- Email: [email protected]
The effect of cholin bodies on auricular systole
SELECTED
71i.‘,
ABSTRACTS
nervous impulses. They believe that physical transmission is at least of quai importance. They recall the usual objections to their form of experiment, namel:<. that amount of acetylcholine and site of liberation may differ from normal. J. M. R.
Thiel, K.:
Action
of Artilicial
Breathing.
Ned. Klin.
32: 633, 1936.
Dogs were asphyxiated under morphine anesthesia until no flow could be measured in the carotid artery with a Rein stromuhr. The heart was revived by massage anIl by artificial breathing. While blood flow quickly returned to normal, the electricardiogram remained abnormal for some time. The use of 0, rich air did not :tff~t the rate of restoration. Cardiazol and sympatol, however, did. L. KY. K.
Gotsev, T.:
Vasomotor
Centers I.
Pfliiger’s
Arch.
f. d. ges.
Physiol.
237:
fili!).
1036. The author presents the effect of a large number of vasomotor substanres dctcrmined before and after decapitation of dogs. No difference was noted. ‘1’111: conclusion is arrived at that these vasomotor centers play little r81e in the actioil of these substances. Among substances used were pituitary derivatives, aretyl choline, lactic acid, ergotamine, caffeine, sodium herrzoate. and histamine, L. N. K.
Gollwitzer-Meier, Kl, Kramer, K., and Kriiger, E.: Action Energy of the Heart. Pfliiger’s Arch. f. d. ges. Physiol.
of Adrenalin 237:
639,
on the 1936.
Adrenalin (l/200 to l/100 mg.) increases the gaseous metabolism of thcx 11r:art alrout 3,50 per cent over normal. The peak of gaseous metaholism lags I~innd the peak of work. Hence, there is an anoxybiotic phase of increased n-ark. ‘i’hc* action of adrenalin on gaseous metabolism is decrrased in the presences of anoscrrli:~, hut unaffected by the level of venous flow and arterial resistance. The inrrP:lsPd mrtaholism is in part brought about by increased coronary flow but chit+l,v l,!. irl creased A-‘\’ O2 difference. T,. K.
Puddu, V.: 467,
The Action
of Cardiac
Nerves.
L’fiiiger’s
hrch.
f. (1. I$VS. t’hyric~l.
I<.
238:
1937.
The author found that there are two phases to the changes in the electrtlcardiogram following stimulation of the sympathetic nerves in the dog, and furthc~~ that the right and left nerve have opposite effect,s on the ventricular complex. Both nerves appear to go to all parts of the hearts. He could not demonstrate that s,-mpathin played any r81e. I~‘olloming complete A-V block on cutting both bundles in the (log, VaglIs rtilllll lation causes a slowing of the idioventriculxr pacemaker. The author attrillutc~~ this to lihcration of ncet.plcholinc-lilte snbstitnccs transported to this port
Sachs, A.: 74,
The Effect of Cholin
Bodies
on Auricular
Systole.
C’ardiol
1037.
The choline derivatives (loses required to diminish 0.S doryl, 1 cholinechloride,
which were investigated had similar the force of auricular contraction 50 cholazyl, in 40 c.c. of the fluid
actions. The smallest were 0.1 acetylcholine, in which the nmic~li:~r
1:
766
THE
AMERICAN
HEART
JOURNAL
muscle was suspended. Smaller doses increased the force of contraction, and still smaller doses were ineffective. With large doses slowing of the rate of contraction was only observed associated with diminution of force. Frequently, however, the force of contraction was diminished without slowing. No reduction of tonic activity of the auricular muscle was observed. The action of these compounds depends not so much on the absolute amount but on the effective concentration inside the cell. This applies to acetylcholine and doryl, and to a smaller extent to cholinechloride and cholazyl. It is suggested that this explains the variable responses obtained with equal doses on the same auricular strip. The auricular strip of the rabbit’s heart is suitable for tho assay of unknown .
Zimmermann, Wien. klin.
0.: Pathogenesis of Gonococcal Wchnschr. 49: 1518, 1936.
