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The amount of circulating blood before and after mercury diuresis
Eoome, Norman W., and Wilson, Harwell: Experimental Extracts From Traumatized Limbs on Blood Pressure. 1935.
Shock. -2reh.
The Effects Surg. 31:
of 361,
Two theories suggrstetl as the me~~hanism of traumalic -hock have receic-ed most attention recently: (I) that of absorption of metabolic toxins from traumatized area which effect vasodilation an(t increased permeability of capillaries and (2) that of local loss of blood or plasma, or both, resulting in a nerjous decrease Experiments on dogs are described in which in the volume of circulating blood. extracts obtained from traumatized limbs were perfusetl in a seconil animal. Preliminary experiments showed that such extracts were markedly hemoeoagulant, and almost invariably caused death contained particles of fat and of tissues, when injected intralrenously. Extracts purified by centrifugution when injected into a heparinized animal caused a rise in blood pressure; if the bloody fluid was removed before centrifugxtion, t,l:e extract did not cause a sustaine~d fall in blood pressure merits.
Goldhammer, Before
and
or death.
The
St., Leiner, G., After Mercury
“toxic
theory”
and Scherf, D.: Diuresis. Klin.
was
not
supported
by
t,he experid
The Amount of Circulating Wchnschr. 46: L109, 1936.
Blood
Determination of the amount of circulating bloo~l w.vith CO antL trypan reel method in fourteen cases of heart failure showed a diminution in the amount of T?re Gminution circulating blood twenty-four hours a.ftrr salyrgan injections. paralleled the amount of diuresis anti loss of weight. The plasma volume and The results are not due t,o redueed red cell count were found to he diminishetl. Ther,e appears amount of blood but to diminished water retention in the tissues. to be a shift of blood from the liver and large ITeins to the periphery. J. KY. IV. Starr, Isaac, Jr.: Acetyl-~-~et~ylcholin: Paroxysmal Tachycardia and in Certain Rhythm, AILI. J. M. SC. 191: 210, KG&
Further Other
Studies of Disturbances
Its of
Action in Cardiac
Xoetyl-P-nlethvlcholin has been used in the treatment of 76 attacks of paroxysma1 tachycardia in 37 patients. Jn 66 instances (88 per cent) the attack was promptly brought to an end. The dosage necessary to terminate attacks of paroxysma. tachpcardia raries with the age as, well as with the meight of the patient. Quinidine antagonizes the cardiac action of aeetyl-P-n~ethylcholin and may well be responsible for the failure to bring attatks of paroxysmal tachyeardix to an end in certain cases. In aurieular flutter change in the rhythm can occasionally be brought about by acetyl-P-methylcholin. In one case the frequency of ventricular estrasystoles was diminished by the drug. The symptoms arc closeThe effects of overdosage of the drug are described. ly analogous to those of the ordinary attack of syncope. ATTHOR.
Shock. -2reh.
The Effects Surg. 31:
of 361,
Two theories suggrstetl as the me~~hanism of traumalic -hock have receic-ed most attention recently: (I) that of absorption of metabolic toxins from traumatized area which effect vasodilation an(t increased permeability of capillaries and (2) that of local loss of blood or plasma, or both, resulting in a nerjous decrease Experiments on dogs are described in which in the volume of circulating blood. extracts obtained from traumatized limbs were perfusetl in a seconil animal. Preliminary experiments showed that such extracts were markedly hemoeoagulant, and almost invariably caused death contained particles of fat and of tissues, when injected intralrenously. Extracts purified by centrifugution when injected into a heparinized animal caused a rise in blood pressure; if the bloody fluid was removed before centrifugxtion, t,l:e extract did not cause a sustaine~d fall in blood pressure merits.
Goldhammer, Before
and
or death.
The
St., Leiner, G., After Mercury
“toxic
theory”
and Scherf, D.: Diuresis. Klin.
was
not
supported
by
t,he experid
The Amount of Circulating Wchnschr. 46: L109, 1936.
Blood
Determination of the amount of circulating bloo~l w.vith CO antL trypan reel method in fourteen cases of heart failure showed a diminution in the amount of T?re Gminution circulating blood twenty-four hours a.ftrr salyrgan injections. paralleled the amount of diuresis anti loss of weight. The plasma volume and The results are not due t,o redueed red cell count were found to he diminishetl. Ther,e appears amount of blood but to diminished water retention in the tissues. to be a shift of blood from the liver and large ITeins to the periphery. J. KY. IV. Starr, Isaac, Jr.: Acetyl-~-~et~ylcholin: Paroxysmal Tachycardia and in Certain Rhythm, AILI. J. M. SC. 191: 210, KG&
Further Other
Studies of Disturbances
Its of
Action in Cardiac
Xoetyl-P-nlethvlcholin has been used in the treatment of 76 attacks of paroxysma1 tachycardia in 37 patients. Jn 66 instances (88 per cent) the attack was promptly brought to an end. The dosage necessary to terminate attacks of paroxysma. tachpcardia raries with the age as, well as with the meight of the patient. Quinidine antagonizes the cardiac action of aeetyl-P-n~ethylcholin and may well be responsible for the failure to bring attatks of paroxysmal tachyeardix to an end in certain cases. In aurieular flutter change in the rhythm can occasionally be brought about by acetyl-P-methylcholin. In one case the frequency of ventricular estrasystoles was diminished by the drug. The symptoms arc closeThe effects of overdosage of the drug are described. ly analogous to those of the ordinary attack of syncope. ATTHOR.