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The chemistry of antitumor antibiotics, vol. 2
Eur.
J. Med.
Chem.
24 (1989)
203
203-204
@ El sevier, Paris
Recent books The Chemistry of Antitumor Antibiotics, Vol. 2, edited by W.A. Remers. John Wiley & Sons Limited, Chichester, 1988, pp. 290, f 31.95
Nine years have passed since Volume 1 of this series was published. During this time a large number of new antitumor antibiotics have been discovered and evaluated for potential clinical use. The authors decided to select new types of antibiotics, rather than to revise material on older types, despite the significance of advances in anthracyclines, mitomytins, and to some extent, bleomycins. The remarkable structures of some of these recent compounds have provided new concepts in mode of action and new targets for synthesis. They provide some outstanding examples of the remarkable diversity that nature shows in the construction of antitumor antibiotics. The contents are as follows: chapter 1. Streptozocin; 2. Pyrrolo (1,4)benzodiazepines; 3. Saframycins, Renieramycins and Safracins; 4. Naphthyridinomycin, Cyanocyclines and Quinocarcin; 5. CC) 1065; 6. Nogalamycin and Related Compounds; 7. Streptonigrin and Lavendamycin. Progress in Medicinal Chemistry, Vol. 25, edited by G.P. Ellis and G.B. West. Elsevier Science Publishers, Amsterdam, 1988, pp. 351, Dfl270.00
The discovery of cyclosporins and the development of immunosuppressants in organ transplantation are reviewed in this book. Various physical characteristics and other properties of significance in the design of antineoplastic agents are next surveyed, and cancer chemotherapy is also the theme of a chapter on analogues of folic acid, aminopterins and methotrexate. The antifilarial action of 5-substituted arylmethylbenzimidazole carbamates, and one application of vitamin E - protection against hypoxia damage - constitute two further chapters. The volume concludes with a description of multivariate statistical analysis and its advantages over the unkariate approach.
and Cellular Oscillators. Cellular Clocks Series 2, edited by J.W. Jacklet. Marcel Dekker Inc., New York, 1989, pp. 576, US $ 125.00 (US and Canada); US $ 150.00 (all other countries)
.Neuronal
Providing refined explanations for many of the known oscillators, this valuable reference book describes the membrane and cellular mechanisms of biological tissues that are repetitively active, including heart tissue, most neurons, and secretory cells. It carefully examines three major types of oscillator: network oscillators involving synaptic interaction among neurons, cvtonlasmic oscillators, and cell membrane oscillators and their associated i’on channels. Neuronal and Cellular Oscillators describes recentlv discovered ion channels relevant to oscillators, explores oscillators’ modulation by hormones and neurotransmitters. discusses reciprocal synaptic oscillators involving two or more neurons and considers cytopiasmic-based slow and circadian oscillators and their contribution to such rhythmic behavior as breathing, feeding, activity/rest, swimming, locomotion, burst-generated secretory cycles, heartbeat, and spike trains/bursts in neurons.
Polysaccharides. Syntheses, Modifications Relations, edited by M. Yalpani. Elsevier
and
Structure
-
Property
Science Publishers, Amsterdam, 1988, pp. 500, US $ 171.00, Dfl. 325.00 This book provides coverage of the structures and properties of polysaccharides, methods for their characterization, de nova synthesis, and modification, as well as advances in structure /function correlations. Many of these topics have been summarized for the first time.
