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The Association Between Body Morphotype and Progression of Nontuberculous Mycobacterial Lung Disease: A Prospective Cohort Study
Respiratory Care SESSION TITLE: Chest Infections SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM
The Association Between Body Morphotype and Progression of Nontuberculous Mycobacterial Lung Disease: A Prospective Cohort Study Soo Jung Kim MD* Soon Ho Yoon Sun Mi Choi Jinwoo Lee Chang-Hoon Lee Sung Koo Han; and Jae-Joon Yim Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea (the Republic of) PURPOSE: It has been known that patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, there is little data about association between body morphotype and progression of NTM-LD. The objective of the study is to find predictors of progression of NTM-LD focusing on the impact of body morphotype through a prospective cohort study. METHODS: Data of patients with NTM-LD participated in NTM cohort, started at July, 2011 was analyzed. Inclusion criteria were patients with NTM-LD who fulfilled the 2007 American Thoracic Society/Infectious Diseases Society of America guideline. Progression was defined as requirement of initiation of anti-NTM treatment by clinician based on symptomatic and radiologic aggravation. Body morphotype was measured using the bioelectrical impedance analysis.
RESPIRATORY CARE
RESULTS: Among 150 patients, 47 patients showed progression of NTM-LD during study period. Univariate analysis indicated that the lowest tertile of weight, body mass index, waist and hip circumference, skeletal muscle mass, body fat, body fat percentage or abdominal fat ratio were related to progression of NTM-LD. After adjusting bronchiectasis extent and presence of cavity on chest computed tomography and albumin <3.5g/dL, patients with the lowest tertile of abdominal fat ratio had higher risk to disease progression in comparison with the highest tertile. CONCLUSIONS: Progression of NTM-LD is associated with body morphotype. Abdominal fat ratio is an independent predictor of progression of NTM-LD. CLINICAL IMPLICATIONS: Patients with specific body morphotype should be carefully monitored for progression of NTM-LD. DISCLOSURE: The following authors have nothing to disclose: Soo Jung Kim, Soon Ho Yoon, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sung Koo Han, Jae-Joon Yim No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.08.1350
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
1238A
[
150#4S CHEST OCTOBER 2016
]
The Association Between Body Morphotype and Progression of Nontuberculous Mycobacterial Lung Disease: A Prospective Cohort Study Soo Jung Kim MD* Soon Ho Yoon Sun Mi Choi Jinwoo Lee Chang-Hoon Lee Sung Koo Han; and Jae-Joon Yim Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea (the Republic of) PURPOSE: It has been known that patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, there is little data about association between body morphotype and progression of NTM-LD. The objective of the study is to find predictors of progression of NTM-LD focusing on the impact of body morphotype through a prospective cohort study. METHODS: Data of patients with NTM-LD participated in NTM cohort, started at July, 2011 was analyzed. Inclusion criteria were patients with NTM-LD who fulfilled the 2007 American Thoracic Society/Infectious Diseases Society of America guideline. Progression was defined as requirement of initiation of anti-NTM treatment by clinician based on symptomatic and radiologic aggravation. Body morphotype was measured using the bioelectrical impedance analysis.
RESPIRATORY CARE
RESULTS: Among 150 patients, 47 patients showed progression of NTM-LD during study period. Univariate analysis indicated that the lowest tertile of weight, body mass index, waist and hip circumference, skeletal muscle mass, body fat, body fat percentage or abdominal fat ratio were related to progression of NTM-LD. After adjusting bronchiectasis extent and presence of cavity on chest computed tomography and albumin <3.5g/dL, patients with the lowest tertile of abdominal fat ratio had higher risk to disease progression in comparison with the highest tertile. CONCLUSIONS: Progression of NTM-LD is associated with body morphotype. Abdominal fat ratio is an independent predictor of progression of NTM-LD. CLINICAL IMPLICATIONS: Patients with specific body morphotype should be carefully monitored for progression of NTM-LD. DISCLOSURE: The following authors have nothing to disclose: Soo Jung Kim, Soon Ho Yoon, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sung Koo Han, Jae-Joon Yim No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.08.1350
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
1238A
[
150#4S CHEST OCTOBER 2016
]