The Association Between Parenting Stress And The Child’s Quality of Life Among Parents of Asthmatic Children

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(p< 0.05).  Results: A one-factor model in which all of the items were regressed onto a latent variable (CFI= 0.97, RMSEA= 0.12, FL range= 0.85-0.92) was rejected in favor of a five-factor CFA, which demonstrated the best fit (CFI= 0.99, RMSEA= 0.080) of the structures considered. The factors were 1) Basic ADLs (8-items; range: FL= .86-.93), including items such as dressing, toileting, and bending and picking something up, and getting out of a car); 2) Fine Motor Coordination (6-items; FL range: 0.88-0.96) which included items assessing the ability to use utensils to cut food and opening a milk carton; 3) Ambulating (2 items; FL range= 0.94-0.96); 4) Standing Upright (2-items; FL range= 0.94-0.94); and 5) Advanced ADLs (2-items; FL range= 0.91-0.94), which included running errands and vacuuming.  Conclusions: The Improved HAQ is the latest iteration of a widely used instrument that, according to these analyses, has a multidimensional factor structure. Future analyses should determine whether scoring reflecting this structure would better describe impairment to ADLs among Europeans with RA. PHS74 Health-Related Quality of Life In Patients with Systemic Lupus Erythematosus (SLE): A Spanish Study Based on Patient Reports Fernández-Llanio-Comella N1, San-Martín-Álvarez A2, Vivas-Consuelo D3, Jordán-Alfonso A3, Román Ivorra JA1, Vela-Casasempere P2, Saurí-Ferrer MI4 1Conselleria de Sanidad Universal y Salud Pública, Valencia, Spain, 2Conselleria de Sanidad Universal y Salud Pública, Alicante, Spain, 3Universitat Politècnica de València (UPV), Valencia, Spain, 4General Directorate for Pharmacy and Healthcare Products, Valencia, Spain

Objectives: Published studies agree that systemic lupus erythematosus (SLE) is a disease that significantly affects the quality of life and welfare of patients, with repercussions on their daily lives. The objective of this study is to determine the affectation index of SLE in the patients’ quality of life.  Methods: A questionnaire was administered to 190 patients with SLE through 4 hospital centres. This questionnaire collects information on the main factors that affect patient health as a result of the disease. The factors studied are health status, which is quantified by the five-item EQ-5D instrument and a Visual Analogue Scale (VAS), disease activity obtained with SLAI/SELENA Index, damage quantified by SLICC/ACR Index, and severity determined with IGK Index. The study was conducted between October 2015 and March 2016. Statistical analyses: A descriptive analysis was developed. Bivariate correlation analyses were conducted to identify parameters significantly affecting patients’ quality of life.  Results: From the 190 patients which answered the questionnaire, 92.06% are women, having an average age of 46.95 years. The age of the patients negatively affects their quality of life, its correlation being -0.266. Disease activity and damage are negatively correlated with five-item EQ-5D its values being -0.239 and -0.255 respectively. These parameters are also significantly correlated with severity (0.179 and 0.291 respectively). Five-item EQ-5D instrument and VAS are high, correlated with a value of 0.699.  Conclusions: Patient’s quality of life is related with age, disease activity, damage, and severity, age being the parameter which most affects quality of life. PHS75 Pessoa Study – Evaluating The Burden of Psoriasis In Portugal From The Patients’ Perspective (A Patient Reported Outcomes Analysis) Moital I1, Carrasco J1, Adegas P1, Cabrita J2, Oliveira Martins S2 Farma Portugal, Porto Salvo, Portugal, 2Faculty of Pharmacy UL, Lisbon, Portugal