A brief survey of polysaccharide structures is given, highlighting the most significant advances in analytical and spectroscopic technology (NMR, MS, etc.). A chapter is devoted to glycan properties, including conformational aspects, rheological and compatibility characteristics, etc. There is a comprehensive overview of the de ltovo synthesis of carbohydrate polymers, the transformation of glycans into novel types of polymers, and the preparation of linear and branched polysaccharide analogues and conjugates with synthetic polymers via chemical and enzymatic approaches. The book also details the factors controlling the uniformity of substitutions in homogeneous and heteregeneous derivatization processes and the elucidation of the substitution of partially modified polysaccharides, through combined spectroscopic and statistical methods. The contents are as follows: chapter 1: Introduction; 2. Structures; 3. General Polysaccharide Methods; 4. Properties; 5. Synthesis of New Carbohydrate Polymers, Polysaccharide Analogues and Conjugates; 6. Substitution Patterns of Polysaccharide Derivatives; 7. Chemical Modifications; 8. Enzymatic Modifications; 9. Alterations of Polysaccharide Integritv and Electrochemical Modifications; 10. Structure /Propertly Relationships; References; and Subject Index. Synthetic
Aspects
of
Aminodeoxy
I.F. Pelyvas, C. Monneret 1988, pp. 244, DM 168
Sugars
of
Antibiotics,
and P. Herczegh. Springer-Verlag,
edited by Berlin,
The book critically summarizes applied and potentially useful strategies for the synthesis of the specific aminodeoxy sugars occurring in antibiotics, with particular emphasis on 3-amino-polydeoxyhexoses. With the purpose of providing hitherto unexplored contexts and offering a general outlook on the syntheses of such compounds, the book is concerned with the methodical construction and systemic layout of the molecules of the daunosamine-type non-branched and branched-chain natural aminosugars, as well as their synthetic derivatives starting from both carbohydrates and non-sugar precursors. Throughout the chapters the methodologies employed for the presentation of 2-deoxyhexoses, for the introduction of a nitrogen function into such sugars, and also for the conversion of aminodeoxyhexoses into polydeoxy analogues are outlined, together with further transformations into non-carbohydrate organic substances with potential biological activities.
Statistical Reliability Theory, of Textbooks and Reference
Probability: Books/4,
Pure
and Applied.
A Series
edited by LB. Gertsbakh, Mar-
cel Dekker Inc., 1989, pp. 331 Presenting a balanced survey of the major areas of reliability, this exhaustive volume details probabilistic models, the theory of repairable systems, optimal preventive maintenance models, statistical inferential aspects of lifetime data analysis in reliability, including the theory of lifetime distributions, renewable and redundant systems and structural reliability theory.
Current B-Cell
Topics in Microbiology Neoplasia, edited by
and Immunology
141.
Mechanisms
in
M. Potter and F. Melchers. SpringerVerlag, Berlin, 1988, pp. 340, DM 160.00 The papers featured in this volume focus on models of B-cell tumor development, such as Burkitt’s lymphoma, plasmacytomagenesis in mice, bursal lymphomatosis in chickens, follicular lymphomagenesis in man, and B-cell lymphomagenesis in myc transgenic mice. One prominent oncogene involved in B-cell neoplasia (c-myc) is dealt with in detail.
J. Med.
Chem.
24 (1989)
203
203-204
@ El sevier, Paris
Recent books The Chemistry of Antitumor Antibiotics, Vol. 2, edited by W.A. Remers. John Wiley & Sons Limited, Chichester, 1988, pp. 290, f 31.95
Nine years have passed since Volume 1 of this series was published. During this time a large number of new antitumor antibiotics have been discovered and evaluated for potential clinical use. The authors decided to select new types of antibiotics, rather than to revise material on older types, despite the significance of advances in anthracyclines, mitomytins, and to some extent, bleomycins. The remarkable structures of some of these recent compounds have provided new concepts in mode of action and new targets for synthesis. They provide some outstanding examples of the remarkable diversity that nature shows in the construction of antitumor antibiotics. The contents are as follows: chapter 1. Streptozocin; 2. Pyrrolo (1,4)benzodiazepines; 3. Saframycins, Renieramycins and Safracins; 4. Naphthyridinomycin, Cyanocyclines and Quinocarcin; 5. CC) 1065; 6. Nogalamycin and Related Compounds; 7. Streptonigrin and Lavendamycin. Progress in Medicinal Chemistry, Vol. 25, edited by G.P. Ellis and G.B. West. Elsevier Science Publishers, Amsterdam, 1988, pp. 351, Dfl270.00
The discovery of cyclosporins and the development of immunosuppressants in organ transplantation are reviewed in this book. Various physical characteristics and other properties of significance in the design of antineoplastic agents are next surveyed, and cancer chemotherapy is also the theme of a chapter on analogues of folic acid, aminopterins and methotrexate. The antifilarial action of 5-substituted arylmethylbenzimidazole carbamates, and one application of vitamin E - protection against hypoxia damage - constitute two further chapters. The volume concludes with a description of multivariate statistical analysis and its advantages over the unkariate approach.
