The action of testosterone in functional uterine haemorrhage

The action of testosterone in functional uterine haemorrhage

547 .\HRTRA('I'S The authors do not mention the number of patients treated with testosterone. They state, however, that the largest group was in the...

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547

.\HRTRA('I'S

The authors do not mention the number of patients treated with testosterone. They state, however, that the largest group was in the premenopausal period. Five cases are report,ed in detail. In Case 3 they add an interesting observation that the circumference of the pat,ient’s hips, thighs, and knees decreased in size and the pat.ient, lost 2 kg. of weight. The writers are enthusiastic about their good results hut warn t,hat every patient must have her treatment individualized. CIAIR E. For~solw~.

Turpault

:

The Male

Gynecalogie

38:

Hormone

281,

in Women

Especially

in Cases of Hemorrhage,

1939.

In the opinion of Turpault male hormones are indicated in women for the fullowing conditions: mastopathies, uterine fibroids, functional uterine bleeding, especially at puberty and at the menopause, intermenstrual pain, uterine hyperplasia, hypertrophy of the cervix, and disturbances of the menopause. He cautions, however, that in addit,ion to the favorable effects of the male hormone there are certain inconveniences. These are as follows: fatigue, which may lle overcome by adrenal therapy, excitement, liver disturbances, deepening of the voice, and enlargement of the clitoris. The dose of male hormone varies with the indications for its use. Rowever, it is best to begin with small doses, such as 5 my. For mastopathies, from 5 to 30 mg. should be given each month, distributed in from 1 to 5 doses, beginning the tenth day after the onset of the menses. For functional uterine bleeding as much as 50 to 60 mg. must usually be given each month. For fibroids of the uterus very large doses, from 50 to 500 mg., must be administered. Not infrequently after the hormone is stopped, the ‘symptoms reappear. lo such cases one may try implantation of testosterone in the form of crystals in the skin, as suggested by Parkes. J. P. GREENHILL.

Moricard, R., and Saulnier, F.: Artikial by Means of the Esters of Testosterone,

Development Gynecologie

of the Genital

Apparatus

38: 272, 1939.

These authors were able to produce a marked development of the genital apparatus in human beings by means of the synthetic esters of testosterone. This could be accomplished with 100 mg. administered over a period of a month and a half. When 400 mg. were given, there was an almost constant appearance of signs of puberty in children, who had the adiposogenital syndrome. Among women the injection of the esters of testosterone resulted in a disappearance of the Likewise this substance was capable of neurovegetative symptoms of castration. stopping functional uterine bleeding. J. P. GREENHILL

Mascio, Aquino: Folia

The. Action

demograph-gynaec.

The author considers and reports results in doses employed by him observed. He found a uterine bleeding hoth in

of Testosterone 36:

165,

in Functional

Uterine

Haemorrhage,

1939.

the mechanism of the therapeutic action of testosterone several cases of functional uterine bleeding. With the (5 to 10 mg. on alternate days) no untoward effects were constant and favorable action in controlling functional puberty and in the preclimacteric. MARIO A. CASTALLO.