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THE CHANGES OF VARIOUS CYTOKINES FROM PERIPHERAL BLOOD AND THEIR RELATIONSHIP WITH LEFT VENTRICULAR SYSTOLIC FUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WHO UNDERWENT SUCCESSFUL PERCUTANEOUS CORONARY INTERVENTION
E565 JACC March 27, 2012 Volume 59, Issue 13
Acute Coronary Syndromes THE CHANGES OF VARIOUS CYTOKINES FROM PERIPHERAL BLOOD AND THEIR RELATIONSHIP WITH LEFT VENTRICULAR SYSTOLIC FUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WHO UNDERWENT SUCCESSFUL PERCUTANEOUS CORONARY INTERVENTION ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 11:00 a.m.-Noon
Session Title: Acute Coronary Syndromes: Basic II Abstract Category: 6. Acute Coronary Syndromes: Basic Presentation Number: 1176-573 Authors: Young Keun Ahn, Jin-Sook Kwon, Ae Shin Cho, Hyang Hee Cho, Jeong Sook Kim, Moon Hwa Hong, Wan Seok Kang, Myung Ho Jeong, Jong Chun Park, Jung Chaee Kang, Chonnam National University Hospital, Gwangju, South Korea, Heart Research Center, Gwangju, South Korea Background: Various cytokines such as granulocyte colony stimulating factor (G-CSF), stem cell factor (SCF), and vascular endothelial growth factor (VEGF) have been used to improve the therapeutic effects of stem cells. SCF plays a role in the regulation of hematopoietic stem cells (HSCs) in the stem cell niche in bone marrow. While G-CSF and VEGF are triggered by acute myocardial infarction (MI), high levels of SCF are observed in peripheral blood of both healthy person and MI patients. However, changes of SCF level after percutaneous coronary intervention (PCI) has not been known well. The aim of this study was to elucidate the relationship between SCF level and left ventricular (LV) systolic function in patients with acute ST-elevation MI (STEMI) and non-STEMI who underwent PCI. Methods and Results: A total of 74 patients (29 STEMI, 33 NSTEMI, and 12 control patients) who underwent successful PCI were recruited. Peripheral blood was obtained before (basal level) and at 72 hours after PCI (follow-up level). The levels of VEGF, G-CSF, c-kit, and SCF were measured by ELISA kit (R&D system). The basal level of SCF in STEMI patients was lower than those in NSTEMI patients (466.1 ± 121.9 vs. 652.5 ± 297.1 pg/ml, p < 0.05) and control patients (656.8 ± 124.2 pg/ml, p < 0.01). At 72 hours after PCI, the levels of VEGF, G-CSF, and SCF were increased but the level of c-kit was not changed. The follow-up level of SCF in NSTEMI patients was higher than that in control patients (894.2 ± 329.2 vs. 656.8 ± 124.2 pg/ml, p < 0.05). The level of ΔSCF between basal and follow-up was 270.6 ± 135.6 in STEMI and 241.7 ± 129.1 pg/ml in NSTEMI patients. In STEMI patients, abnormal distribution divided by the level of SCF (500 pg/ml) was present. In STEMI patients who had lower level of SCF (< 500 pg/ml) showed negatively correlated with LV ejection fraction at six month follow-up echocardiogram (r=-0.843, p < 0.01). Conclusions: The levels of VEGF, G-CSF, and SCF were increased after PCI. Especially, SCF could be a predictor for LV systolic function recovery after acute MI.
Acute Coronary Syndromes THE CHANGES OF VARIOUS CYTOKINES FROM PERIPHERAL BLOOD AND THEIR RELATIONSHIP WITH LEFT VENTRICULAR SYSTOLIC FUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WHO UNDERWENT SUCCESSFUL PERCUTANEOUS CORONARY INTERVENTION ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 11:00 a.m.-Noon
Session Title: Acute Coronary Syndromes: Basic II Abstract Category: 6. Acute Coronary Syndromes: Basic Presentation Number: 1176-573 Authors: Young Keun Ahn, Jin-Sook Kwon, Ae Shin Cho, Hyang Hee Cho, Jeong Sook Kim, Moon Hwa Hong, Wan Seok Kang, Myung Ho Jeong, Jong Chun Park, Jung Chaee Kang, Chonnam National University Hospital, Gwangju, South Korea, Heart Research Center, Gwangju, South Korea Background: Various cytokines such as granulocyte colony stimulating factor (G-CSF), stem cell factor (SCF), and vascular endothelial growth factor (VEGF) have been used to improve the therapeutic effects of stem cells. SCF plays a role in the regulation of hematopoietic stem cells (HSCs) in the stem cell niche in bone marrow. While G-CSF and VEGF are triggered by acute myocardial infarction (MI), high levels of SCF are observed in peripheral blood of both healthy person and MI patients. However, changes of SCF level after percutaneous coronary intervention (PCI) has not been known well. The aim of this study was to elucidate the relationship between SCF level and left ventricular (LV) systolic function in patients with acute ST-elevation MI (STEMI) and non-STEMI who underwent PCI. Methods and Results: A total of 74 patients (29 STEMI, 33 NSTEMI, and 12 control patients) who underwent successful PCI were recruited. Peripheral blood was obtained before (basal level) and at 72 hours after PCI (follow-up level). The levels of VEGF, G-CSF, c-kit, and SCF were measured by ELISA kit (R&D system). The basal level of SCF in STEMI patients was lower than those in NSTEMI patients (466.1 ± 121.9 vs. 652.5 ± 297.1 pg/ml, p < 0.05) and control patients (656.8 ± 124.2 pg/ml, p < 0.01). At 72 hours after PCI, the levels of VEGF, G-CSF, and SCF were increased but the level of c-kit was not changed. The follow-up level of SCF in NSTEMI patients was higher than that in control patients (894.2 ± 329.2 vs. 656.8 ± 124.2 pg/ml, p < 0.05). The level of ΔSCF between basal and follow-up was 270.6 ± 135.6 in STEMI and 241.7 ± 129.1 pg/ml in NSTEMI patients. In STEMI patients, abnormal distribution divided by the level of SCF (500 pg/ml) was present. In STEMI patients who had lower level of SCF (< 500 pg/ml) showed negatively correlated with LV ejection fraction at six month follow-up echocardiogram (r=-0.843, p < 0.01). Conclusions: The levels of VEGF, G-CSF, and SCF were increased after PCI. Especially, SCF could be a predictor for LV systolic function recovery after acute MI.