and Cellular Oscillators. Cellular Clocks Series 2, edited by J.W. Jacklet. Marcel Dekker Inc., New York, 1989, pp. 576, US $ 125.00 (US and Canada); US $ 150.00 (all other countries)
.Neuronal
Providing refined explanations for many of the known oscillators, this valuable reference book describes the membrane and cellular mechanisms of biological tissues that are repetitively active, including heart tissue, most neurons, and secretory cells. It carefully examines three major types of oscillator: network oscillators involving synaptic interaction among neurons, cvtonlasmic oscillators, and cell membrane oscillators and their associated i’on channels. Neuronal and Cellular Oscillators describes recentlv discovered ion channels relevant to oscillators, explores oscillators’ modulation by hormones and neurotransmitters. discusses reciprocal synaptic oscillators involving two or more neurons and considers cytopiasmic-based slow and circadian oscillators and their contribution to such rhythmic behavior as breathing, feeding, activity/rest, swimming, locomotion, burst-generated secretory cycles, heartbeat, and spike trains/bursts in neurons.
Polysaccharides. Syntheses, Modifications Relations, edited by M. Yalpani. Elsevier
and
Structure
-
Property
Science Publishers, Amsterdam, 1988, pp. 500, US $ 171.00, Dfl. 325.00 This book provides coverage of the structures and properties of polysaccharides, methods for their characterization, de nova synthesis, and modification, as well as advances in structure /function correlations. Many of these topics have been summarized for the first time.
A brief survey of polysaccharide structures is given, highlighting the most significant advances in analytical and spectroscopic technology (NMR, MS, etc.). A chapter is devoted to glycan properties, including conformational aspects, rheological and compatibility characteristics, etc. There is a comprehensive overview of the de ltovo synthesis of carbohydrate polymers, the transformation of glycans into novel types of polymers, and the preparation of linear and branched polysaccharide analogues and conjugates with synthetic polymers via chemical and enzymatic approaches. The book also details the factors controlling the uniformity of substitutions in homogeneous and heteregeneous derivatization processes and the elucidation of the substitution of partially modified polysaccharides, through combined spectroscopic and statistical methods. The contents are as follows: chapter 1: Introduction; 2. Structures; 3. General Polysaccharide Methods; 4. Properties; 5. Synthesis of New Carbohydrate Polymers, Polysaccharide Analogues and Conjugates; 6. Substitution Patterns of Polysaccharide Derivatives; 7. Chemical Modifications; 8. Enzymatic Modifications; 9. Alterations of Polysaccharide Integritv and Electrochemical Modifications; 10. Structure /Propertly Relationships; References; and Subject Index. Synthetic
Aspects
of
Aminodeoxy
I.F. Pelyvas, C. Monneret 1988, pp. 244, DM 168
Sugars
of
Antibiotics,
and P. Herczegh. Springer-Verlag,
edited by Berlin,
The book critically summarizes applied and potentially useful strategies for the synthesis of the specific aminodeoxy sugars occurring in antibiotics, with particular emphasis on 3-amino-polydeoxyhexoses. With the purpose of providing hitherto unexplored contexts and offering a general outlook on the syntheses of such compounds, the book is concerned with the methodical construction and systemic layout of the molecules of the daunosamine-type non-branched and branched-chain natural aminosugars, as well as their synthetic derivatives starting from both carbohydrates and non-sugar precursors. Throughout the chapters the methodologies employed for the presentation of 2-deoxyhexoses, for the introduction of a nitrogen function into such sugars, and also for the conversion of aminodeoxyhexoses into polydeoxy analogues are outlined, together with further transformations into non-carbohydrate organic substances with potential biological activities.
Statistical Reliability Theory, of Textbooks and Reference
Probability: Books/4,
Pure
and Applied.
A Series
edited by LB. Gertsbakh, Mar-
cel Dekker Inc., 1989, pp. 331 Presenting a balanced survey of the major areas of reliability, this exhaustive volume details probabilistic models, the theory of repairable systems, optimal preventive maintenance models, statistical inferential aspects of lifetime data analysis in reliability, including the theory of lifetime distributions, renewable and redundant systems and structural reliability theory.
Current B-Cell
Topics in Microbiology Neoplasia, edited by
and Immunology
141.
Mechanisms
in
M. Potter and F. Melchers. SpringerVerlag, Berlin, 1988, pp. 340, DM 160.00 The papers featured in this volume focus on models of B-cell tumor development, such as Burkitt’s lymphoma, plasmacytomagenesis in mice, bursal lymphomatosis in chickens, follicular lymphomagenesis in man, and B-cell lymphomagenesis in myc transgenic mice. One prominent oncogene involved in B-cell neoplasia (c-myc) is dealt with in detail.