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The assay of renin in rabbits with experimental renal hypertension
Foi,
P. P., Woods, W. W., Feet, M. M., and FOB, N. L.: Effective Renal Blood Flow, Glomerular Filtration Rate and Tubular Excretory Mass in Arterial Hypertension. II. Effect of Supradiaphragmatic Splanchnicect’omy With Lower Dorsal Sympathetic Ganglionectomy. Arch. Int. Med. 71: 357, 1943.
Diodrast and inulin clearances were used to measure the effective renal blood flow and filtration rate in seventeen patients with arterial hypertension. Measurements were made before bilateral supradixphragmatic splanc.hnicectomy with lower dorsal sympathetic ganglionectomy, and from two’qeeks to twelve months after the operaThe results indicate that the operation did not change the renal blood flow tion. significantly, even when the blood pressure was reduced. There was a reduction of blood pressure in eight patients. Constancy of renal blood flow, combined with reduced blood pressure, suggests decreased vascular resistance and intrarenal arteriolar rasodilatation, with a resultant increase in pulse pressure within the kidney. The patients with the highest effective renal blood flow, the greatest vasomotility, and the least thickening of the systemic arterioles receiver1 the most benefit from the operation. It is suggested that the determination of elective renal blood flow, and the measurement of the wall/lumen ratio of the systemic arterioles in biopsy specimens of muscle, might prove to be valuable in the preoperative study of patients with arterial hypertension. The authors’ results are eonaistent with the hypothesis that reduced intrarenal pulse pressure, and not renal ischemia, is a causal factor in human hypertension. AriTHORS. Pickering, Rabbits
6. W., Frinzmetai, With Experimental
M., and Kelsall, Renal Hypertension.
A.
R.: Clin.
The Assay -?c. 4: 401j
of Renin 1942.
in
Extracts of rabbit kidneys made by three diberent methods have been assayed for their renin content by finding the amount raising the unanesthetized rabbit’s blood pressure to the same extent a#s a given dose of a standard preparation. The standard was stable for at least two and one-half years. The renin content of normal causes of which are undetermined, that are immature than in those
rabbits’ kidneys shows sonsiderable variations, the although higher values tend to occur in rabbits tllat are fully grown.
When hypertension is produced by constricting the renal artery in the rabbit, the renin content of the kidney depends on the degree of constriction and on the duration of the hypertension. When the constriction is severe enough to produce renal one tu two days the renal renin necrosis, the hypertension is fleeting, and after When the constriction is severe enough to produce content is abnormally low. hypertension within twelve hours, but not to produce renal necrosis, the hypertension is maintained, and in the first eight days the renal renin content tends to be abnormally high. When hypertension has lasted two to seventeen monihs, the renal renin content is normal. By a method ten to fifteen from the blood
of extraction described in the text renin can be recovered from blood minutes after its intravenous injection. Nune has been recovered of rabbits with hypertension of two to five months’ duration.
The results obtianed are consistent with the hypothesis that the hypertension which occurs in the first few days after constricting the renal arteries is due to the release The normal renal content of animals with prolonged of renin from the kidney. hypertension suggests that factors other than the enhanced secretion of renin may contribute materially to the genesis of prolonged hypertension after renal artery These factors have not yet been identified. constriction. AUTIIOW.
P. P., Woods, W. W., Feet, M. M., and FOB, N. L.: Effective Renal Blood Flow, Glomerular Filtration Rate and Tubular Excretory Mass in Arterial Hypertension. II. Effect of Supradiaphragmatic Splanchnicect’omy With Lower Dorsal Sympathetic Ganglionectomy. Arch. Int. Med. 71: 357, 1943.
Diodrast and inulin clearances were used to measure the effective renal blood flow and filtration rate in seventeen patients with arterial hypertension. Measurements were made before bilateral supradixphragmatic splanc.hnicectomy with lower dorsal sympathetic ganglionectomy, and from two’qeeks to twelve months after the operaThe results indicate that the operation did not change the renal blood flow tion. significantly, even when the blood pressure was reduced. There was a reduction of blood pressure in eight patients. Constancy of renal blood flow, combined with reduced blood pressure, suggests decreased vascular resistance and intrarenal arteriolar rasodilatation, with a resultant increase in pulse pressure within the kidney. The patients with the highest effective renal blood flow, the greatest vasomotility, and the least thickening of the systemic arterioles receiver1 the most benefit from the operation. It is suggested that the determination of elective renal blood flow, and the measurement of the wall/lumen ratio of the systemic arterioles in biopsy specimens of muscle, might prove to be valuable in the preoperative study of patients with arterial hypertension. The authors’ results are eonaistent with the hypothesis that reduced intrarenal pulse pressure, and not renal ischemia, is a causal factor in human hypertension. AriTHORS. Pickering, Rabbits
6. W., Frinzmetai, With Experimental
M., and Kelsall, Renal Hypertension.
A.
R.: Clin.
The Assay -?c. 4: 401j
of Renin 1942.
in
Extracts of rabbit kidneys made by three diberent methods have been assayed for their renin content by finding the amount raising the unanesthetized rabbit’s blood pressure to the same extent a#s a given dose of a standard preparation. The standard was stable for at least two and one-half years. The renin content of normal causes of which are undetermined, that are immature than in those
rabbits’ kidneys shows sonsiderable variations, the although higher values tend to occur in rabbits tllat are fully grown.
When hypertension is produced by constricting the renal artery in the rabbit, the renin content of the kidney depends on the degree of constriction and on the duration of the hypertension. When the constriction is severe enough to produce renal one tu two days the renal renin necrosis, the hypertension is fleeting, and after When the constriction is severe enough to produce content is abnormally low. hypertension within twelve hours, but not to produce renal necrosis, the hypertension is maintained, and in the first eight days the renal renin content tends to be abnormally high. When hypertension has lasted two to seventeen monihs, the renal renin content is normal. By a method ten to fifteen from the blood
of extraction described in the text renin can be recovered from blood minutes after its intravenous injection. Nune has been recovered of rabbits with hypertension of two to five months’ duration.
The results obtianed are consistent with the hypothesis that the hypertension which occurs in the first few days after constricting the renal arteries is due to the release The normal renal content of animals with prolonged of renin from the kidney. hypertension suggests that factors other than the enhanced secretion of renin may contribute materially to the genesis of prolonged hypertension after renal artery These factors have not yet been identified. constriction. AUTIIOW.