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The application of tissue engineering principles toward the construction of improved bioprosthetic heart valves
CARDIOVASCULAR AWLICAYUXS ~63%A~WHXAL Smumm~ PROTEINS PRCIDUCED BY RECOMB~AWT TECXINCXCXXES DAVID
A. TIRRELL
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003 USA
This lecture will discussthe construction of artificial proteins for use in biomaterials applications. The design of such materials draws on ideas taken in part from polymer chemistry and physics and in part from structural biology, and expioits the sequence control and chain-length uniformity provided by genetic engineering. Severalexamplesof artificial protein designswill be describedand the potential for application of such methods to the preparation of materials for vasculargrafts will be considered.
The Ap,pB Heart Valves
@f Tii
Christopher K. Breuer, To&i Shin’oka, John E. Mayer, FL&LX&LaAtr;erand JosephP. Vacanti, Harvard University/MassachusettsInstitute of TeclmoIogy~~~~~~~~~~* USA) The construction of a tissue engineeredheart valve has several poWGal advantagesover the curr4tiy used
matrix composedof a copolymer of surgically implanted into don0 function was evaluatedusing twelve week time courseand e demonstratethat the structure and firnction of the tissueengineeredcunstr~ts a@r@aches thoseof &ive tissue when they are exposedto physiologic forcesover an extendedperiod of time.
A. TIRRELL
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003 USA
This lecture will discussthe construction of artificial proteins for use in biomaterials applications. The design of such materials draws on ideas taken in part from polymer chemistry and physics and in part from structural biology, and expioits the sequence control and chain-length uniformity provided by genetic engineering. Severalexamplesof artificial protein designswill be describedand the potential for application of such methods to the preparation of materials for vasculargrafts will be considered.
The Ap,pB Heart Valves
@f Tii
Christopher K. Breuer, To&i Shin’oka, John E. Mayer, FL&LX&LaAtr;erand JosephP. Vacanti, Harvard University/MassachusettsInstitute of TeclmoIogy~~~~~~~~~~* USA) The construction of a tissue engineeredheart valve has several poWGal advantagesover the curr4tiy used
matrix composedof a copolymer of surgically implanted into don0 function was evaluatedusing twelve week time courseand e demonstratethat the structure and firnction of the tissueengineeredcunstr~ts a@r@aches thoseof &ive tissue when they are exposedto physiologic forcesover an extendedperiod of time.