- Email: [email protected]
The aphrodisiac effect of (-)deprenyl in non-copulator male rats
Pharmaco/ogica/ Research Communications, Vol. 20, Supplement !, 1988 THE APHRODISIAC
EFFECT OF
(-)DEPRENYL
25
IN NON-COPULATOR
MALE
RATS Dallo,
J., Yen,
macology,
T.T., Farago,
J. Department
Semmelweis University of Medicine,
(-)Deprenyl,
aphrodisiac
inhibitor
that
of monoamine oxidase
long-lasting
aphrodisiac
(-)deprenyl,
in sexually
1983).
(body weight 400-450 g) were tested with re-
The copulatory patterns
and ejaculation)
the selective
sluggish old male
ceptive females for four weekly mating tests min.).
Hungary
(MAC) B form exerted a true,
effect
(for review see Knoll,
CFY male rats
Budapest,
of Phar-
effect
We have found previously,
rats
I., Knoll,
of males
were registered
(test duration
(mounting,
by tape recorder
intromission
(Dallo e t a l . ,
1986).
Males Which failed to show any copulatory patterns
chosen
a s non~copulators.
non-copulators.
30
were
37 males out of 140 proved the be
Of the 37 non-copulators
with a single dose of 0.9.5 mg/kg
ten males were treated
(-)deprenyl,
ten males with
the same dose three times a week for 1 7 consecutive seventeen untreated males served as controls.
weeks and
Copulatory
acti-
vity was checked once a week. The results
are summarized
in Table I. Control males
failed to reach ejaculation
during the observation
mountings
and intromissions
were detectable
testings.
Single dose of
in non-copulator males, a~d facilitated renyl
but
during repeated
(~i) elicited ejaculation
as well. Repeated
a m o r e pronounced
in non-oopulator
0031-6989/88/20S10025-2/$03.00/0
period,
which effect lasted for several weeks
intromissions
(D2) exerted
patterns
(-)deprenyl
(C)
males:
doses of
stimulation
the ejaculations
(-)dep-
of mating and intro-
© 1988 The Italian Pharmacological Society
Pharmacological Research Communications, Vol. 20, Suppleme/It l, 1988
26
Table I.
Total number of mountings (M), intromlssions (1) and ejaculations (E) in non-copulator male rats treated with (-)deprenyl in comparison to the control males during an observation period of 17 weeks
M
I
E
M
I
E
M
I
E
M
C
0
0
0
39
3
0
106
25
0
167
DI
O
0
0
50
55
6
i0
20
4
D2
0
0
0
25
50
6
166
I01
I
E
62
0
no further
I0
78
113
te~ ii
weekly mating test 1-4
5-8
9-12
13-17
C: untreated males (N=17); DI: single dose of 0.25 mg/kg ( - ) d e ~ renyl, s.c. administered 24 ~ours prior to the fifth test (N=IO); D 2 : 0 . 2 5 mg/kg (-)deprenyl, s.c. three times a week. Third injection 24 hours prior ~o the fifth test (N=IO) missions were consistently maintained the observation.
Thus
(-)deprenyl proved to be a true aphrodi-
siac also in non-copulator males. ration of this effect sluggish males (-)deprenyl
on a high level during
The later onset and long du-
is similar to the observation
(Knoll et al.,
in non-copulator
1983).
The peculiar
(Knoll,
sexual activity
effect of
males is thought to be the con-
sequence of its special mechanism of activation ergic system
in sexually
of the dopamin-
1987) which is known to facilitate male
(Gessa and Napoli-Farris,
1983).
REFERENCES Dallo, J., Lekka, N., Knoll, J., Pol. J. Pharmacol. Pharm., 38, 251, 1986. Gessa, G.L., Napoli-Farris, L. i n : P s y c h o p h a r m a c o l o g y and sexual disorders. Ed: D. W h e a t l y , O x f o r d U n i v e r s i t y P r e s s , L o n d o n , pp. 15, 1983. K n o l l , J . , A c t a N e u r o l . S c a n d . S u p p l . 95, 57, 1983. K n o l l , J . , J . N e u r a l Transm. S u p p l . 25, 45, 1987. K n o l l , J . , Yen. T . T . , D a l l o , J . , Mod. P r o b l . P h a r m a c o p s ~ h i a t r ~ 19, 135, 1983.
