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THE ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE POLYMORPHISM WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE SUSCEPTIBILITY IN HAN NATIONALITY OF SOUTHWESTERN CHINA
October 2006, Vol 130, No. 4_MeetingAbstracts Abstract: Poster Presentations | October 2006
THE ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE POLYMORPHISM WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE SUSCEPTIBILITY IN HAN NATIONALITY OF SOUTHWESTERN CHINA Yi Ming Yuan, MD*; Xiao Jing Liu, PhD; Jian Wei Li, PhD West China Hospital of Sichuan University, Chengdu, Peoples Rep of China
Chest. 2006;130(4_MeetingAbstracts):277S. doi:10.1378/chest.130.4_MeetingAbstracts.277S-d
Abstract PURPOSE: To study the relationship between the matrix metalloproteinase-9(MMP-9) gene polymorphism and genetic susceptibility to COPD in Han nationality of southwestern China. METHODS: The genotypes of MMP-9 gene in 65 patients with COPD and 101 healthy controls were detected by polymerase chain reaction(PCR) based restriction fragment length polymorphism(RFLP) technique.Retrospective case-control study was performed to analyze the odds ratio(OR) which was representative of relative risk rate of COPD susceptibility. RESULTS: The frequency of MMP-9 C/C,C/T genotype were 88%,16% in COPD group,respectively,and 96%,2% in controll group,respectively.There were significant differences between the two groups (P < 0.01).Taking C/T as the reference,the C/C group showed a reduced risk rate(OR=0.467,95%CI=0.237-0.924,P<0.05). CONCLUSION: MMP-9(C/C) genotype reduces the susceptibility to COPD in Han nationality of southwestern China. CLINICAL IMPLICATIONS: Smokers should receive MMP-9 gene polymorphism detection in order to predict the possibility of developing COPD.
DISCLOSURE: Yi Ming Yuan, None. Wednesday, October 25, 2006 12:30 PM - 2:00 PM
THE ASSOCIATION OF MATRIX METALLOPROTEINASE-9 GENE POLYMORPHISM WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE SUSCEPTIBILITY IN HAN NATIONALITY OF SOUTHWESTERN CHINA Yi Ming Yuan, MD*; Xiao Jing Liu, PhD; Jian Wei Li, PhD West China Hospital of Sichuan University, Chengdu, Peoples Rep of China
Chest. 2006;130(4_MeetingAbstracts):277S. doi:10.1378/chest.130.4_MeetingAbstracts.277S-d
Abstract PURPOSE: To study the relationship between the matrix metalloproteinase-9(MMP-9) gene polymorphism and genetic susceptibility to COPD in Han nationality of southwestern China. METHODS: The genotypes of MMP-9 gene in 65 patients with COPD and 101 healthy controls were detected by polymerase chain reaction(PCR) based restriction fragment length polymorphism(RFLP) technique.Retrospective case-control study was performed to analyze the odds ratio(OR) which was representative of relative risk rate of COPD susceptibility. RESULTS: The frequency of MMP-9 C/C,C/T genotype were 88%,16% in COPD group,respectively,and 96%,2% in controll group,respectively.There were significant differences between the two groups (P < 0.01).Taking C/T as the reference,the C/C group showed a reduced risk rate(OR=0.467,95%CI=0.237-0.924,P<0.05). CONCLUSION: MMP-9(C/C) genotype reduces the susceptibility to COPD in Han nationality of southwestern China. CLINICAL IMPLICATIONS: Smokers should receive MMP-9 gene polymorphism detection in order to predict the possibility of developing COPD.
DISCLOSURE: Yi Ming Yuan, None. Wednesday, October 25, 2006 12:30 PM - 2:00 PM