1Novartis

Objectives: Although psoriasis is a chronic disease with many associated comorbidities and a high impact on the patient’s Quality of Life (QoL), its the social and economic impact on patients and Healthcare Systems (HS) is frequently undervalued. There is evidence that characterizes healthcare resource use from a societal and HS perspective but there is scarce information on the patient’s perspective. On the other hand, despite the availability of a number of treatment options, surveys show that patients do not receive the optimal care that is necessary to clear their skin symptoms and to improve their health-related quality of life. PeSsOA study aims to generate data on the burden of PsO in Portugal from patient’s perspective. The main objectives are to characterize the Portuguese psoriasis population, evaluate the impact on patients QoL, social and day-to-day activities, quantify direct and indirect economic burden and characterize patient access to healthcare and use of health resources.  Methods: Observational cross-sectional study in psoriasis adult patients (≥ 18 years old). A structured questionnaire was developed in collaboration with the Patients’ National Association, researchers from the Faculty of Pharmacy and Healthcare Professionals, aiming to characterize sociodemographic profile, health behaviors, clinical and therapeutic profile , psoriasis related social impact, QoL and healthcare resource use. QoL is evaluated using DLQI and EQ5D and social impact through analysis of absenteeism, impact on labor activity and family life. Economic impact is evaluated by analysis of healthcare resources consumption and therapeutic related costs. The questionnaire was placed on an online platform.  Results: In terms of sample size, the goal was to recruit approximately 400 patients, considering an estimated Portuguese prevalence of 2% (200.000) and a 95% CI (P< 0.05)  Conclusions: Generate data aims to contribute to have a better understanding on the impact of Psoriasis in the patient’s perspective identifying needs and aspirations. (300 words) PHS76 Economic And Humanistic Burden of Chronic Spontaneous Urticaria In Brazil: Impact on Work Productivity, Resource Utilization And Quality of Life Balp M1, Lopes N2, Tian H3, Vietri J4, Ensina LF5 1Novartis Pharma AG, Basel, Switzerland, 2Novartis Brazil, Sao Paulo, Brazil, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, 4Kantar Health, Horsham, PA, USA, 5Federal University of São Paulo, São Paulo, SP, Brazil

Objectives: Data on economic and humanistic burden associated with chronic urticaria (CU) or chronic spontaneous urticaria (CSU) in Brazil are scarce. The current study assesses the economic and humanistic burden of CSU among Brazilian adult patients currently treated for chronic urticaria as a proxy for CSU.  Methods:

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A retrospective, cross-sectional analysis of Brazil National Health and Wellness Survey data was conducted. Economic outcomes included work productivity and activity impairment (past 7 days) and self-reported healthcare use (past 6 months). Humanistic outcomes included Health-related quality of life (HRQoL) using SF-12v2 or SF-36v2 (4-week recall version), and self-reported psychological complaints (past 12 months). Adult patients currently treated for CU were matched 1:4 to controls (never experienced CU) by survey year, age, sex, private insurance and socioeconomic status. Generalized linear models were conducted to compare the patients and matched controls, adjusting for race, income, smoking, obesity, and other comorbidities, using distributions and link functions appropriate for each outcome.  Results: Among the patients currently treated for CU (N= 127) and matched controls (N= 508), 80.3% and 78.9% respectively were in labor force (p= 0.73). Employed patients reported significantly higher presenteeism (33.9% vs 21.0%), and overall work impairment (39.1% vs 25.9%); patients also reported higher activity impairment (35.5% vs 23.7%) relative to controls (all p< 0.01). Mean healthcare practitioner (9.7 vs 5.0), emergency room (1.32 vs 0.63) and allergist visits (0.54 vs 0.07) were higher in patients compared to controls (all p< 0.01).  Patients had worse HRQoL, including lower mental (5 points) and physical (2.5 points) component summary scores (both p< 0.01), lower (0.06 points) health utility scores (p< 0.001), and were more likely to report anxiety (adjusted odds ratio [OR] = 2.7) and sleep difficulties (OR= 2.2) than controls (both p< 0.001).  Conclusions: CSU is likely to impose substantial economic and humanistic burden in Brazilian adults with high impact on patients’ HRQoL and on society.