Arthritis,
Endocarditis,
and
Sepsis.
A case report is presented with a late involvement of the heart in the form of inflammatory perforation of the aorta through the ventricular septum into the right ventricle. There was a nonarthritic involvement eighteen years after gonorrhea1 urethral infection and the cardiac complication occurred six years after the joint involvement. This last was associated with mitral, aortic valvulitis, and gonorrhea1 sepsis. The aortic valvulitis was superimposed on a congenital bicuspid valve with stenosis. L. N. K. HolzlShner, Flow of Biol. 97:
E. : The Respiratory Blood to the Heart. 409, 1936.
Pulse (Cardiopneumogram) I. Its Relation to Posture
in
and Man.
the
Return Zt,schr. f.
A record on a man taken from the air passages during respiratory arrest showed a decrease in lung volume occurring at the onset of ejection of the heart and an increase in lung volume at the end of the ejection period. The latter indicates an augmented venous return flow into the chest greater than arterial outflow, indicating a systolic suction. In the extended posture the suction action is less; in the flexed posture, it is augmented. The greatest suction action occurs on reclining and in deep inspiration. L. N. K. Raab, W., and Friedman, and Alcoholics. Ztschr.
R.: The State of the Circulatory f. klin. Med. 130: 505, 1936.
Tree
in
Vegetarians
It was found that alcohol excess has no detrimental effect on arteriosclerosis and hypertension. The avoidance of meat does not check the development of arteriosclerosis but blood pressure and central vasomotor excitability is decreased. This is especially marked if eggs and milk products are also eliminated. L. N. K. Fabian, G., and Dyspnea Test.
Scriba, Ztschr.
J.: The Determination of f. klin. Med. 130: 773, 1936.
the
Basedow
Heart
by
the
CO, dyspnea is produced and the relation of maximum depth to the rate of breathing is determined. This was done in 33 patients with hyperthyroidism. The older the individual the more heart involvement present; the same relationship holds with regard to the increase in basal metabolism and the duration of the hyperthyroid state. L. N. K.
71i.‘,
ABSTRACTS
nervous impulses. They believe that physical transmission is at least of quai importance. They recall the usual objections to their form of experiment, namel:<. that amount of acetylcholine and site of liberation may differ from normal. J. M. R.
Thiel, K.:
Action
of Artilicial
Breathing.
Ned. Klin.
32: 633, 1936.
Dogs were asphyxiated under morphine anesthesia until no flow could be measured in the carotid artery with a Rein stromuhr. The heart was revived by massage anIl by artificial breathing. While blood flow quickly returned to normal, the electricardiogram remained abnormal for some time. The use of 0, rich air did not :tff~t the rate of restoration. Cardiazol and sympatol, however, did. L. KY. K.
Gotsev, T.:
Vasomotor
Centers I.
Pfliiger’s
Arch.
f. d. ges.
Physiol.
237:
fili!).
1036. The author presents the effect of a large number of vasomotor substanres dctcrmined before and after decapitation of dogs. No difference was noted. ‘1’111: conclusion is arrived at that these vasomotor centers play little r81e in the actioil of these substances. Among substances used were pituitary derivatives, aretyl choline, lactic acid, ergotamine, caffeine, sodium herrzoate. and histamine, L. N. K.
Gollwitzer-Meier, Kl, Kramer, K., and Kriiger, E.: Action Energy of the Heart. Pfliiger’s Arch. f. d. ges. Physiol.
of Adrenalin 237:
639,
on the 1936.
Adrenalin (l/200 to l/100 mg.) increases the gaseous metabolism of thcx 11r:art alrout 3,50 per cent over normal. The peak of gaseous metaholism lags I~innd the peak of work. Hence, there is an anoxybiotic phase of increased n-ark. ‘i’hc* action of adrenalin on gaseous metabolism is decrrased in the presences of anoscrrli:~, hut unaffected by the level of venous flow and arterial resistance. The inrrP:lsPd mrtaholism is in part brought about by increased coronary flow but chit+l,v l,!. irl creased A-‘\’ O2 difference. T,. K.