EFFECT OF
(-)DEPRENYL
25
IN NON-COPULATOR
MALE
RATS Dallo,
J., Yen,
macology,
T.T., Farago,
J. Department
Semmelweis University of Medicine,
(-)Deprenyl,
aphrodisiac
inhibitor
that
of monoamine oxidase
long-lasting
aphrodisiac
(-)deprenyl,
in sexually
1983).
(body weight 400-450 g) were tested with re-
The copulatory patterns
and ejaculation)
the selective
sluggish old male
ceptive females for four weekly mating tests min.).
Hungary
(MAC) B form exerted a true,
effect
(for review see Knoll,
CFY male rats
Budapest,
of Phar-
effect
We have found previously,
rats
I., Knoll,
of males
were registered
(test duration
(mounting,
by tape recorder
intromission
(Dallo e t a l . ,
1986).
Males Which failed to show any copulatory patterns
chosen
a s non~copulators.
non-copulators.
30
were
37 males out of 140 proved the be
Of the 37 non-copulators
with a single dose of 0.9.5 mg/kg
ten males were treated
(-)deprenyl,
ten males with
the same dose three times a week for 1 7 consecutive seventeen untreated males served as controls.
weeks and
Copulatory
acti-
vity was checked once a week. The results
are summarized
in Table I. Control males
failed to reach ejaculation
during the observation
mountings
and intromissions
were detectable
testings.
Single dose of
in non-copulator males, a~d facilitated renyl
but
during repeated
(~i) elicited ejaculation
as well. Repeated
a m o r e pronounced
in non-oopulator
0031-6989/88/20S10025-2/$03.00/0
period,
which effect lasted for several weeks
intromissions
(D2) exerted
patterns
(-)deprenyl
(C)
males:
doses of
stimulation
the ejaculations
(-)dep-
of mating and intro-
© 1988 The Italian Pharmacological Society
Pharmacological Research Communications, Vol. 20, Suppleme/It l, 1988
26
Table I.
Total number of mountings (M), intromlssions (1) and ejaculations (E) in non-copulator male rats treated with (-)deprenyl in comparison to the control males during an observation period of 17 weeks
M
I
E
M
I
E
M
I
E
M
C
0
0
0
39
3
0
106
25
0
167
DI
O
0
0
50
55
6
i0
20
4
D2
0
0
0
25
50
6
166
I01
I
E
62
0
no further
I0
78
113
te~ ii
weekly mating test 1-4
5-8
9-12
13-17
C: untreated males (N=17); DI: single dose of 0.25 mg/kg ( - ) d e ~ renyl, s.c. administered 24 ~ours prior to the fifth test (N=IO); D 2 : 0 . 2 5 mg/kg (-)deprenyl, s.c. three times a week. Third injection 24 hours prior ~o the fifth test (N=IO) missions were consistently maintained the observation.
Thus
(-)deprenyl proved to be a true aphrodi-
siac also in non-copulator males. ration of this effect sluggish males (-)deprenyl
on a high level during
The later onset and long du-
is similar to the observation
(Knoll et al.,
in non-copulator
1983).
The peculiar
(Knoll,
sexual activity
effect of
males is thought to be the con-
sequence of its special mechanism of activation ergic system
in sexually
of the dopamin-
1987) which is known to facilitate male
(Gessa and Napoli-Farris,
1983).
REFERENCES Dallo, J., Lekka, N., Knoll, J., Pol. J. Pharmacol. Pharm., 38, 251, 1986. Gessa, G.L., Napoli-Farris, L. i n : P s y c h o p h a r m a c o l o g y and sexual disorders. Ed: D. W h e a t l y , O x f o r d U n i v e r s i t y P r e s s , L o n d o n , pp. 15, 1983. K n o l l , J . , A c t a N e u r o l . S c a n d . S u p p l . 95, 57, 1983. K n o l l , J . , J . N e u r a l Transm. S u p p l . 25, 45, 1987. K n o l l , J . , Yen. T . T . , D a l l o , J . , Mod. P r o b l . P h a r m a c o p s ~ h i a t r ~ 19, 135, 1983.