PHS77 The Association Between Parenting Stress And The Child’s Quality of Life Among Parents of Asthmatic Children Sansgiry SS, Almogbel Y University of Houston, Houston, TX, USA

Objectives: Parenting stress is an important variable to consider in the treatment of asthmatic children, as parents usually take care of their child’s medical symptoms. The aim of this study was to explore the association between parenting stress and the child’s quality of life among parents of asthmatic children.  Methods: An online non-experimental cross-sectional study of parents with children diagnosed with asthma was conducted in 19 asthma/pediatric clinics in Houston, Texas, USA. A pre-tested and validated questionnaire was administered, between November 2015- June 2016 using Qualtrics®, to evaluate the effect of the child’s quality of life on parenting stress. Also, information was collected about factors that might impact parenting stress, such as family support with children, perceived disease severity, health literacy, and relationship with the physician, along with socio-demographics factors for children and parents. Descriptive and regression analyses were performed using SAS® 9.3.  Results: Of the 262 online completed questionnaires received, 79% of parents were female. The mean age was 35.1 (±8.9) for parents. The distribution by race was: Whites (34.7%), Hispanics (33.2%), African-Americans (25.6%), Asian (3.4%), and other (3.1%). Mean parenting stress scores were 35.9 (±11.9) and ranged from 18 to 86 . Furthermore the average child’s quality of life score was 65 (±17) and ranged from zero to 100. The results of the multiple linear regression analysis indicated negative association between parenting stress and child’s quality of life (β = -0.162, p< 0.0151), a negative relationship with the healthcare provider (β = -0.37382, p= 0.0096), and a positive relationship with health literacy (β = 2.05, p< 0.0151) after controlling for family support with children. Conclusions: Parenting stress is affected by child’s quality of life, health literacy, and the relationship with their healthcare provider. Identifying and treating parental stress is the key to future psychological and physiological diseases and complications associated with parents of asthmatic children. PHS78 The EQ-5D-5L Instrument Demontrates Better Performance Compared With The EQ-5D-3L In Psoriatic Patients Yfantopoulos I, Chantzaras A, Kontodimas S University of Athens, Athens, Greece

Objectives: Several studies have compared the measurement properties of the EQ-5D-3L and EQ-5D-5L in various general and patient groups. The aim of this study was to assess the psychometric properties of the 5-level (EQ-5D-5L) in comparison with the standard 3-level (EQ-5D-3L) classification systems of the EQ-5D in a sample of psoriatic patients in Greece.  Methods: Psoriatic subjects (n= 396) recruited from 16 private practicing centers from various areas of Greece self-completed the two EQ-5D versions and the Dermatology Life Quality Index, while information was also collected on socio-demographics, clinical characteristics and comorbidities. The EQ-5D-5L and EQ-5D-3L were evaluated in terms of agreement, feasibility, ceiling effect, redistribution properties, inconsistency, informativity, and convergent and known-groups validity.  Results: Missing values were negligible in both versions. The agreement between the EQ-5D-5L and EQ-5D-3L was very high (ICC= 0.94), while the largest differences were identified for subjects with moderate health status. Ceiling effects decreased in the EQ-5D-5L system by 14.08% (p< 0.05), with “anxiety/ depression” showing the highest relative reduction (-10.31%; p< 0.05). Overall inconsistency was rather low (1.7%) and respondents preferred to report milder problems in the EQ-5D-5L. Absolute informativity improved by 56.42% in the EQ-5D-5L, while relative informativity declined by 9.24%, with only “anxiety/depression” demonstrating a small increase (6.77%). Both instruments demonstrated good convergent and known-groups validity, with evidence of a slightly better convergent performance and discriminatory efficiency of the EQ-5D-5L.  Conclusions: Both instruments demonstrated consistency, valid redistribution and good construct validity. The EQ-5D-5L system may be preferable to the EQ-5D-3L in psoriatic patients, as it demonstrated a marginally better performance in terms of reduced ceiling effects, increased informativity, and improved convergent and known-groups validity efficiency, particularly in the domain of “anxiety/depression”.