Puddu, V.: 467,
The Action
of Cardiac
Nerves.
L’fiiiger’s
hrch.
f. (1. I$VS. t’hyric~l.
I<.
238:
1937.
The author found that there are two phases to the changes in the electrtlcardiogram following stimulation of the sympathetic nerves in the dog, and furthc~~ that the right and left nerve have opposite effect,s on the ventricular complex. Both nerves appear to go to all parts of the hearts. He could not demonstrate that s,-mpathin played any r81e. I~‘olloming complete A-V block on cutting both bundles in the (log, VaglIs rtilllll lation causes a slowing of the idioventriculxr pacemaker. The author attrillutc~~ this to lihcration of ncet.plcholinc-lilte snbstitnccs transported to this port
Sachs, A.: 74,
The Effect of Cholin
Bodies
on Auricular
Systole.
C’ardiol
1037.
The choline derivatives (loses required to diminish 0.S doryl, 1 cholinechloride,
which were investigated had similar the force of auricular contraction 50 cholazyl, in 40 c.c. of the fluid
actions. The smallest were 0.1 acetylcholine, in which the nmic~li:~r
1:
766
THE
AMERICAN
HEART
JOURNAL
muscle was suspended. Smaller doses increased the force of contraction, and still smaller doses were ineffective. With large doses slowing of the rate of contraction was only observed associated with diminution of force. Frequently, however, the force of contraction was diminished without slowing. No reduction of tonic activity of the auricular muscle was observed. The action of these compounds depends not so much on the absolute amount but on the effective concentration inside the cell. This applies to acetylcholine and doryl, and to a smaller extent to cholinechloride and cholazyl. It is suggested that this explains the variable responses obtained with equal doses on the same auricular strip. The auricular strip of the rabbit’s heart is suitable for tho assay of unknown .
Zimmermann, Wien. klin.
0.: Pathogenesis of Gonococcal Wchnschr. 49: 1518, 1936.
Arthritis,
Endocarditis,
and
Sepsis.
A case report is presented with a late involvement of the heart in the form of inflammatory perforation of the aorta through the ventricular septum into the right ventricle. There was a nonarthritic involvement eighteen years after gonorrhea1 urethral infection and the cardiac complication occurred six years after the joint involvement. This last was associated with mitral, aortic valvulitis, and gonorrhea1 sepsis. The aortic valvulitis was superimposed on a congenital bicuspid valve with stenosis. L. N. K. HolzlShner, Flow of Biol. 97:
E. : The Respiratory Blood to the Heart. 409, 1936.
Pulse (Cardiopneumogram) I. Its Relation to Posture
in
and Man.
the
Return Zt,schr. f.
A record on a man taken from the air passages during respiratory arrest showed a decrease in lung volume occurring at the onset of ejection of the heart and an increase in lung volume at the end of the ejection period. The latter indicates an augmented venous return flow into the chest greater than arterial outflow, indicating a systolic suction. In the extended posture the suction action is less; in the flexed posture, it is augmented. The greatest suction action occurs on reclining and in deep inspiration. L. N. K. Raab, W., and Friedman, and Alcoholics. Ztschr.
R.: The State of the Circulatory f. klin. Med. 130: 505, 1936.
Tree
in
Vegetarians
It was found that alcohol excess has no detrimental effect on arteriosclerosis and hypertension. The avoidance of meat does not check the development of arteriosclerosis but blood pressure and central vasomotor excitability is decreased. This is especially marked if eggs and milk products are also eliminated. L. N. K. Fabian, G., and Dyspnea Test.
Scriba, Ztschr.
J.: The Determination of f. klin. Med. 130: 773, 1936.
the
Basedow
Heart
by
the
CO, dyspnea is produced and the relation of maximum depth to the rate of breathing is determined. This was done in 33 patients with hyperthyroidism. The older the individual the more heart involvement present; the same relationship holds with regard to the increase in basal metabolism and the duration of the hyperthyroid state. L. N. K.