIDENCE
John GRUZELIER Department
of Psychiatry,
Charing Cross & Westminster
Medical School, London, U.K.
Although prominance was given in the last century to the possibility of primary neurogenic involvement in migraine (Gowers, lSSS>, until recently most research has sought an explanation in changes in the extra-cranial vasculature, notably dilatation of the cephalic artery found to coincide with the experience of throbbing pain. Reasons for the renewal of interest in the neural hypothesis will be outlined including the nature of cerebral bloodflow during the various stages of the migraine at-tack, consideration of prodromal and precipitating factors, but giving particular emphasis to psychophysiological studies of migraineurs during interictal phases. The neural mechanisms that underly abnormalities in the focal regulation of cortical activation revealed by the psychophysiological investigations (including research in our laboratory outlined in a companion poster) implicate the nonspecific thalamo-cortical system and its interconnections with the hypothalamus and reticular system. This hypothesis is compatible with the accessory sensory, motor and prodromal symptoms of the migraine syndrome, and finds support in recent neuropathological case studies.
References Gowers, W.R. (1888). Churchill.
A manual
of diseases of the nervous system
4.3. CNS DYSFUNCTION IN SCHIZOPHRENIA: PSYCHOPHYSIOLOGICAL APPROACHES
Symposium convened by John GRUZELIER
(Vol. 2, p. 789). London: